Salvador Martinez

Summary

Country: Spain

Publications

  1. doi request reprint Cerebellar oligodendroglial cells have a mesencephalic origin
    Nora Mecklenburg
    Instituto de Neurociencias UMH CSIC, Universidad Miguel Hernandez, San Juan, Alicante, Spain
    Glia 59:1946-57. 2011
  2. pmc Molecular regionalization of the diencephalon
    Almudena Martinez-Ferre
    Instituto de Neurociencias, UMH CSIC Alicante, Spain
    Front Neurosci 6:73. 2012
  3. pmc Mesenchymal stromal-cell transplants induce oligodendrocyte progenitor migration and remyelination in a chronic demyelination model
    J Jaramillo-Merchán
    Neuroscience Institute, University Miguel Hernandez Spanish Council for Scientific Research UMH CSIC, Alicante, Spain
    Cell Death Dis 4:e779. 2013
  4. pmc Cellular and molecular basis of cerebellar development
    Salvador Martinez
    Experimental Embryology Lab, Consejo Superior de Investigaciones Cientificas, Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Alicante, Spain
    Front Neuroanat 7:18. 2013
  5. doi request reprint The development of the thalamic motor learning area is regulated by Fgf8 expression
    Almudena Martinez-Ferre
    Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, 03550 San Juan de Alicante, Spain
    J Neurosci 29:13389-400. 2009
  6. pmc Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling
    Noelia Urbán
    Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, IDIBAPS, Universitat de Barcelona, C Casanova 143, 08036 Barcelona, Spain
    Neural Dev 5:21. 2010
  7. doi request reprint Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes-diencephalic basal plate
    Juan Antonio Moreno-Bravo
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Cientificas, and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Dev Dyn 239:2094-101. 2010
  8. doi request reprint Oligodendrocyte precursors originate in the parabasal band of the basal plate in prosomere 1 and migrate into the alar prosencephalon during chick development
    Raquel Garcia-Lopez
    Developmental Biology Unit, Instituto de Neurociencias, UMH CSIC, Alicante, Spain
    Glia 58:1437-50. 2010
  9. doi request reprint Human adult periodontal ligament-derived cells integrate and differentiate after implantation into the adult mammalian brain
    Carlos Bueno
    Instituto de Neurociencias de Alicante UMH CSIC, Sant Juan, Alicante, Spain
    Cell Transplant 22:2017-28. 2013
  10. ncbi request reprint Changes in liver and plasma acetylcholinesterase in rats with cirrhosis induced by bile duct ligation
    M Salud García-Ayllón
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, San Juan de Alicante, Spain
    Hepatology 43:444-53. 2006

Collaborators

Detail Information

Publications36

  1. doi request reprint Cerebellar oligodendroglial cells have a mesencephalic origin
    Nora Mecklenburg
    Instituto de Neurociencias UMH CSIC, Universidad Miguel Hernandez, San Juan, Alicante, Spain
    Glia 59:1946-57. 2011
    ..As a result, the majority of the cerebellar oligodendrocytes originate from the parabasal plate of the mesencephalon...
  2. pmc Molecular regionalization of the diencephalon
    Almudena Martinez-Ferre
    Instituto de Neurociencias, UMH CSIC Alicante, Spain
    Front Neurosci 6:73. 2012
    ..We will review some experimental data to approach the study of the molecular regulation of diencephalic regionalization, with special interest in the cellular mechanisms underlying planar inductions...
  3. pmc Mesenchymal stromal-cell transplants induce oligodendrocyte progenitor migration and remyelination in a chronic demyelination model
    J Jaramillo-Merchán
    Neuroscience Institute, University Miguel Hernandez Spanish Council for Scientific Research UMH CSIC, Alicante, Spain
    Cell Death Dis 4:e779. 2013
    ..In conclusion, we demonstrate here that in chronic demyelinated white matter, BM-MSC transplantation activates oligodendrocyte progenitors and induces remyelination in the tissue surrounding the stem cell graft...
  4. pmc Cellular and molecular basis of cerebellar development
    Salvador Martinez
    Experimental Embryology Lab, Consejo Superior de Investigaciones Cientificas, Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez Alicante, Spain
    Front Neuroanat 7:18. 2013
    ....
  5. doi request reprint The development of the thalamic motor learning area is regulated by Fgf8 expression
    Almudena Martinez-Ferre
    Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, 03550 San Juan de Alicante, Spain
    J Neurosci 29:13389-400. 2009
    ..This region specializes to permit the development of adaptive control of the motor function in the vertebrate brain...
  6. pmc Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling
    Noelia Urbán
    Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, IDIBAPS, Universitat de Barcelona, C Casanova 143, 08036 Barcelona, Spain
    Neural Dev 5:21. 2010
    ..Nolz1 is a zinc finger transcription factor whose expression is enriched in the lateral ganglionic eminence (LGE), although its function is still unknown...
  7. doi request reprint Dynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes-diencephalic basal plate
    Juan Antonio Moreno-Bravo
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Cientificas, and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Dev Dyn 239:2094-101. 2010
    ..The nuclei integrated in this domain would be the rostral interstitial nucleus, the interstitial nucleus of Cajal, and a mesencephalic equivalent to these nuclei...
  8. doi request reprint Oligodendrocyte precursors originate in the parabasal band of the basal plate in prosomere 1 and migrate into the alar prosencephalon during chick development
    Raquel Garcia-Lopez
    Developmental Biology Unit, Instituto de Neurociencias, UMH CSIC, Alicante, Spain
    Glia 58:1437-50. 2010
    ....
  9. doi request reprint Human adult periodontal ligament-derived cells integrate and differentiate after implantation into the adult mammalian brain
    Carlos Bueno
    Instituto de Neurociencias de Alicante UMH CSIC, Sant Juan, Alicante, Spain
    Cell Transplant 22:2017-28. 2013
    ..The engraftment and differentiation properties of hPDL-derived cells in the adult brain indicate that they are a potential stem cell source to be used in neuroregenerative and/or neurotrophic medicine. ..
  10. ncbi request reprint Changes in liver and plasma acetylcholinesterase in rats with cirrhosis induced by bile duct ligation
    M Salud García-Ayllón
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, San Juan de Alicante, Spain
    Hepatology 43:444-53. 2006
    ..In conclusion, the liver is an important source of serum AChE; altered AChE levels may be a useful biomarker for liver cirrhosis...
  11. doi request reprint Pallial origin of basal forebrain cholinergic neurons in the nucleus basalis of Meynert and horizontal limb of the diagonal band nucleus
    Ana Pombero
    Instituto de Neurociencias, 03550 San Juan, Alicante, Spain
    Development 138:4315-26. 2011
    ..Also, we demonstrate that Fgf8 signaling in the telencephalic midline attracts these neurons from the pallium to follow a tangential migratory route towards the basal forebrain...
  12. doi request reprint Wnt signal specifies the intrathalamic limit and its organizer properties by regulating Shh induction in the alar plate
    Almudena Martinez-Ferre
    Institute of Neurosciences, Miguel Hernández University Spanish National Research Council, 03550 San Juan, Alicante, Spain
    J Neurosci 33:3967-80. 2013
    ..Early Wnt expression in the ZLI regulates Gli3 and L-fng to generate a permissive territory in which Shh is progressively induced by planar signals of the basal plate...
  13. pmc Brain cholinergic impairment in liver failure
    María Salud García-Ayllón
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, San Juan de Alicante, Spain
    Brain 131:2946-56. 2008
    ..In conclusion, this study is the first direct evidence of a cholinergic imbalance in the brain as a consequence of liver failure and points to the possible role of the cholinergic system in the pathogenesis of hepatic encephalopathy...
  14. ncbi request reprint Haematopoietic progenitor cells from adult bone marrow differentiate into cells that express oligodendroglial antigens in the neonatal mouse brain
    Sonia Bonilla
    Instituto de Neurociencias, UMH CSIC, Campus San Juan, Alicante, Spain
    Eur J Neurosci 15:575-82. 2002
    ....
  15. doi request reprint Shh dependent and independent maintenance of basal midbrain
    Ariadna Perez-Balaguer
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, Sant Joan d Alacant, Spain
    Mech Dev 126:301-13. 2009
    ..Based on our results and recently published data, we suggest the existence of a specific genetic pathway for the specification of the mesencephalic red nucleus. Foxa2 could be the candidate gene that might control this genetic pathway...
  16. ncbi request reprint Thalamic development induced by Shh in the chick embryo
    Claudia Vieira
    Neuroscience Institute, Miguel Hernandez University N 332, Km 87, E 03550 Alicante, Spain
    Dev Biol 284:351-63. 2005
    ..Overall, these results indicate that Shh expressed in the ZLI plays an important role in diencephalic growth and in the development of the thalamus...
  17. doi request reprint Developmental dynamics of PAFAH1B subunits during mouse brain development
    Teresa Escámez
    Unidad Mixta de Investigación UVEG UMH CIBERSAM, Centro de Investigación Biomédica en Red en el Area de Salud Mental, 03550 San Juan de Alicante, Spain
    J Comp Neurol 520:3877-94. 2012
    ....
  18. pmc Fgf8-related secondary organizers exert different polarizing planar instructions along the mouse anterior neural tube
    Ivan Crespo-Enríquez
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, Alicante, Spain
    PLoS ONE 7:e39977. 2012
    ....
  19. pmc Stem cells from wildtype and Friedreich's ataxia mice present similar neuroprotective properties in dorsal root ganglia cells
    Jonathan Jones
    Department of Experimental Embryology, Neuroscience Institute Miguel Hernandez University UMH CSIC, Alicante, Spain
    PLoS ONE 8:e62807. 2013
    ..The results presented confirm the possibility that autologous stem cell transplantation may be a viable therapeutic approach in protecting dorsal root ganglia neurons of Friedreich's ataxia patients...
  20. doi request reprint Expression analysis of Sulf1 in the chick forebrain at early and late stages of development
    Raquel Garcia-Lopez
    Institute of Neuroscience UMH CSIC, Campus de San Juan, San Juan, Alicante, Spain
    Dev Dyn 238:2418-29. 2009
    ..Later in development, Sulf1 is expressed by a subset of nuclei derived from these regions...
  21. doi request reprint Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice
    Maria Ximena Silveyra
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Sant Joan d Alacant, Spain
    Neurobiol Aging 33:624.e23-34. 2012
    ..Colocalization of human P-tau and AChE supports the conclusion that P-tau can act to increase AChE. This study is the first direct evidence of a modulatory effect of P-tau on brain AChE expression...
  22. doi request reprint Molecular mechanisms controlling brain development: an overview of neuroepithelial secondary organizers
    Claudia Vieira
    Alicante Neuroscience Institute, Miguel Hernandez University, CSIC, San Juan de Alicante, Alicante, Spain
    Int J Dev Biol 54:7-20. 2010
    ..We will pay special attention to the cellular and molecular mechanisms involved in neural tube regionalization and the key role played by localized secondary organizers in the patterning of neural primordia...
  23. ncbi request reprint Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer
    Diego Echevarria
    Instituto de Neurociencias, University of Miguel Hernández UMH CSIC, Carretera de Valencia N 332, Campus de San Juan, 03550 Alicante, Spain
    Dev Biol 277:114-28. 2005
    ..Here, we demonstrate that MKP3 has a negative feedback action on the MAPK/ERK-mediated FGF8 pathway in the mouse neuroepithelium...
  24. pmc Red nucleus and rubrospinal tract disorganization in the absence of Pou4f1
    Jesus E Martinez-Lopez
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez, Consejo Superior de Investigaciones Cient ficas UMH CSIC San Juan de Alicante, Alicante, Spain
    Front Neuroanat 9:8. 2015
    ..These data suggest that Pou4f1 is necessary for the maturation of RN neurons but not for their specification and maintenance...
  25. pmc Mesencephalic basolateral domain specification is dependent on Sonic Hedgehog
    Jesus E Martinez-Lopez
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez, Consejo Superior de Investigaciones Cient ficas UMH CSIC Alicante, Spain
    Front Neuroanat 9:12. 2015
    ..In this study we confirmed the localization of the alar-basal boundary dorsal to the BL domain and demonstrated that the development of the BL domain highly depends on Shh...
  26. pmc Developmental guidance of the retroflex tract at its bending point involves Robo1-Slit2-mediated floor plate repulsion
    Juan A Moreno-Bravo
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Sant Joan d Alacant, 03550, Alicante, Spain
    Brain Struct Funct 221:665-78. 2016
    ..This pathfinding mechanism is essential to establish the functionally important habenulo-interpeduncular connection. ..
  27. ncbi request reprint Postnatal alterations of the inhibitory synaptic responses recorded from cortical pyramidal neurons in the Lis1/sLis1 mutant mouse
    Lourdes Valdés-Sánchez
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Campus de San Juan, Apartado 18, San Juan, 03550 Alicante, Spain
    Mol Cell Neurosci 35:220-9. 2007
    ..These results demonstrate the presence of functional alterations in the postnatal Lis1/sLis1 cortex and point to abnormalities in GABAA receptor subunit switching processes during postnatal development...
  28. doi request reprint Telencephalic morphogenesis during the process of neurulation: an experimental study using quail-chick chimeras
    Ana Pombero
    Instituto de Neurociencias, UMH CSIC, San Juan, Alicante, Spain
    J Comp Neurol 512:784-97. 2009
    ....
  29. doi request reprint Mesenchymal stem cells rescue Purkinje cells and improve motor functions in a mouse model of cerebellar ataxia
    Jonathan Jones
    Neuroscience Institute, University Miguel Hernandez UMH CSIC, San Juan, Alicante, Spain
    Neurobiol Dis 40:415-23. 2010
    ..This is an adequate and feasible model that could be translated into a therapeutic approach for clinical assays in neurodegenerative diseases...
  30. ncbi request reprint Fate map of the diencephalon and the zona limitans at the 10-somites stage in chick embryos
    Raquel Garcia-Lopez
    Instituto de Neurociencias, UMH CSIC, Universidad Miguel Hernandez, Alicante, Spain
    Dev Biol 268:514-30. 2004
    ..Moreover, we show that the presumptive epithelium of ZLI can be localized at early developmental stages in the diencephalic alar plate at the anterior limit of the Wnt8b gene expression domain...
  31. ncbi request reprint Reelin is overexpressed in the liver and plasma of bile duct ligated rats and its levels and glycosylation are altered in plasma of humans with cirrhosis
    Arancha Botella-Lopez
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Sant Joan d Alacant, Spain
    Int J Biochem Cell Biol 40:766-75. 2008
    ....
  32. doi request reprint Fate map of the chick embryo neural tube
    Raquel Garcia-Lopez
    Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, Av Ramon y Cajal s n, San Juan de Alicante, 03550, Spain
    Dev Growth Differ 51:145-65. 2009
    ..This analysis is mainly focused on experimental fate mapping results using quail-chick chimeras...
  33. pmc Differences in number and distribution of striatal calbindin medium spiny neurons between a vocal-learner (Melopsittacus undulatus) and a non-vocal learner bird (Colinus virginianus)
    Elena Garcia-Calero
    Department of Experimental Embryology, Instituto de Neurociencias, Universidad Miguel Hern ndez Consejo Superior de Investigaciones Cient ficas San Juan, Alicante, Spain
    Front Neuroanat 7:46. 2013
    ....
  34. pmc Mesencephalic origin of the rostral Substantia nigra pars reticulata
    M Pilar Madrigal
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, 03550, Sant Joan d Alacant, Alicante, Spain
    Brain Struct Funct 221:1403-12. 2016
    ..Understanding the development, molecular identity and functional characteristics of these diverse neuronal populations might lead to better diagnosis and treatment of several forms of neurological and psychiatric disease. ..
  35. pmc Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation
    Maria Ximena Silveyra
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Crta Alicante Valencia Km 87, Sant Joan d Alacant E 03550, Spain
    Mol Cell Biol 28:2908-19. 2008
    ..The results indicate that PS1 can interact with AChE and influence its expression, supporting the notion of cholinergic-amyloid interrelationships...
  36. ncbi request reprint Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration
    Carmen Cabanes
    Instituto de Neurociencias, Universidad Miguel Hernandez CSIC, E 03550 San Juan de Alicante, Alicante, Spain
    Neurobiol Dis 26:408-18. 2007
    ..Thus, these experiments demonstrate the neuroprotective effect of adult hSCs in the model employed and indicate that this cell type may contribute to ameliorating motor function in degenerative spinal motor diseases...