M Navarro

Summary

Country: Spain

Publications

  1. pmc Glossina palpalis palpalis populations from Equatorial Guinea belong to distinct allopatric clades
    Carlos Cordon-Obras
    Centro Nacional de Medicina Tropical, Instituto de Salud Carlos III, Sinesio Delgado, 4, Pabellón 13, Madrid 28029, Spain
    Parasit Vectors 7:31. 2014
  2. pmc Nuclear repositioning of the VSG promoter during developmental silencing in Trypanosoma brucei
    David Landeira
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Spanish National Research Council, 18100 Granada, Spain
    J Cell Biol 176:133-9. 2007
  3. pmc Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity
    Carlos Cordon-Obras
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Consejo Superior de Investigaciones Cientificas, Granada, Spain
    PLoS ONE 8:e85072. 2013
  4. ncbi request reprint A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei
    M Navarro
    Present address Instituto de Parasitología y Biomedicina López Neyra, CSIC, C Ventanilla 11, 18001 Granada, Spain
    Nature 414:759-63. 2001
  5. ncbi request reprint Nuclear architecture underlying gene expression in Trypanosoma brucei
    Miguel Navarro
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Científicas Spanish National Research Council, Avda del Conocimiento s n, 18100 Granada, Spain
    Trends Microbiol 15:263-70. 2007
  6. pmc Cohesin regulates VSG monoallelic expression in trypanosomes
    David Landeira
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, 18100 Granada, Spain
    J Cell Biol 186:243-54. 2009
  7. ncbi request reprint Increased glucagon-like peptide-1 receptor expression in glia after mechanical lesion of the rat brain
    J A Chowen
    Department of Psychobiology, Instituto Cajal C S I C, Madrid, Spain
    Neuropeptides 33:212-5. 1999
  8. ncbi request reprint Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia
    M D Julian
    Instituto Cajal C S I C, Dr Arce 37, 28002 Madrid, Spain
    Neuroscience 119:309-18. 2003
  9. pmc RNA pol II subunit RPB7 is required for RNA pol I-mediated transcription in Trypanosoma brucei
    Xenia Peñate
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, CSIC Spanish National Research Council, Avda del Conocimiento s n, 18100 Granada, Spain
    EMBO Rep 10:252-7. 2009
  10. ncbi request reprint Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1h-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif
    Nadine Jagerovic
    Instituto de Química Médica, Consejo Superior de Investigaciones Cientificas, Juan de la Cierva, 3, E 28006 Madrid, Spain
    J Med Chem 47:2939-42. 2004

Collaborators

  • Agustin Benito
  • K Gull
  • F Rodriguez De Fonseca
  • Nadine Jagerovic
  • Jose L Crespo
  • D Piomelli
  • Carlos Cordon-Obras
  • Roberto Ciccocioppo
  • Emilio Fernandez Espejo
  • J A Chowen
  • M D Julian
  • M Heilig
  • A C Hansson
  • Antonio Barquilla
  • Jose Antonio Lopez-Moreno
  • Ainhoa Bilbao
  • David Landeira
  • Gustavo González-Cuevas
  • Belen Ferrer
  • Andrea Cippitelli
  • Miguel Angel Gorriti
  • Raquel Gomez
  • Xenia Peñate
  • Teresa Asúa
  • Inmaculada Crespo
  • Ana Belén Martín
  • Rosario Moratalla
  • Emilio Fernandez-Espejo
  • Francisco Javier Pavon
  • Francisco Javier Bermudez-Silva
  • Carmen Manzanedo
  • Ignacio del Arco
  • Daria Van Tyne
  • Isabel Vidal
  • Jean Mathieu Bart
  • Diana López-Farfán
  • Amy Wentland
  • Ana Perez-Castillo
  • Maria Scherma
  • Raquel Gómez de Heras
  • Angel Santos
  • Maria Del Mar Alvarez
  • Walter Fratta
  • Remi Martin-Fardon
  • Yolanda de Diego
  • Isolde Gornemann
  • Ana Palomino
  • Friedbert Weiss
  • Harinder Aujla
  • Pilar Goya
  • Manuel Macias
  • Antonia Serrano
  • Laura Hernandez-Folgado
  • Gumersindo Abellán
  • M A Isabel Rodríguez-Franco
  • Mauricio Massi
  • Wolfgang Sommer
  • Fernando Rodriguez de Fonseca
  • Maria A Aguilar
  • Marta Rodriguez-Arias
  • Jose Minarro
  • Felice Nava
  • Jose M Trigo

Detail Information

Publications26

  1. pmc Glossina palpalis palpalis populations from Equatorial Guinea belong to distinct allopatric clades
    Carlos Cordon-Obras
    Centro Nacional de Medicina Tropical, Instituto de Salud Carlos III, Sinesio Delgado, 4, Pabellón 13, Madrid 28029, Spain
    Parasit Vectors 7:31. 2014
    ..The existence of cryptic species within this vector taxon has been previously suggested, although no data are available regarding the evolutionary history of tsetse flies populations in Bioko...
  2. pmc Nuclear repositioning of the VSG promoter during developmental silencing in Trypanosoma brucei
    David Landeira
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Spanish National Research Council, 18100 Granada, Spain
    J Cell Biol 176:133-9. 2007
    ..Subsequently, the VSG promoter region was subjected to chromatin condensation. We propose a model whereby the VSG expression site pol I promoter is selectively targeted by temporal nuclear repositioning during developmental silencing...
  3. pmc Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity
    Carlos Cordon-Obras
    Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Consejo Superior de Investigaciones Cientificas, Granada, Spain
    PLoS ONE 8:e85072. 2013
    ..These results suggest a better suitability of swine to maintain T. b. gambiense infection supporting previous epidemiological results. ..
  4. ncbi request reprint A pol I transcriptional body associated with VSG mono-allelic expression in Trypanosoma brucei
    M Navarro
    Present address Instituto de Parasitología y Biomedicina López Neyra, CSIC, C Ventanilla 11, 18001 Granada, Spain
    Nature 414:759-63. 2001
    ..We propose that the recruitment of a single expression site and the concomitant exclusion of inactive loci from a discrete transcriptional body define the mechanism responsible for VSG mono-allelic expression...
  5. ncbi request reprint Nuclear architecture underlying gene expression in Trypanosoma brucei
    Miguel Navarro
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Científicas Spanish National Research Council, Avda del Conocimiento s n, 18100 Granada, Spain
    Trends Microbiol 15:263-70. 2007
    ..Here, we discuss recent advances in understanding the role of chromosomal nuclear positioning in the regulation of gene expression in T. brucei...
  6. pmc Cohesin regulates VSG monoallelic expression in trypanosomes
    David Landeira
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, 18100 Granada, Spain
    J Cell Biol 186:243-54. 2009
    ..Thus, in addition to maintaining sister chromatid cohesion during mitosis, the cohesin complex plays an essential role in the correct epigenetic inheritance of the active transcriptional VSG ES state...
  7. ncbi request reprint Increased glucagon-like peptide-1 receptor expression in glia after mechanical lesion of the rat brain
    J A Chowen
    Department of Psychobiology, Instituto Cajal C S I C, Madrid, Spain
    Neuropeptides 33:212-5. 1999
    ....
  8. ncbi request reprint Neuroanatomical relationship between type 1 cannabinoid receptors and dopaminergic systems in the rat basal ganglia
    M D Julian
    Instituto Cajal C S I C, Dr Arce 37, 28002 Madrid, Spain
    Neuroscience 119:309-18. 2003
    ..In conclusion, these data provide a neuroanatomical basis to explain functional interactions between endocannabinoid and dopaminergic systems in the basal ganglia...
  9. pmc RNA pol II subunit RPB7 is required for RNA pol I-mediated transcription in Trypanosoma brucei
    Xenia Peñate
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, CSIC Spanish National Research Council, Avda del Conocimiento s n, 18100 Granada, Spain
    EMBO Rep 10:252-7. 2009
    ..These results represent a unique example of a functional RNA polymerase chimaera consisting of a core pol I complex that recruits a specific pol II subunit...
  10. ncbi request reprint Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1h-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif
    Nadine Jagerovic
    Instituto de Química Médica, Consejo Superior de Investigaciones Cientificas, Juan de la Cierva, 3, E 28006 Madrid, Spain
    J Med Chem 47:2939-42. 2004
    ..It did not have intrinsic activity in these bioassays, and therefore, it did not behave as a partial agonist or an inverse agonist...
  11. ncbi request reprint Trypanosome TOR complex 2 functions in cytokinesis
    Antonio Barquilla
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, CSIC, Spanish National Research Council, Avda del Conocimiento s n, Granada, Spain
    Cell Cycle 8:697-9. 2009
    ....
  12. pmc Rapamycin inhibits trypanosome cell growth by preventing TOR complex 2 formation
    Antonio Barquilla
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Avenida del Conocimiento s n, 18100 Granada, Spain
    Proc Natl Acad Sci U S A 105:14579-84. 2008
    ....
  13. ncbi request reprint Trypanosome TOR as a major regulator of cell growth and autophagy
    Antonio Barquilla
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, CSIC, Spanish National Research Council, Granada, Spain
    Autophagy 5:256-8. 2009
    ....
  14. doi request reprint Changed accumbal responsiveness to alcohol in rats pre-treated with nicotine or the cannabinoid receptor agonist WIN 55,212-2
    Jose Antonio Lopez-Moreno
    Laboratory of Psychobiology, Faculty of Psychology, Campus de Somosaguas, Complutense University of Madrid, 28223, Madrid, Spain
    Neurosci Lett 433:1-5. 2008
    ..Therefore, cannabinoid and nicotine exposure may have important implications on the rewarding effects of alcohol, because these drugs lead to long-lasting changes in accumbal dopamine transmission...
  15. ncbi request reprint Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats
    Miguel Navarro
    Instituto Complutense de Drogodependencias, Departamento de Psicobiologia, Facultad de Psicologia, Universidad Complutense de Madrid, Spain
    Eur J Pharmacol 501:235-7. 2004
    ..03-3.0 mg/kg) suppresses heroin self-administration only in opiate-dependent rats but not in non-dependent animals. These results further support the study of cannabinoid CB(1) receptor antagonists for the treatment of opiate addiction...
  16. ncbi request reprint A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding
    Raquel Gomez
    University Institute of Drug Dependencies, Department of Psychobiology, University Complutense of Madrid, Madrid 28223, Spain
    J Neurosci 22:9612-7. 2002
    ..Pretreatment with SR141716A enhanced the inhibition of feeding induced by intraperitoneal administration of oleoylethanolamide. The results reveal an unexpected role for peripheral CB1 receptors in the regulation of feeding...
  17. doi request reprint Implication of the endocannabinoid system in the locomotor hyperactivity associated with congenital hypothyroidism
    Teresa Asúa
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense 28040 Madrid, Spain
    Endocrinology 149:2657-66. 2008
    ..Thus, the present study suggests that impairment in the endocannabinoid system can underlay the hyperactive phenotype associated with hypothyroidism...
  18. ncbi request reprint Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors
    Ana Belén Martín
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Neuropsychopharmacology 33:1667-79. 2008
    ..This study indicates that the endocannabinoid system is a relevant negative modulator of both dopamine D1 and D2 receptor-mediated behaviors, a finding that may contribute to our understanding of basal ganglia motor disorders...
  19. ncbi request reprint Pretreatment with subeffective doses of Rimonabant attenuates orexigenic actions of orexin A-hypocretin 1
    Inmaculada Crespo
    Departamento de Psicobiologia, Facultad de Psicologia, Universidad Complutense de Madrid, Campus de Somosaguas E 28223 Madrid, Spain
    Neuropharmacology 54:219-25. 2008
    ....
  20. ncbi request reprint Cannabinoid agonist-induced sensitisation to morphine place preference in mice
    Carmen Manzanedo
    Departamento de Psicobiologia, Facultad de Psicologia, Universidad Complutense de Madrid, 28223 Madrid, Spain
    Neuroreport 15:1373-7. 2004
    ..Our results suggest the existence of cross-talk between cannabinoids and opiates on the sensitisation to morphine and the implication of the endocannabinoid system in the process of sensitisation to opiates...
  21. ncbi request reprint Cannabinoid CB1 receptor antagonism markedly increases dopamine receptor-mediated stereotypies
    Belen Ferrer
    Fundacion IMABIS, Hospital Carlos Haya, Malaga 29010, Spain
    Eur J Pharmacol 559:180-3. 2007
    ..05, 0.1 and 1 mg/kg) and the dopamine D2 receptor agonist quinpirole (0.25 mg/kg). Thus, the endocannabinoid system acts as a brake for abnormal behavior associated with dopaminergic overactivation...
  22. ncbi request reprint Long-lasting increase of alcohol relapse by the cannabinoid receptor agonist WIN 55,212-2 during alcohol deprivation
    Jose Antonio Lopez-Moreno
    Departamento de Psicobiologia, Facultad de Psicologia, Universidad Complutense de Madrid, E 28223 Madrid, Spain
    J Neurosci 24:8245-52. 2004
    ....
  23. ncbi request reprint Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21
    Francisco Javier Pavon
    Fundacion IMABIS, Neuropharmacology, Hospital Carlos Haya, Avenida Carlos Haya 82, 7 a planta, Pabellon A, Malaga 29010, Spain
    Neuropharmacology 51:358-66. 2006
    ....
  24. ncbi request reprint Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats
    Andrea Cippitelli
    Fundacion Hospital Carlos Haya, Avenida Carlos Haya 82, 7 Planta, Pabellon A, 29010 Malaga, Spain
    Eur J Neurosci 21:2243-51. 2005
    ..In addition, current pharmacological and neuroanatomical data suggest that an altered function of the CB1 receptor system exists between genetically selected alcohol-preferring msP rats and a heterogeneous animal population...
  25. ncbi request reprint The endocannabinoid system: physiology and pharmacology
    Fernando Rodriguez de Fonseca
    Fundacion IMABIS, Hospital Carlos Haya de Malaga, Avenida Carlos Haya 82, 29010 Malaga, Spain
    Alcohol Alcohol 40:2-14. 2005
    ..Recent advances have specifically linked the endogenous cannabinoid system to alcoholism, and cannabinoid receptor antagonism now emerges as a promising therapeutic alternative for alcohol dependence and relapse...
  26. ncbi request reprint Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior
    Gustavo González-Cuevas
    Laboratorio de Psicobiologia, Facultad de Psicologia, Universidad Complutense de Madrid, Campus de Somosaguas S N, E 28223, Pozuelo de Alarcon, Madrid, Spain
    Neuropsychopharmacology 32:2260-6. 2007
    ..However, further studies will be necessary to understand possible implications of these findings for a role of the cannabinoid system as a treatment target for human cocaine abuse...