Eva Siles

Summary

Country: Spain

Publications

  1. doi request reprint Hydroxytyrosol decreases the oxidative and nitrosative stress levels and promotes angiogenesis through HIF-1 independent mechanisms in renal hypoxic cells
    Esther Martinez-Lara
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, 23071 Jaen, Spain
    Food Funct 7:540-8. 2016
  2. ncbi request reprint Age modulates the nitric oxide system response in the ischemic cerebellum
    Santos Blanco
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, 23071, Jaen, Spain
    Brain Res 1157:66-73. 2007
  3. pmc Study of the nitric oxide system in the rat cerebellum during aging
    Santos Blanco
    Department of Experimental Biology, University of Jaen, Campus Las Lagunillas s n, 23071, Jaen, Spain
    BMC Neurosci 11:78. 2010
  4. ncbi request reprint Immunohistochemistry of neuronal nitric oxide synthase and protein nitration in the striatum of the aged rat
    Maria Luisa del Moral
    Department of Experimental Biology, University of Jaen, Jaen, Spain
    Microsc Res Tech 64:304-11. 2004
  5. doi request reprint Nitric oxide modulates hypoxia-inducible factor-1 and poly(ADP-ribose) polymerase-1 cross talk in response to hypobaric hypoxia
    Rubén Martínez-Romero
    Department of Experimental Biology, University of Jaen, Jaen, Spain
    J Appl Physiol (1985) 112:816-23. 2012
  6. pmc Steatosis recovery after treatment with a balanced sunflower or olive oil-based diet: involvement of perisinusoidal stellate cells
    Raquel Hernandez
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, E 23071 Jaén, Spain
    World J Gastroenterol 11:7480-5. 2005
  7. ncbi request reprint Glutathione S-transferase isoenzymatic response to aging in rat cerebral cortex and cerebellum
    Esther Martinez-Lara
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, 23071, Jaen, Spain
    Neurobiol Aging 24:501-9. 2003
  8. doi request reprint The hypoxic preconditioning agent deferoxamine induces poly(ADP-ribose) polymerase-1-dependent inhibition of the mitochondrial respiratory chain
    Ana Cañuelo
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, 23071, Jaen, Spain
    Mol Cell Biochem 363:101-8. 2012
  9. doi request reprint PARP-1 modulates deferoxamine-induced HIF-1alpha accumulation through the regulation of nitric oxide and oxidative stress
    Rubén Martínez-Romero
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, 23071 Jaen, Spain
    J Cell Biochem 104:2248-60. 2008
  10. doi request reprint Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans
    Ana Cañuelo
    Departamento de Biologia Experimental, Universidad de Jaen, Edif B 3, 23071 Jaen, Spain
    Mech Ageing Dev 133:563-74. 2012

Collaborators

  • Ana Cañuelo
  • Maria A Peinado
  • Antonio Miranda-Vizuete
  • Alma Rus
  • Esther Martinez-Lara
  • Santos Blanco
  • Raquel Hernandez
  • Rubén Martínez-Romero
  • Maria Luisa del Moral
  • Ana Jimenez
  • Juan Angel Pedrosa
  • F Javier Oliver
  • Lourdes Castro
  • Ana Pena
  • Jesús Calahorra
  • Francisco J Molina
  • Maria L Del Moral
  • Andreina Peralta
  • Rocío Aguilar-Quesada
  • Alharilla Ruiz
  • Francisco José Esteban
  • Gloria Viedma
  • Francisco Javier Molina
  • Juan C López-Ramos
  • Francisco J Esteban
  • M Luisa del Moral
  • Juan A Pedrosa

Detail Information

Publications11

  1. doi request reprint Hydroxytyrosol decreases the oxidative and nitrosative stress levels and promotes angiogenesis through HIF-1 independent mechanisms in renal hypoxic cells
    Esther Martinez-Lara
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, 23071 Jaen, Spain
    Food Funct 7:540-8. 2016
    ..In conclusion, our results suggest that in renal hypoxia, HT treatment might act as an effective preventive therapeutic approach to decrease stress and to improve the adaptive response to this pathological situation. ..
  2. ncbi request reprint Age modulates the nitric oxide system response in the ischemic cerebellum
    Santos Blanco
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, 23071, Jaen, Spain
    Brain Res 1157:66-73. 2007
    ....
  3. pmc Study of the nitric oxide system in the rat cerebellum during aging
    Santos Blanco
    Department of Experimental Biology, University of Jaen, Campus Las Lagunillas s n, 23071, Jaen, Spain
    BMC Neurosci 11:78. 2010
    ..Consequently, in the present study, we investigate the expression, location, and activity of nitric oxide synthase isoenzymes; the protein nitration; and the production of nitric oxide in the cerebellum of adult and old rats...
  4. ncbi request reprint Immunohistochemistry of neuronal nitric oxide synthase and protein nitration in the striatum of the aged rat
    Maria Luisa del Moral
    Department of Experimental Biology, University of Jaen, Jaen, Spain
    Microsc Res Tech 64:304-11. 2004
    ..Taken together, these results support the contention that NADPH-d staining is not such an unambiguous marker for nNOS, and that increased protein nitration may participate in striatal aging...
  5. doi request reprint Nitric oxide modulates hypoxia-inducible factor-1 and poly(ADP-ribose) polymerase-1 cross talk in response to hypobaric hypoxia
    Rubén Martínez-Romero
    Department of Experimental Biology, University of Jaen, Jaen, Spain
    J Appl Physiol (1985) 112:816-23. 2012
    ..As a whole, these results provide new data about the molecular mechanism underlying the beneficial effects of controlling NO production under hypobaric hypoxic conditions...
  6. pmc Steatosis recovery after treatment with a balanced sunflower or olive oil-based diet: involvement of perisinusoidal stellate cells
    Raquel Hernandez
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, E 23071 Jaén, Spain
    World J Gastroenterol 11:7480-5. 2005
    ..To analyze the relationship between perisinusoidal stellate cell (PSC) activation and the dietary fat quantity and composition in the treatment of hepatic steatosis...
  7. ncbi request reprint Glutathione S-transferase isoenzymatic response to aging in rat cerebral cortex and cerebellum
    Esther Martinez-Lara
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, 23071, Jaen, Spain
    Neurobiol Aging 24:501-9. 2003
    ..The GSTA4 and GSTP1 expression increased from young to adult/aged brain and GSTA4 even augmented in the aged cerebral cortex. These results suggest a GST isoenzymatic response with aging, but above all with the maturation process...
  8. doi request reprint The hypoxic preconditioning agent deferoxamine induces poly(ADP-ribose) polymerase-1-dependent inhibition of the mitochondrial respiratory chain
    Ana Cañuelo
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, 23071, Jaen, Spain
    Mol Cell Biochem 363:101-8. 2012
    ..Consequently, we recommend that PARP-1 activation be taken into account when using DFO as a hypoxia-mimetic agent, because it mediates alteration of the mitochondrial respiratory chain...
  9. doi request reprint PARP-1 modulates deferoxamine-induced HIF-1alpha accumulation through the regulation of nitric oxide and oxidative stress
    Rubén Martínez-Romero
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, 23071 Jaen, Spain
    J Cell Biochem 104:2248-60. 2008
    ..Taken together, these results suggest that the absence of PARP-1 modulates HIF-1 accumulation by reducing both NO and oxidative stress...
  10. doi request reprint Tyrosol, a main phenol present in extra virgin olive oil, increases lifespan and stress resistance in Caenorhabditis elegans
    Ana Cañuelo
    Departamento de Biologia Experimental, Universidad de Jaen, Edif B 3, 23071 Jaen, Spain
    Mech Ageing Dev 133:563-74. 2012
    ..Together, our results point to hormesis as a possible mechanism to explain the effects of tyrosol on longevity in C. elegans...
  11. ncbi request reprint Age-related changes of the nitric oxide system in the rat brain
    Eva Siles
    Department of Experimental Biology, University of Jaen, Paraje Las Lagunillas s n, E 23071, Jaen, Spain
    Brain Res 956:385-92. 2002
    ..According to these results, the NO pathway is differently modified with age in the three CNS regions analyzed...