Stefan Stamm

Summary

Publications

  1. ncbi request reprint Regulation of alternative splicing by reversible protein phosphorylation
    Stefan Stamm
    Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, 741 South Limestone, Lexington, KY 40536 0509, USA
    J Biol Chem 283:1223-7. 2008
  2. pmc The activity of the serotonin receptor 2C is regulated by alternative splicing.
    Stefan Stamm
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA
    Hum Genet 136:1079-1091. 2017
  3. pmc Molecular characterization of a patient presumed to have prader-willi syndrome
    Marina Falaleeva
    University of Kentucky, Department of Molecular and Cellular Biochemistry, South Limestone, Lexington, KY
    Clin Med Insights Case Rep 6:79-86. 2013
  4. doi request reprint The orthographic sensitivity to written Chinese in the occipital-temporal cortex
    Haicheng Liu
    Institute of Psychology, Chinese Academy of Sciences, Beijing 10010, China
    Exp Brain Res 227:387-96. 2013
  5. pmc The ER repeat protein YT521-B localizes to a novel subnuclear compartment
    O Nayler
    Max Planck Institute of Neurobiology, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    J Cell Biol 150:949-62. 2000
  6. ncbi request reprint An alternative-exon database and its statistical analysis
    S Stamm
    Institute of Biochemistry, University of Erlangen Nuremberg, Erlangen, Germany
    DNA Cell Biol 19:739-56. 2000
  7. ncbi request reprint Function of alternative splicing
    Stefan Stamm
    Institute for Biochemistry, University of Erlangen, Fahrstrasse 17, 91054 Erlangen, Germany
    Gene 344:1-20. 2005
  8. ncbi request reprint Signals and their transduction pathways regulating alternative splicing: a new dimension of the human genome
    Stefan Stamm
    Institute of Biochemistry, Fahrstrasse 17, 91054 Erlangen, Germany
    Hum Mol Genet 11:2409-16. 2002
  9. pmc Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA
    Bettina Heinrich
    Institute for Biochemistry, University of Erlangen, Fahrstrasse 17, 91054 Erlangen, Germany
    J Biol Chem 284:14303-15. 2009
  10. pmc The YTH domain is a novel RNA binding domain
    Zhaiyi Zhang
    Institute for Biochemistry, Universität Erlangen Nuremberg, Fahrstrasse 17, 91054 Erlangen, Germany
    J Biol Chem 285:14701-10. 2010

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Regulation of alternative splicing by reversible protein phosphorylation
    Stefan Stamm
    Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, 741 South Limestone, Lexington, KY 40536 0509, USA
    J Biol Chem 283:1223-7. 2008
    ..This knowledge can be applied to human diseases that are caused by the selection of wrong splice sites...
  2. pmc The activity of the serotonin receptor 2C is regulated by alternative splicing.
    Stefan Stamm
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA
    Hum Genet 136:1079-1091. 2017
    ..Thus, the 5HT2C system is a candidate for RNA therapy in multiple models of CNS disorders...
  3. pmc Molecular characterization of a patient presumed to have prader-willi syndrome
    Marina Falaleeva
    University of Kentucky, Department of Molecular and Cellular Biochemistry, South Limestone, Lexington, KY
    Clin Med Insights Case Rep 6:79-86. 2013
    ..Molecular characterization of PWS tissue donors can confirm the diagnosis and identify those patients that have been misdiagnosed...
  4. doi request reprint The orthographic sensitivity to written Chinese in the occipital-temporal cortex
    Haicheng Liu
    Institute of Psychology, Chinese Academy of Sciences, Beijing 10010, China
    Exp Brain Res 227:387-96. 2013
    ..These results together suggest that the orthographic rules are likely represented in a distributed neural network with the VWFA containing the most specific information regarding a stimulus' orthographic regularity...
  5. pmc The ER repeat protein YT521-B localizes to a novel subnuclear compartment
    O Nayler
    Max Planck Institute of Neurobiology, Max Planck Institute of Biochemistry, D 82152 Martinsried, Germany
    J Cell Biol 150:949-62. 2000
    ..On the basis of our experiments, we propose that YT521-B may participate in the assembly of genes into transcription centers, thereby allowing efficient regulation of gene expression...
  6. ncbi request reprint An alternative-exon database and its statistical analysis
    S Stamm
    Institute of Biochemistry, University of Erlangen Nuremberg, Erlangen, Germany
    DNA Cell Biol 19:739-56. 2000
    ..Together, these data indicate a combinatorial effect of weak splice sites, atypical nucleotide usage at certain positions, and functional enhancers as an important contribution to alternative-exon regulation...
  7. ncbi request reprint Function of alternative splicing
    Stefan Stamm
    Institute for Biochemistry, University of Erlangen, Fahrstrasse 17, 91054 Erlangen, Germany
    Gene 344:1-20. 2005
    ..Therefore, evidence is now accumulating that alternative splicing coordinates physiologically meaningful changes in protein isoform expression and is a key mechanism to generate the complex proteome of multicellular organisms...
  8. ncbi request reprint Signals and their transduction pathways regulating alternative splicing: a new dimension of the human genome
    Stefan Stamm
    Institute of Biochemistry, Fahrstrasse 17, 91054 Erlangen, Germany
    Hum Mol Genet 11:2409-16. 2002
    ..This is achieved by de novo protein synthesis, by regulation of the intracellular localization and by phosphorylation...
  9. pmc Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA
    Bettina Heinrich
    Institute for Biochemistry, University of Erlangen, Fahrstrasse 17, 91054 Erlangen, Germany
    J Biol Chem 284:14303-15. 2009
    ....
  10. pmc The YTH domain is a novel RNA binding domain
    Zhaiyi Zhang
    Institute for Biochemistry, Universität Erlangen Nuremberg, Fahrstrasse 17, 91054 Erlangen, Germany
    J Biol Chem 285:14701-10. 2010
    ..Our data show that the YTH domain conveys RNA binding ability to a new class of proteins that are found in all eukaryotic organisms...
  11. ncbi request reprint Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing
    Tatyana Novoyatleva
    University of Erlangen, Institute for Biochemistry, Germany
    Hum Mol Genet 17:52-70. 2008
    ..Our data indicate that the binding of PP1 to evolutionary conserved motifs in several RRMs is the link between known signal transduction pathways regulating PP1 activity and pre-mRNA processing...
  12. pmc C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1
    Chiranthani Sumanasekera
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536, USA
    Nucleic Acids Res 40:4025-39. 2012
    ..Our results indicate that lipids can influence pre-mRNA processing by regulating the phosphorylation status of specific regulatory factors, which is mediated by protein phosphatase activity...
  13. pmc Dual function of C/D box small nucleolar RNAs in rRNA modification and alternative pre-mRNA splicing
    Marina Falaleeva
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536
    Proc Natl Acad Sci U S A 113:E1625-34. 2016
    ..Thus, some SNORDs likely function in both rRNA and pre-mRNA processing, which increases the repertoire of splicing regulators and links both processes...
  14. pmc DARPP-32 binds to tra2-beta1 and influences alternative splicing
    Natalya Benderska
    University of Erlangen Nuremberg, Institute for Biochemistry, Fahrstrasse 17, 91054 Erlangen, Germany
    Biochim Biophys Acta 1799:448-53. 2010
    ..DARPP-32 changes the usage of tra2-beta1 dependent alternative exons in a concentration-dependent manner, suggesting that the DARPP-32:tra2-beta1 interaction is a molecular link between signaling pathways and pre-mRNA processing...
  15. pmc Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure
    Manli Shen
    Department of Molecular and Cellular Biochemistry, University of Kentucky, 741 South Limestone, Lexington, KY 40536, USA
    Nucleic Acids Res 41:3819-32. 2013
    ..Our data demonstrate that alternative splicing of structured pre-mRNAs can be regulated by small molecules that directly bind to the RNA, which is reminiscent to an RNA riboswitch...
  16. ncbi request reprint The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation
    Ilona Rafalska
    University of Erlangen, Institute for Biochemistry, Germany
    Hum Mol Genet 13:1535-49. 2004
    ..We propose that tyrosine phosphorylation causes sequestration of YT521-B in an insoluble nuclear form, which abolishes the ability of YT521-B to change alternative splice sites...
  17. pmc The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing
    Shivendra Kishore
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536, USA
    Hum Mol Genet 19:1153-64. 2010
    ..This processed snoRNA functions in alternative splice-site selection. Its substitution could be a therapeutic principle for PWS...
  18. pmc Synthesis of a norcantharidin-tethered guanosine: Protein phosphatase-1 inhibitors that change alternative splicing
    Stefan Kwiatkowski
    Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40536 0509, United States Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, Lexington, KY 40536 0596, United States
    Bioorg Med Chem Lett 26:965-8. 2016
    ..2.1]heptane-2-carboxylate, which showed activity in an assay for SMN2 pre-mRNA splicing. ..
  19. ncbi request reprint Human tra2-beta1 autoregulates its protein concentration by influencing alternative splicing of its pre-mRNA
    Peter Stoilov
    Institute of Biochemistry, University of Erlangen, Erlangen, Germany
    Hum Mol Genet 13:509-24. 2004
    ..We propose that the regulation of the tra2-beta pre-mRNA alternative splicing provides a robust and sensitive molecular sensor that measures the ratio between HTRA2-BETA1 and its interacting proteins...
  20. pmc Function of alternative splicing
    Olga Kelemen
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA
    Gene 514:1-30. 2013
    ..Due to its widespread usage and molecular versatility, alternative splicing emerges as a central element in gene regulation that interferes with almost every biological function analyzed...
  21. pmc The 5' untranslated region of the serotonin receptor 2C pre-mRNA generates miRNAs and is expressed in non-neuronal cells
    Zhaiyi Zhang
    Department of Molecular and Cellular Biochemistry, University of Kentucky, 741 South Limestone, Lexington, KY, 40536, USA
    Exp Brain Res 230:387-94. 2013
    ..The data indicate that the transcriptional unit expressing HTR2C is more complex than previously recognized and likely deregulated in Prader-Willi syndrome. ..
  22. pmc Genome wide array analysis indicates that an amyotrophic lateral sclerosis mutation of FUS causes an early increase of CAMK2N2 in vitro
    Paolo Convertini
    Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, 741 South Limestone, Lexington, KY 40536 0509, USA
    Biochim Biophys Acta 1832:1129-35. 2013
    ..It indicates that, despite the obvious cytoplasmic accumulation, FUS-ΔNLS can act through a nuclear gain of function mechanism...
  23. pmc A retroelement modifies pre-mRNA splicing: the murine Glrb(spa) allele is a splicing signal polymorphism amplified by long interspersed nuclear element insertion
    Kristina Becker
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    J Biol Chem 287:31185-94. 2012
    ..Conversely, the LINE1 effect on splicing may be modulated by individual polymorphisms, depending on the insertional environment within the host genome...
  24. pmc Sudemycin E influences alternative splicing and changes chromatin modifications
    Paolo Convertini
    Department of Molecular and Cellular Biochemistry, University of Kentucky, 741 South Limestone, Lexington, KY 40536, USA, Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA and GenoSplice Technology, Hopital Saint Louis, Av Claude Vellefaux, 75010 Paris, France
    Nucleic Acids Res 42:4947-61. 2014
    ..Thus, in addition to the reversible changes in alternative splicing, sudemycin E causes changes in chromatin modifications that result in chromatin condensation, which is a likely contributing factor to cancer cell death. ..
  25. ncbi request reprint Pre-mRNA missplicing as a cause of human disease
    Tatyana Novoyatleva
    University of Erlangen, Institute for Biochemistry, Fahrstrasse 17, 91054 Erlangen, Germany
    Prog Mol Subcell Biol 44:27-46. 2006
    ..Recently, a growing number of low molecular weight drugs have been discovered that influence splice site selection in vivo. These findings prove the principle that diseases caused by missplicing events could eventually be cured...
  26. pmc Rapid generation of splicing reporters with pSpliceExpress
    Shivendra Kishore
    Department of Molecular and Cellular Biochemistry, B283 Biomedical Biological Sciences Research Building, 741 South Limestone, University of Kentucky, College of Medicine, Lexington, KY 40536 0509, USA
    Gene 427:104-10. 2008
    ..Minigenes generated with pSpliceExpress show the same regulation as displayed by conventionally cloned reporter constructs and provide an alternate avenue to study splice site selection in vivo...
  27. pmc Synthesis and characterization of pseudocantharidins, novel phosphatase modulators that promote the inclusion of exon 7 into the SMN (survival of motoneuron) pre-mRNA
    Zhaiyi Zhang
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 286:10126-36. 2011
    ..Our data show that subtle changes in similar compounds can turn a phosphatase inhibitor into an activator. These chemically related compounds influence alternative splicing by distinct mechanisms...
  28. ncbi request reprint Ischemia induces a translocation of the splicing factor tra2-beta 1 and changes alternative splicing patterns in the brain
    Rosette Daoud
    Institute of Biochemistry, University of Erlangen Nurenberg, 91054 Erlangen, Germany
    J Neurosci 22:5889-99. 2002
    ..Our findings suggest that a change in the calcium concentration associated with ischemia is part of a signaling event, which changes pre-mRNA splicing pathways by causing relocalization of proteins that regulate splice-site selection...
  29. pmc Oligonucleotide-induced alternative splicing of serotonin 2C receptor reduces food intake
    Zhaiyi Zhang
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA
    EMBO Mol Med 8:878-94. 2016
    ....
  30. ncbi request reprint Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism
    Peter Stoilov
    Friedrich Alexander University Erlangen, Institute for Biochemistry, Fahrstrasse 17, Erlangen, 91054, Germany
    Biochem Biophys Res Commun 290:1054-65. 2002
    ..Coimmunoprecipitation experiments show that TrkB-T-Shc is not phosphorylated by the full length receptor, indicating that it could be a negative regulator of TrkB signaling in the brain...
  31. pmc Valproic acid causes proteasomal degradation of DICER and influences miRNA expression
    Zhaiyi Zhang
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America
    PLoS ONE 8:e82895. 2013
    ..VPA can be used experimentally to down regulate DICER protein levels, which likely reflects a natural regulation of DICER. ..
  32. ncbi request reprint Defects in pre-mRNA processing as causes of and predisposition to diseases
    Peter Stoilov
    University of Erlangen Nurenberg, Institute of Biochemistry, 91054 Erlangen, Germany
    DNA Cell Biol 21:803-18. 2002
    ..The elucidation of genetic mechanisms regulating pre-mRNA processing, combined with the development of drugs targeted at consensus RNA sequences and/or corresponding proteins, can lead to novel diagnostic and therapeutic approaches...
  33. ncbi request reprint YTH: a new domain in nuclear proteins
    Peter Stoilov
    Institute of Biochemistry, Friedrich Alexander University Erlangen Nuremberg, Fahrstrasse 17, 91054, Erlangen, Germany
    Trends Biochem Sci 27:495-7. 2002
    ..It is predicted to adopt a mixed alpha-helix-beta-sheet fold and to bind to RNA. We propose the name YTH (for YT521-B homology) for the domain...
  34. pmc Direct cloning of double-stranded RNAs from RNase protection analysis reveals processing patterns of C/D box snoRNAs and provides evidence for widespread antisense transcript expression
    Manli Shen
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, 40536, USA
    Nucleic Acids Res 39:9720-30. 2011
    ..The data suggest a conserved processing pattern for some C/D box snoRNAs and abundant expression of longer, non-coding RNAs in the cell that can potentially form dsRNAs...
  35. pmc SNORD116 and SNORD115 change expression of multiple genes and modify each other's activity
    Marina Falaleeva
    Department of Molecular and Cellular Biochemistry, University of Kentucky, College of Medicine, Lexington, KY 40536, United States
    Gene 572:266-73. 2015
    ..Together our results indicate that SNORD115 and SNORD116 influence expression levels of multiple genes and modify each other activity. ..
  36. pmc Regulation of alternative splicing by short non-coding nuclear RNAs
    Amit Khanna
    University of Kentucky, Molecular and Cellular Biochemistry, South Limestone, Lexington, KY, USA
    RNA Biol 7:480-5. 2010
    ..We review the current knowledge of this emerging class of RNAs and discuss evidence that some of these short RNAs could function in alternative splice site selection...
  37. doi request reprint Analysis of mutations that influence pre-mRNA splicing
    Zhaiyi Zhang
    Department of Molecular and Cellular Biochemistry, Biomedical Biological Sciences Research Building, College of Medicine, University of Kentucky, Lexington, KY, USA
    Methods Mol Biol 703:137-60. 2011
    ..We describe a recombination-based system that allows for the generation of splicing reporter constructs in the first week and their subsequent analysis in the second week...
  38. ncbi request reprint The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C
    Shivendra Kishore
    Institut fur Biochemie, Emil Fischer Zentrum, Friedrich Alexander Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Science 311:230-2. 2006
    ..Our results show that a snoRNA regulates the processing of an mRNA expressed from a gene located on a different chromosome, and the results indicate that a defect in pre-mRNA processing contributes to the Prader-Willi syndrome...
  39. doi request reprint Substances that can change alternative splice-site selection
    Chiranthani Sumanasekera
    Department of Molecular and Cellular Biochemistry, University of Kentucky, College of Medicine, B283, Biomedical Biological Sciences Research Building, 741 South Limestone, Lexington, KY 40536, USA
    Biochem Soc Trans 36:483-90. 2008
    ....
  40. doi request reprint Direct cloning of double-stranded RNAs
    Manli Shen
    University of Kentucky, Lexington, KY, 40536, USA
    Methods Mol Biol 1296:53-64. 2015
    ..Most annotated genomes show a large number of sense-antisense transcripts that can generate double-stranded RNAs. We describe a method to clone these dsRNAs from total RNA preparations. ..
  41. pmc Processing of snoRNAs as a new source of regulatory non-coding RNAs: snoRNA fragments form a new class of functional RNAs
    Marina Falaleeva
    Department of Molecular and Cellular Biochemistry, University of Kentucky, College of Medicine, Lexington, KY, USA
    Bioessays 35:46-54. 2013
    ..We propose that processed snoRNAs acquire new roles in gene expression and represent a new class of regulatory RNAs distinct from canonical snoRNAs...
  42. pmc Involvement of PARP1 in the regulation of alternative splicing
    Elena Matveeva
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA
    Cell Discov 2:15046. 2016
    ..These studies add another function to the multi-functional protein, Poly (ADP) ribose polymerase, and provide a platform for further investigation of this protein's function in organizing chromatin during gene regulatory processes. ..
  43. pmc Pre-mRNA secondary structures influence exon recognition
    Michael Hiller
    Bioinformatics Group, Albert Ludwigs University Freiburg, Freiburg, Germany
    PLoS Genet 3:e204. 2007
    ..Our results explain the action of mutations that affect splicing and indicate that the structural context of splicing motifs is part of the mRNA splicing code...
  44. ncbi request reprint Genomic checkpoints for exon 10 usage in the luteinizing hormone receptor type 1 and type 2
    Jorg Gromoll
    Institute of Reproductive Medicine, University Hospital, D 48129 Munster, Germany
    Mol Endocrinol 21:1984-96. 2007
    ....
  45. ncbi request reprint Differential regulation of 5' splice variants of the glutamate transporter EAAT2 in an in vivo model of chemical hypoxia induced by 3-nitropropionic acid
    Christoph Munch
    Department of Neurology, University of Ulm, Ulm, Germany
    J Neurosci Res 71:819-25. 2003
    ..Our findings contribute to the hypothesis that RNA splicing events can serve as a molecular mechanism of posthypoxic gene regulation...
  46. pmc Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta
    Zhihong Jiang
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:18997-9007. 2003
    ..Our results implicate the human tau gene as a target gene for the alternative splicing regulator Tra2 beta, suggesting that Tra2 beta may play a role in aberrant tau exon 10 alternative splicing and in the pathogenesis of tauopathies...
  47. ncbi request reprint Emerin interacts in vitro with the splicing-associated factor, YT521-B
    Fiona L Wilkinson
    Biochemistry Group, North East Wales Institute, Wrexham, UK
    Eur J Biochem 270:2459-66. 2003
    ..YT521-B joins a growing list of candidates for a role in a gene expression model of the pathogenesis of EDMD...
  48. pmc ASD: the Alternative Splicing Database
    T A Thanaraj
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
    Nucleic Acids Res 32:D64-9. 2004
    ..The data are presented on our ASD web pages (http://www.ebi.ac.uk/asd)...
  49. ncbi request reprint Single molecule profiling of tau gene expression in Alzheimer's disease
    Chris Conrad
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease MIND, Charlestown, Massachusetts, USA
    J Neurochem 103:1228-36. 2007
    ..Furthermore, splicing-based therapeutics is an emerging area of drug development, and a well-defined and quantitative assay for monitoring single-gene transcriptome will be relevant for such development...
  50. ncbi request reprint Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3
    Meltem Cevik Arikan
    Department of Biomedical Sciences, E K Shriver Center for Mental Retardation, Waltham, MA 02454, USA
    Brain Res Mol Brain Res 101:109-21. 2002
    ..Furthermore, we demonstrate that known splicing regulators affect the ratio of exon 3 isoforms, Lastly, we tentatively pinpoint the site of action of several splicing factors which regulate tau exon 3...
  51. ncbi request reprint Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors
    Junning Wang
    Shriver Center at UMMS, Waltham, Massachusetts 02452, USA
    J Neurochem 88:1078-90. 2004
    ..Lastly, we identified the domains of regulators SWAP and hnRNPG, which are required for regulation of exon 10 splicing...
  52. ncbi request reprint p59(fyn)-mediated phosphorylation regulates the activity of the tissue-specific splicing factor rSLM-1
    Oliver Stoss
    Klinikum Kassel, Pathology, Mönchebergstr 41 43, D 34125 Kassel, Germany
    Mol Cell Neurosci 27:8-21. 2004
    ..Together, our data indicate that rSLM-1 is a tissue-specific splicing factor whose activity is regulated by tyrosine phosphorylation signals emanating from p59(fyn)...
  53. ncbi request reprint The alternative splicing of tau exon 10 and its regulatory proteins CLK2 and TRA2-BETA1 changes in sporadic Alzheimer's disease
    Daniela C Glatz
    Molecular and Clinical Neurobiology, Department of Psychiatry Ludwig Maximilians University, Munich, Germany
    J Neurochem 96:635-44. 2006
    ..These findings suggest that a misregulation of alternative splicing seems to contribute to sporadic AD...
  54. pmc ASD: a bioinformatics resource on alternative splicing
    Stefan Stamm
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK
    Nucleic Acids Res 34:D46-55. 2006
    ..ASD data has been integrated with Ensembl genome annotation project as a Distributed Annotation System (DAS) resource and can be viewed on Ensembl genome browser. The ASD resource is presented at (http://www.ebi.ac.uk/asd)...
  55. ncbi request reprint Splicing factor Tra2-beta1 is specifically induced in breast cancer and regulates alternative splicing of the CD44 gene
    Dirk O Watermann
    Department of Obstetrics and Gynecology, University of Freiburg, Freiburg, Germany
    Cancer Res 66:4774-80. 2006
    ..Induction of this splicing factor might be responsible for splicing of CD44 isoforms associated with tumor progression and metastasis...
  56. ncbi request reprint WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo
    M Andrea Markus
    Basic and Clinical Genomics Laboratory, School of Medical Sciences and Bosch Institute, Building F13, The University of Sydney, NSW 2006, Australia
    Exp Cell Res 312:3379-88. 2006
    ..We found that overexpressed WT1(+KTS) abrogated this effect of RBM4 on splice-site selection, whereas WT1(-KTS) did not. We conclude that the (+KTS) form of WT1 is able to inhibit the effect of RBM4 on alternative splicing...