Malin Jonsson Fagerlund

Summary

Affiliation: Karolinska Institutet
Country: Sweden

Publications

  1. pmc Propofol and AZD3043 Inhibit Adult Muscle and Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes
    Malin Jonsson Fagerlund
    Department of Anesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Pharmaceuticals (Basel) 9:. 2016
  2. doi request reprint Reduced efficacy of the intravenous anesthetic agent AZD3043 at GABA(A) receptors with β2 (N289M) and β3 (N290M) point-mutations
    Malin Jonsson Fagerlund
    Department of Anesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital, SE 17176 Stockholm, Sweden
    Eur J Pharmacol 694:13-9. 2012
  3. doi request reprint Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor
    Malin Jonsson Fagerlund
    Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden
    Anesthesiology 110:1244-52. 2009
  4. doi request reprint Reduced effect of propofol at human {alpha}1{beta}2(N289M){gamma}2 and {alpha}2{beta}3(N290M){gamma}2 mutant GABA(A) receptors
    M Jonsson Fagerlund
    Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden
    Br J Anaesth 104:472-81. 2010
  5. doi request reprint The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesia
    Malin Jonsson Fagerlund
    Section for Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Anesthesiology 113:1270-9. 2010
  6. doi request reprint Sedation with Dexmedetomidine or Propofol Impairs Hypoxic Control of Breathing in Healthy Male Volunteers: A Nonblinded, Randomized Crossover Study
    Åse Lodenius
    From the Department of Anesthesiology, Surgical Services and Intensive Care, Karolinska University Hospital, Stockholm, Sweden A L, E C, J U, L I E, M J F Section for Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology Å L, A E, A H C, S M, E C, J U, L I E, M J F and Medical Statistics Unit, Department of Learning, Informatics, Managements and Ethics E H, Karolinska Institutet, Stockholm, Sweden Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland M S and Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland M S
    Anesthesiology 125:700-15. 2016

Collaborators

  • Souren Mkrtchian
  • Jessica Kåhlin
  • Åse Lodenius
  • Lars I Eriksson
  • Anette Ebberyd
  • Malin Jonsson Fagerlund
  • Mika Scheinin
  • Anna Hårdemark Cedborg
  • Johan Ullman
  • Eva Hagel
  • Eva Christensson
  • Gunnar Schulte

Detail Information

Publications6

  1. pmc Propofol and AZD3043 Inhibit Adult Muscle and Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes
    Malin Jonsson Fagerlund
    Department of Anesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital, SE 171 76 Stockholm, Sweden
    Pharmaceuticals (Basel) 9:. 2016
    ..This finding needs to be evaluated in an in vitro nerve-muscle preparation and suggests one possible explanation for the muscle relaxant effect of propofol seen during higher doses. ..
  2. doi request reprint Reduced efficacy of the intravenous anesthetic agent AZD3043 at GABA(A) receptors with β2 (N289M) and β3 (N290M) point-mutations
    Malin Jonsson Fagerlund
    Department of Anesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital, SE 17176 Stockholm, Sweden
    Eur J Pharmacol 694:13-9. 2012
    ..Similar to propofol, the effect of AZD3043 is dramatically reduced by point-mutations in the β2(N289M) and β3(N290M) subunits, indicating similar molecular mechanisms of action for propofol and AZD3043 at the human GABA(A) receptor...
  3. doi request reprint Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor
    Malin Jonsson Fagerlund
    Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden
    Anesthesiology 110:1244-52. 2009
    ..The aim of this study was to investigate the effect of clinically used nondepolarizing NMBAs at human adult muscle nAChRs and the mechanisms behind the inhibition...
  4. doi request reprint Reduced effect of propofol at human {alpha}1{beta}2(N289M){gamma}2 and {alpha}2{beta}3(N290M){gamma}2 mutant GABA(A) receptors
    M Jonsson Fagerlund
    Department of Anesthesiology and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden
    Br J Anaesth 104:472-81. 2010
    ..The aim of this study was to investigate the effect of propofol on human beta2 and beta3 GABA(A) subunits with point mutations corresponding to the N265M mutation in the rat beta2 and beta3 subunits...
  5. doi request reprint The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesia
    Malin Jonsson Fagerlund
    Section for Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Anesthesiology 113:1270-9. 2010
    ....
  6. doi request reprint Sedation with Dexmedetomidine or Propofol Impairs Hypoxic Control of Breathing in Healthy Male Volunteers: A Nonblinded, Randomized Crossover Study
    Åse Lodenius
    From the Department of Anesthesiology, Surgical Services and Intensive Care, Karolinska University Hospital, Stockholm, Sweden A L, E C, J U, L I E, M J F Section for Anesthesiology and Intensive Care Medicine, Department of Physiology and Pharmacology Å L, A E, A H C, S M, E C, J U, L I E, M J F and Medical Statistics Unit, Department of Learning, Informatics, Managements and Ethics E H, Karolinska Institutet, Stockholm, Sweden Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland M S and Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland M S
    Anesthesiology 125:700-15. 2016
    ..To obtain a more comprehensive understanding of the regulation of breathing during sedation with dexmedetomidine, the authors compared ventilatory responses to hypoxia and hypercapnia during sedation with dexmedetomidine and propofol...