C Ling

Summary

Affiliation: Lund University
Country: Sweden

Publications

  1. doi request reprint Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver
    Sonia García-Calzón
    Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre, Jan Waldenströms gata 35, CRC 91 12, 205 02 Malmo, Sweden
    Clin Epigenetics 9:102. 2017
  2. doi request reprint 36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner
    Line Hjort
    Department of Endocrinology Diabetes and Metabolism, Rigshospitalet, Section 7652, Tagensvej 20, DK 2200 Copenhagen N, Denmark
    Clin Epigenetics 9:40. 2017
  3. pmc Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy
    Elisabet Agardh
    Department of Clinical Sciences, Ophthalmology, Lund University, Scania University Hospital, 205 02, Malmo, Sweden
    BMC Med 13:182. 2015
  4. doi request reprint Epigenetic markers to further understand insulin resistance
    Charlotte Ling
    Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Scania University Hospital, Jan Waldenströms gata 35, 205 02, Malmo, Sweden
    Diabetologia 59:2295-7. 2016
  5. doi request reprint Epigenetic adaptation to regular exercise in humans
    Charlotte Ling
    Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre, CRC, Scania University Hospital, 205 02 Malmo, Sweden Electronic address
    Drug Discov Today 19:1015-8. 2014
  6. pmc Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets
    Elin Hall
    Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, CRC, Lund University, Scania University Hospital, Malmo, Sweden
    BMC Med 12:103. 2014
  7. pmc Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo
    Anders H Olsson
    Department of Clinical Sciences, Lund University, Scania University Hospital, Malmo, Sweden
    Eur J Endocrinol 164:765-71. 2011
  8. pmc Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes
    Anders H Olsson
    Department of Clinical Sciences, Lund University Diabetes Centre, CRC, Scania University Hospital, Malmo, Sweden
    Eur J Endocrinol 165:589-95. 2011
  9. doi request reprint Epigenetics: a molecular link between environmental factors and type 2 diabetes.
    Charlotte Ling
    Department of Clinical Sciences, Lund University Diabetes Center, Lund University, Malm, Sweden
    Diabetes 58:2718-25. 2009
  10. pmc Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion
    Tasnim Dayeh
    Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Malmo, Sweden
    PLoS Genet 10:e1004160. 2014

Collaborators

Detail Information

Publications41

  1. doi request reprint Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver
    Sonia García-Calzón
    Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre, Jan Waldenströms gata 35, CRC 91 12, 205 02 Malmo, Sweden
    Clin Epigenetics 9:102. 2017
    ..We examined the DNA methylation of these genes in the liver of subjects with type 2 diabetes and tested whether epigenetic alterations associate with diabetes medication, i.e., metformin or insulin plus metformin treatment...
  2. doi request reprint 36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner
    Line Hjort
    Department of Endocrinology Diabetes and Metabolism, Rigshospitalet, Section 7652, Tagensvej 20, DK 2200 Copenhagen N, Denmark
    Clin Epigenetics 9:40. 2017
    ..Here, we aimed to study the effects of short-term fasting on leptin (LEP) and adiponectin (ADIPOQ) DNA methylation and gene expression in subcutaneous adipose tissue (SAT) from subjects with LBW and NBW...
  3. pmc Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy
    Elisabet Agardh
    Department of Clinical Sciences, Ophthalmology, Lund University, Scania University Hospital, 205 02, Malmo, Sweden
    BMC Med 13:182. 2015
    ..However, studies examining the association between PDR and the genome-wide DNA methylation pattern are lacking. Our aim was to identify epigenetic modifications that associate with and predict PDR in subjects with type 1 diabetes (T1D)...
  4. doi request reprint Epigenetic markers to further understand insulin resistance
    Charlotte Ling
    Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Scania University Hospital, Jan Waldenströms gata 35, 205 02, Malmo, Sweden
    Diabetologia 59:2295-7. 2016
    ..Together, identifying novel molecular mechanisms contributing to insulin resistance and type 2 diabetes may help advance the search for new therapeutic alternatives. ..
  5. doi request reprint Epigenetic adaptation to regular exercise in humans
    Charlotte Ling
    Department of Clinical Sciences, Epigenetics and Diabetes Unit, Lund University Diabetes Centre, CRC, Scania University Hospital, 205 02 Malmo, Sweden Electronic address
    Drug Discov Today 19:1015-8. 2014
    ..However, until recently it was unknown that regular exercise can modify the genome-wide DNA methylation pattern in humans. This review will focus on recent progress in the field of regular exercise and epigenetics. ..
  6. pmc Effects of palmitate on genome-wide mRNA expression and DNA methylation patterns in human pancreatic islets
    Elin Hall
    Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, CRC, Lund University, Scania University Hospital, Malmo, Sweden
    BMC Med 12:103. 2014
    ....
  7. pmc Two common genetic variants near nuclear-encoded OXPHOS genes are associated with insulin secretion in vivo
    Anders H Olsson
    Department of Clinical Sciences, Lund University, Scania University Hospital, Malmo, Sweden
    Eur J Endocrinol 164:765-71. 2011
    ..Mitochondrial ATP production is important in the regulation of glucose-stimulated insulin secretion. Genetic factors may modulate the capacity of the β-cells to secrete insulin and thereby contribute to the risk of type 2 diabetes...
  8. pmc Decreased expression of genes involved in oxidative phosphorylation in human pancreatic islets from patients with type 2 diabetes
    Anders H Olsson
    Department of Clinical Sciences, Lund University Diabetes Centre, CRC, Scania University Hospital, Malmo, Sweden
    Eur J Endocrinol 165:589-95. 2011
    ..In this study, we examined if genes involved in oxidative phosphorylation (OXPHOS) show differential gene expression and DNA methylation in pancreatic islets from patients with T2D compared with non-diabetic donors...
  9. doi request reprint Epigenetics: a molecular link between environmental factors and type 2 diabetes.
    Charlotte Ling
    Department of Clinical Sciences, Lund University Diabetes Center, Lund University, Malm, Sweden
    Diabetes 58:2718-25. 2009
  10. pmc Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion
    Tasnim Dayeh
    Epigenetics and Diabetes, Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Malmo, Sweden
    PLoS Genet 10:e1004160. 2014
    ..We provide new target genes with altered DNA methylation and expression in human T2D islets that contribute to perturbed insulin and glucagon secretion. These results highlight the importance of epigenetics in the pathogenesis of T2D...
  11. pmc DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets
    Elin Hall
    Department of Clinical Sciences, Lund University Diabetes Centre, CRC, Lund University, Scania University Hospital, Malmo, Sweden
    BMC Med Genet 14:76. 2013
    ....
  12. pmc Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes
    Marloes Dekker Nitert
    Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, CRC, Scania University Hospital, Malmo, Sweden
    Diabetes 61:3322-32. 2012
    ..In addition, both expression and methylation of several genes, i.e., ADIPOR1, BDKRB2, and TRIB1, changed after exercise. These findings provide new insights into how genetic background and environment can alter the human epigenome...
  13. pmc Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes
    Beatrice T Yang
    Department of Clinical Sciences, Unit of Epigenetics and Diabetes, Lund University Diabetes Centre, Scania University Hospital, 205 02 Malmoe, Sweden
    Mol Endocrinol 26:1203-12. 2012
    ..The expression levels of PDX-1 were further associated with insulin secretion in the human islets...
  14. pmc Epigenetics and obesity: the devil is in the details
    Paul W Franks
    Department of Clinical Sciences, Skane University Hospital, Lund University, Malmo, Sweden
    BMC Med 8:88. 2010
    ....
  15. ncbi request reprint Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscle
    C Ling
    Department of Clinical Sciences Diabetes and Endocrinology, Lund University, CRC, University Hospital MAS, 205 02 Malmo, Sweden
    Diabetologia 50:1615-20. 2007
    ..The aim of this study was to investigate whether the PGC-1beta Ala203Pro polymorphism influences the age-related decline in skeletal muscle PGC-1beta expression, in vivo metabolism and markers for muscle fibre type composition...
  16. pmc Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle
    Charlotte Ling
    Department of Clinical Sciences, Lund University, University Hospital MAS, Malmo, Sweden
    J Clin Invest 117:3427-35. 2007
    ....
  17. pmc Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion
    C Ling
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, CRC, 205 02 Malmo, Sweden
    Diabetologia 51:615-22. 2008
    ..We also tested if experimental downregulation of PPARGC1A expression in human islets influenced insulin secretion...
  18. pmc Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes
    Charlotte Ling
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Clinical Research Centre CRC, Malmo, Sweden
    PLoS ONE 4:e6558. 2009
    ..We also tested if polymorphisms in the CAPN10 gene are associated with gene expression and insulin secretion in vitro...
  19. doi request reprint Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle
    T Rönn
    Department of Clinical Sciences, CRC Malmö University Hospital, Lund University, 205 02, Malmo, Sweden
    Diabetologia 51:1159-68. 2008
    ....
  20. pmc Telomere length in blood and skeletal muscle in relation to measures of glycaemia and insulinaemia
    S Ahmad
    Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Department of Clinical Sciences, Skane University Hospital, Lund University, Malmo, Sweden
    Diabet Med 29:e377-81. 2012
    ..The purpose of this study was to determine the extent of these relationships...
  21. pmc Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets
    T A Dayeh
    Department of Clinical Sciences, Epigenetics and Diabetes, Lund University Diabetes Centre, Clinical Research Centre, Scania University Hospital, Jan Waldenströmsgata 35, 205 02 Malmo, Sweden
    Diabetologia 56:1036-46. 2013
    ....
  22. ncbi request reprint Genetic and nongenetic regulation of CAPN10 mRNA expression in skeletal muscle
    Emma Carlsson
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmo University Hospital, S 205 02 Malmo, Sweden
    Diabetes 54:3015-20. 2005
    ..Glucose-tolerant but not glucose-intolerant individuals upregulate their CAPN10 mRNA levels in response to prolonged exposure to fat...
  23. doi request reprint Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a 6-month exercise intervention
    T Rönn
    Department of Clinical Sciences, Epigenetics and Diabetes, Lund University Diabetes Centre, CRC, Malmo, Sweden
    Acta Physiol (Oxf) 211:188-200. 2014
    ..We also investigated the difference in adipose tissue mRNA expression between individuals with or without a family history of type 2 diabetes...
  24. doi request reprint A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals
    T Rönn
    Department of Clinical Sciences, CRC Malmö University Hospital, Lund University Diabetes Center, Malmo, Sweden
    Diabetologia 52:830-3. 2009
    ..In the present study, we investigated whether a single MTNR1B polymorphism was associated with type 2 diabetes in Han Chinese individuals, to elucidate whether this is a cross-populational effect...
  25. pmc Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins
    Charlotte Ling
    Department of Endocrinology, Lund University, Wallenberg Laboratory, Malmo University Hospital, Malmo, Sweden
    J Clin Invest 114:1518-26. 2004
    ....
  26. pmc Less pronounced response to exercise in healthy relatives to type 2 diabetic subjects compared with controls
    C Ekman
    Department of Clinical Sciences, Clinical Research Centre, Malmo University Hospital, Lund University, Malmo, Sweden
    J Appl Physiol (1985) 119:953-60. 2015
    ..The FH+ background might limit muscle adaptation to exercise, which may contribute to the increased susceptibility to type 2 diabetes in FH+ individuals. ..
  27. pmc Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets
    B T Yang
    Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, University Hospital Malmoe, 205 02 Malmoe, Sweden
    Diabetologia 54:360-7. 2011
    ..Here, we examined DNA methylation of the insulin gene promoter in pancreatic islets from patients with type 2 diabetes and non-diabetic human donors and related it to insulin expression, HbA(1c) levels, BMI and age...
  28. pmc Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion
    Siri Malmgren
    Department of Clinical Sciences in Malmo, Unit of Molecular Metabolism, Lund University Diabetes Centre, 205 02 Malmo, Sweden
    J Biol Chem 284:32395-404. 2009
    ..The 832 beta-cell lines may be helpful tools to resolve metabolic perturbations occurring in Type 2 diabetes...
  29. pmc Genetic variation in ATP5O is associated with skeletal muscle ATP50 mRNA expression and glucose uptake in young twins
    Tina Rönn
    Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, CRC Malmö University Hospital, Lund University, Malmo, Sweden
    PLoS ONE 4:e4793. 2009
    ..Our aims were to investigate mechanisms regulating ATP5O expression in skeletal muscle and association with glucose metabolism, and the relationship between ATP5O single nucleotide polymorphisms (SNPs) and risk of T2D...
  30. doi request reprint Mitochondrial dysfunction in pancreatic beta-cells in Type 2 diabetes
    Hindrik Mulder
    Department of Clinical Sciences in Malmo, Unit of Molecular Metabolism, Lund University Diabetes Centre, Clinical Research Center, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Mol Cell Endocrinol 297:34-40. 2009
    ..The emerging picture is that alterations in mitochondria may be a culprit in the pathogenetic processes culminating in Type 2 Diabetes. Such processes may prove to be targets for therapeutic interventions in the disease...
  31. doi request reprint Molecular correlates for maximal oxygen uptake and type 1 fibers
    Hemang Parikh
    Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, University Hospital Malmo, Malmo, Sweden
    Am J Physiol Endocrinol Metab 294:E1152-9. 2008
    ..In contrast, a high expression of AHNAK was associated with a low Vo(2max) and poor muscle fitness...
  32. pmc Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Diabetes and Endocrinology, and Lund University Diabetes Center, Lund University, Malmo, Sweden
    J Clin Invest 117:2155-63. 2007
    ..In conclusion, the increased risk of T2D conferred by variants in TCF7L2 involves the enteroinsular axis, enhanced expression of the gene in islets, and impaired insulin secretion...
  33. ncbi request reprint Transcriptome and proteome analysis of soleus muscle of hormone-sensitive lipase-null mice
    Ola Hansson
    Department of Experimental Medical Science, Lund University, Lund, Sweden
    J Lipid Res 46:2614-23. 2005
    ..The results of this study suggest that in the absence of HSL, a metabolic switch from reliance on lipid to carbohydrate energy substrates takes place, supporting an important role of HSL in soleus muscle lipid metabolism...
  34. doi request reprint First-degree relatives of type 2 diabetic patients have reduced expression of genes involved in fatty acid metabolism in skeletal muscle
    T Elgzyri
    Department of Clinical Sciences, Clinical Research Center, Malmo University Hospital, Lund University, 20502 Malmo, Sweden
    J Clin Endocrinol Metab 97:E1332-7. 2012
    ..In previous studies, it has been difficult to distinguish whether mitochondrial dysfunction and differential regulation of genes are primary (genetic) or due to reduced physical activity, obesity, or other correlated factors...
  35. ncbi request reprint Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet
    M Fex
    Department of Experimental Medical Science, Division of Diabetes, Metabolism, and Endocrinology, Lund University, Lund, Sweden
    Diabetologia 50:74-83. 2007
    ..When this fails, type 2 diabetes ensues. Because mitochondria play a key role in beta cell pathophysiology, we tested the hypothesis that mitochondrial metabolism is critical for beta cell adaptation to insulin resistance...
  36. pmc Regulation of skeletal muscle PPAR delta mRNA expression in twins
    Emma Nilsson
    Steno Diabetes Center, Niels Steensens Vej 1, DK 2820, Gentofte, Denmark
    J Physiol 584:1011-7. 2007
    ..In conclusion, we provide evidence that mRNA expression of PPARdelta in human skeletal muscle is under genetic control but also influenced by factors such as age, birth weight and central adiposity...
  37. ncbi request reprint Relationships of plasma adiponectin level and adiponectin receptors 1 and 2 gene expression to insulin sensitivity and glucose and fat metabolism in monozygotic and dizygotic twins
    Heidi Storgaard
    Steno Diabetes Center, 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 92:2835-9. 2007
    ..Adiponectin is a key insulin-sensitizing adipokine acting on muscle metabolism via two specific receptors [adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2, respectively)]...
  38. ncbi request reprint Genetic and nongenetic determinants of skeletal muscle glucose transporter 4 messenger ribonucleic acid levels and insulin action in twins
    Heidi Storgaard
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 91:702-8. 2006
    ..Thus, skeletal muscle GLUT4 content plays an important role in whole-body insulin sensitivity...
  39. pmc Epigenetic differences arise during the lifetime of monozygotic twins
    Mario F Fraga
    Epigenetics Laboratory, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 102:10604-9. 2005
    ..These findings indicate how an appreciation of epigenetics is missing from our understanding of how different phenotypes can be originated from the same genotype...
  40. ncbi request reprint Developmental and hormonal regulation of progesterone receptor A-form expression in female mouse lung in vivo: interaction with glucocorticoid receptors
    Ruijin Shao
    Department of Physiology Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Goteborg University, SE 40530 Goteborg, Sweden
    J Endocrinol 190:857-70. 2006
    ....
  41. ncbi request reprint Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissue
    Charlotte Ling
    Department of Physiology, Sahlgrenska University Hospital, Goteborg University, 405 30 Goteborg, Sweden
    J Clin Endocrinol Metab 88:1804-8. 2003
    ..Taken together, these results demonstrate a direct effect of PRL, via functional PRLRs, in reducing the LPL activity in human adipose tissue, and these results suggest that LPL might also be regulated in this fashion during lactation...