Henrik Zetterberg

Summary

Affiliation: Sahlgrenska University Hospital
Country: Sweden

Publications

  1. ncbi request reprint Neurochemical aftermath of amateur boxing
    Henrik Zetterberg
    Department of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arch Neurol 63:1277-80. 2006
  2. ncbi request reprint Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease
    Malin E Andersson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Int J Mol Med 20:233-9. 2007
  3. ncbi request reprint Cerebrospinal fluid neurofilament light levels in amyotrophic lateral sclerosis: impact of SOD1 genotype
    H Zetterberg
    Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Eur J Neurol 14:1329-33. 2007
  4. doi request reprint Characterization of tau in cerebrospinal fluid using mass spectrometry
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
    J Proteome Res 7:2114-20. 2008
  5. doi request reprint Subcortical vascular dementia biomarker pattern in mild cognitive impairment
    Maria Bjerke
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Dement Geriatr Cogn Disord 28:348-56. 2009
  6. pmc Amyloid mis-metabolism in idiopathic normal pressure hydrocephalus
    A Jeppsson
    Hydrocephalus Research Unit, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, 413 45, Gothenburg, Sweden
    Fluids Barriers CNS 13:13. 2016
  7. pmc Targeting LAMP2 in human cerebrospinal fluid with a combination of immunopurification and high resolution parallel reaction monitoring mass spectrometry
    Simon Sjödin
    Department of Psychiatry and Neurochemistry, Institution of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital at Mölndal, University of Gothenburg, House V3, 431 80 Mölndal, Sweden
    Clin Proteomics 13:4. 2016
  8. doi request reprint Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke
    Ann De Vos
    ADx NeuroSciences NV, Technologiepark 4, 9052, Ghent, Belgium
    BMC Neurol 17:170. 2017
  9. doi request reprint Study protocol: Insight 46 - a neuroscience sub-study of the MRC National Survey of Health and Development
    Christopher A Lane
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    BMC Neurol 17:75. 2017
  10. pmc Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson's disease - a multicenter study.
    Malin von Otter
    BMC Med Genet 15:131. 2014

Detail Information

Publications187 found, 100 shown here

  1. ncbi request reprint Neurochemical aftermath of amateur boxing
    Henrik Zetterberg
    Department of Experimental Neuroscience, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Arch Neurol 63:1277-80. 2006
    ..Little solid information is available on the possible risks for neuronal injury in amateur boxing...
  2. ncbi request reprint Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease
    Malin E Andersson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Int J Mol Med 20:233-9. 2007
    ..018). These findings support earlier indications that genetic variability in the KNS2 gene may play a role during early stages of AD pathogenesis...
  3. ncbi request reprint Cerebrospinal fluid neurofilament light levels in amyotrophic lateral sclerosis: impact of SOD1 genotype
    H Zetterberg
    Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, Goteborg University, Goteborg, Sweden
    Eur J Neurol 14:1329-33. 2007
    ..518, P = 0.001). NF-L levels were lower in SOD1 mutation-associated ALS compared with SOD1 wild-type (wt) ALS (P = 0.03). In conclusion, CSF NF-L levels may provide both diagnostic and prognostic information, particularly in SOD1 wt ALS...
  4. doi request reprint Characterization of tau in cerebrospinal fluid using mass spectrometry
    Erik Portelius
    Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, University of Goteborg, Sahlgrenska University Hospital, S 431 80 Molndal, Sweden
    J Proteome Res 7:2114-20. 2008
    ..Nineteen tryptic fragments of tau were detected, of which 16 are found in all tau isoforms while 3 represented unique tau isoforms. These results pave the way for clinical CSF studies on the tauopathies...
  5. doi request reprint Subcortical vascular dementia biomarker pattern in mild cognitive impairment
    Maria Bjerke
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Dement Geriatr Cogn Disord 28:348-56. 2009
    ..Mild cognitive impairment (MCI) is an etiologically unclear disorder. Cerebrospinal fluid (CSF) biomarkers are potentially useful for the differentiation between various MCI etiologies...
  6. pmc Amyloid mis-metabolism in idiopathic normal pressure hydrocephalus
    A Jeppsson
    Hydrocephalus Research Unit, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, 413 45, Gothenburg, Sweden
    Fluids Barriers CNS 13:13. 2016
    ....
  7. pmc Targeting LAMP2 in human cerebrospinal fluid with a combination of immunopurification and high resolution parallel reaction monitoring mass spectrometry
    Simon Sjödin
    Department of Psychiatry and Neurochemistry, Institution of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital at Mölndal, University of Gothenburg, House V3, 431 80 Mölndal, Sweden
    Clin Proteomics 13:4. 2016
    ..Thus there is a potential for proteins involved in the normal function of endo-lysosomal vesicles to act as biomarkers of disease. Herein we focused on the lysosomal protein LAMP2 that is involved in chaperone mediated autophagy...
  8. doi request reprint Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke
    Ann De Vos
    ADx NeuroSciences NV, Technologiepark 4, 9052, Ghent, Belgium
    BMC Neurol 17:170. 2017
    ..This evokes the question whether there are changes in neurogranin levels in blood in other conditions of brain injury, such as acute ischemic stroke (AIS)...
  9. doi request reprint Study protocol: Insight 46 - a neuroscience sub-study of the MRC National Survey of Health and Development
    Christopher A Lane
    Dementia Research Centre, Institute of Neurology, University College London, London, UK
    BMC Neurol 17:75. 2017
    ..This enables potential determinants of dementia to be delineated earlier, and therefore opens a pre-symptomatic window where intervention may prevent the onset of cognitive symptoms...
  10. pmc Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson's disease - a multicenter study.
    Malin von Otter
    BMC Med Genet 15:131. 2014
    ..Functional studies are now needed to explore these results further...
  11. pmc Soluble CD14 in cerebrospinal fluid is associated with markers of inflammation and axonal damage in untreated HIV-infected patients: a retrospective cross-sectional study
    Sofie Jespersen
    Department of Infectious Diseases, Viro immunology Research Unit, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    BMC Infect Dis 16:176. 2016
    ..We hypothesised that microbial translocation contributes to inflammation and axonal damage in the central nervous system (CNS) in untreated HIV infection...
  12. doi request reprint Cerebrospinal fluid in the differential diagnosis of Alzheimer's disease: clinical utility of an extended panel of biomarkers in a specialist cognitive clinic.
    Ross W Paterson
    Dementia Research Centre, UCL Institute of Neurology, 8 11 Queen Square, London, WC1N 3BG, UK
    Alzheimers Res Ther 10:32. 2018
    ..CSF AβX-42/X-40 and T-tau/Aβ1-42 ratios have utility in distinguishing AD from controls, bvFTD, and SD. None of the biomarkers tested had good specificity at distinguishing AD from DLB or PNFA...
  13. doi request reprint White paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming barriers in biomarker development and clinical translation.
    Charlotte E Teunissen
    Neurochemistry Lab and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Alzheimers Res Ther 10:30. 2018
    ..The society has a broad scope, as its vision is that the gaps in development and implementation of biomarkers are shared among almost all neurological diseases and thus they can benefit from the activities of the society...
  14. doi request reprint The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology
    Sarah Westwood
    Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, OX3 7JX, UK
    Alzheimers Res Ther 9:31. 2017
    ..Here, we examined the influence of IR on AD using plasma and cerebrospinal fluid (CSF) biomarkers related to IR and AD in cognitively healthy men. We also aimed to characterise the shared protein signatures between IR and AD...
  15. doi request reprint The effects of different familial Alzheimer's disease mutations on APP processing in vivo.
    Steinunn Thordardottir
    Department NVS, Division of Neurogeriatrics, Center for Alzheimer Disease Research, Karolinska Institutet, 141 57, Huddinge, Sweden
    Alzheimers Res Ther 9:9. 2017
    ..This may also be important from a therapeutic standpoint, by opening a window to monitor effects of disease-modifying drugs on AD pathophysiology...
  16. doi request reprint A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid.
    Ting Yang
    Ann Romney Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School Boston, 77 Avenue Louis Pasteur, Harvard Institute Medical, Room 730, Boston, MA 02115 USA
    Alzheimers Res Ther 7:14. 2015
    ..Aβ oligomers are detectable in most human CSFs, but AD and controls overlap. MCI CSFs may have a modest elevation in mean value by this assay...
  17. doi request reprint Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson's disease with dementia and dementia with Lewy bodies compared to Alzheimer's disease.
    Oskar Hansson
    Department of Clinical Sciences, Lund University, Lund, Sweden Memory Clinic, Sk ne University Hospital, Lund, Sweden
    Alzheimers Res Ther 6:25. 2014
    ..80. The levels of α-synuclein oligomers were increased in the CSF from α-synucleinopathy patients with dementia compared with AD cases...
  18. doi request reprint Amyloid-beta 42 adsorption following serial tube transfer.
    Jamie Toombs
    Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, UK
    Alzheimers Res Ther 6:5. 2014
    ..This would be sufficient to alter biomarker ratios enough to mislead diagnosis. The introduction of Tween 20 at the initial aliquoting stage was observed to significantly mitigate this effect...
  19. doi request reprint Modulation of β-amyloid by a single dose of GSK933776 in patients with mild Alzheimer's disease: a phase I study.
    Thomas Leyhe
    Department of Psychiatry and Psychotherapy, University Hospital of T bingen, Calwerstrasse 14, D 72076 T bingen, Germany Center of Old Age Psychiatry, Psychiatric University Hospital, Wilhelm Klein Strasse 27, CH 4012 Basel, Switzerland
    Alzheimers Res Ther 6:19. 2014
    ..ClinicalTrials.gov Identifier: NCT01424436. Registered 4 August 2011...
  20. doi request reprint The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer's disease.
    Signar Makitalo
    Department of Infectious Diseases, G vle Hospital, G vle, Sweden
    AIDS Res Ther 12:23. 2015
    ..Assessment of CSF biomarkers may be a valuable tool for clinicians to distinguish between HAD and AD...
  21. pmc A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans
    Mikko Hölttä
    Department of Psychiatry and Neurochemistry, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, SU Mölndal Hospital, 431 80, Molndal, Sweden
    Alzheimers Res Ther 8:11. 2016
    ..Here we evaluate if peptidomic analysis in cerebrospinal fluid (CSF) can be used for this purpose...
  22. pmc Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer's disease
    Konstantin Hellwig
    Department of Psychiatry and Psychotherapy, University clinic Erlangen and Friedrich Alexander University Erlangen Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Alzheimers Res Ther 7:74. 2015
    ..Neurogranin and YKL-40 in cerebrospinal fluid (CSF) are newly discovered markers indicating synaptic damage and microglial activation, respectively...
  23. pmc APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment
    Simon Sjödin
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Molndal, S 431 80, Sweden
    Alzheimers Res Ther 7:77. 2015
    ..Herein we investigated whether the GSM E2012 affects APLP1 processing in the central nervous system by measuring APLP1 peptide levels in cerebrospinal fluid (CSF) before and after E2012 treatment in dogs...
  24. doi request reprint Characterization of the postsynaptic protein neurogranin in paired cerebrospinal fluid and plasma samples from Alzheimer's disease patients and healthy controls.
    Hlin Kvartsberg
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, House V3 SU M lndal, SE 431 80 M lndal, Sweden AlzeCure Foundation, Karolinska Institutet Science Park, H lsov gen 7, SE 141 57 Huddinge, Sweden
    Alzheimers Res Ther 7:40. 2015
    ..The results suggest that CSF Ng, in particular Ng48-76, might reflect the neurodegenerative processes within the brain, indicating a role for Ng as a potential novel clinical biomarker for synaptic function in AD...
  25. doi request reprint The predictive value of T-tau and AB1-42 levels in idiopathic normal pressure hydrocephalus
    Claudia L Craven
    Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Acta Neurochir (Wien) 159:2293-2300. 2017
    ..In particular, we pay attention to the subset of INPH patients with raised T-tau, who are often expected to be poor surgical candidates...
  26. doi request reprint Neurofilament Light: A Dynamic Cross-Disease Fluid Biomarker for Neurodegeneration
    Henrik Zetterberg
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, 40530 Goteborg, Sweden Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 41345 Goteborg, Sweden Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK Electronic address
    Neuron 91:1-3. 2016
    ..2016). ..
  27. pmc SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer's disease
    Ann Brinkmalm
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, S 431 80 Molndal, Sweden
    Mol Neurodegener 9:53. 2014
    ....
  28. pmc Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegeneration
    Rahul S Desikan
    Department of Radiology, University of California, San Diego, 8950 Villa La Jolla Drive, Suite C101, La Jolla, CA 92037 0841, USA
    Mol Neurodegener 8:39. 2013
    ..Epidemiological and molecular findings suggest a relationship between Alzheimer's disease (AD) and dyslipidemia, although the nature of this association is not well understood...
  29. pmc Fluid biomarkers in Alzheimer's disease - current concepts
    Christoffer Rosén
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg Mölndal, S 431 80, Molndal, Sweden
    Mol Neurodegener 8:20. 2013
    ..But before drawing any major conclusions, these results need to be verified in independent studies. ..
  30. pmc Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
    Kathryn Rogers
    EnVivo Pharmaceuticals, Inc, 500 Arsenal Street, Watertown, MA 02472, USA
    Mol Neurodegener 7:61. 2012
    ..This approach, frequently called γ-secretase modulation, appears more promising and has lead to the development of new therapeutic candidates for disease modification in Alzheimer's disease...
  31. pmc Changes in serum and cerebrospinal fluid cytokines in response to non-neurological surgery: an observational study
    Sara Bromander
    Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
    J Neuroinflammation 9:242. 2012
    ..Our aim was to compare inflammatory markers in serum and cerebrospinal fluid (CSF) before and after surgery and evaluate their association with measures of blood-brain barrier (BBB) integrity...
  32. pmc Cerebrospinal fluid neurofilament light chain protein levels in subtypes of frontotemporal dementia
    Maria Landqvist Waldö
    Section of Geriatric Psychiatry, Department of Clinical Sciences, Lund University Hospital, Klinikgatan 22, Lund SE 221 85, Sweden
    BMC Neurol 13:54. 2013
    ..NFL has been shown to be elevated in CSF in patients with FTD compared with AD and controls. Our hypothesis was that the levels of NFL also differ between the subtypes of FTD and may indicate the underlying pathological subtype...
  33. pmc Cerebrospinal fluid CXCL13 in Lyme neuroborreliosis and asymptomatic HIV infection
    Daniel Bremell
    Department of Infectious Medicine, Institute of Biomedicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    BMC Neurol 13:2. 2013
    ..Like Borrelia burgdorferi, HIV also has neurotropic properties. Elevated serum CXCL13 concentrations have been reported in HIV patients, but data on CSF levels are limited...
  34. pmc The cerebrospinal fluid proteome in HIV infection: change associated with disease severity
    Thomas E Angel
    Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA
    Clin Proteomics 9:3. 2012
    ..To further characterize CNS HIV infection and its effects, we applied advanced high-throughput proteomic methods to CSF to identify novel proteins and their changes with disease progression and treatment...
  35. pmc Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid β levels in humans
    Henrik Zetterberg
    Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    PLoS ONE 6:e28263. 2011
    ..These data provide the first direct evidence in living humans that ischemia acutely increases Aβ levels in blood. The results point to the possibility that hypoxia may play a role in the amyloidogenic process of AD...
  36. pmc BACE1 gene variants do not influence BACE1 activity, levels of APP or Aβ isoforms in CSF in Alzheimer's disease
    Annica Sjölander
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, University of Gothenburg, Sweden
    Mol Neurodegener 5:37. 2010
    ..e., total-tau and phospho-tau181. Gene variants of BACE1 were neither associated with amyloid-related biomarkers, nor with markers for axonal degeneration in AD...
  37. pmc Effects of cerebrovascular disease on amyloid precursor protein metabolites in cerebrospinal fluid
    Per Selnes
    Department of Neurology, Akershus University Hospital, Norway
    Cerebrospinal Fluid Res 7:10. 2010
    ..Through measurements of CSF APP metabolite levels in patients with a wide range of WML volumes, this study aimed to determine how SVD influences APP metabolism...
  38. pmc Neuroinflammation in Lyme neuroborreliosis affects amyloid metabolism
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    BMC Neurol 10:51. 2010
    ..We have previously found altered cerebral amyloid metabolism in other neuroinflammatory conditions. To further elucidate this, we investigated amyloid metabolism in patients with Lyme neuroborreliosis (LNB)...
  39. pmc Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Bla Straket 15, 413 45 Gothenburg, Sweden
    BMC Med Genet 11:36. 2010
    ..Here, we hypothesize that variation in NFE2L2 and KEAP1, the genes encoding the two major regulators of the phase II response, may affect the risk of Parkinson's disease...
  40. pmc A novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alzheimer disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, SE 431 80, Sweden
    Alzheimers Res Ther 2:7. 2010
    ..Here, we test the hypothesis that these shorter Abeta isoforms may be biomarkers of gamma-secretase inhibitor treatment in clinical trials...
  41. ncbi request reprint Increased frequency of combined methylenetetrahydrofolate reductase C677T and A1298C mutated alleles in spontaneously aborted embryos
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, Sweden
    Eur J Hum Genet 10:113-8. 2002
    ..The present finding of high prevalence of mutated MTHFR genotypes in spontaneously aborted embryos emphasises the potential protective role of periconceptional folic acid supplementation...
  42. ncbi request reprint Influence of the apolipoprotein E epsilon4 allele on human embryonic development
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, 41345 Gothenburg, Sweden
    Neurosci Lett 324:189-92. 2002
    ..005), suggesting that epsilon4 may have protective effects during embryogenesis. These protective effects might counterbalance the deleterious age-related effects of the epsilon4 allele in natural selection...
  43. ncbi request reprint The transcobalamin codon 259 polymorphism influences the risk of human spontaneous abortion
    H Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
    Hum Reprod 17:3033-6. 2002
    ..Transcobalamin (TC) transports vitamin B(12) to the tissues. The objective of the present investigation was to explore the putative association between the major TC genetic polymorphism (Pro259Arg) and human spontaneous abortion...
  44. ncbi request reprint No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, Sweden
    Thromb Res 108:127-31. 2002
  45. ncbi request reprint Gene-gene interaction between fetal MTHFR 677C>T and transcobalamin 776C>G polymorphisms in human spontaneous abortion
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
    Hum Reprod 18:1948-50. 2003
    ..It was hypothesized that there may be a significant interaction between MTHFR and TC genotypes which affects the pathogenesis of spontaneous abortion...
  46. pmc Methylenetetrahydrofolate reductase and transcobalamin genetic polymorphisms in human spontaneous abortion: biological and clinical implications
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
    Reprod Biol Endocrinol 2:7. 2004
    ....
  47. ncbi request reprint Multiple EBNA1-binding sites within oriPI are required for EBNA1-dependent transactivation of the Epstein-Barr virus C promoter
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
    Int J Oncol 25:693-6. 2004
    ....
  48. ncbi request reprint Increased cerebrospinal fluid levels of transforming growth factor-beta1 in Alzheimer's disease
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg University, S 413 45 Gothenburg, Sweden
    Neurosci Lett 367:194-6. 2004
    ..35; P = 0.020), although this correlation failed to reach significance in the AD group alone (r = -0.38; P = 0.099). Taken together, the data indicate that TGF-beta1 plays a role in the processes that affect amyloid metabolism in AD...
  49. ncbi request reprint [New investigations in suspected Creutzfeldt-Jakob disease. Analysis of 14-3-3 protein and T-tau in cerebrospinal fluid for safer diagnosis]
    Henrik Zetterberg
    Institutionen för klinisk neurovetenskap, Göteborgs Universitet, Sweden
    Lakartidningen 102:956-8, 960-1. 2005
    ..Here, we review how CSF T-tau and P-tau may aid in the diagnosis of CJD and illustrate this by presenting cases from routine clinical practice...
  50. pmc No neurochemical evidence for brain injury caused by heading in soccer
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Neurochemistry and Psychiatry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Br J Sports Med 41:574-7. 2007
    ..The possible injurious effect to the brain of heading in soccer is a matter of discussion...
  51. ncbi request reprint Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years
    Henrik Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Alzheimers Dis 12:255-60. 2007
    ..Thus, even minor biochemical changes induced by treatment against AD should be detectable using these biomarkers, which bodes well for their usefulness as surrogate markers for drug efficacy in clinical trials...
  52. doi request reprint Clinical proteomics in neurodegenerative disorders
    H Zetterberg
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Sweden
    Acta Neurol Scand 118:1-11. 2008
    ....
  53. doi request reprint Association of APOE with age at onset of sporadic amyotrophic lateral sclerosis
    Henrik Zetterberg
    Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, Goteborg University, Sweden
    J Neurol Sci 273:67-9. 2008
    ..027). These data support APOE epsilon4 as a subordinate contributing factor in ALS...
  54. pmc The szilard hypothesis on the nature of aging revisited
    Henrik Zetterberg
    Department of Clinical Chemistry and Transfusion Medicine, University of Gothenburg, S 413 45 Gothenburg, Sweden
    Genetics 182:3-9. 2009
    ..Here, we review Szilard's assumptions in the light of current knowledge on aging and reassess his mathematical model in an attempt to reach a conclusion on the relevance of Szilard's aging hypothesis today...
  55. ncbi request reprint Aspects of beta-amyloid as a biomarker for Alzheimer's disease
    Ulf Andreasson
    , , S 431 80, , , Sweden
    Biomark Med 1:59-78. 2007
    ....
  56. doi request reprint Association of complement factor H Y402H gene polymorphism with Alzheimer's disease
    Madeleine Zetterberg
    Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Am J Med Genet B Neuropsychiatr Genet 147:720-6. 2008
    ..The CFH 1277C allele may predispose patients for co-morbidity in AD and AMD...
  57. pmc Association of the RAGE G82S polymorphism with Alzheimer's disease
    Jonny Daborg
    Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 432, 405 30, Gothenburg, Sweden
    J Neural Transm (Vienna) 117:861-7. 2010
    ..4), and none of the AGER SNPs showed association with Abeta(42), T-tau, P-tau(181) or mini-mental state examination scores. The data speak for a weak, but significant effect of AGER on risk of AD...
  58. doi request reprint Evaluation of the cerebrospinal fluid amyloid-β1-42/amyloid-β1-40 ratio measured by alpha-LISA to distinguish Alzheimer's disease from other dementia disorders
    Magdalena Nutu
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    Dement Geriatr Cogn Disord 36:99-110. 2013
    ..This study aimed to evaluate whether the cerebrospinal fluid (CSF) amyloid-β (Aβ)1-42/Aβ1-40 ratio, measured by a novel method, could improve the differential diagnosis of AD, DLB and PDD...
  59. ncbi request reprint The PPAR-alpha gene in Alzheimer's disease: lack of replication of earlier association
    Annica Sjölander
    Department of Clinical Neuroscience, Unit of Neurochemistry, The Sahlgrenska Academy at Goteborg University, Sweden
    Neurobiol Aging 30:666-8. 2009
    ..We found no significant differences in genotype or allele distributions between AD patients and controls. None of the PPAR-alpha gene variants influenced markers for AD...
  60. doi request reprint Nrf2-encoding NFE2L2 haplotypes influence disease progression but not risk in Alzheimer's disease and age-related cataract
    Malin von Otter
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Bla Straket 15, the Sahlgrenska Academy at University of Gothenburg, S 413 45 Gothenburg, Sweden
    Mech Ageing Dev 131:105-10. 2010
    ..009). Our findings do not support NFE2L2 or KEAP1 as susceptibility genes for AD or cataract. However, common variants of the NFE2L2 gene may affect disease progression, potentially altering clinically recognized disease onset...
  61. pmc Variability in the kinesin light chain 1 gene may influence risk of age-related cataract
    Malin E Andersson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Mol Vis 13:993-6. 2007
    ..Here, we test the hypothesis that the rs8702 polymorphism in the kinesin light chain 1 gene (KLC1), previously linked to Alzheimer disease (AD), may play a role in cataractogenesis...
  62. doi request reprint Cerebrospinal Fluid Fatty Acid-Binding Protein 3 is Related to Dementia Development in a Population-Based Sample of Older Adult Women Followed for 8 Years
    Maria Bjerke
    Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    J Alzheimers Dis 49:733-41. 2016
    ..Cerebrospinal fluid (CSF) FABP-3 has therefore been proposed as a putative marker for dementia. Population-based studies examining whether CSF FABP-3 predicts later development of dementia are lacking...
  63. doi request reprint Cerebrospinal fluid biomarkers of β-amyloid metabolism in multiple sclerosis
    Kristin Augutis
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Mult Scler 19:543-52. 2013
    ....
  64. doi request reprint A novel ARC gene polymorphism is associated with reduced risk of Alzheimer's disease
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    J Neural Transm (Vienna) 119:833-42. 2012
    ..However, further investigation of the importance of this SNP for ARC function, ARC processing and the pathology of AD is needed...
  65. doi request reprint Do alcohol-dependent individuals with DRD2 A1 allele have an increased risk of relapse? A pilot study
    Angelica Dahlgren
    Department of Psychology, University of Gothenburg, PO Box 500, SE 405 30 Goteborg, Sweden
    Alcohol Alcohol 46:509-13. 2011
    ..In the present study, we investigated whether the TaqI A1 allele of the DRD2 gene region was associated with a higher relapse rate in alcohol-dependent individuals...
  66. ncbi request reprint TAU haplotype and the Saitohin Q7R gene polymorphism do not influence CSF Tau in Alzheimer's disease and are not associated with frontotemporal dementia or Parkinson's disease
    Annica Johansson
    Department of Clinical Neuroscience, Unit of Neurochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Neurodegener Dis 2:28-35. 2005
    ..A single nucleotide polymorphism in the STH gene has been suggested to be involved in sporadic AD and is in complete linkage disequilibrium with the TAU haplotype H1...
  67. doi request reprint Kinesin light chain 1 gene haplotypes in three conformational diseases
    Malin von Otter
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Neuromolecular Med 12:229-36. 2010
    ..Altogether, these results do not convincingly support KLC1 as a major susceptibility gene in any of the studied diseases, although there is a small effect of KLC1 in relation to cataract...
  68. doi request reprint Reward-related genes and personality traits in alcohol-dependent individuals: a pilot case control study
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Neuropsychobiology 64:38-46. 2011
    ..In conclusion, this pilot study suggests that reward-related genes are associated with altered personality scores in type 1 alcohol dependence, which warrants future studies of these associations in larger study samples...
  69. doi request reprint Low cerebrospinal fluid sulfatide predicts progression of white matter lesions: The LADIS study
    Michael Jonsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Sweden
    Dement Geriatr Cogn Disord 34:61-7. 2012
    ..The neurochemistry of ongoing WML is only partially known. We explored cerebrospinal fluid (CSF) substances as markers of brain tissue damage in relation to progression of WML rated on magnetic resonance imaging...
  70. doi request reprint Leukocyte telomere length (LTL) is reduced in stable mild cognitive impairment but low LTL is not associated with conversion to Alzheimer's disease: a pilot study
    Sofia Movérare-Skrtic
    Institute of Medicine, Department of Internal Medicine, The Sahlgrenska Academy, University of Gothenburg, S 41345 Gothenburg, Sweden
    Exp Gerontol 47:179-82. 2012
    ..Patients with stable MCI that did not progress to dementia had reduced LTL compared to controls, which might suggest a more marked biological aging as a cause of the cognitive symptoms in this group...
  71. pmc Increased CSF levels of phosphorylated neurofilament heavy protein following bout in amateur boxers
    Sanna Neselius
    Department of Orthopaedics, Sahlgrenska University Hospital, Gothenburg, Sweden Institution for Clinical Sciences, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 8:e81249. 2013
    ..The aims of this study were to find other biomarkers of mild TBI, which may help clinicians diagnose and monitor mild TBI, and to calculate the role of APOE ε4 allele genotype which has been associated with poor outcome after TBI...
  72. doi request reprint Cerebrospinal fluid brain injury biomarkers in children: a multicenter study
    Pashtun Shahim
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Neurochemistry, Sahlgrenska University Hospital Molndal, Sweden
    Pediatr Neurol 49:31-39.e2. 2013
    ....
  73. doi request reprint Mass spectrometric characterization of amyloid-β species in the 7PA2 cell model of Alzheimer's disease
    Erik Portelius
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 33:85-93. 2013
    ..The formation of these AβPP/Aβ peptides may have implications for the use of the 7PA2 cell line as a model for Aβ pathology. The enzyme(s) responsible for this particular BACE1-independent AβPP-processing remains to be identified...
  74. doi request reprint Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma
    Sanna Neselius
    Department of Orthopaedics, Sahlgrenska University Hospital, Gothenburg, Sweden
    Brain Inj 27:425-33. 2013
    ..The aim of this study was to investigate if olympic (amateur) boxing is associated with elevation of brain injury biomarkers in peripheral blood compared to controls...
  75. doi request reprint Soluble amyloid precursor protein α and β in CSF in Alzheimer's disease
    Gunnar Brinkmalm
    Department of Psychiatry and Neurochemistry, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Brain Res 1513:117-26. 2013
    ....
  76. doi request reprint Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women
    Jaana Gustavsson
    Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden
    Atherosclerosis 220:486-92. 2012
    ..However, these associations may be modified by lifestyle factors. Therefore, we studied whether smoking, physical inactivity or overweight interact with APOE on cholesterol levels and CHD risk...
  77. doi request reprint Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid
    Erik Portelius
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, S 431 80 Molndal, Sweden
    Exp Neurol 223:351-8. 2010
    ....
  78. doi request reprint Association of nAChR gene haplotypes with heavy alcohol use and body mass
    Sara Landgren
    Institute of Neuroscience and Physiology, Department of Pharmacology, University of Gothenburg, Sweden
    Brain Res 1305:S72-9. 2009
    ....
  79. doi request reprint No association of VEGF polymorphims with Alzheimer's disease
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Medicinaregatan 13A, Gothenburg, Sweden
    Neuromolecular Med 12:224-8. 2010
    ..No significant associations with risk for AD or any of the studied biomarkers could be found in this study, thus not supporting VEGF as being a major risk gene for AD...
  80. doi request reprint Genetic variation of the ghrelin signaling system in females with severe alcohol dependence
    Sara Landgren
    Department of Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    Alcohol Clin Exp Res 34:1519-24. 2010
    ....
  81. pmc Ubiquitin carboxyl-terminal esterase L1 (UCHL1) S18Y polymorphism in patients with cataracts
    Thiemo Rudolph
    Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Section of Ophthalmology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden
    Ophthalmic Genet 32:75-9. 2011
    ..A protective role of the p.S18Y polymorphism of the UCHL1 gene has been shown in Parkinson`s disease. The current study aimed to examine possible effects on cataract formation...
  82. ncbi request reprint Methylenetetrahydrofolate reductase genetic polymorphisms in patients with cataract
    Madeleine Zetterberg
    Institute of Clinical Neuroscience, Section of Ophthalmology, Sahlgrenska University Hospital, Goteborg University, Molndal, Sweden
    Am J Ophthalmol 140:932-4. 2005
    ..The level of homocysteine can be lowered by dietary intake of folate. A protective effect of folate supplementation has been reported against cataract. Here we investigate MTHFR polymorphisms in human cataract...
  83. doi request reprint Serum but not cerebrospinal fluid levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 (IGFBP-3) are increased in Alzheimer's disease
    Per Johansson
    Department of Neuropsychiatry, Skaraborg Hospital, SE 521 85 Falköping, Sweden Department of Internal Medicine, Sahlgrenska Academy, University of Gothenburg, SE 413 45 Gothenburg, Sweden
    Psychoneuroendocrinology 38:1729-37. 2013
    ..Although insulin-like growth factor-I (IGF-I) is of importance for the adult function of the central nervous system (CNS), little is known of the significance of IGF-I in cerebrospinal fluid (CSF) in relation to Alzheimer's disease (AD)...
  84. doi request reprint Superoxide dismutase gene polymorphisms in patients with age-related cataract
    Dragana Celojevic
    Department of Clinical Neuroscience and Rehabilitation Ophthalmology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Ophthalmic Genet 34:140-5. 2013
    ..In this study, we investigated a number of disease-associated single nucleotide polymorphisms (SNPs) of SOD1, SOD2 and SOD3, in patients with age-related cataract...
  85. ncbi request reprint Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma
    Madeleine Zetterberg
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Ophthalmic Genet 28:47-50. 2007
    ..The purpose of the present study was to determine if hyperhomocysteinemia-associated polymorphisms of the methylenetetrahydrofolate reductase gene (MTHFR) are overrepresented in primary open-angle glaucoma...
  86. doi request reprint Cerebrospinal fluid biomarkers mirror rate of cognitive decline
    Sindre Rolstad
    Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Gothenburg University, Molndal, Sweden
    J Alzheimers Dis 34:949-56. 2013
    ..CSF predicted subsequent decline in more cognitive domains among MCI cases, but the impact was most pronounced in patients with dementia...
  87. doi request reprint Longitudinal cerebrospinal fluid biomarkers over four years in mild cognitive impairment
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 30:767-78. 2012
    ..Knowledge on these biomarkers and their trajectories may facilitate early diagnosis of AD and be useful in future clinical trials to track effects of disease modifying drugs...
  88. doi request reprint Extreme stability of chitotriosidase in cerebrospinal fluid makes it a suitable marker for microglial activation in clinical trials
    Bob Olsson
    Department of Psychiatry and Neurochemistry, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 32:273-6. 2012
    ..Thus, chitotriosidase may be useful in clinical trials where microglia is targeted or as a safety biomarker in other trials where the brain is a bystander organ...
  89. doi request reprint Cerebrospinal fluid matrix metalloproteinases and tissue inhibitor of metalloproteinases in combination with subcortical and cortical biomarkers in vascular dementia and Alzheimer's disease
    Maria Bjerke
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 27:665-76. 2011
    ..The CSF biomarkers reflecting AD pathology (T-tau, P-tau(181), and Aβ(1-42)), white matter lesions (NF-L and MBP) and matrix remodeling (MMP-9 and TIMP-1) perform well in differentiating between SVD and AD patients...
  90. doi request reprint An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid β and amyloid precursor protein in human and cat cerebrospinal fluid
    Gunnar Brinkmalm
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    J Mass Spectrom 47:591-603. 2012
    ..We here describe a detailed characterization of endogenous APP/Aβ peptide species in CSF by using an online top-down MS-based method...
  91. ncbi request reprint Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma
    Madeleine Zetterberg
    Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    Am J Ophthalmol 143:1059-60. 2007
    ..To investigate apolipoprotein E (APOE) polymorphisms, which are known to influence the risk of Alzheimer disease (AD), in patients with primary open-angle glaucoma (POAG)...
  92. doi request reprint Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?
    Annika Ohrfelt
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    Neurosci Lett 450:332-5. 2009
    ..The lower alpha-syn levels in AD, as well as the association of alpha-syn reduction with AD severity, approximated by MMSE, suggests that it may be a general marker of synapse loss, a hypothesis that warrants further investigation...
  93. doi request reprint Converging pathways of chromogranin and amyloid metabolism in the brain
    Niklas Mattsson
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Gothenburg and Mölndal, Sweden
    J Alzheimers Dis 20:1039-49. 2010
    ..Cell medium from BACE1-inhibited cells had decreased CgB levels. These results suggest that a large part of AbetaPP in the human central nervous system is processed in the regulated secretory pathway of neurons...
  94. doi request reprint High education may offer protection against tauopathy in patients with mild cognitive impairment
    Sindre Rolstad
    Institute of Neuroscience and Physiology, Section for Neurochemistry and Psychiatry, The Sahlgrenska Academy at Goteborg University, Molndal, Sweden
    J Alzheimers Dis 21:221-8. 2010
    ..Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy...
  95. doi request reprint Proteomic profiling of cerebrospinal fluid in parkinsonian disorders
    Radu Constantinescu
    Institute of Neuroscience and Physiology, Department of Neurology, The Sahlgrenska Academy at the University of Gothenburg, 413 45 Goteborg, Sweden
    Parkinsonism Relat Disord 16:545-9. 2010
    ..However, they could not differentiate PD patients from controls. As none of these changes were APD subgroup-specific, they most likely reflect the intensity and/or extent of the neurodegenerative process in general...
  96. doi request reprint Microglial markers are elevated in the prodromal phase of Alzheimer's disease and vascular dementia
    Bob Olsson
    Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 33:45-53. 2013
    ..Moreover, YKL-40 differentiates between AD and controls and between stable MCI to AD and those that convert to AD and VaD...
  97. pmc CSF biomarker variability in the Alzheimer's Association quality control program
    Niklas Mattsson
    Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Molndal, Sweden
    Alzheimers Dement 9:251-61. 2013
    ..However, there are large variations in biomarker measurements among and within laboratories...
  98. pmc Evaluating amyloid-β oligomers in cerebrospinal fluid as a biomarker for Alzheimer's disease
    Mikko Hölttä
    Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, the Sahlgrenska Academy at University of Gothenburg, Molndal, Sweden
    PLoS ONE 8:e66381. 2013
    ..These results indicate that presence of high or measurable Aβo levels in CSF is clearly associated with AD, but the overlap is too large for the test to have any diagnostic potential on its own. ..
  99. doi request reprint Complement gene single nucleotide polymorphisms and biomarker endophenotypes of Alzheimer's disease
    Jonny Daborg
    Institute of Neuroscience and Physiology, Department of Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
    J Alzheimers Dis 35:51-7. 2013
    ..023) and Mini-Mental State Examination scores (p = 0.012), both of which may be considered markers of disease intensity/severity...
  100. doi request reprint Cerebrospinal fluid levels of heart fatty acid binding protein are elevated prodromally in Alzheimer's disease and vascular dementia
    Bob Olsson
    Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Molndal, Sweden
    J Alzheimers Dis 34:673-9. 2013
    ..In conclusion, HFABP seems to be a stable CSF biomarker that reflects neuronal cell death in several neurodegenerative disorders, including early stages of AD and VaD...
  101. doi request reprint Aβ1-15/16 as a potential diagnostic marker in neurodegenerative diseases
    Magdalena Nutu
    Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital Molndal, S 431 80, Molndal, Sweden
    Neuromolecular Med 15:169-79. 2013
    ..We found reduced levels of Aβ1-15 in parkinsonian disease groups. The molecular mechanism behind this reduction is at present unknown...