Jacques Antoine Haefliger

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. ncbi request reprint Hypertension increases connexin43 in a tissue-specific manner
    J A Haefliger
    Department of Internal Medicine B, University Hospital, CHUV 1011 Lausanne, Switzerland
    Circulation 95:1007-14. 1997
  2. ncbi request reprint Connexins 43 and 26 are differentially increased after rat bladder outlet obstruction
    Jacques Antoine Haefliger
    Department of Internal Medicine, University Hospital, Lausanne, CHUV 1011, Switzerland
    Exp Cell Res 274:216-25. 2002
  3. ncbi request reprint The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic beta cells
    Jacques Antoine Haefliger
    Department of Internal Medicine, CHUV 1011 Lausanne, Switzerland
    J Cell Sci 116:1463-9. 2003
  4. ncbi request reprint Connexins 40 and 43 are differentially regulated within the kidneys of rats with renovascular hypertension
    J A Haefliger
    Department of Internal Medicine, Laboratory of Clinical Chemistry, Division of Physiopathology, University Hospital, Lausanne, Switzerland
    Kidney Int 60:190-201. 2001
  5. ncbi request reprint Connexin37 in normal and pathological development of mouse heart and great arteries
    J A Haefliger
    Department of Internal Medicine, University Hospital, Lausanne, Switzerland
    Dev Dyn 218:331-44. 2000
  6. ncbi request reprint Chronic hypertension alters the expression of Cx43 in cardiovascular muscle cells
    J A Haefliger
    Department of Internal Medicine B, University Hospital, Lausanne, Switzerland
    Braz J Med Biol Res 33:431-8. 2000
  7. ncbi request reprint Cellular localization, expression and regulation of neuropeptide Y in kidneys of hypertensive rats
    J A Haefliger
    Department of Internal Medicine B, University Hospital, CHUV 1011 Lausanne, Switzerland
    Regul Pept 82:35-43. 1999
  8. ncbi request reprint Aortic connexin43 is decreased during hypertension induced by inhibition of nitric oxide synthase
    J A Haefliger
    Department of Internal Medicine, Division of Hypertension and Vascular Medicine, University Hospital, Lausanne, Switzerland
    Arterioscler Thromb Vasc Biol 19:1615-22. 1999
  9. ncbi request reprint Hypertension differentially affects the expression of the gap junction protein connexin43 in cardiac myocytes and aortic smooth muscle cells
    J A Haefliger
    Department of Internal Medicine B, University Hospital, CHUV 1011 Lausanne, Switzerland
    Adv Exp Med Biol 432:71-82. 1997
  10. ncbi request reprint Contribution of connexins to the function of the vascular wall
    Jacques Antoine Haefliger
    Laboratory of Molecular Biology, Department of Internal Medicine, University Hospital, 19 135S Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Cardiovasc Res 62:345-56. 2004

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Hypertension increases connexin43 in a tissue-specific manner
    J A Haefliger
    Department of Internal Medicine B, University Hospital, CHUV 1011 Lausanne, Switzerland
    Circulation 95:1007-14. 1997
    ..The aim of this study was to investigate the effects of experimental hypertension on Cx43 expression in rat aorta and heart...
  2. ncbi request reprint Connexins 43 and 26 are differentially increased after rat bladder outlet obstruction
    Jacques Antoine Haefliger
    Department of Internal Medicine, University Hospital, Lausanne, CHUV 1011, Switzerland
    Exp Cell Res 274:216-25. 2002
    ..The data show that Cx43 and Cx26 are differentially regulated during bladder outlet obstruction and contribute to the response of the bladder wall to increased voiding pressure, possibly to control its elasticity...
  3. ncbi request reprint The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic beta cells
    Jacques Antoine Haefliger
    Department of Internal Medicine, CHUV 1011 Lausanne, Switzerland
    J Cell Sci 116:1463-9. 2003
    ..These data demonstrate that modulation of the IB1-JIP-1 content in beta cells is a crucial regulator of JNK signaling pathway and of cytokine-induced apoptosis...
  4. ncbi request reprint Connexins 40 and 43 are differentially regulated within the kidneys of rats with renovascular hypertension
    J A Haefliger
    Department of Internal Medicine, Laboratory of Clinical Chemistry, Division of Physiopathology, University Hospital, Lausanne, Switzerland
    Kidney Int 60:190-201. 2001
    ..Connexin 40 (Cx40) is a gap junction protein expressed in endothelial cells of vessels, endocardium, and conducting cells of the His-Purkinje system of heart. Its distribution in the kidney remains to be fully investigated...
  5. ncbi request reprint Connexin37 in normal and pathological development of mouse heart and great arteries
    J A Haefliger
    Department of Internal Medicine, University Hospital, Lausanne, Switzerland
    Dev Dyn 218:331-44. 2000
    ..The data indicate that Cx37 is widely distributed in multiple compartments of cardiovascular system, in patterns which are modulated during development, by retinoic acid...
  6. ncbi request reprint Chronic hypertension alters the expression of Cx43 in cardiovascular muscle cells
    J A Haefliger
    Department of Internal Medicine B, University Hospital, Lausanne, Switzerland
    Braz J Med Biol Res 33:431-8. 2000
    ..The data suggest that localized mechanical forces induced by hypertension affect Cx43 expression and that the cell-to-cell communication mediated by Cx43 channels may contribute to regulating the elasticity of the vascular wall...
  7. ncbi request reprint Cellular localization, expression and regulation of neuropeptide Y in kidneys of hypertensive rats
    J A Haefliger
    Department of Internal Medicine B, University Hospital, CHUV 1011 Lausanne, Switzerland
    Regul Pept 82:35-43. 1999
    ....
  8. ncbi request reprint Aortic connexin43 is decreased during hypertension induced by inhibition of nitric oxide synthase
    J A Haefliger
    Department of Internal Medicine, Division of Hypertension and Vascular Medicine, University Hospital, Lausanne, Switzerland
    Arterioscler Thromb Vasc Biol 19:1615-22. 1999
    ..The data suggest that the cell-to-cell communication mediated by Cx43 channels may help regulate the elasticity of the vascular wall...
  9. ncbi request reprint Hypertension differentially affects the expression of the gap junction protein connexin43 in cardiac myocytes and aortic smooth muscle cells
    J A Haefliger
    Department of Internal Medicine B, University Hospital, CHUV 1011 Lausanne, Switzerland
    Adv Exp Med Biol 432:71-82. 1997
    ..These results suggest that localized mechanical forces induced by hypertension are major tissue-specific regulators of Cx43 expression...
  10. ncbi request reprint Contribution of connexins to the function of the vascular wall
    Jacques Antoine Haefliger
    Laboratory of Molecular Biology, Department of Internal Medicine, University Hospital, 19 135S Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Cardiovasc Res 62:345-56. 2004
    ..Finally, to address the possible regulation of connexin expression by fluid pressure, we summarize the effects of elevated transmural urine pressure on bladder Cx43 expression...
  11. ncbi request reprint Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines
    David Martin
    Department of Internal Medicine, University Hospital, CHUV 1011 Lausanne, Switzerland
    J Biol Chem 278:53082-9. 2003
    ..The data showed that cx36 gene expression in insulin-producing beta-cell lines is strictly controlled by the transcriptional repressor NRSF/REST indicating that Cx36 participates to the neuronal phenotype of the pancreatic beta-cells...
  12. pmc An angiotensin II- and NF-kappaB-dependent mechanism increases connexin 43 in murine arteries targeted by renin-dependent hypertension
    Florian Alonso
    Service of Internal Medicine, Laboratory of Experimental Medicine 19 135S, University Hospital, CHUV 1011 Lausanne, Switzerland
    Cardiovasc Res 87:166-76. 2010
    ..We investigated how connexins of the endothelial cells (ECs; Cx37, Cx40) and smooth muscle cells (SMCs; Cx43, Cx45) of the aorta change during renin-dependent and -independent hypertension...
  13. ncbi request reprint Neuronal traits are required for glucose-induced insulin secretion
    Amar Abderrahmani
    Department of Internal Medicine, University of Lausanne, CHUV 1011 Lausanne, Switzerland
    FEBS Lett 565:133-8. 2004
    ..These data provide evidence that REST target genes are required for an appropriate glucose-induced insulin secretion...
  14. ncbi request reprint The scaffold protein IB1/JIP-1 controls the activation of JNK in rat stressed urothelium
    Thomas Tawadros
    Department of Internal Medicine, Service of Urology, University Hospital, CHUV 1011 Lausanne, Switzerland
    J Cell Sci 115:385-93. 2002
    ..This result highlights a critical role for that scaffold protein in the homeostasis of the urothelium and unravels a new potential target to regulate the JNK pathway in this tissue...
  15. pmc Reduction of connexin36 content by ICER-1 contributes to insulin-secreting cells apoptosis induced by oxidized LDL particles
    Jacques Antoine Haefliger
    Service of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    PLoS ONE 8:e55198. 2013
    ..These data demonstrate that the reduction of Cx36 content in beta-cells by oxLDL particles is mediated by ICER-1 and contributes to oxLDL-induced beta-cell apoptosis...
  16. pmc Specific silencing of the REST target genes in insulin-secreting cells uncovers their participation in beta cell survival
    David Martin
    Service of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    PLoS ONE 7:e45844. 2012
    ..Together, these data document that a set of REST target genes, including Cdk5r2, is important for beta cell survival...
  17. ncbi request reprint Sepsis up-regulates the expression of connexin 40 in rat aortic endothelium
    Stéphanie Rignault
    Division de physiopathologie clinique, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Crit Care Med 33:1302-10. 2005
    ..e., Cx37, Cx40, and Cx43). We also examined a possible association between such changes and endothelial dysfunction in this model...
  18. ncbi request reprint Insulin-secreting beta-cell dysfunction induced by human lipoproteins
    Marc Estienne Roehrich
    Department of Internal Medicine and Institute of Cellular Biology and Morphology, University Hospital, Lausanne 1011, Switzerland
    J Biol Chem 278:18368-75. 2003
    ..In conclusion, human lipoproteins are critical regulators of beta-cell survival and may therefore contribute to the beta-cell dysfunction observed during the development of type 2 diabetes...
  19. ncbi request reprint IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation
    Thomas Tawadros
    Service of Urology, University Hospital, Lausanne, Switzerland
    Cell Signal 17:929-39. 2005
    ..Together, these results indicated that IB1/JIP-1 participates to the neuronal phenotype of the human LNCaP cells and is a regulator of JNK signaling pathway...
  20. ncbi request reprint Glucose represses connexin36 in insulin-secreting cells
    Florent Allagnat
    Department of Internal Medicine, Laboratory of Molecular Biology 19 135S, University Hospital, CHUV 1011 Lausanne, Switzerland
    J Cell Sci 118:5335-44. 2005
    ..Taken together, these data provide evidence that glucose represses the expression of Cx36 through the cAMP-PKA pathway, which activates a member of the CRE binding protein family...
  21. doi request reprint Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ
    Jacques Antoine Haefliger
    Service of Internal Medicine, Department of Physiology, University Hospital Lausanne, Lausanne, Switzerland
    J Mol Endocrinol 51:49-58. 2013
    ..This mechanism may contribute to the reduced glucose sensitivity and altered insulin secretion, which contribute to the pathophysiology of diabetes...
  22. ncbi request reprint The repressor element silencing transcription factor (REST)-mediated transcriptional repression requires the inhibition of Sp1
    Valérie Plaisance
    Department of Internal Medicine, University of Lausanne, 1005 Lausanne, Switzerland
    J Biol Chem 280:401-7. 2005
    ..We conclude that the interplay between REST and Sp1 determines the cell-specific expression of REST target genes...
  23. pmc Connexin43-dependent mechanism modulates renin secretion and hypertension
    Jacques Antoine Haefliger
    Department of Internal Medicine, University Hospital, Lausanne, Switzerland
    J Clin Invest 116:405-13. 2006
    ..The data indicate that replacement of Cx43 by Cx32 is associated with decreased expression and secretion of renin, thus preventing the renin-dependent hypertension that is normally induced in the 2K1C model...
  24. ncbi request reprint Connexin-36 contributes to control function of insulin-producing cells
    Sabine Le Gurun
    Department of Internal Medicine, University Hospital, CHUV 1011 Lausanne, Switzerland
    J Biol Chem 278:37690-7. 2003
    ..The data indicate that large changes in Cx36 alter insulin content and, at least in INS-1E cells, also affect glucose-induced insulin release...
  25. doi request reprint Increased expression of renal cyclooxygenase-2 and neuronal nitric oxide synthase in hypertensive Cx40-deficient mice
    Nathalie Krattinger
    Department of Medicine, University Hospital, Lausanne, Switzerland
    J Vasc Res 46:188-98. 2009
    ..These data document that renal COX-2 and nNOS are differentially regulated due to the elevation of renin-dependent blood pressure in mice lacking Cx40...
  26. ncbi request reprint Increased vulnerability to kainic acid-induced epileptic seizures in mice underexpressing the scaffold protein Islet-Brain 1/JIP-1
    Fulvio Magara
    Department of Internal Medicine, BH 10 640, University Hospital CHUV, 1011 Lausanne, Switzerland
    Eur J Neurosci 17:2602-10. 2003
    ..Taken together, these data indicate that IB1/JIP-1 in hippocampus participates in the regulation of the neuronal response to excitotoxic stress in a level-dependent fashion...
  27. doi request reprint Loss of connexin40 is associated with decreased endothelium-dependent relaxations and eNOS levels in the mouse aorta
    Florian Alonso
    Service of Internal Medicine, Laboratory of Experimental Medicine 19 135S, University Hospital, CHUV, Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 299:H1365-73. 2010
    ..Altogether, our data suggest that the endothelial connexins may participate in the control of eNOS expression levels and function...
  28. doi request reprint The use of external mesh reinforcement to reduce intimal hyperplasia and preserve the structure of human saphenous veins
    Alban Longchamp
    Department of Thoracic and Vascular Surgery, University Hospital, Laboratory of Experimental Medicine, Bugnon 21, 1011 Lausanne, Switzerland
    Biomaterials 35:2588-99. 2014
    ....
  29. ncbi request reprint Increased connexin43 expression in human saphenous veins in culture is associated with intimal hyperplasia
    Sebastien Deglise
    Department of Thoracic and Vascular Surgery, University Hospital, Lausanne, Switzerland
    J Vasc Surg 41:1043-52. 2005
    ....
  30. pmc Targeting endothelial connexin40 inhibits tumor growth by reducing angiogenesis and improving vessel perfusion
    Florian Alonso
    Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland
    Oncotarget 7:14015-28. 2016
    ..The data identify Cx40 as a potential novel target in cancer treatment...
  31. doi request reprint Atorvastatin-loaded hydrogel affects the smooth muscle cells of human veins
    Céline Dubuis
    Department of Thoracic and Vascular Surgery, University Hospital, Laboratory of Experimental Medicine, Lausanne, Switzerland C D, L M, F A, S D, J M C, F S, J A H School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland L L, I M, F D, O J and Department of Cell Physiology and Metabolism, University of Geneva, Medical Center, Geneva, Switzerland P M
    J Pharmacol Exp Ther 347:574-81. 2013
    ..The data demonstrate that ATV released from a hydrogel has effects on HSMCs similar to the drug being freely dissolved in the environment. ..
  32. ncbi request reprint Acute inflammation decreases the expression of connexin 40 in mouse lung
    Stéphanie Rignault
    Division de physiopathologie clinique, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Shock 28:78-85. 2007
    ....
  33. ncbi request reprint ICER-1gamma overexpression drives palmitate-mediated connexin36 down-regulation in insulin-secreting cells
    Florent Allagnat
    Department of Medicine, University Hospital, CHUV 1011 Lausanne, Switzerland
    J Biol Chem 283:5226-34. 2008
    ..This Cx36 down-regulation may contribute to the reduced glucose sensitivity and altered insulin secretion observed during the pre-diabetic stage and in the metabolic syndrome...
  34. doi request reprint Release of macrophage migration inhibitory factor by neuroendocrine-differentiated LNCaP cells sustains the proliferation and survival of prostate cancer cells
    Thomas Tawadros
    Service of Urology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, Lausanne, Switzerland
    Endocr Relat Cancer 20:137-49. 2013
    ..Thus, MIF could represent an attractive target for PCa therapy...
  35. doi request reprint Role of Connexins and Pannexins in the Pancreas
    Valentina Cigliola
    From the Department of Genetic Medicine, University of Geneva, Geneva and Department of Medicine, University of Lausanne, Lausanne, Switzerland Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark and Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Pancreas 44:1234-44. 2015
    ..Circumstantial evidence further suggests that alterations in the signaling provided by these proteins are involved in pancreatic diseases. ..
  36. pmc Intercellular calcium waves in primary cultured rat mesenteric smooth muscle cells are mediated by connexin43
    Nadia Halidi
    Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, Switzerland
    Cell Commun Adhes 19:25-37. 2012
    ....
  37. doi request reprint Swimming prevents vulnerable atherosclerotic plaque development in hypertensive 2-kidney, 1-clip mice by modulating angiotensin II type 1 receptor expression independently from hemodynamic changes
    Maxime Pellegrin
    Service of Vascular Medicine, Lausanne University Hospital, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Hypertension 53:782-9. 2009
    ..Ang II type 1 downregulation may protect the vessel wall from the Ang II proatherogenic effects. Moreover, data presented herein further emphasize the pivotal and blood pressure-independent role of Ang II in atherogenesis...
  38. doi request reprint Intravaginal and subcutaneous immunization induced vaccine specific CD8 T cells and tumor regression in the bladder
    Sonia Domingos-Pereira
    Department of Urology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Urol 191:814-22. 2014
    ..We compared different immunization routes for the ability to induce vaccine specific antitumor CD8 T cells in the bladder and bladder tumor regression in mice...
  39. pmc GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function
    Mathieu Membrez
    Institute of Physiology, University of Lausanne, Center for Integrative Genomics, Genopode Building, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 26:4268-76. 2006
    ..5 Na+ channel or connexin expression. Thus, absence of GLUT8 expression in the mouse caused complex but mild physiological alterations...
  40. ncbi request reprint Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling
    Zhidong Ling
    Diabetes Research Center, Brussels Free University VUB, Brussels, Belgium
    Diabetes 52:2497-502. 2003
    ..We conclude that the IB1/JIP-1 level in beta-cells can control their susceptibility to apoptosis independent of JNK signaling...
  41. ncbi request reprint [Gap junctions and secretion]
    Jacques Antoine Haefliger
    Département de médicine interne, Laboratoire de Biologie Moleculaire, CHUV, Lausanne
    Rev Med Suisse 1:1134-9. 2005
    ..Understanding the functions of beta-cell connexins are crucial for the engineering of surrogate cells, which is necessary for implementation of a replacement cell therapy in diabetic patients...
  42. ncbi request reprint Expression and regulation of connexins in cultured ventricular myocytes isolated from adult rat hearts
    Lioudmila O Polontchouk
    Institute for Cell Biology, ETH Honggerberg, 8093 Zurich, Switzerland
    Pflugers Arch 443:676-89. 2002
    ..However, the presence of heteromeric channels cannot be excluded. The data are consistent with an up-regulation of Cx45 and Cx43 during re-differentiation...
  43. ncbi request reprint [Connexins, renin and hypertension]
    Jacques Antoine Haefliger
    Med Sci (Paris) 22:826-7. 2006
  44. ncbi request reprint Splice variant-specific stabilization of JNKs by IB1/JIP1
    Jiang Yan Yang
    Department of Physiology, Biology and Medicine Faculty, University of Lausanne, Bugnon 7, 1005 Lausanne, Switzerland
    Cell Signal 19:2201-7. 2007
    ..Modulation of the stability of specific JNK splice variants represents therefore a newly identified mechanism used by IB1 to regulate the JNK MAPK pathway...
  45. ncbi request reprint The mif gene is transcriptionally regulated by glucose in insulin-secreting cells
    Valérie Plaisance
    Department of Internal Medicine and Institute of Cellular Biology and Morphology, University of Lausanne, Lausanne CH 1011, Switzerland
    Biochem Biophys Res Commun 295:174-81. 2002
    ..In conclusion, we identified a minimal region of the MIF promoter which contributes to the glucose stimulation of the mif gene in insulin-secreting cells...
  46. ncbi request reprint [Gap functions and diseases]
    Florent Allagnat
    Faculté de Biologie et Médecine, Departement de Medecine Interne, Laboratoire de biologie moléculaire CHUV, 1011 Lausanne
    Rev Med Suisse 1:1126-30, 1132-3. 2005
    ..This review summarizes the state of knowledge about the implication of connexins in human pathologies...
  47. pmc Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis
    Yok Ai Que
    Department of Fundamental Microbiology, University of Lausanne, 1015 Lausanne, Switzerland
    J Exp Med 201:1627-35. 2005
    ..Thus, fibrinogen and fibronectin binding could cooperate for S. aureus valve colonization and endothelial invasion in vivo...
  48. ncbi request reprint Thyrotropin-releasing hormone-stimulated thyrotropin expression involves islet-brain-1/c-Jun N-terminal kinase interacting protein-1
    Hiroshi Abe
    First Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Endocrinology 145:5623-8. 2004
    ..This effect is not found in the presence of a mutated nonfunctional (IB1S59N) IB1/JIP-1 protein. Together, these facts point to a central role of the IB1/JIP-1 protein in the control of TRH-mediated TSH-beta stimulation...