P M Hauser

Summary

Affiliation: Centre Hospitalier Universitaire Vaudois
Country: Switzerland

Publications

  1. pmc Molecular evidence of interhuman transmission of Pneumocystis pneumonia among renal transplant recipients hospitalized with HIV-infected patients
    Meja Rabodonirina
    Hopital de la Croix Rousse, Lyon, France
    Emerg Infect Dis 10:1766-73. 2004
  2. pmc Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia
    Aimable Nahimana
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Emerg Infect Dis 9:864-7. 2003
  3. pmc Risk for Pneumocystis carinii transmission among patients with pneumonia: a molecular epidemiology study
    Elodie Senggen Manoloff
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Emerg Infect Dis 9:132-4. 2003
  4. pmc Typing of Pneumocystis carinii f. sp. hominis by single-strand conformation polymorphism of four genomic regions
    P M Hauser
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Clin Microbiol 35:3086-91. 1997
  5. ncbi request reprint The development of a typing method for an uncultivable microorganism: the example of Pneumocystis jirovecii
    Philippe M Hauser
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Infect Genet Evol 4:199-203. 2004
  6. pmc Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiae
    I Meneau
    Institute of Microbiology, University Hospital of Lausanne, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 48:2610-6. 2004
  7. ncbi request reprint Typing methods to approach Pneumocystis carinii genetic heterogeneity
    P M Hauser
    Centre Hospitalier Universitaire Vaudois, Division Autonome de Médecine Préventive Hospitalière, Lausanne, Switzerland
    FEMS Immunol Med Microbiol 22:27-35. 1998
  8. ncbi request reprint Prophylaxis failure is associated with a specific Pneumocystis carinii genotype
    P M Hauser
    Division Autonome de Médecine Préventive Hospitalière, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Clin Infect Dis 33:1080-2. 2001
  9. ncbi request reprint Genetic diversity of Pneumocystis carinii in HIV-positive and -negative patients as revealed by PCR-SSCP typing
    P M Hauser
    , Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    AIDS 15:461-6. 2001
  10. ncbi request reprint Methicillin-resistant Staphylococcus aureus: phylogenetic relatedness between European epidemic clones and Swiss sporadic strains
    D S Blanc
    Division Autonome de Médecine Préventive Hospitalière, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Microb Drug Resist 6:231-8. 2000

Collaborators

Detail Information

Publications28

  1. pmc Molecular evidence of interhuman transmission of Pneumocystis pneumonia among renal transplant recipients hospitalized with HIV-infected patients
    Meja Rabodonirina
    Hopital de la Croix Rousse, Lyon, France
    Emerg Infect Dis 10:1766-73. 2004
    ..jirovecii molecular type as that found in the encountered PCP patients. The data suggest that part of the PCP cases observed in this building, particularly those observed in RTRs, were related to nosocomial interhuman transmission...
  2. pmc Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia
    Aimable Nahimana
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Emerg Infect Dis 9:864-7. 2003
    ..The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug...
  3. pmc Risk for Pneumocystis carinii transmission among patients with pneumonia: a molecular epidemiology study
    Elodie Senggen Manoloff
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Emerg Infect Dis 9:132-4. 2003
    ..Our analysis suggests that transmission from patients with active PCP to susceptible persons caused only a few, if any, PCP cases in our setting...
  4. pmc Typing of Pneumocystis carinii f. sp. hominis by single-strand conformation polymorphism of four genomic regions
    P M Hauser
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Clin Microbiol 35:3086-91. 1997
    ..Multitarget typing of P. carinii hominis by PCR-SSCP should allow investigation of strain diversity and thus be useful for future epidemiological studies...
  5. ncbi request reprint The development of a typing method for an uncultivable microorganism: the example of Pneumocystis jirovecii
    Philippe M Hauser
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Infect Genet Evol 4:199-203. 2004
    ..Its main disadvantage is that about 30% of the specimens cannot be typed because of the complexity of the alleles configuration. This multitarget typing method has been used for several epidemiological purposes...
  6. pmc Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiae
    I Meneau
    Institute of Microbiology, University Hospital of Lausanne, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 48:2610-6. 2004
    ..jiroveci. Taken together, our results suggest that the DHPS polymorphisms observed in P. jiroveci confer sulfa drug resistance on this pathogen...
  7. ncbi request reprint Typing methods to approach Pneumocystis carinii genetic heterogeneity
    P M Hauser
    Centre Hospitalier Universitaire Vaudois, Division Autonome de Médecine Préventive Hospitalière, Lausanne, Switzerland
    FEMS Immunol Med Microbiol 22:27-35. 1998
    ..carinii and the frequency of potential co-infections is going to be crucial for a better understanding of its epidemiology, and thus for a better prevention of P. carinii pneumonia in humans...
  8. ncbi request reprint Prophylaxis failure is associated with a specific Pneumocystis carinii genotype
    P M Hauser
    Division Autonome de Médecine Préventive Hospitalière, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Clin Infect Dis 33:1080-2. 2001
    ..carinii genotype and receiving anti-PCP prophylaxis (odds ratio, 4.4; 95% confidence interval, 1.0-18.6; P=.05), although no association with a specific drug was detected...
  9. ncbi request reprint Genetic diversity of Pneumocystis carinii in HIV-positive and -negative patients as revealed by PCR-SSCP typing
    P M Hauser
    , Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    AIDS 15:461-6. 2001
    ..There was no evidence that in our study population inter-human transmission played a significant role in the epidemiology of P. carinii...
  10. ncbi request reprint Methicillin-resistant Staphylococcus aureus: phylogenetic relatedness between European epidemic clones and Swiss sporadic strains
    D S Blanc
    Division Autonome de Médecine Préventive Hospitalière, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Microb Drug Resist 6:231-8. 2000
    ..Most of the sporadic Swiss strains were distributed into these seven different genetic clusters, together with the epidemic MRSA clones. This suggests that there is no phylogenetic cluster specific to epidemic clones of MRSA...
  11. pmc Rapid PCR-single-strand conformation polymorphism method to differentiate and estimate relative abundance of Pneumocystis carinii special forms infecting rats
    A Nahimana
    , Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Clin Microbiol 39:4563-5. 2001
    ..The results suggest that the method described will help to further standardize the immunosuppressed rat model of P. carinii infection and, thus, contribute to a better understanding of P. carinii infection in humans...
  12. pmc Mutations of Pneumocystis jirovecii dihydrofolate reductase associated with failure of prophylaxis
    Aimable Nahimana
    Institute of Microbiology, University Hospital of Lausanne, Rue du Bugnon 48, 1011 Lausanne, Switzerland
    Antimicrob Agents Chemother 48:4301-5. 2004
    ..The results suggest that P. jirovecii populations may evolve under selective pressure from DHFR inhibitors, in particular pyrimethamine, and that DHFR mutations may contribute to P. jirovecii drug resistance...
  13. pmc Epidemiological validation of pulsed-field gel electrophoresis patterns for methicillin-resistant Staphylococcus aureus
    D S Blanc
    Division Autonome de Médecine Préventive Hospitalière, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    J Clin Microbiol 39:3442-5. 2001
    ..During seven nosocomial epidemics lasting from 1 to 15 months, only 2 of 120 isolates (1.7%) showed a pattern which was different, although related, from the predominant one involved in each of these outbreaks...
  14. ncbi request reprint Pneumocystis jirovecii dihydrofolate reductase polymorphisms associated with failure of prophylaxis
    Aimable Nahimana
    Hospital Preventive Medicine, University Hospital, 1011 Lausanne, Switzerland
    J Eukaryot Microbiol 50:656-7. 2003
  15. ncbi request reprint Association between a specific Pneumocystis jiroveci dihydropteroate synthase mutation and failure of pyrimethamine/sulfadoxine prophylaxis in human immunodeficiency virus-positive and -negative patients
    Aimable Nahimana
    Hospital of Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland
    J Infect Dis 188:1017-23. 2003
    ..Hospitalization in a specific hospital was an independent risk factor for having P. jiroveci harboring the same DHPS mutation, which indirectly supports that interhuman transmission may affect the dissemination of the mutant strains...
  16. doi request reprint Interhuman transmission as a potential key parameter for geographical variation in the prevalence of Pneumocystis jirovecii dihydropteroate synthase mutations
    Philippe M Hauser
    Institute of Microbiology, Swiss HIV Cohort Study, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland
    Clin Infect Dis 51:e28-33. 2010
    ..This retrospective study sought to better understand the geographical variation in the prevalence of these mutations...
  17. doi request reprint Isothermal microcalorimetry: a novel method for real-time determination of antifungal susceptibility of Aspergillus species
    U Furustrand Tafin
    Infectious Diseases Service, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland
    Clin Microbiol Infect 18:E241-5. 2012
    ..This proof-of-concept study demonstrated the potential of isothermal microcalorimetry for growth evaluation of Aspergillus spp. and real-time antifungal susceptibility testing...
  18. doi request reprint Evaluation of a polymerase chain reaction-restriction fragment length polymorphism assay for dermatophyte and nondermatophyte identification in onychomycosis
    O Bontems
    Department of Dermatology, Laboratoire de Mycologie, BT422, Centre Hospitalier Universitaire Vaudois, CH 1011 Lausanne, Switzerland
    Br J Dermatol 161:791-6. 2009
    ..The correct identification of the aetiological agent of nail infections is necessary in order to recommend appropriate treatment...
  19. doi request reprint Functional Characterization of the Pneumocystis jirovecii Potential Drug Targets dhfs and abz2 Involved in Folate Biosynthesis
    A Luraschi
    Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
    Antimicrob Agents Chemother 59:2560-6. 2015
    ..jirovecii, the dihydrofolate synthase (dhfs) and the aminodeoxychorismate lyase (abz2). The function of these enzymes was demonstrated by the rescue of the null allele of the orthologous gene of Saccharomyces cerevisiae. ..
  20. ncbi request reprint Poor value of pulsed-field gel electrophoresis to investigate long-term scale epidemiology of methicillin-resistant Staphylococcus aureus
    D S Blanc
    Division Autonome de Médecine Préventive Hospitalière, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland
    Infect Genet Evol 2:145-8. 2002
    ..However, given the technical difficulties to obtain a good resolution of these bands and the putative presence of plasmids among them, PFGE does not appear to be a method of choice for the long-term epidemiology analysis of MRSA...
  21. ncbi request reprint Site-directed mutagenesis of the Saccharomyces cerevisiae dihydropteroate synthase FOL1 gene to study Pneumocystis jirovecii mutations in the orthologue gene FAS
    Isabelle Meneau
    Microbiology Institute, University Hospital, 1011 Lausanne, Switzerland
    J Eukaryot Microbiol 50:652-3. 2003
  22. pmc Functional characterization of Pneumocystis carinii brl1 by transspecies complementation analysis
    Libera Lo Presti
    Institute of Microbiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1011 Lausanne, Switzerland
    Eukaryot Cell 6:2448-52. 2007
    ..The ectopic expression of this gene rescues null alleles of essential nuclear membrane proteins of the Brr6/Brl1 family in both yeasts...
  23. doi request reprint Histoplasma capsulatum var. duboisii infection in a patient with AIDS: rapid diagnosis using polymerase chain reaction-sequencing
    Cyril Pellaton
    Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, Switzerland
    Diagn Microbiol Infect Dis 64:85-9. 2009
    ..The variety duboisii of Hc was established using DNA sequencing of the polymorphic genomic region OLE. Molecular tools allow diagnosis of histoplasmosis in 24 h, which is drastically shorter than culture procedures...
  24. pmc Molecular evidence of Pneumocystis transmission in pediatric transplant unit
    Britta Höcker
    University Children s Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany
    Emerg Infect Dis 11:330-2. 2005
    ..An infant with mitochondriopathy was the probable index patient...
  25. pmc Strain typing methods and molecular epidemiology of Pneumocystis pneumonia
    Charles Ben Beard
    Division of Vector Borne Infectious Disease, Centers for Disease Control and Prevention, Fort Collins, Colorado 80521, USA
    Emerg Infect Dis 10:1729-35. 2004
    ..One concern, however, is the lack of guidance regarding the appropriateness of different methods and standardization of these methods, which would facilitate comparing results reported by different laboratories...
  26. ncbi request reprint Geographical variation in the prevalence of Pneumocystis jirovecii dihydropteroate synthase mutations within Western Europe
    Meja Rabodonirina
    Parasitology Unit, Croix Rousse Hospital, Hospices Civils de Lyon, 103 Grande Rue de la Croix Rousse, 69317 Lyon Cedex 04, France
    J Eukaryot Microbiol 53:S112-3. 2006
  27. ncbi request reprint Isolation of the Pneumocystis carinii dihydrofolate synthase gene and functional complementation in Saccharomyces cerevisiae
    Philippe M Hauser
    Institute of Microbiology, University Hospital of Lausanne, Lausanne, Switzerland
    FEMS Microbiol Lett 256:244-50. 2006
    ..carinii mono-functional enzyme DHFS, to investigate a possible role of DHFS in the resistance to antifolates of P. jirovecii, the species infecting specifically humans, and to develop a new class of antifolates...
  28. ncbi request reprint Analysis of Pneumocystis carinii gene function by complementation in yeast mutants
    Philippe M Hauser
    Microbiology Institute, University Hospital, 1011 Lausanne, Switzerland
    J Eukaryot Microbiol 53:S149-50. 2006