Reto Stocklin

Summary

Country: Switzerland

Publications

  1. doi request reprint Structural identification by mass spectrometry of a novel antimicrobial peptide from the venom of the solitary bee Osmia rufa (Hymenoptera: Megachilidae)
    Reto Stocklin
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    Toxicon 55:20-7. 2010
  2. doi request reprint Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach
    Aude Violette
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    J Proteomics 75:5215-25. 2012
  3. ncbi request reprint Mass spectrometry strategies for venom mapping and peptide sequencing from crude venoms: case applications with single arthropod specimen
    Philippe Favreau
    Atheris Laboratories, Research and Development, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    Toxicon 47:676-87. 2006
  4. doi request reprint Position-specific scoring matrix and hidden Markov model complement each other for the prediction of conopeptide superfamilies
    Dominique Koua
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    Biochim Biophys Acta 1834:717-24. 2013
  5. ncbi request reprint Peptidomics and proteomics studies of transformed lymphocytes from patients mutated for the eukaryotic initiation factor 2B
    Anne Fogli
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 840:20-8. 2006
  6. pmc Recruitment of glycosyl hydrolase proteins in a cone snail venomous arsenal: further insights into biomolecular features of Conus venoms
    Aude Violette
    Atheris Laboratories, Bernex Geneva, Switzerland
    Mar Drugs 10:258-80. 2012
  7. ncbi request reprint The venom of the snake genus Atheris contains a new class of peptides with clusters of histidine and glycine residues
    Philippe Favreau
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    Rapid Commun Mass Spectrom 21:406-12. 2007
  8. doi request reprint Dramatic intraspecimen variations within the injected venom of Conus consors: an unsuspected contribution to venom diversity
    Sebastien Dutertre
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    Toxicon 55:1453-62. 2010
  9. doi request reprint High throughput screening of bradykinin-potentiating peptides in Bothrops moojeni snake venom using precursor ion mass spectrometry
    Laure Menin
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex, Geneva, Switzerland
    Toxicon 51:1288-302. 2008
  10. doi request reprint Uncovering intense protein diversification in a cone snail venom gland using an integrative venomics approach
    Daniel Biass
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    J Proteome Res 14:628-38. 2015

Collaborators

Detail Information

Publications19

  1. doi request reprint Structural identification by mass spectrometry of a novel antimicrobial peptide from the venom of the solitary bee Osmia rufa (Hymenoptera: Megachilidae)
    Reto Stocklin
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    Toxicon 55:20-7. 2010
    ..Preliminary antimicrobial and antifungal tests indicate that both peptides are able to inhibit bacterial and fungal growth at micromolar concentrations...
  2. doi request reprint Large-scale discovery of conopeptides and conoproteins in the injectable venom of a fish-hunting cone snail using a combined proteomic and transcriptomic approach
    Aude Violette
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    J Proteomics 75:5215-25. 2012
    ..This study demonstrates the feasibility of this analytical approach and paves the way for transcriptomics-assisted strategies in drug discovery...
  3. ncbi request reprint Mass spectrometry strategies for venom mapping and peptide sequencing from crude venoms: case applications with single arthropod specimen
    Philippe Favreau
    Atheris Laboratories, Research and Development, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    Toxicon 47:676-87. 2006
    ..After presenting the MS-based sequence elucidation, perspectives in using MS and MS/MS techniques in toxinology are discussed...
  4. doi request reprint Position-specific scoring matrix and hidden Markov model complement each other for the prediction of conopeptide superfamilies
    Dominique Koua
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    Biochim Biophys Acta 1834:717-24. 2013
    ..The 97 models were validated and offer a straightforward method applicable to large sequence datasets...
  5. ncbi request reprint Peptidomics and proteomics studies of transformed lymphocytes from patients mutated for the eukaryotic initiation factor 2B
    Anne Fogli
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    J Chromatogr B Analyt Technol Biomed Life Sci 840:20-8. 2006
    ..However, liquid chromatography based peptidomics studies revealed one apparently instable candidate compound in five out of the six mutated lymphoblastoid cell lines investigated...
  6. pmc Recruitment of glycosyl hydrolase proteins in a cone snail venomous arsenal: further insights into biomolecular features of Conus venoms
    Aude Violette
    Atheris Laboratories, Bernex Geneva, Switzerland
    Mar Drugs 10:258-80. 2012
    ....
  7. ncbi request reprint The venom of the snake genus Atheris contains a new class of peptides with clusters of histidine and glycine residues
    Philippe Favreau
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    Rapid Commun Mass Spectrom 21:406-12. 2007
    ..The novel pHpG peptides found in Atheris venoms might also act on the cardiovascular system by inhibiting particular metalloproteases, which however remain to be identified...
  8. doi request reprint Dramatic intraspecimen variations within the injected venom of Conus consors: an unsuspected contribution to venom diversity
    Sebastien Dutertre
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    Toxicon 55:1453-62. 2010
    ..Our study defines the notion of intraspecimen variation and demonstrates how this phenomenon contributes to the overall venom diversity...
  9. doi request reprint High throughput screening of bradykinin-potentiating peptides in Bothrops moojeni snake venom using precursor ion mass spectrometry
    Laure Menin
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex, Geneva, Switzerland
    Toxicon 51:1288-302. 2008
    ..A total of 15 new sequences have been identified using this approach...
  10. doi request reprint Uncovering intense protein diversification in a cone snail venom gland using an integrative venomics approach
    Daniel Biass
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    J Proteome Res 14:628-38. 2015
    ....
  11. pmc A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors
    Philippe Favreau
    Atheris Laboratories, Bernex Geneva, Switzerland
    Br J Pharmacol 166:1654-68. 2012
    ..We characterized the pharmacology of a new µ-conopeptide (µ-CnIIIC) on a range of preparations and molecular targets to assess its potential as a myorelaxant...
  12. ncbi request reprint Insect antimicrobial peptides: structures, properties and gene regulation
    Philippe Bulet
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex, Geneva, Switzerland
    Protein Pept Lett 12:3-11. 2005
    ..The diverse activity spectrum of these peptides may indicate different modes of action. Genetic analysis in the Drosophila model evidenced that multiple signal transduction pathways are activating the genes coding AMPs...
  13. ncbi request reprint Profiling and in vivo quantification of proteins by high resolution mass spectrometry: the example of goserelin, an analogue of luteinizing hormone-releasing hormone
    Sophie Michalet
    Atheris Laboratories, Bernex Geneva, Switzerland
    Clin Chem Lab Med 41:1589-98. 2003
    ..999. The relative standard deviation was found to be lower than 15%. A lower limit of detection (LLOD) of 0.17 microg/l and a lower limit of quantification (LLOQ) of 0.3 microg/l were determined...
  14. doi request reprint Comparative proteomic study of the venom of the piscivorous cone snail Conus consors
    Daniel Biass
    Atheris Laboratories, CH 1233 Bernex Geneva, Switzerland
    J Proteomics 72:210-8. 2009
    ..With regards to the current knowledge of the cone snail venom composition, our results emphasize the complementary nature of the mass spectrometry methods and of the two techniques used in venom collection...
  15. doi request reprint When everything converges: integrative taxonomy with shell, DNA and venomic data reveals Conus conco, a new species of cone snails (Gastropoda: Conoidea)
    Nicolas Puillandre
    Museum national d histoire naturelle, Departement Systematique et Evolution, ISyEB Institut UMR 7205 CNRS UPMC MNHN EPHE, 43, rue Cuvier, 75231 Paris, France Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland Electronic address
    Mol Phylogenet Evol 80:186-92. 2014
    ..Furthermore, this new species evolved new transcripts giving rise to original toxin structures, probably each carrying specific biological activity. ..
  16. pmc ConoDictor: a tool for prediction of conopeptide superfamilies
    Dominique Koua
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    Nucleic Acids Res 40:W238-41. 2012
    ..Sequence matching is performed with hmmsearch from HMMER 3 and ps_scan.pl from the pftools 2.3 package. ConoDictor is freely accessible at http://conco.ebc.ee...
  17. ncbi request reprint Challenges in mass spectrometry
    Reto Stocklin
    Atheris Laboratories, Bernex Geneva, Switzerland
    Proteomics 2:825-7. 2002
    ..Although it was one of the final events of the meeting, this MS round table attracted an audience of some fifty participants of the congress who were actively involved in the debate...
  18. doi request reprint Marine snail venoms: use and trends in receptor and channel neuropharmacology
    Philippe Favreau
    Atheris Laboratories, Case Postale 314, CH 1233 Bernex Geneva, Switzerland
    Curr Opin Pharmacol 9:594-601. 2009
    ..These advances will hopefully help further uncovering new pharmacologically important venom molecules...
  19. ncbi request reprint Anti-microbial peptides: from invertebrates to vertebrates
    Philippe Bulet
    Atheris Laboratories, Geneva, Switzerland
    Immunol Rev 198:169-84. 2004
    ..This review focuses on AMPs forming alpha-helices, beta-hairpin-like beta-sheets, beta-sheets, or alpha-helix/beta-sheet mixed structures from invertebrate and vertebrate origins. These molecules show some promise for therapeutic use...