Yvan Gosmain

Summary

Affiliation: University Hospital
Country: Switzerland

Publications

  1. ncbi request reprint Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression
    Yvan Gosmain
    Diabetes Unit, Division of Endocrinology, Diabetes and Nutrition, University Hospital, University of Geneva Medical School, 1211 Geneva 14, Switzerland
    J Biol Chem 282:35024-34. 2007
  2. doi request reprint Pax6 is a key component of regulated glucagon secretion
    Yvan Gosmain
    Diabetes Unit, University Hospital, University of Geneva Medical School, 1211 Geneva 14, Switzerland
    Endocrinology 153:4204-15. 2012
  3. doi request reprint Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion
    Yvan Gosmain
    Diabetes Unit, Division of Endocrinology, Diabetes, and Nutrition, University Hospital, University of Geneva Medical School, 1211 Geneva 14, Switzerland
    Mol Endocrinol 26:696-709. 2012
  4. doi request reprint Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion
    Y Gosmain
    Division of Endocrinology, Diabetes and Nutrition, University Hospital Geneva, Rue Gabrielle Perret Gentil 4, 1211 Geneva 14, Switzerland
    Diabetes Obes Metab 13:31-8. 2011
  5. pmc Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function
    Yvan Gosmain
    Diabetes Unit, Division of Endocrinology, Diabetes and Nutrition, University Hospital, University Medical Center, University of Geneva, 1211 Geneva 4, Switzerland
    J Biol Chem 285:33381-93. 2010
  6. pmc Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2
    Liora S Katz
    Division of Endocrinology, Diabetes and Nutrition, University Hospital, University of Geneva Medical School, 1211 Geneva, Switzerland
    Mol Cell Biol 29:2322-34. 2009
  7. ncbi request reprint Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia
    Rodolphe Dusaulcy
    Molecular Diabetes Laboratory R D, S H, S S, F V, M H M, J P, Y G, Division of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital Diabetes Center University of Geneva Medical School and Department of Cell Physiology and Metabolism C V, University of Geneva School of Medicine, 1211 Geneva, Switzerland and Wellcome Trust Medical Research Council Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit F R, F G, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    Endocrinology 157:3832-3843. 2016
  8. pmc The beta-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6
    Benoit R Gauthier
    Diabetes Unit, Geneva University Hospital, 1211 Geneva 4, Switzerland
    Biochem J 403:593-601. 2007
  9. doi request reprint Foxa1 and Foxa2 regulate α-cell differentiation, glucagon biosynthesis, and secretion
    Mounia Heddad Masson
    Department of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital of Geneva, Medical School, 1211 Geneva 14, Switzerland
    Endocrinology 155:3781-92. 2014
  10. doi request reprint Glucagon: the renewal of an old hormone in the pathophysiology of diabetes
    Yvan Gosmain
    Service of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital Geneva, Geneva, Switzerland
    J Diabetes 5:102-9. 2013

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression
    Yvan Gosmain
    Diabetes Unit, Division of Endocrinology, Diabetes and Nutrition, University Hospital, University of Geneva Medical School, 1211 Geneva 14, Switzerland
    J Biol Chem 282:35024-34. 2007
    ..We conclude that Pax-6 and c-Maf interact with G1 to activate basal expression of the glucagon gene...
  2. doi request reprint Pax6 is a key component of regulated glucagon secretion
    Yvan Gosmain
    Diabetes Unit, University Hospital, University of Geneva Medical School, 1211 Geneva 14, Switzerland
    Endocrinology 153:4204-15. 2012
    ..We propose that Pax6 is not only critical for glucagon biosynthesis but also for glucagon secretion particularly in response to nutrients...
  3. doi request reprint Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion
    Yvan Gosmain
    Diabetes Unit, Division of Endocrinology, Diabetes, and Nutrition, University Hospital, University of Geneva Medical School, 1211 Geneva 14, Switzerland
    Mol Endocrinol 26:696-709. 2012
    ..We provide further evidence that Pax6 represents a key element of mature β-cell function...
  4. doi request reprint Glucagon gene expression in the endocrine pancreas: the role of the transcription factor Pax6 in α-cell differentiation, glucagon biosynthesis and secretion
    Y Gosmain
    Division of Endocrinology, Diabetes and Nutrition, University Hospital Geneva, Rue Gabrielle Perret Gentil 4, 1211 Geneva 14, Switzerland
    Diabetes Obes Metab 13:31-8. 2011
    ..We conclude that Pax6 independently of Arx and Foxa2 is critical for α-cell function by coordinating glucagon gene expression as well as glucagon biosynthesis and secretion...
  5. pmc Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function
    Yvan Gosmain
    Diabetes Unit, Division of Endocrinology, Diabetes and Nutrition, University Hospital, University Medical Center, University of Geneva, 1211 Geneva 4, Switzerland
    J Biol Chem 285:33381-93. 2010
    ..We conclude that Pax6 is critical for α cell function and differentiation through the transcriptional control of key genes involved in glucagon gene transcription, proglucagon processing, and α cell differentiation...
  6. pmc Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2
    Liora S Katz
    Division of Endocrinology, Diabetes and Nutrition, University Hospital, University of Geneva Medical School, 1211 Geneva, Switzerland
    Mol Cell Biol 29:2322-34. 2009
    ..We conclude that Pax6 is critical for glucagon biosynthesis and processing by directly and indirectly activating the glucagon gene through cMaf and Beta2/NeuroD1, as well as the PC2 and 7B2 genes...
  7. ncbi request reprint Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia
    Rodolphe Dusaulcy
    Molecular Diabetes Laboratory R D, S H, S S, F V, M H M, J P, Y G, Division of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital Diabetes Center University of Geneva Medical School and Department of Cell Physiology and Metabolism C V, University of Geneva School of Medicine, 1211 Geneva, Switzerland and Wellcome Trust Medical Research Council Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit F R, F G, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    Endocrinology 157:3832-3843. 2016
    ....
  8. pmc The beta-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6
    Benoit R Gauthier
    Diabetes Unit, Geneva University Hospital, 1211 Geneva 4, Switzerland
    Biochem J 403:593-601. 2007
    ..We suggest that cell-specific expression of the glucagon gene may only proceed when Nkx6.1, in combination with Pdx1 and Pax4, are silenced in early alpha-cell precursors...
  9. doi request reprint Foxa1 and Foxa2 regulate α-cell differentiation, glucagon biosynthesis, and secretion
    Mounia Heddad Masson
    Department of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital of Geneva, Medical School, 1211 Geneva 14, Switzerland
    Endocrinology 155:3781-92. 2014
    ..Our results indicate that Foxa1 and Foxa2 control glucagon biosynthesis and secretion as well as α-cell differentiation with both common and unique target genes...
  10. doi request reprint Glucagon: the renewal of an old hormone in the pathophysiology of diabetes
    Yvan Gosmain
    Service of Endocrinology, Diabetes, Hypertension and Nutrition, University Hospital Geneva, Geneva, Switzerland
    J Diabetes 5:102-9. 2013
    ..Understanding the dysregulation of α-cells in diabetes will be critical to better define the pathophysiology of diabetes and develop new antidiabetic treatment...
  11. doi request reprint α-Cell Dysfunctions and Molecular Alterations in Male Insulinopenic Diabetic Mice Are Not Completely Corrected by Insulin
    Rodolphe Dusaulcy
    Molecular Diabetes Laboratory R D, S H, M H M, F V, J P, Y G, Division of Endocrinology Diabetes Hypertension and Nutrition, University Hospital University of Geneva Medical School, 1211 Geneva, Switzerland Cambridge Institute for Medical Research F R, F G, Wellcome Trust Medical Research Council, Addenbrooke s Hospital, Cambridge, United Kingdom and Department of Cell Physiology and Metabolism C V, University of Geneva Medical School, 1211 Geneva, Switzerland
    Endocrinology 157:536-47. 2016
    ..1, and SUMO1. Our results indicate that insulinopenic diabetes induce marked α-cell dysfunction and molecular alteration, which are only partially corrected by in vivo insulin treatment. ..
  12. ncbi request reprint Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues
    Yvan Gosmain
    Unité Mixte de Recherche Institut National de la Santé et de la Recherche Médicale U449 Institut National de la Recherche Agronomique U1235, Institut, Lyon, France
    J Lipid Res 46:697-705. 2005
    ..These data elucidate the important role of SREBP-1 not only in the regulation of lipid metabolism but also of glucose metabolism and energy homeostasis...