Christian J Leumann

Summary

Affiliation: University of Bern
Country: Switzerland

Publications

  1. pmc Molecular beacons with a homo-DNA stem: improving target selectivity
    Caroline Crey-Desbiolles
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Nucleic Acids Res 33:e77. 2005
  2. pmc The chemical stability of abasic RNA compared to abasic DNA
    Pascal A Küpfer
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Nucleic Acids Res 35:58-68. 2007
  3. pmc Trans-lesion synthesis and RNaseH activity by reverse transcriptases on a true abasic RNA template
    Pascal A Küpfer
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Nucleic Acids Res 35:6846-53. 2007
  4. ncbi request reprint DNA analogues: from supramolecular principles to biological properties
    Christian J Leumann
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012, Bern, Switzerland
    Bioorg Med Chem 10:841-54. 2002
  5. ncbi request reprint Fluorinated olefinic peptide nucleic acid: synthesis and pairing properties with complementary DNA
    Marcel Hollenstein
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    J Org Chem 70:3205-17. 2005
  6. doi request reprint Synthesis, pairing, and cellular uptake properties of C(6')-functionalized tricyclo-DNA
    Jory Lietard
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012, Bern, Switzerland
    J Org Chem 77:4566-77. 2012
  7. ncbi request reprint Synthesis of a cyclopentane amide DNA analogue and its base pairing properties
    Dae Ro Ahn
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 22:1207-10. 2003
  8. ncbi request reprint Photochemically induced RNA and DNA abasic sites
    Pascal A Küpfer
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 26:1177-80. 2007
  9. ncbi request reprint Synthesis of cyclopentane amide DNA (cpa-DNA) and its pairing properties
    Dae Ro Ahn
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    J Org Chem 68:7693-9. 2003
  10. pmc Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: a comparison of tricyclo-DNA with LNA
    Damian Ittig
    Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH 3012 Berne, Switzerland
    Nucleic Acids Res 32:346-53. 2004

Collaborators

Detail Information

Publications60

  1. pmc Molecular beacons with a homo-DNA stem: improving target selectivity
    Caroline Crey-Desbiolles
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Nucleic Acids Res 33:e77. 2005
    ..Furthermore, our results show that the homo-adenylate stem is excluded from DNA target binding, which leads to a significant increase in target binding selectivity...
  2. pmc The chemical stability of abasic RNA compared to abasic DNA
    Pascal A Küpfer
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Nucleic Acids Res 35:58-68. 2007
    ..Thus abasic RNA is significantly more stable than abasic DNA. The higher stability of abasic RNA is discussed in the context of its potential biological role...
  3. pmc Trans-lesion synthesis and RNaseH activity by reverse transcriptases on a true abasic RNA template
    Pascal A Küpfer
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Nucleic Acids Res 35:6846-53. 2007
    ..These experiments clearly point to a higher promiscuity of lesion bypass on abasic RNA. Given their known higher chemical stability, such rAS sites can clearly contribute to (retro)viral evolution...
  4. ncbi request reprint DNA analogues: from supramolecular principles to biological properties
    Christian J Leumann
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012, Bern, Switzerland
    Bioorg Med Chem 10:841-54. 2002
    ..A particularly successful concept turned out to be that of conformational restriction. This review focuses on recent advances in this area and tries to summarize scope and limitations of this design principle...
  5. ncbi request reprint Fluorinated olefinic peptide nucleic acid: synthesis and pairing properties with complementary DNA
    Marcel Hollenstein
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    J Org Chem 70:3205-17. 2005
    ..An asymmetric F-OPA pentadecamer was found to form a stable self-complex (T(m) approximately 65 degrees C) of unknown structure. The generally reduced affinity to DNA may therefore be due to an increased propensity for self-aggregation...
  6. doi request reprint Synthesis, pairing, and cellular uptake properties of C(6')-functionalized tricyclo-DNA
    Jory Lietard
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012, Bern, Switzerland
    J Org Chem 77:4566-77. 2012
    ..A decamer containing five tc(hd)-T residues was readily taken up by HeLa and HEK 293T cells without the use of a transfection agent...
  7. ncbi request reprint Synthesis of a cyclopentane amide DNA analogue and its base pairing properties
    Dae Ro Ahn
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 22:1207-10. 2003
    ..Fully modified homo-cpa-A sequences lead to duplex destabilization by -1.4 degrees C/mod. relative to DNA. As its congener bca-DNA, cpa-DNA prefers left-handed duplex formation where possible...
  8. ncbi request reprint Photochemically induced RNA and DNA abasic sites
    Pascal A Küpfer
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 26:1177-80. 2007
    ..Another building block which releases a 2'-O-methylated abasic site upon UV radiation is also described...
  9. ncbi request reprint Synthesis of cyclopentane amide DNA (cpa-DNA) and its pairing properties
    Dae Ro Ahn
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    J Org Chem 68:7693-9. 2003
    ..As its congener bca-DNA, cpa-DNA seems to prefer left-handed helical duplex structures with DNA or with itself as indicated by the CD spectra...
  10. pmc Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: a comparison of tricyclo-DNA with LNA
    Damian Ittig
    Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH 3012 Berne, Switzerland
    Nucleic Acids Res 32:346-53. 2004
    ..The obtained results confirm the power of tc-DNA for nuclear antisense applications. Moreover, CyPA may become an interesting therapeutic target due to its important role in the early steps of the viral replication of HIV-1...
  11. doi request reprint Screening the structural and functional properties of bicyclo-DNA: bc(ox)-DNA
    Samuel Luisier
    Department of Chemistry and Biochemistry, University of Bern, Switzerland
    Chembiochem 9:2244-53. 2008
    ..While no cellular uptake of bc(ox)-oligonucleotides into HeLa cells occurred without transfecting agents, a significant increase in the transfection rate relative to unmodified DNA was observed in complexation with lipofectamine...
  12. pmc Position-dependent effects on stability in tricyclo-DNA modified oligonucleotide duplexes
    Damian Ittig
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleic Acids Res 39:373-80. 2011
    ..These results rationalize the observed affinity differences and are of relevance for the design of tc-DNA containing oligonucleotides for applications in antisense or RNAi therapy...
  13. ncbi request reprint Stability and kinetics of nucleic acid triplexes with chimaeric DNA/RNA third strands
    Eloy Bernal-Mendez
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Biochemistry 41:12343-9. 2002
    ..In contrast, the single-stranded TFOs showed high structural variability, as determined in the same way. The results are discussed in the context of the design of TFOs for therapeutic or biochemical applications...
  14. ncbi request reprint Bicyclo[3.2.1]amide-DNA: a chiral, nonchiroselective base-pairing system
    Dae Ro Ahn
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Chemistry 8:5312-22. 2002
    ..The obtained data are discussed with respect to the structural and energetic role of the ribofuranose entities in DNA and RNA association...
  15. doi request reprint Base pairing and miscoding properties of 1,N(6)-ethenoadenine- and 3,N(4)-ethenocytosine-containing RNA oligonucleotides
    Alessandro Calabretta
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Biochemistry 52:1990-7. 2013
    ..The properties of these RNA lesions are discussed in the context of its putative biological role...
  16. ncbi request reprint Synthesis and incorporation into DNA of a chemically stable, functional abasic site analogue
    Markus Mosimann
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Org Lett 7:5211-4. 2005
    ..Corresponding oligodeoxynucleotides were shown to be chemically stable under basic conditions and fully functional at the respective hemiacetal center...
  17. ncbi request reprint Synthesis and pairing properties of alpha-tricyclo-DNA
    Simon P Scheidegger
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Chemistry 12:8014-23. 2006
    ..The base-pairing properties of alpha-tc-DNA are discussed in the context of alpha-DNA, alpha-RNA, and alpha-LNA...
  18. ncbi request reprint Recognition properties of donor- and acceptor-modified biphenyl-DNA
    Alain Zahn
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Chemistry 14:1087-94. 2008
    ..Oligonucleotides containing amino biphenyl residues are fluorescent. Their fluorescence is largely quenched when they are paired with themselves or with nitrobiphenyl-containing duplex partners...
  19. ncbi request reprint Olefinic peptide nucleic acid (OPA)
    Daniel Gautschi
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 22:1211-3. 2003
    ..Fully modified oligomers containing these units were prepared and their pairing properties assessed by means of UV-melting experiments...
  20. doi request reprint Synthesis and properties of isobicyclo-DNA
    Anna Barbara Gerber
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Chemistry 19:6990-7006. 2013
    ..Self-paired duplexes show a yet unknown structure, as judged from CD spectroscopy. Biochemical tests revealed that isobicyclo-DNA is stable in fetal bovine serum and does not elicit RNaseH activity...
  21. doi request reprint Synthesis, binding and cellular uptake properties of oligodeoxynucleotides containing cationic bicyclo-thymidine residues
    Jory Lietard
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Bioorg Med Chem 19:5869-75. 2011
    ....
  22. ncbi request reprint pentafluorophenyl-phenyl interactions in biphenyl-DNA
    Alain Zahn
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Chemistry 11:2125-9. 2005
    ..They do not support a model in which van der Waals dispersive forces (induced dipoles) or electrostatic (quadrupole) interactions play a dominant role...
  23. ncbi request reprint Stable and selective recognition of three base pairs in the parallel triple-helical DNA binding motif
    Sabrina Buchini
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Angew Chem Int Ed Engl 43:3925-8. 2004
  24. pmc Synthesis, base pairing properties and trans-lesion synthesis by reverse transcriptases of oligoribonucleotides containing the oxidatively damaged base 5-hydroxycytidine
    Pascal A Küpfer
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Nucleic Acids Res 39:9422-32. 2011
    ..The properties of this RNA damage is discussed in the context of its putative biological function...
  25. ncbi request reprint Pyrrolidino-DNA
    Adrian Häberli
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 22:1187-9. 2003
    ..Duplexes are destabilized with all pyrrolidino-C-nucleosides...
  26. ncbi request reprint Transition metal ligands as novel DNA-base substitutes
    Christine Brotschi
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 22:1195-7. 2003
    ..In the presence of transition metal ions, melting experiments revealed a decrease in duplex stability which is on a similar order for all metal ions (Mn2+, Cu2+, Zn2+, Ni2+) tested...
  27. ncbi request reprint DNA with hydrophobic base substitutes: a stable, zipperlike recognition motif based on interstrand-stacking interactions
    Christine Brotschi
    Departement fur Chemie und Biochemie, Universitat Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Angew Chem Int Ed Engl 42:1655-8. 2003
  28. doi request reprint 2-Pyrenyl-DNA: synthesis, pairing, and fluorescence properties
    Filip Wojciechowski
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Org Lett 14:5176-9. 2012
    ..This helical pyrene array may find use in DNA-mediated charge transfer and in the creation of DNA-based sensors...
  29. ncbi request reprint Synthesis of functionalized biphenyl-C-nucleosides and their incorporation into oligodeoxynucleotides
    Alain Zahn
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Bioorg Med Chem 14:6174-88. 2006
    ..These nucleosides were subsequently converted into the corresponding phosphoramidite building blocks and efficiently incorporated into oligodeoxynucleotides by standard phosphoramidite chemistry...
  30. ncbi request reprint Recent improvements in antigene technology
    Sabrina Buchini
    Department of Chemistry and Biochemistry, University of Bern, CH 3012 Bern, Switzerland
    Curr Opin Chem Biol 7:717-26. 2003
    ..With this, sequence-specific genomic DNA manipulation is starting to become a useful tool in biotechnology...
  31. ncbi request reprint Watson-Crick base-pairing properties of tricyclo-DNA
    Dorte Renneberg
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    J Am Chem Soc 124:5993-6002. 2002
    ..CD spectroscopic structural investigations indicated that tricyclo-DNA containing duplexes preferrably exist in an A-conformation, a fact which is in agreement with results from molecular modeling...
  32. pmc Antisense properties of tricyclo-DNA
    Dorte Renneberg
    Departement für Chemie und Biochemie der Universität Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Nucleic Acids Res 30:2751-7. 2002
    ..In contrast to 2'-O-Me-PS-RNA, tc-DNA shows antisense activity even in the absence of lipofectamine, albeit only at much higher oligonucleotide concentrations...
  33. doi request reprint Parallel synthesis and nucleic acid binding properties of C(6')-α-functionalized bicyclo-DNA
    Peter Silhár
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Bioorg Med Chem 18:7786-93. 2010
    ..In addition, functional groups can be placed into unique positions in a DNA double helix...
  34. doi request reprint Stable cyclohexyl-phenyl recognition in the center of a DNA duplex
    Marco Kaufmann
    Departement fur Chemie und Biochemie, Universitat Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Angew Chem Int Ed Engl 48:3810-3. 2009
    ..This makes the system an interesting scaffold for studying hydrophobic interactions and allows for the incorporation of additional molecular entities into the double helix...
  35. doi request reprint 2-Phenanthrenyl-DNA: synthesis, pairing, and fluorescence properties
    Nikolay A Grigorenko
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Chemistry 15:639-45. 2009
    ....
  36. ncbi request reprint Fluorinated peptide nucleic acid
    Marcel Hollenstein
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 22:1191-4. 2003
    ..PNAs containing this unit were prepared and their pairing properties assessed by means of UV-melting experiments...
  37. ncbi request reprint Bipyridyl- and biphenyl-DNA: a recognition motif based on interstrand aromatic stacking
    Christine Brotschi
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Chemistry 11:1911-23. 2005
    ..Duplexes with one natural overhang at the end of a I-I base pair tract can both aggregate or form ordered duplexes, depending on the nature of the natural bases in the overhang...
  38. ncbi request reprint Synthesis and triplex forming properties of pyrrolidino pseudoisocytidine containing oligodeoxynucleotides
    Alain Mayer
    Department of Chemistry and Biochemistry, University of Berne, Freiestrasse 3, CH 3012, Berne, Switzerland
    Org Biomol Chem 3:1653-8. 2005
    ..Such TFOs show substantially increased DNA affinity compared to unmodified oligodeoxynucleotides. The increase in affinity is shown to be due to the positive charge at the pyrrolidino subunit...
  39. doi request reprint Enhancement of excess electron transfer efficiency in DNA containing a phenothiazine donor and multiple stable phenanthrenyl base pairs
    Pascal Roethlisberger
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Chemistry 19:11518-21. 2013
    ..Increasing the number of phenanthrenyl base pairs increased EET efficiency. ..
  40. doi request reprint Gas-phase dissociation of homo-DNA oligonucleotides
    Silvan R Stucki
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    J Am Soc Mass Spectrom 24:1997-2006. 2013
    ..Upon MS(3) of the primary base-loss ion, homo-DNA was found to exhibit unspecific backbone dissociation resulting in a balanced distribution of all fragment ion series. ..
  41. doi request reprint Synthesis and pairing properties of oligodeoxynucleotides containing bicyclo-RNA and bicyclo-ANA modifications
    Arben I Haziri
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    J Org Chem 77:5861-9. 2012
    ....
  42. ncbi request reprint Propagation of melting cooperativity along the phosphodiester backbone of DNA
    Jessica Becaud
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    J Am Chem Soc 125:15338-42. 2003
    ..Furthermore, conformational rigidity of the sugar unit increases the distance of coopertivity transfer along the phosphodiester backbone. This is especially the case when the units are asymmetrically distributed in both strands...
  43. ncbi request reprint Exploring Hoogsteen and reversed-Hoogsteen duplex and triplex formation with tricyclo-DNA purine sequences
    Dorte Renneberg
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Chembiochem 5:1114-8. 2004
    ..Triplex formation with antiparallel pyrimidine and purine third strands (reversed-Hoogsteen motif) could not be observed and seem to be unstable...
  44. ncbi request reprint New nucleoside analogues for the recognition of pyrimidine-purine inversion sites
    Sabrina Buchini
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 22:1199-201. 2003
    ..This pathway contains the sugar derivative 9 which is a useful intermediate for the introduction of other natural and unnatural bases into the 2'-aminoethoxy nucleoside containing scaffold...
  45. ncbi request reprint DNA binding properties of oligodeoxynucleotides containing pyrrolidino C-nucleosides
    Adrian Häberli
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, Switzerland
    Org Lett 4:3275-8. 2002
    ..13 to -1 degrees C per modification (relative to thymidine) in a strongly sequence dependent mode. Duplex formation is less destabilizing and more homogeneous with -4 to -2 degrees C per modification...
  46. doi request reprint Homo-DNA templated chemistry and its application to nucleic acid sensing
    Matthias Stoop
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Chem Commun (Camb) 47:7494-6. 2011
    ..In this system the sensing and the reporting unit are bioorthogonal to each other which facilitates sequence design and increases fidelity...
  47. pmc Nucleic acid sensing by an orthogonal reporter system based on homo-DNA
    Matthias Stoop
    University of Bern, Department of Chemistry and Biochemistry, Bern, Switzerland
    Artif DNA PNA XNA 4:28-33. 2013
    ..This allows independent optimization of either domain which may lead to higher selectivity in in vivo imaging...
  48. ncbi request reprint RNA abasic sites: preparation and trans-lesion synthesis by HIV-1 reverse transcriptase
    Pascal A Küpfer
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Chembiochem 6:1970-3. 2005
  49. doi request reprint Alternative DNA base-pairs: from efforts to expand the genetic code to potential material applications
    Filip Wojciechowski
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Chem Soc Rev 40:5669-79. 2011
    ..In this tutorial review we highlight different approaches used to replace natural base-pairs and equip them with novel function. We also discuss the advantages that non-natural base-pairs convey with respect to practical applications...
  50. doi request reprint Polymerase incorporation of pyrene-nucleoside triphosphates
    Marcel Hollenstein
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Bioorg Med Chem Lett 22:4428-30. 2012
    ..The tailing efficiency of the dPTPs compares favorably to other less drastically modified dNTPs...
  51. ncbi request reprint A short, efficient synthesis of 2'-deoxypseudoisocytidine based on Heck-chemistry
    Alain Mayer
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 22:1919-25. 2003
    ..The synthesis is based on Heck-coupling between N-protected pseudoisocytosine and a silyl protected furanoid glycal. With this procedure the corresponding phosphoramidite building block is obtained in 5 steps and an overall yield of 28%...
  52. ncbi request reprint Electrospray tandem mass spectrometry of mixed-sequence RNA/DNA oligonucleotides
    Stefan Schürch
    Department of Chemistry and Biochemistry, University of Bern, Switzerland
    J Am Soc Mass Spectrom 13:936-45. 2002
    ....
  53. ncbi request reprint Synthetic studies towards a novel, chemical stable, abasic site analogue of DNA
    Caroline Hirtz
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 22:1203-6. 2003
    ..Precursor 7 serves for the synthesis and incorporation into DNA of a novel chemically stable abasic site analogue that might act as an inhibitor for DNA glycosylases...
  54. ncbi request reprint Synthesis of the bicyclo-[4.3.0]-thymidyl-nucleoside via pd(II)-mediated ring expansion chemistry
    Andrea Stauffiger
    Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland
    Nucleosides Nucleotides Nucleic Acids 26:615-9. 2007
    ..In the context of conformational restriction we present here the synthesis of the [4.3.0]-bicyclo-DNA thymine monomer via Pd(II)-mediated ring expansion of an intermediate of the tricyclo-DNA synthesis...
  55. pmc The effect of RNA base lesions on mRNA translation
    Alessandro Calabretta
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland
    Nucleic Acids Res 43:4713-20. 2015
    ....
  56. doi request reprint The Contribution of the Activation Entropy to the Gas-Phase Stability of Modified Nucleic Acid Duplexes
    Yvonne Hari
    Department of Chemistry and Biochemistry, University of Bern, CH 3012, Bern, Switzerland
    J Am Soc Mass Spectrom 27:1186-96. 2016
    ..Graphical Abstract ᅟ. ..
  57. doi request reprint Synthesis and biochemical characterization of tricyclothymidine triphosphate (tc-TTP)
    Marcel Hollenstein
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern Switzerland
    Chembiochem 15:1901-4. 2014
    ....
  58. ncbi request reprint Synthesis and incorporation into PNA of fluorinated olefinic PNA (F-OPA) monomers
    Marcel Hollenstein
    Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, CH 3012 Bern, Switzerland
    Org Lett 5:1987-90. 2003
    ..We found a strong dependence of stability from the sequential position of the (Z)-t-F-OPA units, ranging from DeltaT(m) of +2.4 to -8.1 degrees C/modification relative to unmodified PNA...
  59. ncbi request reprint Solution structure of a DNA duplex containing a biphenyl pair
    Zeena Johar
    Laboratory of Organic Chemistry, ETH Zurich, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Chemistry 14:1080-6. 2008
    ..Interestingly, the biphenyl rings are not static in the duplex but are in dynamic motion even at 294 K...
  60. ncbi request reprint Crystal structure of homo-DNA and nature's choice of pentose over hexose in the genetic system
    Martin Egli
    Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Am Chem Soc 128:10847-56. 2006
    ..The structure allows a rationalization of the inability of allo-, altro-, and glucopyranosyl-based oligonucleotides to form stable pairing systems...