Beate Ritz-Laser

Summary

Affiliation: University of Geneva
Country: Switzerland

Publications

  1. ncbi The paired homeodomain transcription factor Pax-2 is expressed in the endocrine pancreas and transactivates the glucagon gene promoter
    B Ritz-Laser
    Diabetes Unit, Centre Medical Universitaire, 1211 Geneve 4, Switzerland
    J Biol Chem 275:32708-15. 2000
  2. ncbi Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription
    B Ritz-Laser
    Diabetes Unit, University Hospital Geneva, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Diabetologia 46:810-21. 2003
  3. ncbi Molecular detection of circulating beta-cells after islet transplantation
    Beate Ritz-Laser
    Diabetes Unit, Department of Internal Medecine, University Hospital Geneva, Geneva, Switzerland
    Diabetes 51:557-61. 2002
  4. ncbi The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6
    Beate Ritz-Laser
    Diabetes Unit, Geneva University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Diabetologia 45:97-107. 2002
  5. ncbi Hepatic nuclear factor-3 (HNF-3 or Foxa2) regulates glucagon gene transcription by binding to the G1 and G2 promoter elements
    Benoit R Gauthier
    Unite de Diabetologie Clinique, Centre Medical Universitaire, 1211 Geneve 4, Switzerland
    Mol Endocrinol 16:170-83. 2002
  6. ncbi Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1
    Valerie M Schwitzgebel
    Pediatric Endocrinology and Diabetology, Geneva University Hospital, CH 1211 Geneva, Switzerland
    J Clin Endocrinol Metab 88:4398-406. 2003
  7. ncbi The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression
    Beate Ritz-Laser
    Diabetes Unit, University Hospital Geneva, 24, Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Mol Endocrinol 19:759-70. 2005
  8. ncbi Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin and glucagon content
    Maia Zaiko
    Diabetes Unit, Department of Medicine, University Hospital Geneva, 24 Micheli du Crest, 1211 Geneva, Switzerland
    Eur J Endocrinol 150:389-95. 2004
  9. ncbi The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter
    Albrecht Hoffmeister
    Centre de Recherche INSERM, EMI 0116, 163 Avenue de Luminy, Campus de Luminy, BP 172, 13276 Marseille Cedex 9, France
    J Biol Chem 277:22314-9. 2002
  10. ncbi Essential interaction of Egr-1 at an islet-specific response element for basal and gastrin-dependent glucagon gene transactivation in pancreatic alpha-cells
    Stéphane Leung-Theung-Long
    INSERM U531, IFR31, Hospital Rangueil, 31059 Toulouse Cedex 9, France
    J Biol Chem 280:7976-84. 2005

Collaborators

Detail Information

Publications10

  1. ncbi The paired homeodomain transcription factor Pax-2 is expressed in the endocrine pancreas and transactivates the glucagon gene promoter
    B Ritz-Laser
    Diabetes Unit, Centre Medical Universitaire, 1211 Geneve 4, Switzerland
    J Biol Chem 275:32708-15. 2000
    ..Our data indicate that Pax-2 is the third paired domain protein present in the endocrine pancreas and that one of its roles may be the regulation of glucagon gene expression...
  2. ncbi Ectopic expression of the beta-cell specific transcription factor Pdx1 inhibits glucagon gene transcription
    B Ritz-Laser
    Diabetes Unit, University Hospital Geneva, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Diabetologia 46:810-21. 2003
    ..Beta-cell specific inactivation of Pdx1 in developing or adult mice leads to an increase in glucagon-expressing cells, suggesting that absence of Pdx1could favour glucagon gene expression by a default mechanism...
  3. ncbi Molecular detection of circulating beta-cells after islet transplantation
    Beate Ritz-Laser
    Diabetes Unit, Department of Internal Medecine, University Hospital Geneva, Geneva, Switzerland
    Diabetes 51:557-61. 2002
    ..This test may allow better estimation of islet cell loss and identification of factors involved in islet graft injury...
  4. ncbi The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6
    Beate Ritz-Laser
    Diabetes Unit, Geneva University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Diabetologia 45:97-107. 2002
    ....
  5. ncbi Hepatic nuclear factor-3 (HNF-3 or Foxa2) regulates glucagon gene transcription by binding to the G1 and G2 promoter elements
    Benoit R Gauthier
    Unite de Diabetologie Clinique, Centre Medical Universitaire, 1211 Geneve 4, Switzerland
    Mol Endocrinol 16:170-83. 2002
    ..We suggest that HNF-3 may play a dual role on glucagon gene transcription by 1) inhibiting the transactivation potential of Pax6 on the G1 and G3 elements and 2) direct activation through G1 and G2...
  6. ncbi Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1
    Valerie M Schwitzgebel
    Pediatric Endocrinology and Diabetology, Geneva University Hospital, CH 1211 Geneva, Switzerland
    J Clin Endocrinol Metab 88:4398-406. 2003
    ..We conclude that the IPF1 level is critical for human pancreas formation...
  7. ncbi The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression
    Beate Ritz-Laser
    Diabetes Unit, University Hospital Geneva, 24, Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
    Mol Endocrinol 19:759-70. 2005
    ....
  8. ncbi Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin and glucagon content
    Maia Zaiko
    Diabetes Unit, Department of Medicine, University Hospital Geneva, 24 Micheli du Crest, 1211 Geneva, Switzerland
    Eur J Endocrinol 150:389-95. 2004
    ..We have concluded that Pax2 may be implicated in the prenatal determination of the relative proportion of the endocrine and exocrine tissues of the pancreas...
  9. ncbi The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter
    Albrecht Hoffmeister
    Centre de Recherche INSERM, EMI 0116, 163 Avenue de Luminy, Campus de Luminy, BP 172, 13276 Marseille Cedex 9, France
    J Biol Chem 277:22314-9. 2002
    ....
  10. ncbi Essential interaction of Egr-1 at an islet-specific response element for basal and gastrin-dependent glucagon gene transactivation in pancreatic alpha-cells
    Stéphane Leung-Theung-Long
    INSERM U531, IFR31, Hospital Rangueil, 31059 Toulouse Cedex 9, France
    J Biol Chem 280:7976-84. 2005
    ..Moreover they open new working hypothesis with reference to a potential role of gastrin in glucagon-producing pancreatic cells...