Richard Warth

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi request reprint The multifaceted phenotype of the knockout mouse for the KCNE1 potassium channel gene
    Richard Warth
    Physiologisches Institut, 8057 Zurich, Switzerland
    Am J Physiol Regul Integr Comp Physiol 282:R639-48. 2002
  2. ncbi request reprint Potassium channels in epithelial transport
    Richard Warth
    Physiologisches Institut, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Pflugers Arch 446:505-13. 2003
  3. ncbi request reprint Function of K+ channels in the intestinal epithelium
    R Warth
    Physiologisches Institut, Winterthurerstr 190, 8057 Zurich, Switzerland
    J Membr Biol 193:67-78. 2003
  4. ncbi request reprint Early aldosterone-induced gene product regulates the epithelial sodium channel by deubiquitylation
    Panagiotis Fakitsas
    Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Am Soc Nephrol 18:1084-92. 2007
  5. ncbi request reprint Kidney and colon electrolyte transport in CHIF knockout mice
    Imeke Goldschmidt
    Physiologisches Institut, Albert Ludwigs Universitat Freiburg, Germany
    Cell Physiol Biochem 14:113-20. 2004
  6. pmc Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport
    Richard Warth
    Institute of Physiology, Universitatsstrasse 31, 93053 Regensburg, Germany
    Proc Natl Acad Sci U S A 101:8215-20. 2004
  7. pmc Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis
    Dirk Heitzmann
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    EMBO J 27:179-87. 2008
  8. ncbi request reprint No potassium, no acid: K+ channels and gastric acid secretion
    Dirk Heitzmann
    Institute of Physiology, Regensburg, Germany
    Physiology (Bethesda) 22:335-41. 2007
  9. ncbi request reprint KCNE beta subunits determine pH sensitivity of KCNQ1 potassium channels
    Dirk Heitzmann
    Institute of Physiology, University of Regensburg
    Cell Physiol Biochem 19:21-32. 2007
  10. ncbi request reprint Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells
    Susanne Ullrich
    Institute of Neurophysiology, University of Koln, Robert Koch Strasse 39, 50931 Cologne, Germany
    Pflugers Arch 451:428-36. 2005

Collaborators

  • Francois Verrey
  • Olivier Staub
  • Carsten A Wagner
  • Florian Lang
  • Florian Lesage
  • Pierre Meneton
  • Dirk Heitzmann
  • Jacques Barhanin
  • Ines Tegtmeier
  • Markus Reichold
  • Christina Sterner
  • Panagiotis Fakitsas
  • Said Bendahhou
  • Susanne Ullrich
  • Uwe Gerlach
  • Florian Grahammer
  • Robert Kleta
  • Sonia Decressac
  • Elisa Romeo
  • Imeke Goldschmidt
  • Abeer El Wakil
  • Celso E Gomez-Sanchez
  • Raymond Mengual
  • Achim Weber
  • M Isabel Aller
  • William Wisden
  • Enzo Lalli
  • Frank Schweda
  • Stefan Jungbauer
  • Renaud Derand
  • Nicolas Guy
  • Sascha Bandulik
  • Simone M R Camargo
  • Viktoria Koren
  • Andrea Patrignani
  • Dorothée Daidié
  • Gabriele Adam
  • Michael Wagner
  • Fatemeh Fouladkou
  • Tilmann Volk
  • Miguel X van Bemmelen
  • Ulrich Wagner
  • Oliver H Wittekindt
  • Martin Rösler
  • Jiping Su
  • Frederic Ris
  • Felicia Ranta
  • Naohiko Anzai
  • Sumiko Inoue
  • Simone R M Camargo
  • Michel Lazdunski
  • Mauricio Arcos-Burgos
  • Gepke Visser
  • Amanda Helip-Wooley
  • Ellappan Babu
  • Detlef Bockenhauer
  • Mital H Dave
  • Yoshikatsu Kanai
  • Isa Bernardini
  • Annette Schulz-Baldes
  • Haim Garty
  • Rainer Greger
  • Norio Matsuura
  • Thomas von Hahn
  • Annette Schmitt-Gräff
  • Hans Jochen Lang
  • Akio Koizumi
  • Michel Franco
  • Zorica Ristic
  • William A Gahl
  • Markus Bleich
  • Promsuk Jutabha
  • Sebastian Knauer
  • Roland Nitschke
  • Toshihiro Ohura
  • Philip Lee
  • Caroline Stuart
  • Arthit Chairoungdua
  • Sirinun Nilwarangkoon
  • Thomas Eggermann

Detail Information

Publications14

  1. ncbi request reprint The multifaceted phenotype of the knockout mouse for the KCNE1 potassium channel gene
    Richard Warth
    Physiologisches Institut, 8057 Zurich, Switzerland
    Am J Physiol Regul Integr Comp Physiol 282:R639-48. 2002
    ..Murine KCNE1 physiology could be helpful for the pathophysiological understanding and perhaps gene-specific treatment of long QT patients...
  2. ncbi request reprint Potassium channels in epithelial transport
    Richard Warth
    Physiologisches Institut, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Pflugers Arch 446:505-13. 2003
    ..This review gives a short overview on the molecular identity of epithelial K(+) channels and summarizes the different mechanisms of K(+) channel function during transport in epithelial cells...
  3. ncbi request reprint Function of K+ channels in the intestinal epithelium
    R Warth
    Physiologisches Institut, Winterthurerstr 190, 8057 Zurich, Switzerland
    J Membr Biol 193:67-78. 2003
  4. ncbi request reprint Early aldosterone-induced gene product regulates the epithelial sodium channel by deubiquitylation
    Panagiotis Fakitsas
    Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Am Soc Nephrol 18:1084-92. 2007
    ..A deubiquitylating enzyme that targets ENaC in vitro and thus may play a role in sodium transport regulation was identified within a series of new in vivo early aldosterone-regulated gene products...
  5. ncbi request reprint Kidney and colon electrolyte transport in CHIF knockout mice
    Imeke Goldschmidt
    Physiologisches Institut, Albert Ludwigs Universitat Freiburg, Germany
    Cell Physiol Biochem 14:113-20. 2004
    ..The present findings support a role of CHIF as an indirect modulator of several different ion transport mechanisms and are consistent with regulation of the Na+-K+-ATPase as the common denominator...
  6. pmc Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport
    Richard Warth
    Institute of Physiology, Universitatsstrasse 31, 93053 Regensburg, Germany
    Proc Natl Acad Sci U S A 101:8215-20. 2004
    ..The consequences of the task2 gene inactivation in mice are reminiscent of the clinical manifestations seen in human proximal renal tubular acidosis syndrome...
  7. pmc Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis
    Dirk Heitzmann
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    EMBO J 27:179-87. 2008
    ..The striking changes in the adrenocortical architecture in task1-/- mice are the first demonstration of the causative role of a potassium channel in development/differentiation...
  8. ncbi request reprint No potassium, no acid: K+ channels and gastric acid secretion
    Dirk Heitzmann
    Institute of Physiology, Regensburg, Germany
    Physiology (Bethesda) 22:335-41. 2007
    ..Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa...
  9. ncbi request reprint KCNE beta subunits determine pH sensitivity of KCNQ1 potassium channels
    Dirk Heitzmann
    Institute of Physiology, University of Regensburg
    Cell Physiol Biochem 19:21-32. 2007
    ..They are modulated by pH in a complex way: homomeric KCNQ1 is inhibited by external acidification (low pH(e)); KCNE2/KCNQ1 is activated; and for KCNE1/KCNQ1, variable effects have been reported...
  10. ncbi request reprint Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells
    Susanne Ullrich
    Institute of Neurophysiology, University of Koln, Robert Koch Strasse 39, 50931 Cologne, Germany
    Pflugers Arch 451:428-36. 2005
    ..These results suggest that 293B- and HMR1556-sensitive channels, probably in concert with other voltage-activated K(+) channels, influence action potential duration and frequency and thus insulin secretion...
  11. pmc Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells
    Dirk Heitzmann
    Institute of Physiology, Universitatsstrasse 31, 93053 Regensburg, Germany
    J Physiol 561:547-57. 2004
    ..IKs124 could serve as a leading compound in the development of subunit-specific KCNE2/KCNQ1 blockers to treat peptic ulcers...
  12. pmc ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6
    Sonia Decressac
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR6097 UNSA, Institut Paul Hamel, 660, route des Lucioles, 06560 Valbonne, France
    EMBO Rep 5:1171-5. 2004
    ..EFA6 interacts with TWIK1 only when it is bound to ARF6. Because ARF6 modulates endocytosis at the apical surface of epithelial cells, the ARF6/EFA6/TWIK1 association is probably important for channel internalization and recycling...
  13. ncbi request reprint Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder
    Robert Kleta
    Medical Genetics Branch, 10 Center Drive, MSC 1851, Building 10, Room 10C 107, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nat Genet 36:999-1002. 2004
    ..The protein product of SLC6A19, the Hartnup transporter, is expressed primarily in intestine and renal proximal tubule and functions as a neutral amino acid transporter...
  14. doi request reprint Physiology and pathophysiology of potassium channels in gastrointestinal epithelia
    Dirk Heitzmann
    Institute of Physiology and Clinic and Policlinic for Internal Medicine II, Regensburg, Germany
    Physiol Rev 88:1119-82. 2008
    ..In the future, integrative approaches using functional and postgenomic/proteomic techniques will help us to gain comprehensive insights into the role of K(+) channels of the gastrointestinal tract...