Zoltan Szolnoki

Summary

Publications

  1. doi request reprint Decreased Number of Mitochondria in Leukoaraiosis
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary Electronic address
    Arch Med Res 46:604-8. 2015
  2. doi request reprint Evaluation of the MTHFR A1298C variant in leukoaraiosis
    Zoltan Szolnoki
    Department of Neurology and Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary
    J Mol Neurosci 46:492-6. 2012
  3. ncbi request reprint Genetic variant-associated endothelial dysfunction behind small-vessel cerebral circulatory disorders: a new pathomechanism behind common cerebral phenotypes
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, H 5600 Békéscsaba, Pipacs köz 9, Hungary
    Mini Rev Med Chem 7:527-30. 2007
  4. ncbi request reprint The combination of homozygous MTHFR 677T and angiotensin II type-1 receptor 1166C variants confers the risk of small-vessel-associated ischemic stroke
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula
    J Mol Neurosci 31:201-7. 2007
  5. ncbi request reprint A genetic variant in cytoskeleton motors amplifies susceptibility to leukoaraiosis in hypertensive smokers: gene-environmental interactions behind vascular white matter demyelinization
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary
    J Mol Neurosci 33:173-9. 2007
  6. ncbi request reprint Evaluation of the roles of the A185C and C406T kinesin light-chain 1 variants in the development of leukoaraiosis
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary
    Neurosci Lett 429:101-4. 2007
  7. ncbi request reprint A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Pipacs köz 9, Bekescsaba 5600, Hungary
    Neuromolecular Med 9:335-9. 2007
  8. doi request reprint Reduced noncovalent connections in leukoaraiosis
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, Hungary
    Expert Rev Neurother 8:205-13. 2008
  9. doi request reprint Characteristic imprint of single nucleotide polymorphisms in multiple sclerosis
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary
    J Mol Neurosci 38:166-72. 2009
  10. doi request reprint Galectin-2 3279TT variant protects against the lymphotoxin-alpha 252GG genotype associated ischaemic stroke
    Zoltan Szolnoki
    Department of Cerebrovascular Disease, Pandy Kalman County Hospital, Gyula, Hungary
    Clin Neurol Neurosurg 111:227-30. 2009

Collaborators

Detail Information

Publications39

  1. doi request reprint Decreased Number of Mitochondria in Leukoaraiosis
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary Electronic address
    Arch Med Res 46:604-8. 2015
    ..Chronic hypoxia of the white matter of the brain may be a factor triggering this entity. LA may develop as a consequence of chronically insufficient cellular energy production and the accumulation of free radicals...
  2. doi request reprint Evaluation of the MTHFR A1298C variant in leukoaraiosis
    Zoltan Szolnoki
    Department of Neurology and Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary
    J Mol Neurosci 46:492-6. 2012
    ..Our results suggest that the MTHFR A1298C variant confers an independent genetic risk of LA, and this pathological role may be amplified by the MTHFR C677T variant...
  3. ncbi request reprint Genetic variant-associated endothelial dysfunction behind small-vessel cerebral circulatory disorders: a new pathomechanism behind common cerebral phenotypes
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, H 5600 Békéscsaba, Pipacs köz 9, Hungary
    Mini Rev Med Chem 7:527-30. 2007
    ..Newly-developed drugs involving phosphodiesterase type-5 inhibitors, which improve the endothelial functions, may comprise a new approach to the treatment and prevention of small-vessel cerebral circulatory disorders...
  4. ncbi request reprint The combination of homozygous MTHFR 677T and angiotensin II type-1 receptor 1166C variants confers the risk of small-vessel-associated ischemic stroke
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula
    J Mol Neurosci 31:201-7. 2007
    ..Although the exact mechanism of action is not known, addition of the unfavourable effects on the endothelial function can be presumed...
  5. ncbi request reprint A genetic variant in cytoskeleton motors amplifies susceptibility to leukoaraiosis in hypertensive smokers: gene-environmental interactions behind vascular white matter demyelinization
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary
    J Mol Neurosci 33:173-9. 2007
    ..76-fold in hypertensive smokers as compared with those not carrying this variant. This finding may be useful in everyday clinical practice by indicating the need for stricter preventive measures in CC carriers...
  6. ncbi request reprint Evaluation of the roles of the A185C and C406T kinesin light-chain 1 variants in the development of leukoaraiosis
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary
    Neurosci Lett 429:101-4. 2007
    ..The present finding supports the involvement of the cytoskeleton in the development of vascular white matter damage, thereby opening up novel fields in the research into LA...
  7. ncbi request reprint A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Pipacs köz 9, Bekescsaba 5600, Hungary
    Neuromolecular Med 9:335-9. 2007
    ..0% vs. 9.7%, P < 0.02; crude OR: 0.19, 95% CI: 0.04-0.82, P < 0.05; adjusted OR: 0.21, 95% CI: 0.018-0.88, P < 0.05). Our results draw attention to possible roles of the cytoskeleton in MS...
  8. doi request reprint Reduced noncovalent connections in leukoaraiosis
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, Hungary
    Expert Rev Neurother 8:205-13. 2008
    ..In accordance with this chemical model, a synchronously evolving slight intracellular ATP depletion along the glial cytoplasm may lead to an unstable biochemical condition in glial cells, which finally predisposes to leukoaraiosis...
  9. doi request reprint Characteristic imprint of single nucleotide polymorphisms in multiple sclerosis
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary
    J Mol Neurosci 38:166-72. 2009
    ..4-51.4, p < 0.0004). The distribution pattern of the SNPs in the UTRs seems to be highly characteristic of relapsing-remitting MS. These findings call attention to the possible roles of the UTRs of the MBPs in the development of MS...
  10. doi request reprint Galectin-2 3279TT variant protects against the lymphotoxin-alpha 252GG genotype associated ischaemic stroke
    Zoltan Szolnoki
    Department of Cerebrovascular Disease, Pandy Kalman County Hospital, Gyula, Hungary
    Clin Neurol Neurosurg 111:227-30. 2009
    ....
  11. doi request reprint Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary
    Clin Biochem 42:630-3. 2009
    ..The aim of this study was to determine the extent to which this genetic variant gives rise to the occurrence of LA and its severity, if the subject is exposed to long-lasting, severe and poorly controlled hypertension...
  12. doi request reprint A homozygous genetic variant of mitochondrial uncoupling protein 4 exerts protection against the occurrence of multiple sclerosis
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Békéscsaba, Pipacs köz 9, 5600, Gyula, Hungary
    Neuromolecular Med 11:101-5. 2009
    ..0000089; OR, 0.32; 95% CI: 0.2-0.56, P < 0.005). The present findings indirectly raise the possibility that a shift or imbalance in the finally regulated MMP plays a role in the development of MS...
  13. ncbi request reprint Evaluation of common unfavourable genetic variants in cerebrovascular diseases: recommendation for supportive genetic examinations and methodological approaches for common genetic variants
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Kálmán Pándy County Hospital, Gyula, Békéscsaba, Hungary
    Curr Med Chem 16:3168-73. 2009
    ..The development of a correct approach to genetic polymorphisms may have a great impact on the understanding and prevention of cerebrovascular diseases...
  14. doi request reprint Evaluation of the genetic variants of kinesin motor protein in ischemic stroke
    Zoltan Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary
    J Stroke Cerebrovasc Dis 18:360-2. 2009
    ..We have now extended our investigations to examine how the above genetic variants affect the occurrence of ischemic stroke...
  15. doi request reprint A homozygous genetic variant of mitochondrial uncoupling protein 4 affects the occurrence of leukoaraiosis
    Z Szolnoki
    Department of Cerebrovascular Diseases, Pandy Kalman County Hospital, Gyula, Hungary
    Acta Neurol Scand 123:352-7. 2011
    ..The mUCPs are presumed to be of great importance in the regulation of the mitochondrial membrane potential (MMP) and the cellular energy metabolism...
  16. ncbi request reprint Common genetic variants of the mitochondrial trafficking system and mitochondrial uncoupling proteins affect the development of two slowly developing demyelinating disorders, leukoaraiosis and multiple sclerosis
    Z Szolnoki
    Department of Neurology and Cerebrovascular Diseases, Pandy County Hospital, Gyula, Hungary
    Curr Med Chem 17:3583-90. 2010
    ..In this context, this article discusses the roles of genetic variants of the kinesin motor proteins and UCPs in slowly developing diseases of the white matter of the brain as multiple sclerosis and leukoaraiosis...
  17. ncbi request reprint Chemical events behind leukoaraiosis: medicinal chemistry offers new insight into a specific microcirculation disturbance in the brain (a chemical approach to a frequent cerebral phenotype)
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, Hungary
    Curr Med Chem 14:1027-36. 2007
    ..This article discusses these hypothetical alternative molecular events behind LA. The review also illustrates how medicinal chemistry can offer new insight into a common, but still mysterious cerebral phenotype...
  18. ncbi request reprint A dynamically changing intracellular water network serves as a universal regulator of the cell: the water-governed cycle
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, H 5600 Békéscsaba, Pipacs köz 9, Hungary
    Biochem Biophys Res Commun 357:331-4. 2007
    ..The roles of such non-covalent networks are examined in terms of a molecular model which postulates a universal enzyme and biochemical mechanism regulating the maintenance of chemical stability in living cells...
  19. ncbi request reprint Evaluation of the roles of the Leiden V mutation and ACE I/D polymorphism in subtypes of ischaemic stroke
    Z Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Semmelweis, Hungary
    J Neurol 248:756-61. 2001
    ..The angiotensin converting enzyme (ACE) D allele indirectly exerts an unfavourable effect on the vasoregulatory system. In this study, the frequency of these mutations was analysed in different subtypes of ischaemic stroke...
  20. ncbi request reprint Evaluation of the roles of common genetic mutations in leukoaraiosis
    Z Szolnoki
    Dept of Neurology and Neurophysiology, Central Laboratory, Pandy Kalman County Hospital, Gyula, Hungary
    Acta Neurol Scand 104:281-7. 2001
    ..However, it can be explained only in part by vascular risk factors. With the assumption of genetic susceptibility, the roles of common genetic polymorphisms and mutations in leukoaraiosis were examined in this study...
  21. ncbi request reprint Evaluation of the interactions of common genetic mutations in stroke subtypes
    Zoltan Szolnoki
    H 5600 Békéscsaba, Pipacs köz 9, Hungary
    J Neurol 249:1391-7. 2002
    ..We hypothesised the clinical importance of the co-occurrence of common, unfavorable genetic mutations in the development of different stroke subtypes...
  22. pmc Evaluation of the modifying effects of unfavourable genotypes on classical clinical risk factors for ischaemic stroke
    Z Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, Hungary
    J Neurol Neurosurg Psychiatry 74:1615-20. 2003
    ..We hypothesised the clinical importance of the interactions between common, unfavourable genetic mutations and clinical risk factors in the development of ischaemic stroke...
  23. ncbi request reprint Specific APO E genotypes in combination with the ACE D/D or MTHFR 677TT mutation yield an independent genetic risk of leukoaraiosis
    Z Szolnoki
    Department of Neurology and Neurophysiology Central Laboratory, Pandy Kalman County Hospital, Gyula, Hungary
    Acta Neurol Scand 109:222-7. 2004
    ....
  24. ncbi request reprint Endothelial nitric oxide synthase gene interactions and the risk of ischaemic stroke
    Z Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, Hungary
    Acta Neurol Scand 111:29-33. 2005
    ....
  25. ncbi request reprint Lymphotoxin-alpha gene 252G allelic variant is a risk factor for large-vessel-associated ischemic stroke
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, and Department of Medical Genetics and Child Development, University of Pecs, Hungary
    J Mol Neurosci 27:205-11. 2005
    ..These data show that besides the role in the development of myocardial infarction, the homozygous carriage of the LTA allele with 252G and 804A SNPs is a novel susceptibility factor for largevesselassociated ischemic stroke...
  26. ncbi request reprint [Interactions between the MTHFR C677T and MTHFR A1298C mutations in ischaemic stroke]
    Zoltan Szolnoki
    Pándy Kálmán Megyei Kórház, I Számú Neurológiai Osztály, Gyula
    Ideggyogy Sz 59:107-12. 2006
    ..In this study, the role of these two mutations in ischaemic stroke was examined:..
  27. ncbi request reprint Gene-gene and gene-environment interplay represent specific susceptibility for different types of ischaemic stroke and leukoaraiosis
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, Hungary
    Curr Med Chem 13:1627-34. 2006
    ..This may facilitate the choice of more effective and specific prevention on the basis of the genotype...
  28. ncbi request reprint Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, and Department of Medical Genetics and Child Development, University of Pecs, Hungary
    J Mol Neurosci 28:285-90. 2006
    ..1, p<0.001) infarction. On a pathophysiological basis, our results suggest the possibility that the AT1R A1166C polymorphism might give rise to ischemic stroke indirectly via an unfavorable effect on the cardiorespiratory function...
  29. ncbi request reprint Coexistence of angiotensin II type-1 receptor A1166C and angiotensin-converting enzyme D/D polymorphism suggests susceptibility for small-vessel-associated ischemic stroke
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, Hungary
    Neuromolecular Med 8:353-60. 2006
    ..Genetic interactions might contribute to the altered functional network in renin-angiotensin system in vascular disorders...
  30. doi request reprint Functional variants of glucokinase regulatory protein and apolipoprotein A5 genes in ischemic stroke
    Luca Jaromi
    Department of Medical Genetics, University of Pecs, Szigeti ut 12, 7624, Pecs, Hungary
    J Mol Neurosci 41:121-8. 2010
    ..In addition, the effect of APOA5 did not change significantly when specific combinations of the two genes were present...
  31. ncbi request reprint Apolipoprotein A5 gene promoter region T-1131C polymorphism associates with elevated circulating triglyceride levels and confers susceptibility for development of ischemic stroke
    Viktoria Havasi
    Department of Medical Genetics and Child Development, University of Pecs, Pecs, Hungary
    J Mol Neurosci 29:177-83. 2006
    ..Being that apoA5 gene is under the control of the peroxisome proliferator-activated receptor alpha, theoretically, the current observations also can have long-term therapeutic consequences...
  32. doi request reprint Triglyceride level-influencing functional variants of the ANGPTL3, CILP2, and TRIB1 loci in ischemic stroke
    Luca Jaromi
    Department of Medical Genetics, University of Pecs, Szigeti ut 12, 7624, Pecs, Hungary
    Neuromolecular Med 13:179-86. 2011
    ..070), or rs12130333-T allele (P = 0.757) and the risk for development of stroke. The data presented here suggest different scale of effect of triglyceride modifier alleles and also their variable susceptibility or protective nature...
  33. ncbi request reprint Increased prevalence of platelet glycoprotein IIb/IIIa PLA2 allele in ischaemic stroke associated with large vessel pathology
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Gyula, Hungary
    Thromb Res 109:265-9. 2003
    ..There are indications that the A2 allele can also be associated with acute thrombosis or stroke. The purpose of this study was to study the distribution of the A2 allele in different vascular subtypes of stroke disease...
  34. doi request reprint Apolipoprotein A5 gene C56G variant confers risk for the development of large-vessel associated ischemic stroke
    Anita Maasz
    University of Pecs, Dept of Medical Genetics and Child Development, Szigeti 12, 7624 Pecs, Hungary
    J Neurol 255:649-54. 2008
    ..Several candidate genes have been shown to have an impact in the pathogenesis of stroke. The aim of our study was to investigate the possible association between the C56G variant of the apolipoprotein A5 (APOA5) gene and ischemic stroke...
  35. ncbi request reprint Apolipoprotein A5 gene IVS3+G476A allelic variant confers susceptibility for development of ischemic stroke
    Anita Maasz
    University of Pecs, Department of Medical Genetics and Child Development, Pecs, Szigeti 12, H 7624, Hungary
    Circ J 72:1065-70. 2008
    ..T-1131C, T1259C and IVS3+G476A are naturally occurring variants of the apolipoprotein A5 (APOA5) gene and their possible impact on the development of ischemic stroke was investigated in the present study...
  36. ncbi request reprint Detection of the Leu40Arg variant of the platelet glycoprotein IIb/IIIa receptor in subjects with thrombotic diseases
    Edit Nadasi
    Department of Medical Genetics and Child Development, Faculty of Medicine, University of Pecs, Pecs, Hungary
    Thromb Res 116:479-82. 2005
  37. ncbi request reprint Evaluation of the interactions of common genetic mutations in stroke
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, Hungary
    Methods Mol Med 104:241-50. 2005
    ..This chapter discusses how to evaluate these interactions and the interpretation of findings...
  38. ncbi request reprint Pathomechanism of leukoaraiosis: a molecular bridge between the genetic, biochemical, and clinical processes (a mitochondrial hypothesis)
    Zoltan Szolnoki
    Department of Neurology and Neurophysiology, Pandy Kalman County Hospital, Gyula, Hungary
    Neuromolecular Med 9:21-33. 2007
    ..On the basis of the current knowledge on LA, this article suggests a hypothetical molecular bridge between the genetic, biochemical, and clinical processes...
  39. ncbi request reprint Search for factor V Arg306 Cambridge and Hong Kong mutations in mixed Hungarian population samples
    K Komlosi
    Department of Medical Genetics and Child Development, Faculty of Medicine, University of Pecs, Pecs, Hungary
    Acta Haematol 110:220-2. 2003