Yao Haur Kuo

Summary

Affiliation: National Research Institute of Chinese Medicine
Country: Taiwan

Publications

  1. ncbi request reprint A novel NO-production-inhibiting triterpene and cytotoxicity of known alkaloids from Euonymus laxiflorus
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, NO 155 1, Li Nong Street, Section 2, Shih Pai, Taipei, 112, Taiwan, Republic of China
    J Nat Prod 66:554-7. 2003
  2. ncbi request reprint A novel cytotoxic C-methylated biflavone, taiwanhomoflavone-B from the twigs of Cephalotaxus wilsoniana
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Taipei, Taiwan, R O C
    Chem Pharm Bull (Tokyo) 50:1607-8. 2002
  3. ncbi request reprint Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Shih Pai, Taipei, Taiwan, R O C
    Chem Pharm Bull (Tokyo) 51:425-6. 2003
  4. doi request reprint Flavanone and diphenylpropane glycosides and glycosidic acyl esters from Viscum articulatum
    Yu Jen Kuo
    Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Nat Prod 73:109-14. 2010
  5. doi request reprint Antioxidant lignans and chromone glycosides from Eurya japonica
    Li Ming Yang Kuo
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Nat Prod 76:580-7. 2013
  6. ncbi request reprint Triterpene acids from Euscaphis japonica and assessment of their cytotoxic and anti-NO activities
    Li Jie Zhang
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Planta Med 78:1584-90. 2012
  7. ncbi request reprint Antihepatitis activity (anti-HBsAg and anti-HBeAg) of C19 homolignans and six novel C18 dibenzocyclooctadiene lignans from Kadsura japonica
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Shih Pai, Taipei, Taiwan, R O C
    Planta Med 71:646-53. 2005
  8. doi request reprint Antiproliferative and hypoglycemic cucurbitane-type glycosides from the fruits of Momordica charantia
    Ping Chun Hsiao
    Divison of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
    J Agric Food Chem 61:2979-86. 2013
  9. ncbi request reprint Syntheses of C(18) dibenzocyclooctadiene lignan derivatives as anti-HBsAg and anti-HBeAg agents
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, NO 155 1, Li Nong St, Sec 2, Shih Pai, Taipei 112, Taiwan
    Bioorg Med Chem 13:1555-61. 2005
  10. pmc Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica
    Li Jie Zhang
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Nat Prod 73:557-62. 2010

Collaborators

Detail Information

Publications72

  1. ncbi request reprint A novel NO-production-inhibiting triterpene and cytotoxicity of known alkaloids from Euonymus laxiflorus
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, NO 155 1, Li Nong Street, Section 2, Shih Pai, Taipei, 112, Taiwan, Republic of China
    J Nat Prod 66:554-7. 2003
    ..Structural elucidations of these compounds were established by spectral analysis. Compound 1 displayed significant nitric oxide (NO) inhibitory effect...
  2. ncbi request reprint A novel cytotoxic C-methylated biflavone, taiwanhomoflavone-B from the twigs of Cephalotaxus wilsoniana
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Taipei, Taiwan, R O C
    Chem Pharm Bull (Tokyo) 50:1607-8. 2002
    ..The structure of 1 was elucidated on the basis of spectroscopic analysis. Taiwanhomoflavone-B is cytotoxic with ED(50) values of 3.8 and 3.5 microg/ml, against KB oral epidermoid carcinoma and Hepa-3B hepatoma cells, respectively...
  3. ncbi request reprint Two novel sesquiterpene lactones, cytotoxic vernolide-A and -B, from Vernonia cinerea
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Shih Pai, Taipei, Taiwan, R O C
    Chem Pharm Bull (Tokyo) 51:425-6. 2003
    ..02, 0.05, 0.53, 0.04 microg/ml for KB, DLD-1, NCI-661, and Hela, respectively); vernolide-B had marginal cytoxicity (ED(50)=3.78, 5.88, 6.42 microg/ml for KB, NCI-661, and Hela, respectively)...
  4. doi request reprint Flavanone and diphenylpropane glycosides and glycosidic acyl esters from Viscum articulatum
    Yu Jen Kuo
    Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Nat Prod 73:109-14. 2010
    ..Biological evaluation showed that 1, 2, and 10 exhibited antioxidant activity using a DPPH method and that compounds 1, 3, and 11 were active in a lipopolysaccharide-induced nitric oxide assay...
  5. doi request reprint Antioxidant lignans and chromone glycosides from Eurya japonica
    Li Ming Yang Kuo
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Nat Prod 76:580-7. 2013
    ..21 μM). On the other hand, compounds 1, 2, 7-9, 12-20, and 32 showed only weak anti-NO production activity when compared to the positive control quercetin...
  6. ncbi request reprint Triterpene acids from Euscaphis japonica and assessment of their cytotoxic and anti-NO activities
    Li Jie Zhang
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Planta Med 78:1584-90. 2012
    ..64 ± 0.87, 2.11 ± 1.54, 1.73 ± 0.64 µM, respectively). Some of the isolated triterpenoids showed marginal inhibitions on NO production induced by LPS...
  7. ncbi request reprint Antihepatitis activity (anti-HBsAg and anti-HBeAg) of C19 homolignans and six novel C18 dibenzocyclooctadiene lignans from Kadsura japonica
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Shih Pai, Taipei, Taiwan, R O C
    Planta Med 71:646-53. 2005
    ..9 and 11.9 microM for taiwanschirins A and B, respectively)...
  8. doi request reprint Antiproliferative and hypoglycemic cucurbitane-type glycosides from the fruits of Momordica charantia
    Ping Chun Hsiao
    Divison of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan
    J Agric Food Chem 61:2979-86. 2013
    ..In addition, compound 14 showed potent hypoglycemic activities by glucose uptake assay...
  9. ncbi request reprint Syntheses of C(18) dibenzocyclooctadiene lignan derivatives as anti-HBsAg and anti-HBeAg agents
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, NO 155 1, Li Nong St, Sec 2, Shih Pai, Taipei 112, Taiwan
    Bioorg Med Chem 13:1555-61. 2005
    ..Among these active C(18) dibenzocyclooctadiene lignan analogues, the lignan with a but-3-enoyl group (6) exhibited the most active inhibition...
  10. pmc Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica
    Li Jie Zhang
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Nat Prod 73:557-62. 2010
    ..Biological evaluation showed that all compounds 1-9 exhibited cytotoxic activity against a small panel of human tumor cell lines (A549, DU145, KB, vincristine-resistant KB)...
  11. doi request reprint New isoflavonoid glycosides and related constituents from astragali radix ( Astragalus membranaceus ) and their inhibitory activity on nitric oxide production
    Li Jie Zhang
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Agric Food Chem 59:1131-7. 2011
    ..Furthermore, characteristic peaks for the 11 major compounds in the chromatogram were unambiguously confirmed...
  12. ncbi request reprint Cytotoxic phenylpropanoid glycosides from the stems of Smilax china
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Taipei, 112 Taiwan, Republic of China
    J Nat Prod 68:1475-8. 2005
    ..Structural elucidation of isolates 1-6 was based on spectroscopic data analysis. These new phenylpropanoids were evaluated against several human tumor cell lines...
  13. ncbi request reprint Cytotoxic constituents from Podocarpus fasciculus
    Yu Jen Kuo
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Chem Pharm Bull (Tokyo) 56:585-8. 2008
    ..Preliminary structure-activity relationship studies of the isolated diterpenoids and biflavonoids are discussed...
  14. ncbi request reprint Antioxidant and anti-nitric oxide components from Quercus glauca
    Chien Chang Shen
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC
    Chem Pharm Bull (Tokyo) 60:924-9. 2012
    ..Moreover, compounds 9 and 14 strongly inhibited nitric oxide (NO) production with IC<inf>50</inf> values of 8.25 and 14.04 µM, respectively, and compounds 1, 4-6, 14, and 15 showed moderate antioxidant activities...
  15. doi request reprint Arisanschinins A-E, lignans from Schisandra arisanensis hay
    Chin Cheng Liu
    College of Medicine, National Taiwan University, Taipei, Taiwan
    Planta Med 76:1605-10. 2010
    ..Compound 1 showed significant inhibition of α-glucosidase IN VITRO. The radical-scavenging activities of these compounds were evaluated using DPPH...
  16. ncbi request reprint New dammarane-type saponins from the galls of Sapindus mukorossi
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Agric Food Chem 53:4722-7. 2005
    ....
  17. doi request reprint New bioactive orange pigments with yellow fluorescence from Monascus-fermented dioscorea
    Ya Wen Hsu
    Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan, ROC
    J Agric Food Chem 59:4512-8. 2011
    ..7 cells. Compounds 1-4 also exhibited antiproliferative activities against human laryngeal carcinoma (HEp-2) and human colon adenocarinoma (WiDr)...
  18. doi request reprint Effects of Monascus-fermented rice extract on malignant cell-associated neovascularization and intravasation determined using the chicken embryo chorioallantoic membrane model
    Bing Ying Ho
    Institute of Microbiology and Biochemistry, College of Life Science, National Taiwan University, Taipei, Taiwan
    Integr Cancer Ther 9:204-12. 2010
    ..In summary, Monascus-fermented products exert a potent effect on tumor growth and activation, suggesting that they may serve as supplementary agents in adjuvant cancer therapy...
  19. doi request reprint 5β,19-epoxycucurbitane triterpenoids from Momordica charantia and their anti-inflammatory and cytotoxic activity
    Chia Ching Liaw
    R and D Department, Starsci Biotech Co Ltd, Taipei, Taiwan
    Planta Med 81:62-70. 2015
    ..In addition, 3 and 4 also showed moderate cytotoxicity against WiDr, Hep G2, MCF-7, and HEp-2 human tumor cell lines. ..
  20. doi request reprint New anti-inflammatory and anti-proliferative constituents from fermented red mold rice Monascus purpureus NTU 568
    Ya Wen Hsu
    Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan
    Molecules 15:7815-24. 2010
    ..Furthermore, 1-4 also showed moderate antiproliferative effects against human laryngeal carcinoma (HEp-2) (IC(50) = 14.81~20.06 μg/mL) and human colon adenocarcinoma (WiDr) (IC(50) = 12.89~21.14 μg/mL)...
  21. ncbi request reprint DNA topoisomerase I inhibitor, ergosterol peroxide from Penicillium oxalicum
    Li Ming Yang Kuo
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Planta Med 71:77-9. 2005
    ..56 microg/mL]...
  22. ncbi request reprint Laxifolone A suppresses LPS/IFN-gamma-induced NO synthesis by attenuating NF-kappaB translocation: role of NF-kappaB p105 level
    Han Chieh Ko
    Division of Basic Chinese Medical Research, National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    Planta Med 71:514-9. 2005
    ..In summary, these results suggest that inhibition of NF-kappaB p105 degradation in cytoplasm may participate in the abrogation of LPS/IFN-gamma-induced NF-kappaB translocation and subsequent NO synthesis by laxifolone A...
  23. ncbi request reprint Four new nonaoxygenated C18 dibenzocylcooctadiene lignans from Kadsura philippinensis
    Ya Ching Shen
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan
    Chem Pharm Bull (Tokyo) 55:280-3. 2007
    ..The stereochemistries of the biphenyl and octadiene moieties were deduced from circular dichorism (CD) and the NOESY spectra, respectively. The in vitro antiplatelet aggregation activity of metabolites 1-4 also have been evaluated...
  24. doi request reprint Monaphilones A-C, three new antiproliferative azaphilone derivatives from Monascus purpureus NTU 568
    Ya Wen Hsu
    Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan, Republic of China
    J Agric Food Chem 58:8211-6. 2010
    ....
  25. pmc Schizandra arisanensis extract attenuates cytokine-mediated cytotoxicity in insulin-secreting cells
    Yi Shin Hsu
    Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei 112, Taiwan, China
    World J Gastroenterol 18:6809-18. 2012
    ..To explore the bioactivity of an ethanolic extract of Schizandra arisanensis (SA-Et) and isolated constituents against interleukin-1β and interferon-γ-mediated β cell death and abolition of insulin secretion...
  26. doi request reprint Triterpenoidal saponins from Hydrocotyle sibthorpioides
    Hui Chi Huang
    National Research Institute of Chinese Medicine, Shih Pai, Taipei, Taiwan, ROC
    Phytochemistry 69:1597-603. 2008
    ..Biological evaluation established that saponins possessing four sugar units (three d-glucoses and one l-arabinose) (4-7) exhibited moderate cytotoxicity against KB, Daoy and WiDr human tumor cell lines...
  27. ncbi request reprint Evaluation of caffeic acid amide analogues as anti-platelet aggregation and anti-oxidative agents
    Chia Cheng Hung
    National Research Institute of Chinese Medicine, Shin Pai, Taipei 112, Taiwan
    Bioorg Med Chem 13:1791-7. 2005
    ..This study also exhibited that caffeic anilides displayed more potent anti-oxidative activity in the radical scavenging activity assay than trolox and vitamin E...
  28. doi request reprint A novel compound with antioxidant activity produced by Serratia ureilytica TKU013
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan
    J Agric Food Chem 60:9043-7. 2012
    ..Furthermore, the major secondary metabolites of EtOAc extract of the cultured supernatant were examined by the fingerprinting data of the HPLC system...
  29. doi request reprint Cytotoxic Hexacyclic Triterpene Acids from Euscaphis japonica
    Jing Jy Cheng
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    J Nat Prod 73:1655-8. 2010
    ..Compounds 3, 4, and 14 showed significant cytotoxicity against different cancer cell lines [IC50 = 2.54 (NCI-H460), 3.61 (MCF-7), and 3.27 μM (CEM) for 3, 4, and 14, respectively]. ..
  30. doi request reprint Antioxidant and Anti-Inflammatory Phenolic Glycosides from Clematis tashiroi
    Li Jie Zhang
    National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan, Republic of China
    J Nat Prod 78:1586-92. 2015
    ..In a DPPH radical-scavenging test, compounds 1, 7, and 8 showed more potent antioxidant activity than that of the positive control, vitamin E. In addition, compound 7 also showed inhibitory activity in an antinitric oxide release assay...
  31. doi request reprint Isolation and identification of a novel antioxidant with antitumour activity from Serratia ureilytica using squid pen as fermentation substrate
    Yao Haur Kuo
    Division of Herbal Medicines and Natural Products, National Research Institute of Chinese Medicine, Taipei, 112, Taiwan
    Mar Biotechnol (NY) 13:451-61. 2011
    ..The structure of Serranticin is analogous to that of siderophores (hexacoordinated catecholamine), which are iron chelators. As such, Serranticin has the potential for use as a deferration agent in various iron overload diseases...
  32. doi request reprint Ajugalide-B (ATMA) is an anoikis-inducing agent from Ajuga taiwanensis with antiproliferative activity against tumor cells in vitro
    Chun Tang Chiou
    Division of Herbal Medicine and Natural Product, National Research Institute of Chinese Medicine, Taipei 112, Taiwan, Republic of China
    Phytochemistry 80:64-9. 2012
    ..Furthermore, ATMA also blocks anchorage-independent growth and cell migration and, therefore, ATMA may serve as a lead compound for the developing of anti-cancer therapeuties with anoikis-inducing properties...
  33. ncbi request reprint Synchronous high-performance liquid chromatography with a photodiode array detector and mass spectrometry for the determination of citrinin, monascin, ankaflavin, and the lactone and acid forms of monacolin K in red mold rice
    Cheng Lun Wu
    Sunway Biotechnology Co, R and D Division, Taipei, Taiwan, Republic of China
    J AOAC Int 94:179-90. 2011
    ..05% trifluoroacetic acid in acetonitrile-water (62.5 + 37.5, v/v)...
  34. ncbi request reprint New cytotoxic 6-oxygenated 8,9-dihydrofurocoumarins, hedyotiscone A - C, from Hedyotis biflora
    Yung Husan Chen
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, R O C
    Planta Med 72:75-8. 2006
    ..4, 17.4, 4.9, 8.0, and 9.2 microg/mL, respectively. Ursolic acid showed significant cytotoxicity against MDA-MB-231 cells (human breast carcinoma cells) with an IC50 value of 1.49 microg/mL...
  35. doi request reprint Labdane diterpenoid glycosides from Alpinia densespicata and their nitric oxide inhibitory activities in macrophages
    Yu Jen Kuo
    National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China
    J Nat Prod 72:1097-101. 2009
    ..Structural elucidation of compounds 1-6 was based on spectroscopic data. Compounds 1-9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 microM against several human tumor cell lines...
  36. doi request reprint New cytotoxic prostanoids from Taiwanese soft coral Clavularia viridis
    Ya Ching Shen
    School of Pharmacy, College of Medicine, National Taiwan University, No 1 Jen Ai Road Sect 1, Taipei, Taiwan, Republic of China
    Chem Biodivers 7:2702-8. 2010
    ..Pharmacological studies revealed that compounds 1-4 exhibited potent cytotoxicity against human cancer cells...
  37. ncbi request reprint Possible involvement of nitric oxide in the progression of diabetic retinopathy
    Der Chong Tsai
    Department of Ophthalmology, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan, ROC
    Ophthalmologica 217:342-6. 2003
    ..However, no significant differences were observed between any of the diabetic subgroups in the plasma NO levels (p = 0.345). We therefore concluded that NO present in the ocular tissues may play important roles in the progression of DR...
  38. doi request reprint Antioxidant phenylpropanoid glycosides from Smilax bracteata
    Lijie Zhang
    National Research Institute of Chinese Medicine, Taipei 112, Taiwan, ROC
    Phytochemistry 69:1398-404. 2008
    ..Their structures were elucidated on the basis of spectroscopic analyses. Moreover, 1-6 exhibited moderate scavenging activities against DPPH radicals...
  39. ncbi request reprint Isodiospyrin as a novel human DNA topoisomerase I inhibitor
    Chun Yuan Ting
    Institute of Biochemistry, School of Life Science, National Yang Ming University, Taipei, Taiwan
    Biochem Pharmacol 66:1981-91. 2003
    ..Thus, these findings have important implications on naphthoquinone and its derivatives' cellular mode of actions, i.e. these novel DNA topoisomerase I inhibitors can prevent both DNA relaxation and kinase activities of htopo I...
  40. doi request reprint New nitrogen-containing sesquiterpenoids from the Taiwanese soft coral Cespitularia taeniata May
    Yuan Bin Cheng
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC
    Chem Biodivers 6:1266-72. 2009
    ..The in vitro cytotoxic activities of the isolated metabolites were tested against KB, Daoy, and WiDr cell lines. A biogenetic pathway for these novel compounds was proposed...
  41. doi request reprint Astragalus membranaceus flavonoids (AMF) ameliorate chronic fatigue syndrome induced by food intake restriction plus forced swimming
    Yao Haur Kuo
    National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC
    J Ethnopharmacol 122:28-34. 2009
    ..Alteration of immune function may be associated with chronic fatigue syndrome (CFS) and this study reveals the immunoregulatory effect of Astragalus membranaceus flavonoids (AMF)...
  42. ncbi request reprint Comparison of the proliferation and differentiation ability between adult rat retinal stem cells and cerebral cortex-derived neural stem cells
    I Hsien Liu
    Department of Ophthalmology, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan, ROC
    Ophthalmologica 219:171-6. 2005
    ..Our data demonstrated that CNSCs displayed a higher ability of proliferation and retinal lineage. This report also offers an alternative protocol of cell reproduction for producing retinal cells...
  43. ncbi request reprint Anti-platelet aggregation triterpene saponins from the galls of Sapindus mukorossi
    Hui Chi Huang
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan
    Chem Pharm Bull (Tokyo) 55:1412-5. 2007
    ..Their structures were elucidated on the basis of spectroscopic analysis and chemical hydrolysis. Biological evaluation showed that both sapinmusaponins Q and R demonstrated more potent anti-platelet aggregation activity than aspirin...
  44. ncbi request reprint Cytotoxic clerodane diterpenoids from Casearia membranacea
    Ya Ching Shen
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 68:1665-8. 2005
    ..The cytotoxic activities of the isolated diterpenoids against human oral epidermoid (KB), medulla (Med), and colon (DLD-1) cancer cell lines were evaluated...
  45. ncbi request reprint Taiwankadsurins A, B, and C, three new C19 homolignans from Kadsura philippinensis
    Ya Ching Shen
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    Org Lett 7:5297-300. 2005
    ..Compound 2 exhibited mild cytotoxicity against human KB and Hela tumor cells...
  46. ncbi request reprint Oxygenated terpenoids from a formosan soft coral Sinularia gibberosa
    Atallah F Ahmed
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 68:1208-12. 2005
    ..Metabolites 2 and 4 were found to exhibit moderate cytotoxicity toward a human liver carcinoma cell line...
  47. ncbi request reprint Scabrolides E-G, three new norditerpenoids from the soft coral Sinularia scabra
    Atallah F Ahmed
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 67:2079-82. 2004
    ..Metabolite 1 was found to exhibit significant cytotoxicity against the growth of Hepa59T/VGH and KB cell lines...
  48. ncbi request reprint Kadsuphilols A-H, oxygenated lignans from Kadsura philippinensis
    Ya Ching Shen
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan 100, Republic of China
    J Nat Prod 70:1139-45. 2007
    ..The in vitro radical-scavenging activities of these compounds using DPPH were tested and evaluated. Compound 3 exhibited more potent activity than vitamins C and E...
  49. ncbi request reprint New beta-caryophyllene-derived terpenoids from the soft coral Sinularia nanolobata
    Atallah F Ahmed
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 67:592-7. 2004
    ..The cytotoxicity of 1-6 against the growth of a limited panel of cancer cell lines is also described...
  50. ncbi request reprint Chromanones and dihydrocoumarins from Calophyllum blancoi
    Ya Ching Shen
    Institute of Marine Resources, National Sun Yat Sen University, Taiwan, Republic of China
    Chem Pharm Bull (Tokyo) 52:402-5. 2004
    ..Compounds 3, 4, 5, 7, and 8 showed mild activity against KB (human oral epidermoid carcinoma) and Hela (human cervical epitheloid carcinoma) tumor cell lines...
  51. ncbi request reprint The anti-HBsAg (human type B hepatitis, surface antigen) and anti-HBeAg (human type B hepatitis, e antigen) C18 dibenzocyclooctadiene lignans from Kadsura matsudai and Schizandra arisanensis
    Ming Der Wu
    Department of Chemistry, National Sun Yat Sen University, Kaohsiung, Taiwan
    Chem Pharm Bull (Tokyo) 51:1233-6. 2003
    ..Preliminary structure-activity relationship studies for these isolated lignans are also discussed...
  52. ncbi request reprint Scabrolides A-D, four new norditerpenoids isolated from the soft coral Sinularia scabra
    Jyh Horng Sheu
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 65:1904-8. 2002
    ..The epimeric metabolites 6 and 7 have been shown to exhibit strong cytotoxic activity against KB and Hepa59T/VGH cancer cell lines...
  53. ncbi request reprint New taxane diterpenoids from the leaves and twigs of Taxus sumatrana
    Ya Ching Shen
    Institute of Marine Resources, National Sun Yat Sen University, 70 Lien Hai Road, Kaohsiung, Taiwan 80424, Republic of China
    J Nat Prod 65:1848-52. 2002
    ..Taxuspine F and compound 5 possessed moderate activity against Hepa cells only, while 3, 6, 7, and 10-deacetylbaccatin III showed only marginal activity against Hepa cells...
  54. ncbi request reprint Cespitulactones A and B, new diterpenoids from Cespitularia taeniata
    Ya Ching Shen
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, ROC
    Bioorg Med Chem Lett 16:2369-72. 2006
    ..Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical derivatization. The isolated compounds were also evaluated for cytotoxicity toward human cancer cell lines...
  55. ncbi request reprint Xenicane-type diterpenes with cytotoxicity from Xenia florida
    Yuan Bin Cheng
    Institute of Marine Resources, National Sun Yat Sen University, 70 Lien Hai Road, Kaohsiung, Taiwan 80424, Republic of China
    J Nat Prod 69:675-8. 2006
    ..The absolute configuration of 1 was determined by NOESY, CD, and Mosher's methods. Florxenilides A (1) and B (2) exhibited cytotoxicity against human colon cancer (WiDr) cells at 4.5 and 3.7 muM, respectively...
  56. ncbi request reprint Two new subergane-based sesquiterpenes from a Taiwanese Gorgonian coral Subergorgia suberosa
    Guey Horng Wang
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 65:1033-6. 2002
    ..Subergorgiol (1) may be the biosynthetic precursor of 2-6. Compound 3 was found to exhibit moderate cytotoxicity against the growth of HeLa cancer cells...
  57. doi request reprint Cembrane diterpenoids from the taiwanese soft coral Sarcophyton stolidotum
    Yuan Bin Cheng
    Institute of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 71:1141-5. 2008
    ..Sarcostolide E (5) exhibited weak to moderate cytotoxic activity against human WiDr and Daoy tumor cell lines. A biogenetic pathway and relationship for compounds 1-7 was also proposed...
  58. doi request reprint Frajunolides E-K, briarane diterpenes from Junceella fragilis
    Chia Ching Liaw
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 71:1551-6. 2008
    ..The structures of 1-7 were determined by analysis of HRESIMS and 2D NMR spectroscopic data. Cytotoxicity and in vitro anti-inflammatory activities of compounds 1-7 were also evaluated...
  59. doi request reprint Tasumatrols U-Z, taxane diterpene esters from Taxus sumatrana
    Ya Ching Shen
    School of Pharmacy, College of Medicine, National Taiwan University, Jen Ai Rd Sec 1, Taipei 100, Taiwan
    J Nat Prod 71:576-80. 2008
    ..The structures were established on the basis of detailed spectroscopic analyses, particularly HRESIMS and 2D NMR techniques. Compound 5 showed cytotoxicity against a human hepatoma (Hep2) cell line...
  60. doi request reprint Anti-inflammatory cembranoids from the soft corals Sinularia querciformis and Sinularia granosa
    Yi Lu
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 71:1754-9. 2008
    ..However, compounds 3, 7, and 8 significantly inhibited the accumulation of the pro-inflammatory iNOS and COX-2 proteins in LPS-stimulated RAW264.7 macrophage cells...
  61. ncbi request reprint Manaarenolides A-I, diterpenoids from the soft coral Sinularia manaarensis
    Jui Hsin Su
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 69:1134-9. 2006
    ..The biosynthetic relationship between these new metabolites and 10 and 11 is also discussed...
  62. ncbi request reprint C18 dibenzocyclooctadiene lignans from Kadsura philippinensis
    Ya Ching Shen
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 69:963-6. 2006
    ..The configurations of the biphenyl and cyclooctadiene moieties were deduced from circular dichroism (CD) and NOESY NMR spectra, respectively. Some of the compounds showed radical-scavenging activity in a DPPH-HPLC method...
  63. doi request reprint New bioactive clerodane diterpenoids from the roots of Casearia membranacea
    Ching Yu Chen
    Center of General Education, Tzu Hui Institute of Technology, Kaohsiung, Taiwan, Republic of China
    Chem Biodivers 5:162-7. 2008
    ..Caseamembrin T (2) exhibited the most potent activity against Daoy cells (ED(50)=10 ng/ml), superior to that of the standard drug mitomycin...
  64. ncbi request reprint 1alpha,3beta,5beta-trihydroxy-24-methylenecholestan-6-one: a novel steroid from a soft coral Sinularia gibberosa
    Atallah F Ahmed
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, ROC
    Steroids 68:377-81. 2003
    ..Gibberoketosterol is the first example of 1alpha,3beta,5beta-trihydroxy-6-oxosteroids isolated from natural sources and was found to exhibit a moderate cytotoxicity against the growth of Hepa59T/VGH cancer cells...
  65. ncbi request reprint Molluscicidal saponins from Sapindus mukorossi, inhibitory agents of golden apple snails, Pomacea canaliculata
    Hui Chi Huang
    Graduate Institute of Natural Products, Kaohsiung Medical University, 100, Shi Chuan first Rd, Kaohsiung, Taiwan
    J Agric Food Chem 51:4916-9. 2003
    ..The bioassay data revealed that 1-7 were molluscicidal, causing 70-100% mortality at 10 ppm against the golden apple snail...
  66. ncbi request reprint Neolemnane-type sesquiterpenoids from a formosan soft coral Paralemnalia thyrsoides
    Ho Cheng Huang
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung, Taiwan
    Chem Pharm Bull (Tokyo) 55:876-80. 2007
    ..Cytotoxicity of these metabolites toward a limited panel of cancer cell lines also is reported...
  67. doi request reprint Triterpenoid saponins from the fruits and galls of Sapindus mukorossi
    Hui Chi Huang
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Phytochemistry 69:1609-16. 2008
    ..Their structures were elucidated by 1D and 2D NMR spectroscopic techniques and acid hydrolysis. Biological evaluation indicated that saponins 1-4 and 7-13 showed moderate cytotoxicity against several human tumor cell lines...
  68. ncbi request reprint Chemical transformation and biological activities of ambrein, a major product of ambergris from Physeter macrocephalus (sperm whale)
    Ya Ching Shen
    School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan 100, Republic of China
    J Nat Prod 70:147-53. 2007
    ..The anti-inflammatory activities of 1-11, in terms of the inhibition of human neutrophil function, were also evaluated...
  69. doi request reprint Maleimide and maleic anhydride derivatives from the mycelia of Antrodia cinnamomea and their nitric oxide inhibitory activities in macrophages
    Ming Der Wu
    Food Industry Research and Development Institute, No 331, Shih Pin Road, Hsinchu 300, Taiwan, Republic of China
    J Nat Prod 71:1258-61. 2008
    ..Structural elucidation of compounds 1-4 was carried out by spectroscopic data. Compound 1 displayed significant inhibitory effect on nitric oxide (NO) production...
  70. ncbi request reprint New taxane diterpenoids from the roots of Taiwanese Taxus mairei
    Ya Ching Shen
    Institute of Marine Resources, National Sun Yat Sen University, Kaohsiung, Taiwan, Republic of China
    Chem Pharm Bull (Tokyo) 50:781-7. 2002
    ....
  71. ncbi request reprint Sapinmusaponins F-J, bioactive tirucallane-type saponins from the galls of Sapindus mukorossi
    Hui Chi Huang
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China
    J Nat Prod 69:763-7. 2006
    ..Compounds 1-5 also showed moderate activity in a 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay...
  72. ncbi request reprint Synthesis and antitumor activity of cis-dichloroplatinum(II) complexes of 1-(2-aminophenyl)-1,2,3,4-tetrahydroisoquinolines
    Chen Yuan Kuo
    Department of Biological Engineering, Yung Ta Institute of Technology and Commerce, Pingtung, Taiwan, ROC
    Eur J Med Chem 41:940-9. 2006
    ..The "trans influence" dominates the control of the stability of [1-(2-aminophenyl)-1,2,3,4-THIQ]dichloroplatinums(II)...