Sheng Nan Wu

Summary

Affiliation: National Cheng Kung University
Country: Taiwan

Publications

  1. ncbi request reprint Underlying mechanism of regulatory actions of diclofenac, a nonsteroidal anti-inflammatory agent, on neuronal potassium channels and firing: an experimental and theoretical study
    C W Huang
    Department of Neurology, National Cheng Kung University Hospital, School of Medicine, National Cheng Kung University, Tainan City, Taiwan
    J Physiol Pharmacol 64:269-80. 2013
  2. doi request reprint Effects of ibandronate sodium, a nitrogen-containing bisphosphonate, on intermediate-conductance calcium-activated potassium channels in osteoclast precursor cells (RAW 264.7)
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, No 1 University Road, Tainan City, 70101, Taiwan
    J Membr Biol 248:103-15. 2015
  3. doi request reprint Investigations on contribution of glial inwardly-rectifying K(+) current to membrane potential and ion flux: an experimental and theoretical study
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City, Taiwan Electronic address
    Kaohsiung J Med Sci 31:9-17. 2015
  4. pmc Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+) currents in motor neuron-like cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan
    Evid Based Complement Alternat Med 2012:148403. 2012
  5. doi request reprint Electrophysiological characterization of sodium-activated potassium channels in NG108-15 and NSC-34 motor neuron-like cells
    S N Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan
    Acta Physiol (Oxf) 206:120-34. 2012
  6. doi request reprint The inhibition by di(2-ethylhexyl)-phthalate of erg-mediated K⁺ current in pituitary tumor (GH₃) cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, No 1 University Road, Tainan City 70101, Taiwan
    Arch Toxicol 86:713-23. 2012
  7. ncbi request reprint Simulations of the cardiac action potential based on the Hodgkin-Huxley kinetics with the use of Microsoft Excel spreadsheets
    Sheng Nan Wu
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan, ROC
    Chin J Physiol 47:15-22. 2004
  8. doi request reprint Contribution of slowly inactivating potassium current to delayed firing of action potentials in NG108-15 neuronal cells: experimental and theoretical studies
    Sheng Nan Wu
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    J Theor Biol 252:711-21. 2008
  9. doi request reprint Analytical studies of rapidly inactivating and noninactivating sodium currents in differentiated NG108-15 neuronal cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan
    J Theor Biol 259:828-36. 2009
  10. doi request reprint Potent activation of large-conductance Ca2+-activated K+ channels by the diphenylurea 1,3-bis-[2-hydroxy-5-(trifluoromethyl)phenyl]urea (NS1643) in pituitary tumor (GH3) cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan
    Mol Pharmacol 74:1696-704. 2008

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Underlying mechanism of regulatory actions of diclofenac, a nonsteroidal anti-inflammatory agent, on neuronal potassium channels and firing: an experimental and theoretical study
    C W Huang
    Department of Neurology, National Cheng Kung University Hospital, School of Medicine, National Cheng Kung University, Tainan City, Taiwan
    J Physiol Pharmacol 64:269-80. 2013
    ..Caution needs to be made in attributing the effects of diclofenac primarily to those produced by the activation of I(KM)...
  2. doi request reprint Effects of ibandronate sodium, a nitrogen-containing bisphosphonate, on intermediate-conductance calcium-activated potassium channels in osteoclast precursor cells (RAW 264.7)
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, No 1 University Road, Tainan City, 70101, Taiwan
    J Membr Biol 248:103-15. 2015
    ..7 cells in a concentration-dependent manner. Therefore, the inhibition by Iban of IKCa channels would be an important mechanism underlying its actions on the functional activity of osteoclasts occurring in vivo...
  3. doi request reprint Investigations on contribution of glial inwardly-rectifying K(+) current to membrane potential and ion flux: an experimental and theoretical study
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City, Taiwan Electronic address
    Kaohsiung J Med Sci 31:9-17. 2015
    ..It is thus anticipated that glial IK(IR) may be a potential target utilized to influence the activity of neuronal and glial cells as well as their interaction. ..
  4. pmc Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k(+) currents in motor neuron-like cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan City 70101, Taiwan
    Evid Based Complement Alternat Med 2012:148403. 2012
    ..Flu-induced block of I(K(DR)) is unlinked to binding to NMDA or GABA receptors and the effects of this agent on K(+) channels are not limited to its action on M-type K(+) channels...
  5. doi request reprint Electrophysiological characterization of sodium-activated potassium channels in NG108-15 and NSC-34 motor neuron-like cells
    S N Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan
    Acta Physiol (Oxf) 206:120-34. 2012
    ..The electrical properties of Na(+) -activated K(+) current (I(K(Na)) ) and its contribution to spike firing has not been characterized in motor neurons...
  6. doi request reprint The inhibition by di(2-ethylhexyl)-phthalate of erg-mediated K⁺ current in pituitary tumor (GH₃) cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, No 1 University Road, Tainan City 70101, Taiwan
    Arch Toxicol 86:713-23. 2012
    ..The effects described herein can contribute to their actions on functional activity of endocrine or neuroendocrine cells if similar results are found in vivo...
  7. ncbi request reprint Simulations of the cardiac action potential based on the Hodgkin-Huxley kinetics with the use of Microsoft Excel spreadsheets
    Sheng Nan Wu
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan, ROC
    Chin J Physiol 47:15-22. 2004
    ..The method employed in these simulation protocols may also be extended or modified to other biological simulation programs...
  8. doi request reprint Contribution of slowly inactivating potassium current to delayed firing of action potentials in NG108-15 neuronal cells: experimental and theoretical studies
    Sheng Nan Wu
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    J Theor Biol 252:711-21. 2008
    ..The results also suggest that aconitine modulation of I(K)(dr) gating is an important molecular mechanism through which it can contribute to neuronal firing...
  9. doi request reprint Analytical studies of rapidly inactivating and noninactivating sodium currents in differentiated NG108-15 neuronal cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan 70101, Taiwan
    J Theor Biol 259:828-36. 2009
    ..The underlying mechanism of the inhibitory actions of ranolazine or riluzole on membrane potential in neurons or neuroendocrine cells in vivo may thus be associated with their blocking of I(Na)(()(NI)())...
  10. doi request reprint Potent activation of large-conductance Ca2+-activated K+ channels by the diphenylurea 1,3-bis-[2-hydroxy-5-(trifluoromethyl)phenyl]urea (NS1643) in pituitary tumor (GH3) cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan
    Mol Pharmacol 74:1696-704. 2008
    ..The alpha-subunit of the channel may be a target for the action of this small compound...
  11. doi request reprint The mechanism of the actions of oxaliplatin on ion currents and action potentials in differentiated NG108-15 neuronal cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, No 1, University Road, Tainan 70101, Taiwan
    Neurotoxicology 30:677-85. 2009
    ..The effects of OXAL on ion currents presented here may contribute to its neurotoxic actions in vivo...
  12. ncbi request reprint Underlying mechanism of actions of tefluthrin, a pyrethroid insecticide, on voltage-gated ion currents and on action currents in pituitary tumor (GH3) cells and GnRH-secreting (GT1-7) neurons
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan
    Toxicology 258:70-7. 2009
    ..Taken together, the effects of Tef and its structural related pyrethroids on ion currents can contribute to the underlying mechanisms through which they affect endocrine or neuroendocrine function in vivo...
  13. ncbi request reprint Cilostazol, an inhibitor of type 3 phosphodiesterase, stimulates large-conductance, calcium-activated potassium channels in pituitary GH3 cells and pheochromocytoma PC12 cells
    Sheng Nan Wu
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, 701 Tainan, Taiwan
    Endocrinology 145:1175-84. 2004
    ..The channel-stimulating properties of cilostazol may, at least in part, contribute to the underlying mechanisms by which it affects neuroendocrine function...
  14. doi request reprint Inhibitory effect of memantine, an NMDA-receptor antagonist, on electroporation-induced inward currents in pituitary GH3 cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan
    Biochem Biophys Res Commun 405:508-13. 2011
    ..The channel-suppressing properties of MEM might contribute to the underlying mechanisms by which it and its structurally related compounds affect neuronal or neuroendocrine function...
  15. doi request reprint Characterization of TRPM8-like channels activated by the cooling agent icilin in the macrophage cell line RAW 264.7
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, No 1, University Road, Tainan, 70101, Taiwan
    J Membr Biol 241:11-20. 2011
    ..Under current-clamp conditions, icilin caused membrane depolarization. Therefore, icilin interacts with the TRPM8-like channel to increase INS and depolarizes the membrane in these cells...
  16. ncbi request reprint Potent stimulation of large-conductance Ca2+-activated K+ channels by rottlerin, an inhibitor of protein kinase C-delta, in pituitary tumor (GH3) cells and in cortical neuronal (HCN-1A) cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan
    J Cell Physiol 210:655-66. 2007
    ..In human cortical HCN-1A cells, rottlerin (1 microM) could also interact with the BK(Ca) channel to stimulate I K(Ca). Therefore, rottlerin may directly activate BK(Ca) channels in neurons or endocrine cells...
  17. ncbi request reprint Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan
    Life Sci 80:378-87. 2007
    ..The present results suggest that these two types of K(ATP) channels may functionally be related to the activity of heart cells...
  18. ncbi request reprint Pharmacological roles of the large-conductance calcium-activated potassium channel
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan, Taiwan
    Curr Top Med Chem 6:1025-30. 2006
    ..Therefore, the regulation by these compounds of BK(Ca) channels may in part be responsible for their regulatory actions on cell functions...
  19. doi request reprint Cholesterol depletion with (2-hydroxypropyl)- β-cyclodextrin modifies the gating of membrane electroporation-induced inward current in pituitary tumor GH3 cells: experimental and analytical studies
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan
    Cell Physiol Biochem 28:959-68. 2011
    ..The channel-suppressing properties during membrane cholesterol depletion with HPβCD might thus contribute to the underlying mechanisms by which such maneuver alters neuronal or neuroendocrine function...
  20. doi request reprint Investigations into the correlation properties of membrane electroporation-induced inward currents: prediction of pore formation
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan
    Cell Biochem Biophys 62:211-20. 2012
    ..The scaling exponents derived from I(Pre) exhibit long-range correlations in these different types of cells, indicating there is a correlated character of the electropore dynamics that may be allowed to predict the MEP process...
  21. ncbi request reprint Contribution of non-inactivating Na+ current induced by oxidizing agents to the firing behavior of neuronal action potentials: experimental and theoretical studies from NG108-15 neuronal cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan
    Chin J Physiol 54:19-29. 2011
    ..Taken together, it is anticipated that the effects of oxidizing agents on I(Na(NI)) could be an important mechanism underlying their neurotoxic actions in neurons or neuroendocrine cells occurring in vivo...
  22. doi request reprint Evidence for aconitine-induced inhibition of delayed rectifier K(+) current in Jurkat T-lymphocytes
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan
    Toxicology 289:11-8. 2011
    ..Taken together, these effects can significantly contribute to its action on functional activity of immune cells if similar results are found in vivo...
  23. ncbi request reprint Diethyl pyrocarbonate, a histidine-modifying agent, directly stimulates activity of ATP-sensitive potassium channels in pituitary GH(3) cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, No 1, University Road, Tainan 70101, Taiwan
    Biochem Pharmacol 71:615-23. 2006
    ..The results indicate that chemical modification with DEPC enhances K(ATP)-channel activity and influences functional activities of pituitary GH(3) cells...
  24. doi request reprint The synergistic inhibitory actions of oxcarbazepine on voltage-gated sodium and potassium currents in differentiated NG108-15 neuronal cells and model neurons
    Chin Wei Huang
    Department of Neurology, National Cheng Kung University School of Medicine, Tainan, Taiwan
    Int J Neuropsychopharmacol 11:597-610. 2008
    ..Taken together, our results suggest that the synergistic blocking effects on INa and IK(DR) may contribute to the underlying mechanisms through which OXC affects neuronal function in vivo...
  25. ncbi request reprint Stimulatory actions of caffeic acid phenethyl ester, a known inhibitor of NF-kappaB activation, on Ca2+-activated K+ current in pituitary GH3 cells
    Ming Wei Lin
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan 701, Taiwan
    J Biol Chem 279:26885-92. 2004
    ..Caution has to be used in attributing its response in the activation of NF-kappaB...
  26. doi request reprint Diazoxide reduces status epilepticus neuron damage in diabetes
    Chin Wei Huang
    Institute of Clinical Medicine, National Cheng Kung University College of Medicine, Tainan, Taiwan
    Neurotox Res 17:305-16. 2010
    ..We conclude that, by opening K(ATP), diazoxide protects against status epilepticus-induced neuron damage during diabetic hyperglycemia...
  27. ncbi request reprint Effects of ranolazine, a novel anti-anginal drug, on ion currents and membrane potential in pituitary tumor GH(3) cells and NG108-15 neuronal cells
    Bing Shuo Chen
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Taiwan
    J Pharmacol Sci 110:295-305. 2009
    ....
  28. ncbi request reprint Block of L-type Ca2+ current by beauvericin, a toxic cyclopeptide, in the NG108-15 neuronal cell line
    Sheng Nan Wu
    Department of Medical Education and Research, Department of Anesthesiology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan
    Chem Res Toxicol 15:854-60. 2002
    ..Under current-clamp configuration, beauvericin reduced the firing frequency of action potentials. Therefore, this study indicates that beauvericin is a relatively specific inhibitor of L-type Ca2+ current in NG108-15 cells...
  29. ncbi request reprint The opening effect of pregabalin on ATP-sensitive potassium channels in differentiated hippocampal neuron-derived H19-7 cells
    Chin Wei Huang
    Department of Neurology, National Cheng Kung University Medical Center, Tainan, Taiwan
    Epilepsia 47:720-6. 2006
    ..We investigated whether the newer antiepileptic drug, pregabalin (PGB), could exert effects on KATP channels in differentiated hippocampal neuron-derived H19-7 cells...
  30. pmc Pregabalin attenuates excitotoxicity in diabetes
    Chin Wei Huang
    Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    PLoS ONE 8:e65154. 2013
    ..These findings might help develop a clinical algorithm for treating patients with epilepsy and comorbid metabolic disorders...
  31. doi request reprint Characterization of aconitine-induced block of delayed rectifier K+ current in differentiated NG108-15 neuronal cells
    Ming Wei Lin
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    Neuropharmacology 54:912-23. 2008
    ..Changes in action potentials induced by ACO in neurons in vivo can be explained mainly by its blocking actions on I K(DR) and I Na...
  32. ncbi request reprint Changes in membrane cholesterol of pituitary tumor (GH3) cells regulate the activity of large-conductance Ca2+-activated K+ channels
    Ming Wei Lin
    Institute of Basic Medical Sciences, Medical College, National Cheng Kung University, Tainan 70101, Taiwan, ROC
    Chin J Physiol 49:1-13. 2006
    ..Therefore, the increase in BK(Ca)-channel activity induced by membrane depletion may influence the functional activities of neurons or neuroendocrine cells if similar results occur in vivo...
  33. ncbi request reprint Glucose and hippocampal neuronal excitability: role of ATP-sensitive potassium channels
    Chin Wei Huang
    Department of Neurology, National Cheng Kung University Medical Center, Tainan, Taiwan
    J Neurosci Res 85:1468-77. 2007
    ..This phenomenon of K(ATP) channel attenuation could be one of the underlying mechanisms of glucose-related neuronal hyperexcitability and propagation...
  34. ncbi request reprint Inhibitory effect of lamotrigine on A-type potassium current in hippocampal neuron-derived H19-7 cells
    Chin Wei Huang
    Department of Neurology, Institute of Clinical Medicine, National Cheng Kung University Medical Center, Tainan, Taiwan
    Epilepsia 45:729-36. 2004
    ..We investigated the effects of lamotrigine (LTG) on the rapidly inactivating A-type K+ current (IA) in embryonal hippocampal neurons...
  35. ncbi request reprint Effect of arvanil (N-arachidonoyl-vanillyl-amine), a nonpungent anandamide-capsaicin hybrid, on ion currents in NG108-15 neuronal cells
    Yuk Keung Lo
    Section of Neurology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, ROC
    Biochem Pharmacol 65:581-91. 2003
    ..The channel-blocking properties of arvanil may, at least in part, contribute to the underlying mechanisms by which it affects neuronal or neuroendocrine function...
  36. ncbi request reprint Activation by zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells
    Chin Wei Huang
    Department of Neurology, National Cheng Kung University Medical College, 1 University Road, Tainan 70101, Taiwan
    J Pharmacol Exp Ther 321:98-106. 2007
    ..Taken together, this study suggests that, in hippocampal neurons during the exposure to ZNS, the ZNS-mediated effects on BK(Ca) channels and A-type K+ current could be potential mechanisms through which it affects neuronal excitability...
  37. ncbi request reprint Stimulatory actions of di-8-butyl-amino-naphthyl-ethylene-pyridinium-propyl-sulfonate (di-8-ANEPPS), voltage-sensitive dye, on the BKCa channel in pituitary tumor (GH3) cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Medical College, No 1, University Road, Tainan 70101 Taiwan, Republic of China
    Pflugers Arch 455:687-99. 2008
    ..Taken together, this study suggests that during the exposure to di-8-ANEPPS, the stimulatory effects on BK(Ca) channels could be one of potential mechanisms through which it may affect cell excitability...
  38. ncbi request reprint Tramadol-induced blockade of delayed rectifier potassium current in NG108-15 neuronal cells
    Tung Ying Tsai
    Department of Anesthesiology, National Cheng Kung University Medical College, No 1 Ta Hsueh Road, Tainan, Tainan City 704, Taiwan, ROC
    Eur J Pain 10:597-601. 2006
    ..Tramadol-induced block of I(K(DR)) observed in this study could be partly responsible for its anti-depressant action...
  39. ncbi request reprint BAY 41-2272, a potent activator of soluble guanylyl cyclase, stimulates calcium elevation and calcium-activated potassium current in pituitary GH cells
    Yen Chin Liu
    Department of Anaesthesiology, National Cheng Kung University Medical College, Tainan, Taiwan
    Clin Exp Pharmacol Physiol 32:1078-87. 2005
    ..The BAY 41-2272-mediated simulation of IK(Ca) may result from direct activation of BKCa channels and indirectly as a result of elevated [Ca2+]i...
  40. ncbi request reprint Riluzole-induced block of voltage-gated Na+ current and activation of BKCa channels in cultured differentiated human skeletal muscle cells
    Ya Jean Wang
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    Life Sci 82:11-20. 2008
    ..Taken together, inhibition of I(Na) and stimulation of BK(Ca)-channel activity caused by this drug are partly, if not entirely, responsible for its muscle relaxant actions in clinical setting...
  41. ncbi request reprint Contribution of BK(Ca)-channel activity in human cardiac fibroblasts to electrical coupling of cardiomyocytes-fibroblasts
    Ya Jean Wang
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, No 1, University Road, Tainan, 701, Taiwan
    J Membr Biol 213:175-85. 2006
    ..The activity of these BK(Ca) channels present in human cardiac fibroblasts may contribute to the functional activities of heart cells through transfer of electrical signals between these two cell types...
  42. ncbi request reprint Cocaine-induced inhibition of ATP-sensitive K+ channels in rat ventricular myocytes and in heart-derived H9c2 cells
    Sheng Nan Wu
    Department of Physiology, National Cheng Kung University Hospital, Tainan, Taiwan
    Basic Clin Pharmacol Toxicol 98:510-7. 2006
    ..The present study provides evidence that cocaine can produce a depressant action on KATP channels in cardiac myocytes, and thus disturb ischaemic preconditioning in clinical settings...
  43. ncbi request reprint Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BK(Ca) channel activity in cultured endothelial cells of human coronary artery
    Yen Chin Liu
    Department of Anesthesiology, Kaohsiung Veterans General Hospital, City, ROC, Kaohsiung, Taiwan
    Biochem Pharmacol 66:2053-63. 2003
    ..The inhibitory effects on these channels may partly contribute to the underlying mechanisms by which ICI-182,780 affects endothelial function...
  44. doi request reprint Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability
    Chin Wei Huang
    Department of Neurology, National Cheng Kung University Hospital, Tainan, Taiwan
    Psychopharmacology (Berl) 221:575-87. 2012
    ..However, its effects on the ionic mechanisms remains incompletely understood...
  45. doi request reprint Time-dependent block of ultrarapid-delayed rectifier K+ currents by aconitine, a potent cardiotoxin, in heart-derived H9c2 myoblasts and in neonatal rat ventricular myocytes
    Ya Jean Wang
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    Toxicol Sci 106:454-63. 2008
    ..This study provides the evidence that ACO can produce a depressant action on I(Kur) in cardiac myocytes...
  46. ncbi request reprint Electrophysiological mechanisms of ventricular arrhythmias in relation to Andersen-Tawil syndrome under conditions of reduced IK1: a simulation study
    Ruey J Sung
    Dept of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan 704
    Am J Physiol Heart Circ Physiol 291:H2597-605. 2006
    ..In patients with ATS, the hypokalemic form of periodic paralysis should have the highest propensity to VAs, especially during physical activity...
  47. ncbi request reprint Inhibitory action of L-type Ca2+ current by paeoniflorin, a major constituent of peony root, in NG108-15 neuronal cells
    Tung Ying Tsai
    Department of Anesthesiology, National Cheng Kung University Medical College, No 1, Tainan 70701, Taiwan
    Eur J Pharmacol 523:16-24. 2005
    ..The effects of paeoniflorin on ion currents may partly, if not entirely, contribute to the underlying mechanisms through which it affects neuronal or neuroendocrine function...
  48. ncbi request reprint Block of erg current by linoleoylamide, a sleep-inducing agent, in pituitary GH3 cells
    Yen Chin Liu
    Department of Anesthesiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC
    Eur J Pharmacol 458:37-47. 2003
    ..In IMR-32 neuroblastoma cells, linoleoylamide also suppressed I(K(IR)). This study provides the evidence that linoleoylamide has a depressant effect on the erg current, and suggests that this effect may affect hormonal secretion...
  49. ncbi request reprint Glucocorticoids stimulate the activity of large-conductance Ca2+ -activated K+ channels in pituitary GH3 and AtT-20 cells via a non-genomic mechanism
    Mei Han Huang
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, No 1, University Road, Tainan, Taiwan
    Steroids 71:129-40. 2006
    ..The non-genomic, channel-stimulating properties of dexamethasone may partly contribute to the underlying mechanisms by which glucocorticoids affect neuroendocrine function...
  50. ncbi request reprint Inhibition of Ca2+-activated and voltage-dependent K+ currents by 2-mercaptophenyl-1,4-naphthoquinone in pituitary GH3 cells: contribution to its antiproliferative effect
    Mei Han Huang
    Department of Pharmaceutical Science, Foo Yin Institute of Technology, Ta Liao, Kaohsiung County, Taiwan, ROC
    Life Sci 70:1185-203. 2002
    ..The 2-MPNQ-mediated inhibition of K+ currents would affect hormone secretion and cell excitability. The blockade of these ionic channels by 2-MPNQ may partly explain its inhibitory effect on the proliferation of GH3 cells...
  51. doi request reprint Functional role of the activity of ATP-sensitive potassium channels in electrical behavior of hippocampal neurons: experimental and theoretical studies
    Bing Shuo Chen
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City, Taiwan
    J Theor Biol 272:16-25. 2011
    ..Taken together, it is anticipated that the increased activity of K(ATP) channels caused by increasing N(O) or τ(bas) contributes to or is responsible for burst firing of APs in hippocampal neurons if similar results occur in vivo...
  52. ncbi request reprint Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells
    Yen Chin Liu
    Department of Anesthesiology, Kaohsiung Veterans General Hospital, City, Kaohsiung, Taiwan
    Brain Res 959:86-97. 2003
    ..The stimulatory effects of chlorzoxazone on these channels may be responsible for the underlying mechanism of chlorzoxazone actions on neurons and neuroendocrine cells...
  53. ncbi request reprint The mechanism of inhibitory actions of S-petasin, a sesquiterpene of Petasites formosanus, on L-type calcium current in NG108-15 neuronal cells
    Sheng Nan Wu
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, ROC
    Planta Med 69:118-24. 2003
    ..These results demonstrate that S-petasin can interact directly with L-type Ca2+ channels in NG108-15 cells. These effects could contribute to the regulation of neuronal activity if similar results were found in neurons in vivo...
  54. doi request reprint The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells
    Yen Ching Liu
    Department of Anesthesiology, National Cheng Kung University Medical College, Tainan, Taiwan
    Eur J Pharmacol 590:93-8. 2008
    ..Propofol can suppress I(K(DR)) in differentiated H9c2 cardiac cells in a concentration- and state-dependent manner. These effects can significantly contribute its action on functional activity of heart cells...
  55. ncbi request reprint Stimulatory actions of thymol, a natural product, on Ca(2+)-activated K(+) current in pituitary GH(3) cells
    Mei Han Huang
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    Planta Med 71:1093-8. 2005
    ..The stimulatory actions of thymol on Ca(2+)-activated K(+) currents may be associated with the underlying cellular mechanisms through which it affects neuronal or neuroendocrine functions...
  56. ncbi request reprint Sodium cyanate-induced opening of calcium-activated potassium currents in hippocampal neuron-derived H19-7 cells
    Chin Wei Huang
    Department of Neurology, National Cheng Kung University Medical Center, No 1, University Road, Tainan, Taiwan
    Neurosci Lett 377:110-4. 2005
    ..These findings suggest that during NaOCN exposure, the activation of BK(Ca) channels in neurons could be one of the ionic mechanisms underlying the decreased neuronal excitability and neurological disorders...
  57. doi request reprint Tramadol-induced block of hyperpolarization-activated cation current in rat pituitary lactotrophs
    Yen Chin Liu
    Department of Anesthesiology, National Cheng Kung University Medical College, Tainan, Taiwan
    Naunyn Schmiedebergs Arch Pharmacol 379:127-35. 2009
    ....
  58. ncbi request reprint Behavior of nonselective cation channels and large-conductance Ca2+-activated K+ channels induced by dynamic changes in membrane stretch in cultured smooth muscle cells of human coronary artery
    Sheng Nan Wu
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, ROC
    J Cardiovasc Electrophysiol 14:44-51. 2003
    ..The effects of membrane stretch on ion channels were investigated in cultured smooth muscle cells of human coronary artery...
  59. ncbi request reprint Diosgenin, a plant-derived sapogenin, stimulates Ca2+-activated K+ current in human cortical HCN-1A neuronal cells
    Ya Jean Wang
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan, Republic of China
    Planta Med 72:430-6. 2006
    ....
  60. ncbi request reprint The activation by estrogen receptor agonists of the BK(Ca)-channel in human cardiac fibroblasts
    Ya Jean Wang
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan, Taiwan
    Biochem Pharmacol 73:1347-57. 2007
    ..PPT- and DPN-stimulated increase in BK(Ca) channels reveal novel pharmacological properties attributable to the activity of these channels, and their increase in BK(Ca) channels activity in HCFs may contribute to cell function...
  61. pmc The effects of magnetite (Fe₃O₄) nanoparticles on electroporation-induced inward currents in pituitary tumor (GH₃) cells and in RAW 264.7 macrophages
    Yen Chin Liu
    Department of Anesthesiology, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan
    Int J Nanomedicine 7:1687-96. 2012
    ..However, the possible effects of these NPs on membrane ion currents that concurrently induce local magnetic field perturbation remain unclear...
  62. doi request reprint Diabetic hyperglycemia is associated with the severity of epileptic seizures in adults
    Chin Wei Huang
    Department of Neurology, National Cheng Kung University Hospital, Tainan, Taiwan
    Epilepsy Res 79:71-7. 2008
    ..DH should be investigated in adult patients with newly diagnosed epileptic seizures and aggressive blood sugar control might benefit seizure management in patients with DH...
  63. doi request reprint Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells
    Ya Yun Hsu
    Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, ROC
    Eur J Pharm Sci 46:415-25. 2012
    ..These results suggest that BBR, which is active at nanomolar concentration, is a potential neuroprotective agent via PI3K/Akt-dependent cytoprotective and antioxidant pathways...
  64. doi request reprint The inhibition of inwardly rectifying K+ channels by memantine in macrophages and microglial cells
    Ke Li Tsai
    Department of Physiology, School of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan
    Cell Physiol Biochem 31:938-51. 2013
    ..In this study, we investigated the effects of MEM and other related compounds on inwardly rectifying K(+) current (IK(IR)) in RAW 264.7 macrophages and in BV2 microglial cells...
  65. doi request reprint The actions of mdivi-1, an inhibitor of mitochondrial fission, on rapidly activating delayed-rectifier K⁺ current and membrane potential in HL-1 murine atrial cardiomyocytes
    Edmund Cheung So
    Department of Anesthesia, Chi Mei Medical Center, Tainan City, Taiwan
    Eur J Pharmacol 683:1-9. 2012
    ..The observed effects of mdivi-1 on ion currents were direct and not associated with its inhibition of mitochondrial division...
  66. doi request reprint Evidence for activation of BK Ca channels by a known inhibitor of focal adhesion kinase, PF573228
    Edmund Cheung So
    Department of Anaesthesiology, Chi Mei Medical Center, Tainan City, Taiwan
    Life Sci 89:691-701. 2011
    ..PF573228 is an inhibitor of focal adhesion kinase (FAK) and recognized to affect cell adhesion and migration in many types of cells. Its effects on ion currents and membrane potential have been investigated in this study...
  67. doi request reprint Diabetic hyperglycemia aggravates seizures and status epilepticus-induced hippocampal damage
    Chin Wei Huang
    Institute of Clinical Medicine, National Cheng Kung University Medical College, Tainan City, Taiwan
    Neurotox Res 15:71-81. 2009
    ..This finding that rats with DH had more brain damage after SE than rats without diabetes suggests the importance of intensively treating hyperglycemia and seizures in diabetic patients with epilepsy...
  68. doi request reprint Beta-adrenergic modulation of arrhythmogenesis and identification of targeted sites of antiarrhythmic therapy in Timothy (LQT8) syndrome: a theoretical study
    Ruey J Sung
    Institute of Life Sciences, National Central University, Taoyuan, Taiwan
    Am J Physiol Heart Circ Physiol 298:H33-44. 2010
    ....
  69. ncbi request reprint An outbreak of food-borne illness due to methomyl contamination
    Ming Jun Tsai
    Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City, Taiwan, ROC
    J Toxicol Clin Toxicol 41:969-73. 2003
    ..Sixty-nine people were sent to the emergency departments of the Municipal Chiching Hospital and Yuan's General Hospital...
  70. ncbi request reprint Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells
    Sheng Nan Wu
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, 813, ROC, Kaohsiung City, Taiwan
    Biochem Pharmacol 63:199-206. 2002
    ..Therefore, the channel-blocking properties of osthole may, at least in part, contribute to the underlying mechanisms by which it affects neuronal or neuroendocrine function...
  71. ncbi request reprint Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines
    Ping Chia Li
    Department of Biological Science, National Sun Yat Sen University, Kaohsiung, Taiwan, Republic of China
    J Cell Physiol 192:188-99. 2002
    ..The stimulatory effects on these channels may, at least in part, contribute to the underlying cellular mechanisms by which LY-171883 affects neuronal or neuroendocrine function...
  72. ncbi request reprint Differential effects of quercetin, a natural polyphenolic flavonoid, on L-type calcium current in pituitary tumor (GH3) cells and neuronal NG108-15 cells
    Sheng Nan Wu
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan
    J Cell Physiol 195:298-308. 2003
    ..Therefore, the effects of quercetin on ion currents may, at least in part, contribute to the underlying mechanisms through which it affects neuronal or neuroendocrine function...
  73. ncbi request reprint The influence of hypotonicity on large-conductance calcium-activated potassium channels in human retinal pigment epithelial cells
    Shwu Jiuan Sheu
    Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
    J Ocul Pharmacol Ther 20:563-75. 2004
    ..These findings support the evidence for the coupling of volume swelling to the functional activity of BK(Ca) channels...
  74. ncbi request reprint Stimulatory effects of squamocin, an Annonaceous acetogenin, on Ca(2+)-activated K+ current in cultured smooth muscle cells of human coronary artery
    Sheng Nan Wu
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Institute of Biomedical Sciences, National Sun Yat Sen University, Kaohsiung City, Taiwan
    Chem Res Toxicol 16:15-22. 2003
    ..The stimulatory effect of squamocin on these channels should affect the functional activity of vascular smooth muscle cells...
  75. ncbi request reprint Mechanism of inhibitory actions of oxidizing agents on calcium-activated potassium current in cultured pigment epithelial cells of the human retina
    Shwu Jiuan Sheu
    Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan
    Invest Ophthalmol Vis Sci 44:1237-44. 2003
    ..To identify the mechanisms by which oxidative stress with oxidizing agents alters the activity of ion channels in human retinal pigment epithelial (RPE) cells...
  76. ncbi request reprint Characterization of chromanol 293B-induced block of the delayed-rectifier K+ current in heart-derived H9c2 cells
    Yi Ching Lo
    Department and Graduate Institute of Pharmacology, Kaohsiung Medical University, Kaohsiung, Taiwan
    Life Sci 76:2275-86. 2005
    ..The chromanol 293B-induced inhibition of these channels could primarily be attributed to open channel block...
  77. doi request reprint Bronchodilatory effects of S-isopetasin, an antimuscarinic sesquiterpene of Petasites formosanus, on obstructive airway hyperresponsiveness
    Ling Hung Lin
    Department of Dentistry, Taipei Medical University Hospital, Taipei 110, Taiwan
    Eur J Pharmacol 584:398-404. 2008
    ..In conclusion, S-isopetasin may be beneficial as a bronchodilator in the treatment of chronic obstructive pulmonary disease and asthma exacerbations...
  78. ncbi request reprint Stretch-stimulated activity of large conductance calcium-activated potassium channels in human retinal pigment epithelial cells
    Shwu Jiuan Sheu
    Department of Ophthalmology, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, Republic of China
    J Ocul Pharmacol Ther 21:429-35. 2005
    ..The aim of this study was to investigate the effect of membrane stretch on the activity of BK(Ca) channels and determine whether change in BK(Ca)-channel activity induced by membrane stretch can be altered in the presence of riluzole...
  79. ncbi request reprint Large-conductance Ca2+- activated K+ channels:physiological role and pharmacology
    Sheng Nan Wu
    Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan
    Curr Med Chem 10:649-61. 2003
    ..Therefore, the modulation of BK(Ca) channel activity in excitable and non-excitable cells can be important for therapeutic interventions...
  80. ncbi request reprint Inhibition of intermediate-conductance Ca2+-activated K+ channel and cytoprotective properties of 4-piperidinomethyl-2-isopropyl-5-methylphenol
    Ai Yu Shen
    Basic Medical Science Education Center, Fooyin University, Ta Liao Hsiang, Kaohsiung Hsien, Taiwan
    J Pharm Pharmacol 59:679-85. 2007
    ....