Khanitha Pudhom

Summary

Affiliation: Chulalongkorn University
Country: Thailand

Publications

  1. ncbi request reprint Cassane furanoditerpenoids from the seed kernels of Caesalpinia bonduc from Thailand
    Khanitha Pudhom
    Research Centre of Bioorganic Chemistry, Department of Chemistry, Chulalongkorn University, Bangkok, Thailand
    J Nat Prod 70:1542-4. 2007
  2. ncbi request reprint Cytotoxic and anti-angiogenic properties of minor 3,4-seco-cycloartanes from Gardenia sootepensis exudate
    Khanitha Pudhom
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Chem Pharm Bull (Tokyo) 60:1538-43. 2012
  3. pmc Spirobisnaphthalenes from the mangrove-derived fungus Rhytidhysteron sp. AS21B
    Khanitha Pudhom
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Mar Drugs 12:1271-80. 2014
  4. doi request reprint Antiangiogenic activity of 3,4-seco-cycloartane triterpenes from Thai Gardenia spp. and their semi-synthetic analogs
    Khanitha Pudhom
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Bioorg Med Chem Lett 22:512-7. 2012
  5. doi request reprint Moluccensins H-J, 30-ketophragmalin limonoids from Xylocarpus moluccensis
    Khanitha Pudhom
    Research Centre for Bioorganic Chemistry, Department of Chemistry, Chulalongkorn University, Bangkok, 10330, Thailand
    J Nat Prod 73:263-6. 2010
  6. ncbi request reprint Furanocembranoids from the stem bark of Croton oblongifolius
    Khanitha Pudhom
    Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Prod 70:659-61. 2007
  7. doi request reprint Protoxylocarpins F-H, protolimonoids from seed kernels of Xylocarpus granatum
    Khanitha Pudhom
    Research Centre of Bioorganic Chemistry, Department of Chemistry, Chulalongkorn University, Bangkok, 10330, Thailand
    J Nat Prod 72:2188-91. 2009
  8. doi request reprint Cytotoxic 3,4-seco-cycloartane triterpenes from Gardenia sootepensis
    Thanesuan Nuanyai
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
    J Nat Prod 72:1161-4. 2009
  9. doi request reprint Antiangiogenic effect of chamigrane endoperoxides from a Thai mangrove-derived fungus
    Supichar Chokpaiboon
    Program in Biotechnology, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Prod 74:2290-4. 2011
  10. doi request reprint Limonoids from seeds of Thai Xylocarpus moluccensis
    Warin Ravangpai
    Research Centre of Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
    Bioorg Med Chem Lett 21:4485-9. 2011

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Cassane furanoditerpenoids from the seed kernels of Caesalpinia bonduc from Thailand
    Khanitha Pudhom
    Research Centre of Bioorganic Chemistry, Department of Chemistry, Chulalongkorn University, Bangkok, Thailand
    J Nat Prod 70:1542-4. 2007
    ..Compounds 1- 3 exhibited good antimalarial activity against the multidrug-resistant K1 strain of Plasmodium falciparum, while compound 4 was inactive. None of the compounds were cytotoxic against any of the tumor cell lines tested...
  2. ncbi request reprint Cytotoxic and anti-angiogenic properties of minor 3,4-seco-cycloartanes from Gardenia sootepensis exudate
    Khanitha Pudhom
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Chem Pharm Bull (Tokyo) 60:1538-43. 2012
    ..Furthermore, its angiogenic effect was found to occur mainly by suppressing endothelial cell proliferation and tubule formation, suggesting the potential of 1 as a lead compound for cancer treatment...
  3. pmc Spirobisnaphthalenes from the mangrove-derived fungus Rhytidhysteron sp. AS21B
    Khanitha Pudhom
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Mar Drugs 12:1271-80. 2014
    ..Compounds 3-5 displayed cytotoxicity against both cancer cell lines, MCF-7 and CaSki, while 2 was active only on CaSKi cells. ..
  4. doi request reprint Antiangiogenic activity of 3,4-seco-cycloartane triterpenes from Thai Gardenia spp. and their semi-synthetic analogs
    Khanitha Pudhom
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Bioorg Med Chem Lett 22:512-7. 2012
    ..46 μM. Its angiogenic effect was found to occur via suppression of endothelial cell proliferation and tubular formation, and was likely mediated by regulation (inhibition) of the Erk1/2 signaling pathway...
  5. doi request reprint Moluccensins H-J, 30-ketophragmalin limonoids from Xylocarpus moluccensis
    Khanitha Pudhom
    Research Centre for Bioorganic Chemistry, Department of Chemistry, Chulalongkorn University, Bangkok, 10330, Thailand
    J Nat Prod 73:263-6. 2010
    ..Their structures were established by extensive spectroscopic analysis. Compound 2 displayed weak antibacterial activity against Staphylococcus hominis and Enterococcus faecalis...
  6. ncbi request reprint Furanocembranoids from the stem bark of Croton oblongifolius
    Khanitha Pudhom
    Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Prod 70:659-61. 2007
    ..Their structures were elucidated on the basis of spectroscopic analysis, mainly NMR and MS. Compounds 1, 3, and 4 exhibited good cytotoxicity against several human tumor cell lines...
  7. doi request reprint Protoxylocarpins F-H, protolimonoids from seed kernels of Xylocarpus granatum
    Khanitha Pudhom
    Research Centre of Bioorganic Chemistry, Department of Chemistry, Chulalongkorn University, Bangkok, 10330, Thailand
    J Nat Prod 72:2188-91. 2009
    ..Their structures were elucidated on the basis of extensive spectroscopic data analyses. All compounds isolated were evaluated for cytotoxic activity against five human tumor cell lines...
  8. doi request reprint Cytotoxic 3,4-seco-cycloartane triterpenes from Gardenia sootepensis
    Thanesuan Nuanyai
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
    J Nat Prod 72:1161-4. 2009
    ..Generally, the compounds possessing an exomethylene gamma-lactone ring showed broad cytotoxicity for all cell lines tested...
  9. doi request reprint Antiangiogenic effect of chamigrane endoperoxides from a Thai mangrove-derived fungus
    Supichar Chokpaiboon
    Program in Biotechnology, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Prod 74:2290-4. 2011
    ..Merulin C also displayed promising activity in a rat aortic ring sprouting (ex vivo) and a mouse Matrigel (in vivo) assay...
  10. doi request reprint Limonoids from seeds of Thai Xylocarpus moluccensis
    Warin Ravangpai
    Research Centre of Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
    Bioorg Med Chem Lett 21:4485-9. 2011
    ....
  11. doi request reprint Xylorumphiins A-D, mexicanolide limonoids from the seed kernels of Xylocarpus rumphii
    Chanin Sarigaputi
    Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Prod 73:1456-9. 2010
    ..Their structures and configurations were established on the basis of spectroscopic data...
  12. doi request reprint Cytotoxic 3,4-seco-cycloartane triterpenes from the exudate of Gardenia tubifera
    Thanesuan Nuanyai
    Research Centre of Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Prod 73:51-4. 2010
    ..The structures of 1-4 were elucidated on the basis of spectroscopic analysis. The cytotoxic activity of compounds 1-4 was evaluated against five human tumor cell lines...
  13. doi request reprint Cytotoxic nor-chamigrane and chamigrane endoperoxides from a basidiomycetous fungus
    Supichar Chokpaiboon
    Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand
    J Nat Prod 73:1005-7. 2010
    ..X-ray crystallographic analysis confirmed the structure of 1. Compounds 1 and 3 displayed significant cytotoxicity against human breast (BT474) and colon (SW620) cancer cell lines...
  14. ncbi request reprint Gardenoins E-H, cycloartane triterpenes from the apical buds of Gardenia obtusifolia
    Thanesuan Nuanyai
    Research Centre of Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
    Chem Pharm Bull (Tokyo) 59:385-7. 2011
    ..Only compound 1 displayed cytotoxicity against colon, hepatic and lung cancer cell lines...
  15. doi request reprint Rearranged limonoids and chromones from Harrisonia perforata and their anti-inflammatory activity
    Siwattra Choodej
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Bioorg Med Chem Lett 23:3896-900. 2013
    ..51 μM. Furthermore, its effect is mediated by reduction of iNOS protein expression, attributable to the inhibitory action of LPS-induced NO production...
  16. ncbi request reprint Cytotoxic constituents from Butea superba Roxb
    Nattaya Ngamrojanavanich
    Research Centre for Bioorganic Chemistry, Faculty of Science, Chulalongkorn University, Pyathai Road, Pathumwan, Bangkok, Thailand
    J Ethnopharmacol 109:354-8. 2007
    ..Compounds 2 and 4 showed moderate cytotoxic activity on KB cell lines with IC(50) (microM) values of 37.3+/-2.5 and 71.1+/-0.8 and on BC cell lines with IC(50) (microM) values of 32.7+/-1.5 and 47.3+/-0.3, respectively...
  17. doi request reprint Highly oxygenated chromones from mangrove-derived endophytic fungus Rhytidhysteron rufulum
    Supichar Chokpaiboon
    Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Phytochemistry 122:172-7. 2016
    ..0 to 23.3μM, while rhytidchromones A and C were active against MCF-7 cells with IC50 values of 19.3 and 17.7μM, respectively. ..
  18. doi request reprint Antiangiogenetic effects of anthranoids from Alternaria sp., an endophytic fungus in a Thai medicinal plant Erythrina variegata
    Phunlap Pompeng
    Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Phytomedicine 20:918-22. 2013
    ..Using human umbilical vein endothelial cells as an in vitro model, the angiogenic effect of 2 was found to occur via suppression of all three main functions of endothelial cells, namely proliferation, tube formation and migration. ..
  19. doi request reprint Weakly anti-inflammatory limonoids from the seeds of Xylocarpus rumphii
    Chanin Sarigaputi
    Program in Biotechnology and Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Prod 77:2037-43. 2014
    ..2-Hydroxyxylorumphiin F (3) and xylorumphiin I (6) displayed moderate inhibitory activity against nitric oxide production from lipopolysaccharide-activated macrophages with IC50 values of 24.5 and 31.3 μM, respectively. ..
  20. doi request reprint Suppression of inducible nitric oxide synthase pathway by 7-deacetylgedunin, a limonoid from Xylocarpus sp
    Chanin Sarigaputi
    Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand
    Planta Med 81:312-9. 2015
    ....
  21. ncbi request reprint Butenolide and furandione from an endophytic Aspergillus terreus
    Paulwatt Nuclear
    Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    Chem Pharm Bull (Tokyo) 58:1221-3. 2010
    ..The structures of these compounds were elucidated by analysis of NMR spectroscopic and mass spectrometric data...
  22. doi request reprint Rhytidenones A-F, Spirobisnaphthalenes from Rhytidhysteron sp. AS21B, an Endophytic Fungus
    Khanitha Pudhom
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330 Thailand
    J Nat Prod 77:1962-6. 2014
    ..Compounds 3 and 4 exhibited significant inhibitory activity against nitric oxide production from activated macrophages with IC50 values of 0.31 and 3.60 μM, respectively. ..
  23. doi request reprint Inhibitory effects of flavonoids from stem bark of Derris indica on the formation of advanced glycation end products
    Pornpat Anusiri
    Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
    J Ethnopharmacol 158:437-41. 2014
    ..The present study was designed to isolate the active compounds from its stem bark and evaluate their inhibitory activity on the formation of advanced glycation end products...
  24. doi request reprint The plant limonoid 7-oxo-deacetoxygedunin inhibits RANKL-induced osteoclastogenesis by suppressing activation of the NF-κB and MAPK pathways
    Chonnaree Wisutsitthiwong
    Graduate Program in Industrial Microbiology, Department of Microbiology, Faculty of Science, Chulalongkorn University, Phayathai Road, Bangkok 10330, Thailand
    Biochem Biophys Res Commun 415:361-6. 2011
    ..Taken together, we present evidence indicating a plant limonoid as a novel osteoclastogenic inhibitor that could be used for osteoporosis and related conditions...
  25. doi request reprint 11-Hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum
    Ruengrit Sappapan
    Program in Biotechnology, Chulalongkorn University, Bangkok 10330 Thailand
    J Nat Prod 71:1657-9. 2008
    ..68 and 7.70 microM, respectively. None of the compounds were cytotoxic against any of the tumor cell lines tested...
  26. ncbi request reprint Synthesis of three classes of rhodacyanine dyes and evaluation of their in vitro and in vivo antimalarial activity
    Khanitha Pudhom
    Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980 8578, Japan
    Bioorg Med Chem 14:8550-63. 2006
    ..The novel [0,0,0]-rhodacynines, 3e and 3h, possessing a benzothiazole moiety, were shown to have highly promising antimalarial activities in vivo. Moreover, the [0,0,0]-rhodacyanines were found to be orally bioavailable...
  27. ncbi request reprint Synthesis and antimalarial efficacy of aza-fused rhodacyanines in vitro and in the P. berghei mouse model
    Kiyosei Takasu
    Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Sendai 980 8578, Japan
    J Med Chem 49:4795-8. 2006
    ..Among them, 3c appeared to be the most effective at a dose of 20-25 mg kg(-1) day(-1) (ip)...