Vichai Reutrakul

Summary

Affiliation: Mahidol University
Country: Thailand

Publications

  1. ncbi request reprint Anti HIV-1 flavonoid glycosides from Ochna integerrima
    Vichai Reutrakul
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Planta Med 73:683-8. 2007
  2. ncbi request reprint Difluorophenylsulfanylmethyl radical and difluoromethylene diradical synthons: gem-difluoromethylene building block
    Vichai Reutrakul
    Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    J Org Chem 69:6913-5. 2004
  3. pmc Sesamin stimulates osteoblast differentiation through p38 and ERK1/2 MAPK signaling pathways
    Orawan Wanachewin
    Thailand Excellence Center for Tissue Engineering and Stem Cells, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand
    BMC Complement Altern Med 12:71. 2012
  4. ncbi request reprint Cytotoxic coumarins from Mammea harmandii
    Vichai Reutrakul
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Planta Med 69:1048-51. 2003
  5. ncbi request reprint Anti-HIV-1 constituents from leaves and twigs of Cratoxylum arborescens
    Vichai Reutrakul
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Planta Med 72:1433-5. 2006
  6. doi request reprint Dichapetalin-type triterpenoids and lignans from the aerial parts of Phyllanthus acutissima
    Patoomratana Tuchinda
    Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Nat Prod 71:655-63. 2008
  7. ncbi request reprint Cytotoxic and anti-HIV-1 caged xanthones from the resin and fruits of Garcinia hanburyi
    Vichai Reutrakul
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Planta Med 73:33-40. 2007
  8. doi request reprint Cytotoxic, antitopoisomerase IIα, and anti-HIV-1 activities of triterpenoids isolated from leaves and twigs of Gardenia carinata
    Naowarat Kongkum
    Department of Chemistry and Center of Excellence for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Nat Prod 76:530-7. 2013
  9. doi request reprint DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata
    Naowarat Kongkum
    Department of Chemistry and Center for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Bangkok, Thailand
    Fitoterapia 83:368-72. 2012
  10. ncbi request reprint Anti-HIV-1 cycloartanes from leaves and twigs of Gardenia thailandica
    Patoomratana Tuchinda
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Planta Med 70:366-70. 2004

Collaborators

  • P Tuchinda
  • Manat Pohmakotr
  • Palangpon Kongsaeree
  • Pawinee Piyachaturawat
  • Narathip Pradidphol
  • Ampai Panthong
  • Naruwan Saowakon
  • Payong Wanikiat
  • Vatcharin Rukachaisirikul
  • Sukathida Ubol
  • A G Rossi
  • ALAN DOUGLAS KINGHORN
  • Barry M Trost
  • Pranee Inprakhon
  • Geoffrey A Cordell
  • Chutima Kuhakarn
  • Darunee Soorukram
  • Kanoknetr Suksen
  • Watcharaporn Thaharn
  • Samran Prabpai
  • Natthinee Anantachoke
  • Praewpan Katrun
  • Chonticha Masusai
  • Surawat Jariyawat
  • Teerachai Punirun
  • Chanita Napaswad
  • Jitra Kasisit
  • Jatuporn Meesin
  • Sakchai Hongthong
  • Thaworn Jaipetch
  • Naowarat Kongkum
  • Chalobon Yoosook
  • Chaveng Pakawatchai
  • Saowanit Saithong
  • Narong Nuntasaen
  • Teerawut Bootwicha
  • Nittaya Boonmuen
  • Pongkorn Chaiyakunvat
  • Supasorn Phae-Nok
  • Korkit Korvorapun
  • Watchara Srimontree
  • Sariya Yodwaree
  • Vannapha Pharikronburee
  • Nolan M Betterley
  • Somkieath Jenjob
  • Saksit Nobsathian
  • Orawan Wanachewin
  • Waraporn Chanakul
  • Soontorn Chooprayoon
  • Arthittaya Chareonkla
  • Chariya Hahnvajanawong
  • Siriporn Saepou
  • Wanlaya Uthaisang
  • Natthakan Thongon
  • Chayaporn Pareseecharoen
  • Arthit Chairoungdua
  • Chutima Jiarpinitnun
  • Wilart Pompimon
  • Phanruethai Pailee
  • Jitra Limthongkul
  • Sornsiri Hlekhlai
  • Charoensak Mueangkaew
  • Sergio R Peraza-Sánchez
  • Panida Surawatanawong
  • Radeekorn Akkarawongsapat
  • Panya Sunintaboon
  • Peraphan Pothacharoen
  • Kanchanit Boonmaleerat
  • Krisana Peewasan
  • Prachya Kongtawelert
  • Tharworn Jaipetch
  • Tapanawan Nasomyon
  • Banchob Sripa
  • Nisana Namwat
  • Wichittra Tassaneeyakul
  • Watcharin Loilome
  • Wises Namwat
  • Wongwarut Boonyanugomol
  • Duanghathai Panichakul
  • Bengt Fadeel
  • Prapon Wilairat
  • Chongkon Krachangchaeng
  • John M Pezzuto
  • Thawatchai Santisuk
  • Norman R Farnsworth
  • Young Geun Shin
  • Hee Byung Chai

Detail Information

Publications57

  1. ncbi request reprint Anti HIV-1 flavonoid glycosides from Ochna integerrima
    Vichai Reutrakul
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Planta Med 73:683-8. 2007
    ..0 and 0.9 microg/mL, respectively, and likewise inhibited HIV-1 reverse transcriptase (RT) with IC(50) values of 2.0 and 2.4 microg/mL, respectively...
  2. ncbi request reprint Difluorophenylsulfanylmethyl radical and difluoromethylene diradical synthons: gem-difluoromethylene building block
    Vichai Reutrakul
    Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    J Org Chem 69:6913-5. 2004
    ..gem-Difluoroalkenes and products containing a midchain CF2 group and with manipulatable functionality can be readily synthesized. The first example of a gem-difluoromethylene radical synthon is also reported...
  3. pmc Sesamin stimulates osteoblast differentiation through p38 and ERK1/2 MAPK signaling pathways
    Orawan Wanachewin
    Thailand Excellence Center for Tissue Engineering and Stem Cells, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand
    BMC Complement Altern Med 12:71. 2012
    ..has a variety of pharmacological effects, though its activity on bone cell function is unclear. Herein we examine the effect of this lignan on osteoblast differentiation and function...
  4. ncbi request reprint Cytotoxic coumarins from Mammea harmandii
    Vichai Reutrakul
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Planta Med 69:1048-51. 2003
    ..Their structures were determined by spectroscopic methods. The assignments of 13C-NMR signals of isomesuol (1), which was isolated for the first time as a natural product, have been revised...
  5. ncbi request reprint Anti-HIV-1 constituents from leaves and twigs of Cratoxylum arborescens
    Vichai Reutrakul
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Planta Med 72:1433-5. 2006
    ..9 and 32.2 microg/mL with TI ranging from 1.5 to 11.7), while 1,3,7-trihydroxy-6-methoxy-4,5-diisoprenylxanthone (3), 4, and 8 - 10 inhibited HIV-1 reverse transcriptase with IC (50) values between 8.7 and 84.9 microg/mL...
  6. doi request reprint Dichapetalin-type triterpenoids and lignans from the aerial parts of Phyllanthus acutissima
    Patoomratana Tuchinda
    Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Nat Prod 71:655-63. 2008
    ..The structures of 1- 7 were determined mainly on the basis of spectroscopic methods. The compounds obtained were evaluated for cytotoxic and anti-HIV-1 activities...
  7. ncbi request reprint Cytotoxic and anti-HIV-1 caged xanthones from the resin and fruits of Garcinia hanburyi
    Vichai Reutrakul
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Planta Med 73:33-40. 2007
    ..This work represents the first report on the anti-HIV-1 activities of caged xanthones...
  8. doi request reprint Cytotoxic, antitopoisomerase IIα, and anti-HIV-1 activities of triterpenoids isolated from leaves and twigs of Gardenia carinata
    Naowarat Kongkum
    Department of Chemistry and Center of Excellence for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Nat Prod 76:530-7. 2013
    ..Their structures were determined on the basis of spectroscopic methods. Cytotoxic, antitopoisomerase IIα, and anti-HIV-1 activities of compounds 1-7, 9, and 10 were investigated. ..
  9. doi request reprint DNA topoisomerase IIα inhibitory and anti-HIV-1 flavones from leaves and twigs of Gardenia carinata
    Naowarat Kongkum
    Department of Chemistry and Center for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Bangkok, Thailand
    Fitoterapia 83:368-72. 2012
    ..Only flavones 1 and 6 showed considerably activity against HIV-1 reverse transcriptase...
  10. ncbi request reprint Anti-HIV-1 cycloartanes from leaves and twigs of Gardenia thailandica
    Patoomratana Tuchinda
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Planta Med 70:366-70. 2004
    ..8 to 110 microg/mL. They also exhibited moderate to high activities in reverse transcriptase (RT) assay; the IC (50) values of compounds 1 - 4, ranged from < 22.5 to 156.8 microg/mL...
  11. doi request reprint Fluoride-catalyzed nucleophilic addition of PhSCF2SiMe3 to anhydrides: synthesis of γ-difluoromethylated γ-lactams
    Vannapha Pharikronburee
    Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    Org Biomol Chem 11:2022-33. 2013
    ....
  12. doi request reprint A new conjugated amide-dimer from the aerial parts of Piper submultinerve
    Saksit Nobsathian
    Department of Chemistry and Center for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Nat Prod Res 26:1824-30. 2012
    ..1 µM and selectivity index 4.7). In the HIV-1 reverse transcriptase assay, only 4 was active with IC₅₀ 50.8 µM...
  13. doi request reprint Asymmetric synthesis of gem-difluoromethylenated dihydroxypyrrolizidines and indolizidines
    Watcharaporn Thaharn
    Center of Excellence for Innovation in Chemistry PERCH CIC and Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Org Chem 77:8465-79. 2012
    ....
  14. ncbi request reprint Cytotoxic arylnaphthalide lignan glycosides from the aerial parts of Phyllanthus taxodiifolius
    Patoomratana Tuchinda
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
    Planta Med 72:60-2. 2006
    ..Compounds and were inactive in all tested cell lines...
  15. doi request reprint Cytotoxic lanostanes from fruits of Garcinia wallichii Choisy (Guttiferae)
    Sakchai Hongthong
    Department of Chemistry and Center of Excellence for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Bioorg Med Chem Lett 26:5773-5779. 2016
    ..The cytotoxicity of all isolated compounds against a panel of cultured cancer cell lines was evaluated. Compound 4 exhibited good cytotoxicity with ED50 values ranging from 3.91 to 7.63μM...
  16. doi request reprint Cytotoxic alkaloids from stems, leaves and twigs of Dasymaschalon blumei
    Waraporn Chanakul
    Department of Chemistry and the Center for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Bangkok, Thailand
    Fitoterapia 82:964-8. 2011
    ..All isolates were evaluated for cytotoxicity against a panel of mammalian cancer cell lines and a noncancerous human embryonic kidney cell Hek 293...
  17. ncbi request reprint Anti-HIV-1 protostane triterpenes and digeranylbenzophenone from trunk bark and stems of Garcinia speciosa
    Vatcharin Rukachaisirikul
    Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, Thailand
    Planta Med 69:1141-6. 2003
    ..0 microg/mL with TI 1.9, respectively). Compound 4 was active in HIV-1 RT assay (IC (50) 23.9 microg/mL), but toxic in the syncytium assay. This work represents the first report on the anti-HIV-1 activities of the protostane triterpenes...
  18. doi request reprint Anti-HIV-1 diterpenoids from leaves and twigs of Polyalthia sclerophylla
    Siriporn Saepou
    Department of Chemistry and Center for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Planta Med 76:721-5. 2010
    ..Among these isolates, compound 3 was the most active in both anti-syncytium (EC (50) 13.7 microg/mL and selectivity index 3.1) and HIV-1 reverse transcriptase (IC (50) 34.1 microg/mL) assays...
  19. ncbi request reprint Cytotoxic styryl-lactones from the leaves and twigs of Polyalthia crassa
    Patoomratana Tuchinda
    Department of Chemistry and Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Nat Prod 69:1728-33. 2006
    ..Cytotoxic evaluation against several mammalian cancer cell lines was performed on all new isolates, aristolactam AII, and the modified (+)-tricinnamate derivative 11 obtained from 1...
  20. doi request reprint Polyoxygenated cyclohexene derivatives isolated from Dasymaschalon sootepense and their biological activities
    Sakchai Hongthong
    Department of Chemistry and Center of Excellence for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok, Thailand
    Fitoterapia 106:158-66. 2015
    ..Several isolated compounds were evaluated for their cytotoxic, anti-HIV-1 RT and anti-inflammatory activities...
  21. doi request reprint Synthesis of gem-difluoromethylenated polycyclic cage compounds
    Chonticha Masusai
    Center of Excellence for Innovation in Chemistry PERCH CIC and Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Org Chem 80:1577-92. 2015
    ....
  22. doi request reprint Asymmetric Synthesis of gem-Difluoromethylenated Linear Triquinanes via Cascade gem-Difluoroalkyl Radical Cyclization
    Watcharaporn Thaharn
    Center of Excellence for Innovation in Chemistry PERCH CIC and Department of Chemistry Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Org Chem 80:816-27. 2015
    ....
  23. doi request reprint Electrophilic difluoro(phenylthio)methylation: generation, stability, and reactivity of α-fluorocarbocations
    Nolan M Betterley
    Department of Chemistry and Center of Excellence for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    Org Lett 15:5666-9. 2013
    ..Detailed mechanistic and electronic studies have provided a fundamental understanding of the reactivity and stability of the difluoro(phenylthio)methylium cation (PhSCF2(+)). ..
  24. doi request reprint Prenylated caged xanthones: chemistry and biology
    Natthinee Anantachoke
    Department of Pharmacognosy and The Center of Excellence for Innovation in Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
    Pharm Biol 50:78-91. 2012
    ..The history, sources, structural diversity, and biological activities of these compounds are covered...
  25. doi request reprint Fluoride-catalyzed addition of PhSCF2SiMe3 to N-substituted cyclic imides followed by radical cyclization: general synthetic strategy of gem-difluoromethylenated 1-azabicyclic compounds
    Teerawut Bootwicha
    Department of Chemistry and Center for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Org Chem 74:3798-805. 2009
    ..The synthesis of highly substituted gem-difluoromethylenated pyrrolizidines 13 and 14 was also demonstrated...
  26. doi request reprint A new diarylheptanoid from the rhizomes of Zingiber mekongense
    Arthittaya Chareonkla
    Department of Chemistry and Center for Innovation in Chemistry, PERCH, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Fitoterapia 82:534-8. 2011
    ..Compounds 1, 4-7 and 9-11 exhibited anti-HIV-1 activities in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, while only compounds 7 and 11 were found active in the HIV-1 reverse transcriptase assay...
  27. ncbi request reprint Highly diastereoselective synthesis of beta-carboxy-gamma-lactams and their ethyl esters via Sc(OTf)(3)-catalyzed imino Mukaiyama-aldol type reaction of 2,5-bis(trimethylsilyloxy)furan with imines
    Manat Pohmakotr
    Department of Chemistry, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    J Org Chem 72:5016-9. 2007
    ....
  28. doi request reprint A synthesis of γ-trifluoromethyl α,β-unsaturated γ-butyrolactones using CF(3)SiMe(3) as a trifluoromethylating agent
    Chonticha Masusai
    Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    Org Biomol Chem 11:6650-8. 2013
    ..The γ-trifluoromethyl α,β-unsaturated γ-butyrolactones 4 were obtained after treatment of the adducts 2 with Grignard reagents, followed by flash-vacuum pyrolysis. ..
  29. doi request reprint Iodine-catalyzed Sulfonylation of Arylacetylenic Acids and Arylacetylenes with Sodium Sulfinates: Synthesis of Arylacetylenic Sulfones
    Jatuporn Meesin
    Department of Chemistry and Center of Excellence for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    J Org Chem 81:2744-52. 2016
    ..The methodology has the advantages of a metal-free strategy, easy to handle reagents, functional group tolerance, a wide range of arylacetylenic acids and arylacetylenes, and easy access to arylacetylenic sulfones. ..
  30. doi request reprint PhI(OAc)2 mediated decarboxylative sulfonylation of β-aryl-α,β-unsaturated carboxylic acids: a synthesis of (E)-vinyl sulfones
    Praewpan Katrun
    Department of Chemistry and Center of Excellence for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Org Biomol Chem 13:4785-94. 2015
    ..This strategy offers a simple and expedient synthesis of (E)-vinyl sulfones bearing a wide variety of functional groups. A radical-based pathway has been proposed for this decarboxylative sulfonylation reaction. ..
  31. ncbi request reprint Radical cyclization/ipso-1,4-aryl migration cascade: asymmetric synthesis of 3,3-difluoro-2-propanoylbicyclo[3.3.0]octanes
    Watcharaporn Thaharn
    Center of Excellence for Innovation in Chemistry PERCH CIC and Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400 Thailand
    Angew Chem Int Ed Engl 53:2212-5. 2014
    ..A novel method for the asymmetric synthesis of 3,3-difluoro-2-propanoylbicyclo-[3.3.0]octanes involves an unprecedented intramolecular radical cyclization/ipso-1,4-aryl migration cascade. ..
  32. ncbi request reprint Synthesis of gem-Difluoromethylenated Bicyclo[m.n.0]alkan-1-ols and Their Ring-Expansion to gem-Difluoromethylenated Macrocyclic Lactones
    Teerachai Punirun
    Center of Excellence for Innovation in Chemistry PERCH CIC and Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    Org Lett 14:1820-3. 2012
    ....
  33. ncbi request reprint A novel cycloheptapeptide exerts strong anticancer activity via stimulation of multiple apoptotic pathways in caspase-3 deficient cancer cells
    Sukathida Ubol
    Departments of Microbiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Anticancer Res 27:2473-9. 2007
    ..Due to its novelty and potency, the molecular process of tumor cell growth inhibition was investigated intensively...
  34. doi request reprint Asymmetric total synthesis of (+)-swainsonine
    Soontorn Chooprayoon
    Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, 10400, Thailand
    Org Biomol Chem 9:531-7. 2011
    ..The method features installation of the indolizidine ring via an intramolecular cyclisation of α-sulfinyl carbanion as a key step. (+)-Swainsonine was obtained in 11.8% overall yield in 10 steps...
  35. ncbi request reprint Morita-Baylis-Hillman reaction of masked 5-alkylidene-2-cyclopentenones: general entry to 5-alkylidene-2-(hydroxyalkyl)- 2-cyclopentenones
    Manat Pohmakotr
    Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Org Chem 72:5418-20. 2007
    ....
  36. ncbi request reprint Alpha-arylsulfanyl-alpha-fluoro carbenoids: their novel chemistry and synthetic applications
    Manat Pohmakotr
    Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Org Lett 6:4547-50. 2004
    ..The reaction is proposed to occur via novel alpha-arylsulfanyl-alpha-fluoro carbenoids. The first examples of arylthiomethane multipole synthons are also reported. [reaction: see text]..
  37. doi request reprint Intramolecular Conjugate Ene Reaction of γ-Difluoromethyl- and γ-Trifluoromethyl-α,β-Unsaturated γ-Butyrolactones
    Watchara Srimontree
    Center of Excellence for Innovation in Chemistry PERCH CIC and Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Org Chem 80:10512-20. 2015
    ....
  38. doi request reprint Stereoselective Synthesis of 1-Fluoro-exo,exo-2,6-diaryl-3,7-dioxabicyclo[3.3.0]octanes: Synthesis of (±)-1-Fluoromembrine
    Teerachai Punirun
    Center of Excellence for Innovation in Chemistry PERCH CIC and Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Org Chem 80:7946-60. 2015
    ..The synthetic protocol also provides an access to (±)-1-fluoromembrine. ..
  39. doi request reprint Stereoselective nucleophilic addition of PhSCF2 SiMe3 to chiral cyclic nitrones: asymmetric synthesis of gem-difluoromethylenated polyhydroxypyrrolizidines and -indolizidines
    Korkit Korvorapun
    Center of Excellence for Innovation in Chemistry PERCH CIC and Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400 Thailand
    Chem Asian J 10:948-68. 2015
    ..High diastereoselectivities were observed with chiral polyoxygenated cyclic nitrones to provide the corresponding adducts, which were further manipulated to afford gem-difluoromethylenated polyhydroxypyrrolizidines and -indolizidines. ..
  40. doi request reprint Formal synthesis of (+)-3-epi-eupomatilone-6 and the 3,5-bis-epimer
    Sariya Yodwaree
    Department of Chemistry and Center of Excellence for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    Org Biomol Chem 12:6885-94. 2014
    ....
  41. doi request reprint Regioselective C2 sulfonylation of indoles mediated by molecular iodine
    Praewpan Katrun
    Department of Chemistry and Center of Excellence for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Org Chem 79:1778-85. 2014
    ..A facile and general method for regioselective C2 sulfonylation reaction of indoles mediated by iodine is described. The 2-sulfonylated products were obtained up to 96% yield under mild reaction conditions (room temperature, 2 h). ..
  42. ncbi request reprint General strategy for stereoselective synthesis of 1-substituted exo,endo-2,6-diaryl-3,7-dioxabicyclo[3.3.0]octanes: total synthesis of (+/-)-gmelinol
    Manat Pohmakotr
    Department of Chemistry and Center of Protein Structure and Function, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Org Chem 71:386-9. 2006
    ..The synthetic sequence involves alpha-methylation or alpha-hydroxylation, reduction, bislactonization, and reduction followed by furofuran formation...
  43. doi request reprint 5-Acetyl goniothalamin suppresses proliferation of breast cancer cells via Wnt/β-catenin signaling
    Nittaya Boonmuen
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Eur J Pharmacol 791:455-464. 2016
    ..Taken together, 5GTN exhibited a promising anticancer effect against breast cancer cells through an inhibition of Wnt/β-catenin signaling. This pathway may be served as a potential chemotherapeutic target for breast cancer by 5GTN...
  44. doi request reprint Convenient synthesis of α,β-unsaturated γ-butyrolactones and γ-butyrolactams via decarboxylative iodination of paraconic acids and β-carboxyl-γ-butyrolactams using 1,3-diiodo-5,5-dimethylhydantoin
    Supasorn Phae-Nok
    Department of Chemistry and Center of Excellence for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    Org Biomol Chem 13:11087-95. 2015
    ....
  45. doi request reprint The anti-inflammatory effects and the inhibition of neutrophil responsiveness by Barleria lupulina and Clinacanthus nutans extracts
    Payong Wanikiat
    Department of Pharmacology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    J Ethnopharmacol 116:234-44. 2008
    ..f.) Lindau extracts using two neutrophil-dependent acute inflammatory models and, in order to elucidate underlying cellular mechanisms, the effects of the extracts on human neutrophil responsiveness was investigated...
  46. ncbi request reprint A general synthetic route to 1-azabicyclo[m.n.0]alkenes via cyclisation based on alpha-sulfinyl carbanions
    Manat Pohmakotr
    Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Org Biomol Chem 1:3495-7. 2003
    ..The intramolecular nucleophilic addition of alpha-sulfinyl carbanions derived from the corresponding sufinyl lactams afforded 1-azabicyclo[m.n.0]alkenes in good yields...
  47. doi request reprint Fasciola gigantica: anthelmintic effect of the aqueous extract of Artocarpus lakoocha
    Naruwan Saowakon
    Department of Anatomy, Faculty of Science, Mahidol University, RamaVI Rd, Bangkok 10400, Thailand
    Exp Parasitol 122:289-98. 2009
    ..Hence, the crude extract of A. lakoocha, may exert its fasciolicidal effect against adult F. gigantica by initially causing the tegumental damage...
  48. doi request reprint Caged xanthones: Potent inhibitors of global predominant MRSA USA300
    Pongkorn Chaiyakunvat
    Department of Chemistry and Center for Innovation in Chemistry PERCH CIC, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    Bioorg Med Chem Lett 26:2980-3. 2016
    ..Synthetically modified 3b retained strong potency in MRSA growth inhibition, yet the toxicity was 20-fold less than natural morellic acid, permitting the possibility of using caged xanthones for MRSA therapeutic. ..
  49. doi request reprint Chitosan-functionalized poly(methyl methacrylate) particles by spinning disk processing for lipase immobilization
    Somkieath Jenjob
    Department of Chemistry, Faculty of Science, Mahidol University, 999 Phuttamonthon 4 Road, Salaya, Nakhon Pathom 73170, Thailand Center of Excellence for Innovation in Chemistry PERCH CIC, Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Carbohydr Polym 89:842-8. 2012
    ..Also, the activity of lipase attached on PMMA-CH particles' surface was preserved and increased with lipase loading...
  50. ncbi request reprint Anti-inflammatory cyclohexenyl chalcone derivatives in Boesenbergia pandurata
    Patoomratana Tuchinda
    Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    Phytochemistry 59:169-73. 2002
    ..Kulturpfl.]. Their structures were assigned on the basis of their spectroscopic data. (-)-Hydroxypanduratin A and (-)-panduratin A showed significant topical anti-inflammatory activity in the assay of TPA-induced ear edema in rats...
  51. ncbi request reprint VR-3848, a novel peptide derived from Euphobiaceae, induces mitochondria-dependent apoptosis in human leukemia cells
    Wanlaya Uthaisang
    Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Cancer Lett 208:171-8. 2004
    ..VR-3848 thus holds the promise of being a potent and selective anti-cancer agent that deserves further exploration...
  52. pmc Apoptotic activity of caged xanthones from Garcinia hanburyi in cholangiocarcinoma cell lines
    Chariya Hahnvajanawong
    Department of Microbiology, Center of Excellence for Innovation in Chemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
    World J Gastroenterol 16:2235-43. 2010
    ..To investigate the growth inhibitory mechanism of four caged xanthones from Garcinia hanburyi in cholangiocarcinoma (CCA) KKU-100 and KKU-M156 cells...
  53. ncbi request reprint Constituents of the leaves and twigs of Ficus hispida
    Sergio R Peraza-Sánchez
    Planta Med 68:186-8. 2002
    ..O-Methyltylophorinidine showed potent cytotoxic activity when tested against a small panel of human cancer cells, while ficustriol was inactive. The structure and stereochemistry of 1 were determined using chemical and spectral methods...
  54. ncbi request reprint Anti-inflammatory activity of methanolic extracts from Ventilago harmandiana Pierre
    Ampai Panthong
    Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    J Ethnopharmacol 91:237-42. 2004
    ..The extracts also showed excellent antipyretic activity on yeast-induced hyperthermia in rats...
  55. pmc A direct catalytic asymmetric Mannich-type reaction via a dinuclear zinc catalyst: synthesis of either anti- or syn-alpha-hydroxy-beta-amino ketones
    Barry M Trost
    Department of Chemistry, Stanford University, Stanford, CA 94305 5080, USA
    J Am Chem Soc 128:2778-9. 2006
    ..The dependence of the diastereoselectivity on the nature of the N-substituent presumably arises from the steric demands of the diphenylphosphinoyl group...
  56. ncbi request reprint Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn
    Ampai Panthong
    Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    J Ethnopharmacol 110:264-70. 2007
    ..e. 90% diosmin and 10% hesperidin. The results obtained confirmed the traditional use of C. quadrangularis for the treatment of pain and inflammation associated with hemorrhoid as well as reducing the size of hemorrhoids...
  57. ncbi request reprint Anti-inflammatory, analgesic and antipyretic activities of the extract of gamboge from Garcinia hanburyi Hook f
    Ampai Panthong
    Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
    J Ethnopharmacol 111:335-40. 2007
    ..It is postulated that the anti-inflammatory, analgesic and antipyretic activities of GH5763 are caused by the inhibition of the prostaglandin biosynthesis...