Apichart Suksamrarn

Summary

Affiliation: Ramkhamhaeng University
Country: Thailand

Publications

  1. ncbi Chemical modifications at the 22-hydroxyl group of ecdysteroids: alternative structural requirements for high moulting activity
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Insect Biochem Mol Biol 32:193-7. 2002
  2. ncbi Antimycobacterial and antioxidant flavones from Limnophila geoffrayi
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Arch Pharm Res 26:816-20. 2003
  3. ncbi Antimycobacterial activity and cytotoxicity of flavonoids from the flowers of Chromolaena odorata
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Arch Pharm Res 27:507-11. 2004
  4. ncbi Antiplasmodial triterpenes from twigs of Gardenia saxatilis
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Huamark, Bangkapi, Bangkok 10240, Thailand
    J Ethnopharmacol 88:275-7. 2003
  5. ncbi Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand
    Chem Pharm Bull (Tokyo) 53:1327-9. 2005
  6. ncbi Ecdysteroids of Vitex scabra stem bark
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    J Nat Prod 65:1690-2. 2002
  7. ncbi Ecdysteroids from a Zoanthus sp
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    J Nat Prod 65:1194-7. 2002
  8. ncbi Iridoids with anti-inflammatory activity from Vitex peduncularis
    A Suksamrarn
    Department of Chemistry, Ramkhamhaeng University, Bangkok, Thailand
    Planta Med 68:72-3. 2002
  9. ncbi Bioactive constituents of the root bark of Artocarpus rigidus subsp. rigidus
    Umalee Namdaung
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bankok, Thailand
    Chem Pharm Bull (Tokyo) 54:1433-6. 2006
  10. doi Erythrina alkaloids and a pterocarpan from the bark of Erythrina subumbrans
    Thitima Rukachaisirikul
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand
    J Nat Prod 71:156-8. 2008

Collaborators

Detail Information

Publications71

  1. ncbi Chemical modifications at the 22-hydroxyl group of ecdysteroids: alternative structural requirements for high moulting activity
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Insect Biochem Mol Biol 32:193-7. 2002
    ..Ecdysteroid without a 22-hydroxyl group may exhibit high moulting activity if a functional group that can enhance activity is present at an appropriate position...
  2. ncbi Antimycobacterial and antioxidant flavones from Limnophila geoffrayi
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Arch Pharm Res 26:816-20. 2003
    ..7 microg/mL. The crude hexane, chloroform and methanol extracts as well as the pure compounds 1 and 2 did not exhibit mutagenic activity in the Bacillus subtilis recassay...
  3. ncbi Antimycobacterial activity and cytotoxicity of flavonoids from the flowers of Chromolaena odorata
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Arch Pharm Res 27:507-11. 2004
    ..6 microM, whereas compound 8 exhibited moderate toxicity against NCI-H187 cells and week toxicity against human breast cancer (BC) cells with the MIC values of 19.2 and 38.4 microM respectively...
  4. ncbi Antiplasmodial triterpenes from twigs of Gardenia saxatilis
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Huamark, Bangkapi, Bangkok 10240, Thailand
    J Ethnopharmacol 88:275-7. 2003
    ..Introduction of a methoxyl group to the 3-position of the p-coumarate moiety to give a ferulate moiety resulted in loss of activity...
  5. ncbi Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand
    Chem Pharm Bull (Tokyo) 53:1327-9. 2005
    ..Compound 1 exhibited antimycobacterial activity with an MIC value of 25 microg/ml and showed antiplasmodial activity with an IC50 value of 7.2 microg/ml. Compounds 2 and 3 were inactive in both assays...
  6. ncbi Ecdysteroids of Vitex scabra stem bark
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    J Nat Prod 65:1690-2. 2002
    ..Compounds 1 and 2 exhibited very low moulting activity in the Musca bioassay. The low biological activity of these two ecdysteroids was in agreement with those of other 22-deoxyecdysteroids...
  7. ncbi Ecdysteroids from a Zoanthus sp
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    J Nat Prod 65:1194-7. 2002
    ..This is the first report of ecdysteroids in a Zoanthus species...
  8. ncbi Iridoids with anti-inflammatory activity from Vitex peduncularis
    A Suksamrarn
    Department of Chemistry, Ramkhamhaeng University, Bangkok, Thailand
    Planta Med 68:72-3. 2002
    ..15 +/- 0.21 mg/ml and 0.026 +/- 0.015 mg/ml respectively, while having only small inhibitory effects on COX-1. Both compounds did not exhibit cytotoxicity against vero cells...
  9. ncbi Bioactive constituents of the root bark of Artocarpus rigidus subsp. rigidus
    Umalee Namdaung
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bankok, Thailand
    Chem Pharm Bull (Tokyo) 54:1433-6. 2006
    ..Compounds 1-3, 5, and 6 were active in the NCI-H187 cytotoxicity assay, with 3 being the most active compound (IC(50) 1.26 microg/ml)...
  10. doi Erythrina alkaloids and a pterocarpan from the bark of Erythrina subumbrans
    Thitima Rukachaisirikul
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand
    J Nat Prod 71:156-8. 2008
    ..Their structures were elucidated on the basis of spectroscopic data. Some isolates were tested for antiplasmodial, antimycobacterial, and cytotoxic activities...
  11. doi Inhibition of topoisomerase II α activity and induction of apoptosis in mammalian cells by semi-synthetic andrographolide analogues
    Jintapat Nateewattana
    Toxicology Graduate Program, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Invest New Drugs 31:320-32. 2013
    ..The analogue 2C may, therefore, have a therapeutic potential as effective anticancer agent targeting the hTopo II α functions...
  12. doi Synthesis of bis, tris and tetra(dihydrocaffeoyl)polyamine conjugates as antibacterial agents against VRSA
    Boon Ek Yingyongnarongkul
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkapi, Bangkok, 10240, Thailand
    Arch Pharm Res 31:698-704. 2008
    ..Tetra(dihydrocaffeoyl)polyamine conjugate exhibited the highest activity. These compounds showed no cytotoxicity against vero cells...
  13. ncbi Antifungal azaphilones from the fungus Chaetomium cupreum CC3003
    Somdej Kanokmedhakul
    Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
    J Nat Prod 69:891-5. 2006
    ..Compounds 1, 3, 4, and 6 exhibited antifungal activity against Candida albicans with IC50 values of 10.5, 16.7, 24.3, and 0.6 microg/mL, respectively...
  14. doi Estrogenic activity of diarylheptanoids from Curcuma comosa Roxb. Requires metabolic activation
    Wipawee Winuthayanon
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    J Agric Food Chem 57:840-5. 2009
    ..comosa. This novel class of natural phytoestrogens has the potential to be developed for use as dietary supplement in the treatment of menopausal symptoms...
  15. pmc Bone sparing effect of a novel phytoestrogen diarylheptanoid from Curcuma comosa Roxb. in ovariectomized rats
    Duangrat Tantikanlayaporn
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    PLoS ONE 8:e78739. 2013
    ..Therefore, DPHD appears to be a promising candidate for preserving bone mass and structure in the estrogen deficient women with a potential role in reducing postmenopausal osteoporosis. ..
  16. doi A protective effect of Curcuma comosa Roxb. on bone loss in estrogen deficient mice
    Jittima Weerachayaphorn
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    J Ethnopharmacol 137:956-62. 2011
    ..Curcuma comosa Roxb. or Wan chak motluk is an indigenous medicinal herb and has traditionally been used among postmenopausal women for relief of unpleasant menopausal symptoms...
  17. ncbi Chemical constituents and bioactivity of Piper sarmentosum
    Thitima Rukachaisirikul
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    J Ethnopharmacol 93:173-6. 2004
    ..This is the first report of the antituberculosis and antiplasmodial activities for these compounds...
  18. pmc Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms
    Wipawee Winuthayanon
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Environ Health Perspect 117:1155-61. 2009
    ..Diarylheptanoids isolated from Curcuma comosa Roxb. have been recently identified as phyto estrogens. However, the mechanism underlying their actions has not yet been identified...
  19. doi Fuscacarpans A-C, new pterocarpans from the stems of Erythrina fusca
    Phongsak Innok
    Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Fitoterapia 81:518-23. 2010
    ..Structures 1-3 were elucidated by spectroscopic and chemical methods. The isolates were evaluated for antibacterial, antiplasmodial and cytotoxic activities...
  20. doi Induction of apoptosis in murine leukemia by diarylheptanoids from Curcuma comosa Roxb
    Surawat Jariyawat
    Department of Physiology, Mahidol University, Bangkok, Thailand
    Cell Biol Toxicol 27:413-23. 2011
    ..The results provide evidence for the pro-oxidant activity of the diarylheptanoid bearing a catechol moiety in the induction of apoptosis in murine P388 leukemia...
  21. doi Labdane-type diterpenes from Hedychium gardnerianum with potent cytotoxicity against human small cell lung cancer cells
    Iyared Kumrit
    Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand
    Phytother Res 24:1009-13. 2010
    ..The very high cytotoxicity against the NCI-H187 cells and the exceptionally high selectivity index (>416) of villosin suggested that this compound may be used as a potential lead molecule for antitumor therapeutic development...
  22. ncbi Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana
    Sunit Suksamrarn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand
    Chem Pharm Bull (Tokyo) 54:535-7. 2006
    ..7, 0.9 and 3.0 microg/ml, respectively. Compounds 1 and 3-8 showed antimycobacterial activity against Mycobacterium tuberculosis with respective MIC values of 25, 25, 25, 12.5, 50, 50 and 100 microg/ml...
  23. ncbi Flavanoids and pterocarpans from the bark of Erythrina fusca
    Phongsak Innok
    Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Thailand
    Chem Pharm Bull (Tokyo) 57:993-6. 2009
    ..For cytotoxicity, compounds 1, 4, 5, 9 and 12 showed moderate to weak activity against KB, BC and NCI-H187 cells, whereas 2 exhibited only weak activity against KB cells...
  24. doi Curcumin I mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 MAPK expression, and caspase-3 activation in 6-hydroxydopamine treated SH-SY5Y cells
    Benjawan Meesarapee
    Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Phytother Res 28:611-6. 2014
    ..This study provides evidence for the therapeutic potential of curcumin I in the chemoprevention of oxidative stress-related neurodegeneration...
  25. pmc A phytoestrogen diarylheptanoid mediates estrogen receptor/Akt/glycogen synthase kinase 3β protein-dependent activation of the Wnt/β-catenin signaling pathway
    Kanit Bhukhai
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    J Biol Chem 287:36168-78. 2012
    ..Our findings provide a scientific rationale for using C. comosa as a dietary supplement to prevent bone loss in postmenopausal women...
  26. pmc Improvements of insulin resistance in ovariectomized rats by a novel phytoestrogen from Curcuma comosa Roxb
    Mujalin Prasannarong
    Department of Physiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand
    BMC Complement Altern Med 12:28. 2012
    ..The present study investigated the long-term effects (12 weeks) of C. comosa hexane extract and compound 049 on insulin resistance in prolonged estrogen-deprived rats...
  27. doi Long-term effect of phytoestrogens from Curcuma comosa Roxb. on vascular relaxation in ovariectomized rats
    Suttira Intapad
    Department of Physiology, Mahidol University, Bangkok, Thailand 10400
    J Agric Food Chem 60:758-64. 2012
    ..These results indicate that C. comosa treatment prevents impairment of vascular relaxation in estrogen-deficient animals via the ER-eNOS pathway as well as through its ability to promote an anti-inflammatory response...
  28. ncbi A bioactive triterpenoid and vulpinic acid derivatives from the mushroom Scleroderma citrinum
    Somdej Kanokmedhakul
    Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
    Planta Med 69:568-71. 2003
    ..Compound 3 and two of its derivatives, the dibromo derivative 5 and acetate derivative 6, exhibited activity towards Mycobacterium tuberculosis. In addition, 5 and 6 also showed cytotoxicity against the NCI-H187 cell line...
  29. ncbi Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids
    Tanud Tanachatchairatana
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkapi, Bangkok, Thailand
    Chem Pharm Bull (Tokyo) 56:194-8. 2008
    ..Structure-activity relationships within the lupane, oleanane and ursane analogues and between these triterpenes are discussed...
  30. ncbi Biological activities of the chemical constituents of Erythrina stricta and Erythrina subumbrans
    Thitima Rukachaisirikul
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand
    Arch Pharm Res 30:1398-403. 2007
    ..For cytotoxicity, erybraedin A (2) showed the highest activity against the NCI-H187 and BC cells (IC50 2.1 and 2.9 microg/mL, respectively), whereas 10 exhibited the highest activity against the KB cells (IC50 4.5 microg/mL)...
  31. ncbi Iridoid glucosides from the flowers of Barleria lupulina
    Sunit Suksamrarn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand
    Planta Med 69:877-9. 2003
    ..When tested for anti-herpes simplex type 1 activity, only compound 3 exhibited antiviral properties. None of the compounds showed cytotoxic effects to the vero cells and none of them inhibited cyclooxygenase-2 enzyme...
  32. ncbi Chabamide, a novel piperine dimer from stems of Piper chaba
    Thitima Rukachaisirikul
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand
    Planta Med 68:853-5. 2002
    ..Chabamide showed antimalarial activity with an IC(50) value of 2.7 microg/ml and antituberculosis activity with the minimum inhibitory concentration (MIC) of 12.5 microg/ml...
  33. ncbi Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana
    Sunit Suksamrarn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand
    Chem Pharm Bull (Tokyo) 51:857-9. 2003
    ..25 microg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds...
  34. ncbi Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana
    Sunit Suksamrarn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Sukhumvit, Bangkok, Thailand
    Chem Pharm Bull (Tokyo) 54:301-5. 2006
    ..46 microg/ml). Compound 12 also showed the highest activity against KB cells, while gartanin (10) displayed the strongest activity against the NCI-H187 cells at the respective IC50 values of 2.08 microg/ml and 1.08 microg/ml...
  35. doi 12-Amino-andrographolide analogues: synthesis and cytotoxic activity
    Sakkasem Kasemsuk
    Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi, 20131, Thailand
    Arch Pharm Res 36:1454-64. 2013
    ..The cytotoxicity of all new amino analogues were evaluated against six cancer cell lines and revealed their potential for being developed as promising anti-cancer agents. ..
  36. doi Abietane diterpenes from Hyptis suaveolens
    Saowanee Prawatsri
    Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Chem Biodivers 10:1494-500. 2013
    ..The structures of 1-3 were established by spectroscopic methods and chemical correlations. Some isolates were tested for their antimycobacterial and cytotoxic activities. ..
  37. doi Diarylheptanoids, new phytoestrogens from the rhizomes of Curcuma comosa: Isolation, chemical modification and estrogenic activity evaluation
    Apichart Suksamrarn
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Bioorg Med Chem 16:6891-902. 2008
    ....
  38. doi Nitric oxide signalling is involved in diarylheptanoid-induced increases in femoral arterial blood flow in ovariectomized rats
    Ganyapong Chaturapanich
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Clin Exp Pharmacol Physiol 40:240-9. 2013
    ..The results of the present study suggest that the phyto-oestrogen D3 increases FBF in ovariectomized rats via oestrogen receptor and nitric oxide-guanylyl cyclase signalling, which, in turn, relaxes femoral vascular resistance...
  39. ncbi Bioactive flavonoids of the flowers of Butea monosperma
    Ratchanaporn Chokchaisiri
    Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand
    Chem Pharm Bull (Tokyo) 57:428-32. 2009
    ..The isolated flavonoids exhibited varying antimycobacterial activity with the chalcone 2 being the most active compound (MIC 12.5 microg/ml)...
  40. doi Protection of centrilobular necrosis by Curcuma comosa Roxb. in carbon tetrachloride-induced mice liver injury
    Jittima Weerachayaphorn
    Department of Physiology, Faculty of Science, Mahidol University, Rachatewee, Bangkok, Thailand
    J Ethnopharmacol 129:254-60. 2010
    ..To investigate the protective effect and possible mechanism of Curcuma comosa hexane extract on CCl(4)-induced liver injury in adult male mice...
  41. ncbi Activation of AMP-activated protein kinase by a plant-derived dihydroisosteviol in human intestinal epithelial cell
    Chatchai Muanprasat
    Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Rajathevi, Bangkok 10400, Thailand
    Biol Pharm Bull 36:522-8. 2013
    ..Our results indicate that DHIS inhibits CFTR-mediated chloride secretion in T84 cells, in part, by activation of AMPK activity. DHIS therefore represents a novel candidate of AMPK activators...
  42. doi Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity
    Chatchawan Changtam
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Eur J Med Chem 45:4446-57. 2010
    ....
  43. ncbi Antibacterial pterocarpans from Erythrina subumbrans
    Thitima Rukachaisirikul
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    J Ethnopharmacol 110:171-5. 2007
    ..39-1.56 microg/ml, which were resistant to both antibiotics. These compounds may prove to be potent phytochemical agents for antibacterial activity, especially against the MRSA and VRSA strains...
  44. ncbi Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs
    Pichit Sudta
    Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand
    Chem Pharm Bull (Tokyo) 61:194-203. 2013
    ..The methyl ether analog was also active against the multidrug-resistant (MDR) strains with pronounced MICs of 0.78-1.56 µg/mL...
  45. doi New substituted C-19-andrographolide analogues with potent cytotoxic activities
    Uthaiwan Sirion
    Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Burapha University, Chonburi 20131, Thailand
    Bioorg Med Chem Lett 22:49-52. 2012
    ..The 19-O-triphenylmethyl ether analogue 18 showed higher cytotoxic activity than the potent anticancer drug ellipticine, and this analogue may serve as a potential structure lead for the development of new anticancer drugs...
  46. doi Enhancement of vascular relaxation in rat aorta by phytoestrogens from Curcuma comosa Roxb
    Suttira Intapad
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Vascul Pharmacol 51:284-90. 2009
    ..comosa acutely increases endothelium-dependent relaxation of aortic rings through the ER-Akt-eNOS pathway. This is the first evidence indicating non-genomic action of a novel phytoestrogen from C. comosa, on vascular relaxation...
  47. ncbi Xanthones from the green fruit hulls of Garcinia mangostana
    Sunit Suksamrarn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand
    J Nat Prod 65:761-3. 2002
    ..The structures of the new xanthones were elucidated by analysis of their spectroscopic data...
  48. doi Protective effect of diarylheptanoids from Curcuma comosa on primary rat hepatocytes against t-butyl hydroperoxide-induced toxicity
    Kanoknetr Suksen
    a Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Pharm Biol 54:853-62. 2016
    ..Curcuma comosa Roxb. (Zingiberaceae) has traditionally been used as an anti-inflammatory agent in liver, and recent study has shown its hepatoprotective effect against CCl4-induced liver injury in vivo...
  49. doi Antiplasmodial and antimycobacterial cyclopeptide alkaloids from the root of Ziziphus mauritiana
    Panomwan Panseeta
    Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand
    Phytochemistry 72:909-15. 2011
    ..7 to 10.3 μM. Compounds 2 and 3 also demonstrated antimycobacterial activity against Mycobacterium tuberculosis with the MIC of 72.8 and 4.5 μM, respectively...
  50. doi Novel racemic tetrahydrocurcuminoid dihydropyrimidinone analogues as potent acetylcholinesterase inhibitors
    Sarawalee Arunkhamkaew
    Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Bioorg Med Chem Lett 23:2880-2. 2013
    ..THBDC-DHPM demonstrated the most potent inhibitory activity with an IC50 value of 1.34±0.03μM which was more active than the approved drug galanthamine (IC50=1.45±0.04μM)...
  51. pmc Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation
    Suwit Duangmano
    School of Allied Health Science and Public Health, Walailak University, Bangkok, Thailand
    BMC Complement Altern Med 12:185. 2012
    ..Cucurbitacin B is great of interest because of its biological activity. This agent inhibits growth of various types of human cancer cells lines...
  52. doi Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species
    Chatchawan Changtam
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Ramkhamhaeng Road, Bangkok 10240, Thailand
    Eur J Med Chem 45:941-56. 2010
    ..The selectivity index for T. b. brucei ranged from 3-fold to 1500-fold. The selectivity index for the most active analog, the enone 40, was 453-fold...
  53. ncbi Antimycobacterial anthraquinone-chromanone compound and diketopiperazine alkaloid from the fungus Chaetomium globosum KMITL-N0802
    Somdej Kanokmedhakul
    Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand
    Planta Med 68:834-6. 2002
    ..These compounds were characterized by spectroscopic methods. Chaetomanone and echinulin exhibited activity towards Mycobacterium tuberculosis...
  54. doi Labdane diterpenes from the aerial parts of Curcuma comosa enhance fetal hemoglobin production in an erythroid cell line
    Ratchanaporn Chokchaisiri
    Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    J Nat Prod 73:724-8. 2010
    ..Compound 6, isocoronarin D, exhibited the highest Hb F induction effect of 1.6-fold at 20 microM...
  55. doi Synthesis, cytotoxicity against human oral cancer KB cells and structure-activity relationship studies of trienone analogues of curcuminoids
    Thipphawan Chuprajob
    Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Bioorg Med Chem Lett 24:2839-44. 2014
    ..46, 33.46 and 31.68, respectively. These analogues are regarded as the potent trienones for anti-oral cancer study. ..
  56. doi Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system
    Prapapan Pimkaew
    Toxicology Graduate Program, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Toxicol In Vitro 27:2005-12. 2013
    ..These findings provide insight on the safety and drug-herb interactions of the Curcuma species...
  57. doi Potent vasorelaxant analogs from chemical modification and biotransformation of isosteviol
    Orawan Wonganan
    Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Eur J Med Chem 62:771-6. 2013
    ..Compound 4 exerted vasorelaxant activity at particularly low concentration and the vasorelaxant profile reached maximum at relatively low concentration, especially when compared with acetylcholine, the positive control...
  58. ncbi Solid-phase synthesis and antibacterial activity of hydroxycinnamic acid amides and analogues against methicillin-resistant Staphylococcus aureus and vancomycin-resistant S. aureus
    Boon Ek Yingyongnarongkul
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkapi, Bangkok 10240, Thailand
    Bioorg Med Chem Lett 16:5870-3. 2006
    ..Dihydrocaffeoyl analogues showed activity against VRSA which were better than the reference drugs, vancomycin and oxacillin. These compounds also exhibited antibacterial activity against MRSA, which were more potent than oxacillin...
  59. ncbi (+)-Bornyl piperate, a new monoterpene ester from Piper aff. pedicellatum roots
    Thitima Rukachaisirikul
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, Thailand
    Chem Pharm Bull (Tokyo) 52:760-1. 2004
    ..3232(4) A, b=11.4705(7) A, c=23.2520(14) A, V=1943.6(2) A(3). This compound showed an antituberculosis activity against Mycobacterium tuberculosis (H(37)Ra strain) with the minimum inhibitor concentration (MIC) of 25 microg/ml...
  60. pmc Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group
    Siritron Samosorn
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand
    Bioorg Med Chem 17:3866-72. 2009
    ..7 microM), which was over 382-fold more active than the parent antibacterial berberine, against this bacterium. This compound was also shown to block the NorA efflux pump in S. aureus...
  61. ncbi Biotransformations of 20-hydroxyecdysone and analogues by Curvularia lunata NRRL 2178
    Chatchawan Changtam
    Department of Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand
    Steroids 71:902-7. 2006
    ..Ponasterone A and pterosterone were similarly biotransformed to the corresponding 2-dehydro-3-epi- and 3alpha,9alpha-cyclo-analogues...
  62. doi Serum lipidomics analysis of ovariectomized rats under Curcuma comosa treatment
    Nawaporn Vinayavekhin
    Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand Omics Sciences and Bioinformatics Center, Chulalongkorn University, Bangkok 10330, Thailand Electronic address
    J Ethnopharmacol 192:273-282. 2016
    ..Curcuma comosa Roxb. (C. comosa) or Wan Chak Motluk, Zingiberaceae family, has been used in Thai traditional medicine for the treatment of gynecological problems and inflammation...
  63. doi Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats
    Tanaporn Khamphaya
    Toxicology Graduate Program, Faculty of Science, Mahidol University, Bangkok, Thailand
    Eur J Pharmacol 789:254-64. 2016
    ..These findings suggest that andrographolide could be a promising therapeutic option in prevention and slowing down the progression of cholestatic liver diseases. ..
  64. ncbi Suppression by Curcuma comosa Roxb. of pro-inflammatory cytokine secretion in phorbol-12-myristate-13-acetate stimulated human mononuclear cells
    Amorntus Sodsai
    Toxicology Graduate Program, Faculty of Science, Mahidol University, Bangkok, Thailand
    Int Immunopharmacol 7:524-31. 2007
    ..These results indicated that C. comosa and its diarylheptanoids have anti-inflammatory properties which could be exploited for clinical use...
  65. doi Curcumin I protects the dopaminergic cell line SH-SY5Y from 6-hydroxydopamine-induced neurotoxicity through attenuation of p53-mediated apoptosis
    Yamaratee Jaisin
    Department of Pharmacology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand
    Neurosci Lett 489:192-6. 2011
    ....
  66. ncbi A sensitive direct ELISA for detection of prostaglandin E2
    Nuntana Aroonrerk
    Faculty of Dentistry, Department of Stomatology, Srinakharinwirot University, Bangkok, Thailand
    J Immunoassay Immunochem 28:319-30. 2007
    ..078-5 microg/mL with a coefficient of determination (r(2)) of 0.99. Our results indicated that the developed direct ELISA was sensitive and suitable for a quick determination of PGE(2) levels from cell culture supernatants...
  67. doi Cytotoxic activities of trichothecenes isolated from an endophytic fungus belonging to order Hypocreales
    Maneekarn Chinworrungsee
    Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand
    Arch Pharm Res 31:611-6. 2008
    ..Compounds 3 and 5 were moderately active against these three cancer cell lines...
  68. doi High transfection efficiency and low toxicity cationic lipids with aminoglycerol-diamine conjugate
    Boon Ek Yingyongnarongkul
    Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkapi, Bangkok 10240, Thailand
    Bioorg Med Chem 17:176-88. 2009
    ..This suggests that these newly described aminoglycerol-based lipids should be very promising in liposome-mediated gene delivery and illustrate the potential of solid phase synthesis method for non-viral vector discovery...
  69. ncbi Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor: potential therapy for cholera and polycystic kidney disease
    Chatchai Muanprasat
    Department of Physiology, Faculty of Science, Mahidol University, Thailand
    J Pharmacol Sci 118:82-91. 2012
    ..This study reveals a novel action of ISLQ as a potent CFTR inhibitor with therapeutic potential for treatment of cholera and polycystic kidney disease...
  70. ncbi Cholesterol lowering effects of a choleretic phloracetophenone in hypercholesterolemic hamsters
    Pawinee Piyachaturawat
    Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Rachatewee, Bangkok, 10400, Thailand scppy mahidol ac th
    Eur J Pharmacol 439:141-7. 2002
    ..This compound may have a potential for future development as a therapeutic agent for lowering lipids in hypercholesterolemic patients...
  71. pmc Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice
    Pornprom Yoysungnoen
    Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand
    World J Gastroenterol 14:2003-9. 2008
    ..To determine the effect of tetrahydrocurcumin (THC) on tumor angiogenesis compared with curcumin (CUR) by using both in vitro and in vivo models of human hepatocellular carcinoma cell line (HepG2)...