A O Verkerk

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Two types of action potential configuration in single cardiac Purkinje cells of sheep
    A O Verkerk
    Department of Physiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol 277:H1299-310. 1999
  2. doi request reprint Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current
    Arie O Verkerk
    Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Int J Mol Sci 16:3071-94. 2015
  3. pmc Re-evaluation of the action potential upstroke velocity as a measure of the Na+ current in cardiac myocytes at physiological conditions
    Géza Berecki
    Department of Anatomy, Embryology, and Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 5:e15772. 2010
  4. doi request reprint Dietary fish oil reduces pacemaker current and heart rate in rabbit
    Arie O Verkerk
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 6:1485-92. 2009
  5. pmc Is sodium current present in human sinoatrial node cells?
    Arie O Verkerk
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Biol Sci 5:201-4. 2009
  6. doi request reprint Pacemaker activity of the human sinoatrial node: role of the hyperpolarization-activated current, I(f)
    Arie O Verkerk
    Department of Physiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Int J Cardiol 132:318-36. 2009
  7. doi request reprint Etiology-dependency of ionic remodeling in cardiomyopathic rabbits
    Arie O Verkerk
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Cardiol 148:154-60. 2011
  8. doi request reprint Dynamic action potential clamp as a powerful tool in the development of a gene-based bio-pacemaker
    Arie O Verkerk
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Conf Proc IEEE Eng Med Biol Soc 2008:133-6. 2008
  9. ncbi request reprint Cellular basis of sex disparities in human cardiac electrophysiology
    A O Verkerk
    Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Acta Physiol (Oxf) 187:459-77. 2006
  10. ncbi request reprint Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome
    Arie O Verkerk
    Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 68:441-53. 2005

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Two types of action potential configuration in single cardiac Purkinje cells of sheep
    A O Verkerk
    Department of Physiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol 277:H1299-310. 1999
    ..We conclude that LP Purkinje cells, HP Purkinje cells, and ventricular cells of sheep each have a unique action potential configuration...
  2. doi request reprint Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current
    Arie O Verkerk
    Department of Anatomy, Embryology and Physiology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Int J Mol Sci 16:3071-94. 2015
    ..Future research may solve apparent inconsistencies between data from clinical studies and data from in vitro and in silico experiments. ..
  3. pmc Re-evaluation of the action potential upstroke velocity as a measure of the Na+ current in cardiac myocytes at physiological conditions
    Géza Berecki
    Department of Anatomy, Embryology, and Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 5:e15772. 2010
    ..We hypothesized that the alternating voltage clamp-current clamp (VC/CC) technique might provide an alternative to traditional voltage clamp (VC) technique for the determination of I(Na) properties under physiological conditions...
  4. doi request reprint Dietary fish oil reduces pacemaker current and heart rate in rabbit
    Arie O Verkerk
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 6:1485-92. 2009
    ..Omega-3 polyunsaturated fatty acids (omega3-PUFAs) from fish oil (FO) reduce heart rate in humans. The mechanism underlying this cardioprotective effect of FO is unknown...
  5. pmc Is sodium current present in human sinoatrial node cells?
    Arie O Verkerk
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Biol Sci 5:201-4. 2009
    ....
  6. doi request reprint Pacemaker activity of the human sinoatrial node: role of the hyperpolarization-activated current, I(f)
    Arie O Verkerk
    Department of Physiology, Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Int J Cardiol 132:318-36. 2009
    ....
  7. doi request reprint Etiology-dependency of ionic remodeling in cardiomyopathic rabbits
    Arie O Verkerk
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int J Cardiol 148:154-60. 2011
    ..Here, we investigated the etiology-dependency of ionic remodeling in standardized rabbit models of ICM and DCM...
  8. doi request reprint Dynamic action potential clamp as a powerful tool in the development of a gene-based bio-pacemaker
    Arie O Verkerk
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Conf Proc IEEE Eng Med Biol Soc 2008:133-6. 2008
    ....
  9. ncbi request reprint Cellular basis of sex disparities in human cardiac electrophysiology
    A O Verkerk
    Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Acta Physiol (Oxf) 187:459-77. 2006
    ..We studied the cellular basis of sex distinctions in human cardiac electrophysiology and dysrhythmia susceptibility using mathematical models of human ventricular myocytes...
  10. ncbi request reprint Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome
    Arie O Verkerk
    Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 68:441-53. 2005
    ..Other causally related genes still await identification. We evaluated the role of HERG (KCNH2), which encodes the alpha-subunit of the rapid delayed rectifier K(+) channel (I(Kr)), in BrS...
  11. ncbi request reprint Identification of swelling-activated Cl(-) current in rabbit cardiac Purkinje cells
    A O Verkerk
    Department of Physiology, Academic Medical Center, Meibergdreef 15, 1105 Amsterdam, The Netherlands
    Cell Mol Life Sci 61:1106-13. 2004
    ..We conclude that I(Cl(swell)) is present in Purkinje cells and its activation leads to action potential shortening and resting membrane potential depolarization, both of which can promote the development of reentrant arrhythmias...
  12. ncbi request reprint Ionic remodeling of sinoatrial node cells by heart failure
    Arie O Verkerk
    Department of Physiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circulation 108:760-6. 2003
    ..In this study, we evaluate the HF-induced remodeling of membrane potentials and currents in SAN cells...
  13. pmc Ca(2+)-activated Cl(-) current in rabbit sinoatrial node cells
    Arie O Verkerk
    Academic Medical Center, University of Amsterdam, Task Force Heart Failure and Aging, Department of Physiology, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Physiol 540:105-17. 2002
    ..In conclusion, I(Cl(Ca)) is present in one third of SA node cells and is activated during the pacemaker cycle. However, I(Cl(Ca)) does not modulate intrinsic interbeat interval, pacemaker synchronization or action potential conduction...
  14. ncbi request reprint Role of Ca(2+)-activated Cl(-) current in ventricular action potentials of sheep during adrenoceptor stimulation
    A O Verkerk
    Department of Physiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Exp Physiol 86:151-9. 2001
    ..Experimental Physiology (2001) 86.2, 151-159...
  15. ncbi request reprint Ionic mechanism of delayed afterdepolarizations in ventricular cells isolated from human end-stage failing hearts
    A O Verkerk
    Department of Physiology, Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, The Netherlands
    Circulation 104:2728-33. 2001
    ..I(ti) is responsible for the proarrhythmic delayed afterdepolarizations (DADs). We investigated the ionic mechanism of I(ti) and DADs in human cardiac cells...
  16. ncbi request reprint Injury current modulates afterdepolarizations in single human ventricular cells
    A O Verkerk
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cardiovasc Res 47:124-32. 2000
    ..However, little is known about the effects of I(injury) on afterdepolarizations. The present study was designed to study the effect of I(injury) on afterdepolarizations and action potentials in single human ventricular cells...
  17. ncbi request reprint Effects of cell-to-cell uncoupling and catecholamines on Purkinje and ventricular action potentials: implications for phase-1b arrhythmias
    A O Verkerk
    Department of Physiology, Cardiovascular Research Institute Amsterdam, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 51:30-40. 2001
    ..In the present study we determined the effects of uncoupling and catecholamines on development of proarrhythmic afterdepolarizations...
  18. ncbi request reprint Calcium-activated Cl(-) current contributes to delayed afterdepolarizations in single Purkinje and ventricular myocytes
    A O Verkerk
    Department of Physiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Circulation 101:2639-44. 2000
    ..In this study, we investigated the ionic nature of I(ti) in single sheep Purkinje and ventricular myocytes and the effects of Cl(-) current blockade on DADs...
  19. pmc Chronic inhibition of the Na+/H+ - exchanger causes regression of hypertrophy, heart failure, and ionic and electrophysiological remodelling
    A Baartscheer
    Department of Experimental Cardiology, Center for Heart Failure Research Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Br J Pharmacol 154:1266-75. 2008
    ..We hypothesized that chronic inhibition of NHE-1, initiated at a later stage, would induce regression of hypertrophy, heart failure, and ionic and electrophysiological remodelling...
  20. pmc The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium
    C A Remme
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Basic Res Cardiol 104:511-22. 2009
    ..This differential distribution of the cardiac sodium channel may have profound consequences for conduction disease phenotypes and arrhythmogenesis in the setting of sodium channel disease...
  21. doi request reprint Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes
    Simona Casini
    Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, AZ 1105 Amsterdam, The Netherlands
    Cardiovasc Res 81:72-81. 2009
    ....
  22. ncbi request reprint Norepinephrine induces action potential prolongation and early afterdepolarizations in ventricular myocytes isolated from human end-stage failing hearts
    M W Veldkamp
    Experimental and Molecular Cardiology Group, Cardiovascular Research Institute Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
    Eur Heart J 22:955-63. 2001
    ..Thus norepinephrine seems to be an important arrhythmogenic factor in congestive heart failure...
  23. ncbi request reprint Role of Ca2+-activated Cl- current during proarrhythmic early afterdepolarizations in sheep and human ventricular myocytes
    A O Verkerk
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Acta Physiol Scand 179:143-8. 2003
    ..The present study was designed to test this hypothesis...
  24. ncbi request reprint Ca2+-activated Cl- current reduces transmural electrical heterogeneity within the rabbit left ventricle
    A O Verkerk
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Acta Physiol Scand 180:239-47. 2004
    ..The role of anionic membrane channels is less intensively studied. We investigated the role of the Ca2+-activated Cl- current, ICl(Ca), in transmural electrical heterogeneity...
  25. ncbi request reprint Gender disparities in cardiac cellular electrophysiology and arrhythmia susceptibility in human failing ventricular myocytes
    Arie O Verkerk
    Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Int Heart J 46:1105-18. 2005
    ..These gender disparities may be due to slightly larger depolarizing I(Ca,L) in conjunction with slightly smaller repolarizing I(QSS) and I(to1) in female myocytes...
  26. ncbi request reprint Incorporated sarcolemmal fish oil fatty acids shorten pig ventricular action potentials
    Arie O Verkerk
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, The Netherlands
    Cardiovasc Res 70:509-20. 2006
    ..Acutely administered omega3-PUFAs modulate the activity of several cardiac ion channels, but the chronic effects of a diet enriched with fish oil leading to omega3-PUFA-incorporation into the sarcolemma on membrane currents are unknown...
  27. ncbi request reprint Novel Brugada syndrome-causing mutation in ion-conducting pore of cardiac Na+ channel does not affect ion selectivity properties
    A S Amin
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Acta Physiol Scand 185:291-301. 2005
    ..Since the mutation is located in a segment of the ion-conducting pore of the cardiac Na+ channel, which putatively determines ion selectivity, it may affect ion selectivity properties...
  28. ncbi request reprint Computational model of rabbit SA node pacemaker activity probed with action potential and calcium transient clamp
    Marcel M J van Borren
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Conf Proc IEEE Eng Med Biol Soc 2007:156-9. 2007
    ..Also, differences between the recorded and the computed net membrane current may prove helpful in identifying shortcomings of the computational model...
  29. ncbi request reprint Single cells isolated from human sinoatrial node: action potentials and numerical reconstruction of pacemaker current
    Arie O Verkerk
    Department of Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
    Conf Proc IEEE Eng Med Biol Soc 2007:904-7. 2007
    ..We conclude that human sinoatrial node pacemaker cells functionally express If and that this If contributes to pacemaking in human sinoatrial node...
  30. ncbi request reprint Conduction slowing by the gap junctional uncoupler carbenoxolone
    Joris R De Groot
    Academic Medical Center, Task Force Heart Failure and Ageing, Department of Experimental Cardiology, Amsterdam, The Netherlands
    Cardiovasc Res 60:288-97. 2003
    ..Known cellular uncoupling agents have severe side effects on membrane ionic currents. We investigated the effect of carbenoxolone on cellular electrical coupling, membrane ionic currents, and atrial and ventricular conduction...
  31. ncbi request reprint Effects of heart failure on brain-type Na+ channels in rabbit ventricular myocytes
    Arie O Verkerk
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Europace 9:571-7. 2007
    ..Heart failure (HF) alters pacemaker activity and excitation-contraction coupling. Here, we studied whether HF alters brain-type Na(+) channel properties...
  32. pmc Effects of muscarinic receptor stimulation on Ca2+ transient, cAMP production and pacemaker frequency of rabbit sinoatrial node cells
    Marcel M G J van Borren
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Basic Res Cardiol 105:73-87. 2010
    ..Thus, we provide functional evidence for the contribution of the Ca (i) (2+) transient to ACh-induced inhibition of pacemaker activity and cAMP content in rabbit SAN cells...
  33. doi request reprint Genetically determined differences in sodium current characteristics modulate conduction disease severity in mice with cardiac sodium channelopathy
    Carol Ann Remme
    Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Room K2 110, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Circ Res 104:1283-92. 2009
    ..In particular, the sodium channel subunit beta4 (SCN4B) may constitute a potential genetic modifier of conduction and cardiac sodium channel disease...
  34. ncbi request reprint Genetic control of sodium channel function
    Hanno L Tan
    Experimental and Molecular Cardiology Group, Department of Cardiology, Academic Medical Center, Room M0 052, P O Box 22700, 1100 DE, Amsterdam, The Netherlands
    Cardiovasc Res 57:961-73. 2003
    ....
  35. doi request reprint Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch
    Mark G Hoogendijk
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 7:238-48. 2010
    ..The Brugada sign has been associated with mutations in SCN5A and with right ventricular structural abnormalities. Their role in the Brugada sign and the associated ventricular arrhythmias is unknown...
  36. doi request reprint Engineering physiologically controlled pacemaker cells with lentiviral HCN4 gene transfer
    Gerard J J Boink
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Gene Med 10:487-97. 2008
    ....
  37. ncbi request reprint A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization
    Connie R Bezzina
    Experimental and Molecular Cardiology Group, Room M0 052, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 59:27-36. 2003
    ....
  38. ncbi request reprint Intrinsic heterogeneity in repolarization is increased in isolated failing rabbit cardiomyocytes during simulated ischemia
    Joris R De Groot
    Experimental and Molecular Cardiology Group, Academic Medical Center, Meibergdreef 9, Room M0 54, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 59:705-14. 2003
    ..We hypothesized that intrinsic heterogeneity in action potential duration (APD) or the occurrence of rigor is larger in failing than in normal rabbit myocytes during SI...
  39. pmc HERG channel (dys)function revealed by dynamic action potential clamp technique
    Géza Berecki
    Experimental and Molecular Cardiology Group and the Department of Physiology, Academic Medical Center, University of Amsterdam, The Netherlands
    Biophys J 88:566-78. 2005
    ..This novel electrophysiological technique allows rapid and unambiguous determination of the effects of an ion channel mutation on the ventricular action potential and can serve as a new tool for investigating cardiac channelopathies...
  40. pmc Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique
    Géza Berecki
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, The Netherlands
    J Physiol 570:237-50. 2006
    ..For both mutants, a 2 s pause following rapid (2 Hz) pacing resulted in distorted AP morphology and beat-to-beat fluctuations of I(Na). Our dAPC data directly demonstrate the arrhythmogenic nature of LQT3-associated SCN5A mutations...
  41. ncbi request reprint Reduced swelling-activated Cl(-) current densities in hypertrophied ventricular myocytes of rabbits with heart failure
    Marcel M G J van Borren
    Department of Physiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 53:869-78. 2002
    ..Hypertrophied myocytes of failing hearts have prolonged action potential durations. It is unknown how the swelling-activated Cl(-) current (I(Cl,swell)) affects the abnormal AP configuration...
  42. ncbi request reprint Larger cell size in rabbits with heart failure increases myocardial conduction velocity and QRS duration
    Rob F Wiegerinck
    Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 113:806-13. 2006
    ..We investigated the relationship between QRS width, heart size, intercellular coupling, and CV in a rabbit model of moderate HF and in computer simulations...
  43. ncbi request reprint Pro- and antiarrhythmic properties of a diet rich in fish oil
    Hester M den Ruijter
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Cardiovasc Res 73:316-25. 2007
    ..Advice to increase intake of omega3-PUFA supplements or fatty fish should be tailored to individual patients with respect to the arrhythmogenic mechanisms associated with the underlying pathology...
  44. ncbi request reprint Dietary fish oil reduces the occurrence of early afterdepolarizations in pig ventricular myocytes
    Hester M den Ruijter
    Department of Clinical and Experimental Cardiology, Experimental and Molecular Cardiology Groups, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Mol Cell Cardiol 41:914-7. 2006
    ..A diet rich in fish oil protects against EAD formation...
  45. ncbi request reprint Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD
    Carol Ann Remme
    Department of Cardiology, Academic Medical Center, Room K2 110, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Circulation 114:2584-94. 2006
    ..We investigated the electrophysiological characteristics of a transgenic model of the murine equivalent mutation 1798insD...
  46. doi request reprint Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failure
    Hester M den Ruijter
    Department of Experimental Cardiology, Center for Heart Failure Research, Academic Medical Center, Room K2 113, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Circulation 117:536-44. 2008
    ..We hypothesized that superfusion with omega3-polyunsaturated fatty acids (omega3-PUFAs) from fish inhibits triggered activity in heart failure...
  47. ncbi request reprint Dietary fish oil reduces the incidence of triggered arrhythmias in pig ventricular myocytes
    Géza Berecki
    Experimental Cardiology Group ECG, Center for Heart Failure Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Heart Rhythm 4:1452-60. 2007
    ..Fish oil reduces the incidence of sudden cardiac death in postmyocardial infarction patients. Triggered activity is the principal mechanism of arrhythmogenesis under these conditions...
  48. pmc Fever-triggered ventricular arrhythmias in Brugada syndrome and type 2 long-QT syndrome
    A S Amin
    Heart Failure Research Centre, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neth Heart J 18:165-9. 2010
    ..Finally, we describe molecular mechanisms that may underlie the proarrhythmic effects of fever in BrS and LQT-2. (Neth Heart J 2010;18:165-9.)...
  49. ncbi request reprint Pacemaker current (I(f)) in the human sinoatrial node
    Arie O Verkerk
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Eur Heart J 28:2472-8. 2007
    ..I(f) is becoming a novel therapy target to modulate heart rate. Yet, no studies have demonstrated that I(f) is functionally present and contributes to pacemaking in human SAN. We aimed to study I(f) properties in human SAN...
  50. pmc Gender disparities in torsade de pointes ventricular tachycardia
    A O Verkerk
    Department of Physiology, Heart Failure Research Centre, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Neth Heart J 15:405-11. 2007
    ..Gender disparities in the incidence of torsade de pointes (TdP) ventricular tachycardia exist, but the mechanisms in humans are unresolved. We addressed this issue using a mathematical model of a human ventricular cell...
  51. ncbi request reprint Right ventricular fibrosis and conduction delay in a patient with clinical signs of Brugada syndrome: a combined electrophysiological, genetic, histopathologic, and computational study
    Ruben Coronel
    Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Circulation 112:2769-77. 2005
    ..The mechanism of ECG changes and arrhythmogenesis in Brugada syndrome (BS) patients is unknown...
  52. doi request reprint Gene expression profiling of the forming atrioventricular node using a novel tbx3-based node-specific transgenic reporter
    Thomas Horsthuis
    Heart Failure Research Center, University of Amsterdam, The Netherlands
    Circ Res 105:61-9. 2009
    ....
  53. pmc Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria
    Willem M H Hoogaars
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Genes Dev 21:1098-112. 2007
    ..These data identify a Tbx3-dependent pathway for the specification and formation of the sinoatrial node, and show that Tbx3 regulates the pacemaker gene expression program and phenotype...