Jan Willem Muntjewerff
Affiliation: GGz Nijmegen
Country: The Netherlands
- Homocysteine metabolism and B-vitamins in schizophrenic patients: low plasma folate as a possible independent risk factor for schizophreniaJan Willem Muntjewerff
GGz Nijmegen, Mental Health Institute, P O Box 7049, 6503 GM Nijmegen, The Netherlands
Psychiatry Res 121:1-9. 2003..Evidence is presented suggesting that folate metabolism is disturbed in schizophrenic patients, independently of Hcy...
- Hyperhomocysteinemia, methylenetetrahydrofolate reductase 677TT genotype, and the risk for schizophrenia: a Dutch population based case-control studyJan Willem Muntjewerff
GGz Nijmegen, Mental Health Institute, Nijmegen, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 135:69-72. 2005..91-1.8]. Elevated homocysteine levels and the MTHFR 677TT genotype are associated with an increased risk for schizophrenia. These observations support a causal relation between disturbed homocysteine metabolism and schizophrenia...
- Aberrant folate status in schizophrenic patients: what is the evidence?Jan Willem Muntjewerff
GGz Nijmegen, Mental Health Institute Nijmegen, P O Box 7049, 6503 GM Nijmegen, The Netherlands
Prog Neuropsychopharmacol Biol Psychiatry 29:1133-9. 2005..In addition, research should also focus on polymorphisms of genes related to folate metabolism...
- Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysisJ W Muntjewerff
GGz Nijmegen, Mental Health Institute Nijmegen, Nijmegen, and Department of Psychiatry, University Medical Center, Utrecht, The Netherlands
Mol Psychiatry 11:143-9. 2006..The elevated risk of schizophrenia associated with the homozygous genotype of the MTHFR 677C>T polymorphism provides support for causality between a disturbed homocysteine metabolism and risk of schizophrenia...
- No evidence for a preferential transmission of the methylenetetrahydrofolate reductase 677T allele in families with schizophrenia offspringJan Willem Muntjewerff
GGz Nijmegen, Mental Health Institute, 6503 GM Nijmegen, The Netherlands
Am J Med Genet B Neuropsychiatr Genet 144:891-4. 2007..In addition, we found no evidence that the maternal genotype influences the risk of having schizophrenia offspring substantially...
- Polymorphisms in catechol-O-methyltransferase and methylenetetrahydrofolate reductase in relation to the risk of schizophreniaJan Willem Muntjewerff
GGz Nijmegen, Mental Health Institute, PO Box 7049, 6503 GM Nijmegen, The Netherlands
Eur Neuropsychopharmacol 18:99-106. 2008..Evidence is emerging for the association of aberrant homocysteine-methylation cycle and increased risk of schizophrenia...
- Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis riskHenkjan Gellekink
Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Thromb Haemost 98:1226-31. 2007..61 [95% CI 0.97 to 2.65], p = 0.06) compared to control subjects. We show that the COMT rs4680 variant modulates tHcy, and might be associated with venous thrombosis risk as well...
- Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patientsJacobine E Buizer-Voskamp
Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
Biol Psychiatry 70:655-62. 2011....