T Mebatsion

Summary

Affiliation: Intervet International BV
Country: The Netherlands

Publications

  1. pmc A recombinant newcastle disease virus with low-level V protein expression is immunogenic and lacks pathogenicity for chicken embryos
    T Mebatsion
    Department of Virology, Intervet International B V, 5830 AA Boxmeer, The Netherlands
    J Virol 75:420-8. 2001
  2. pmc Extensive attenuation of rabies virus by simultaneously modifying the dynein light chain binding site in the P protein and replacing Arg333 in the G protein
    T Mebatsion
    Department of Virology, Intervet International B V, 5830 AA Boxmeer, The Netherlands
    J Virol 75:11496-502. 2001
  3. pmc Newcastle disease virus (NDV) marker vaccine: an immunodominant epitope on the nucleoprotein gene of NDV can be deleted or replaced by a foreign epitope
    Teshome Mebatsion
    Department of Virology, Intervet International B V, PO Box 31, 5830 AA Boxmeer, The Netherlands
    J Virol 76:10138-46. 2002
  4. pmc Identification of a mutation in editing of defective Newcastle disease virus recombinants that modulates P-gene mRNA editing and restores virus replication and pathogenicity in chicken embryos
    Teshome Mebatsion
    Department of Virology, Intervet International B V, 5830 AA Boxmeer, The Netherlands
    J Virol 77:9259-65. 2003
  5. ncbi request reprint The isolation and characterisation of astroviruses from chickens
    William Baxendale
    Intervet UK Ltd, The Elms, Thicket Road, Houghton, Huntingdon, Cambs PE28 2BQ, UK
    Avian Pathol 33:364-70. 2004
  6. ncbi request reprint Comparative pathogenesis of the SAD-L16 strain of rabies virus and a mutant modifying the dynein light chain binding site of the rabies virus phosphoprotein in young mice
    Pamini Rasalingam
    Department of Microbiology and Immunology, Queen s University, Kingston, Ont, Canada
    Virus Res 111:55-60. 2005
  7. pmc Newcastle disease virus expressing H5 hemagglutinin gene protects chickens against Newcastle disease and avian influenza
    Jutta Veits
    Institute of Molecular Biology, Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Boddenblick 5a, D 17493 Greifswald Insel Riems, Germany
    Proc Natl Acad Sci U S A 103:8197-202. 2006
  8. ncbi request reprint Characterization of a recombinant Newcastle disease virus expressing the green fluorescent protein
    Ines Engel-Herbert
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, D 17498, Insel Riems, Germany
    J Virol Methods 108:19-28. 2003
  9. ncbi request reprint Contribution of the length of the HN protein and the sequence of the F protein cleavage site to Newcastle disease virus pathogenicity
    Angela Römer-Oberdörfer
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, D 17493 Greifswald Insel Riems, Germany
    J Gen Virol 84:3121-9. 2003

Collaborators

Detail Information

Publications9

  1. pmc A recombinant newcastle disease virus with low-level V protein expression is immunogenic and lacks pathogenicity for chicken embryos
    T Mebatsion
    Department of Virology, Intervet International B V, 5830 AA Boxmeer, The Netherlands
    J Virol 75:420-8. 2001
    ..Hatched chickens developed high levels of NDV-specific antibodies and were fully protected against lethal challenge, demonstrating the potential use of editing-defective recombinant NDV as a safe embryo vaccine...
  2. pmc Extensive attenuation of rabies virus by simultaneously modifying the dynein light chain binding site in the P protein and replacing Arg333 in the G protein
    T Mebatsion
    Department of Virology, Intervet International B V, 5830 AA Boxmeer, The Netherlands
    J Virol 75:11496-502. 2001
    ..These results demonstrate that elimination of the LC8 ligand and simultaneous substitution of R333 considerably attenuate RV pathogenicity and may be helpful in designing and developing highly safe live-RV-based vaccines...
  3. pmc Newcastle disease virus (NDV) marker vaccine: an immunodominant epitope on the nucleoprotein gene of NDV can be deleted or replaced by a foreign epitope
    Teshome Mebatsion
    Department of Virology, Intervet International B V, PO Box 31, 5830 AA Boxmeer, The Netherlands
    J Virol 76:10138-46. 2002
    ..The identification of a mutation-permissive region on the NP gene allows a rational approach to the insertion of protective epitopes and may be relevant for the design of NDV-based cross-protective marker vaccines...
  4. pmc Identification of a mutation in editing of defective Newcastle disease virus recombinants that modulates P-gene mRNA editing and restores virus replication and pathogenicity in chicken embryos
    Teshome Mebatsion
    Department of Virology, Intervet International B V, 5830 AA Boxmeer, The Netherlands
    J Virol 77:9259-65. 2003
    ..The results indicate that this second-site mutation is required to compensate for the drop in edited mRNAs and consequently to restore the replication capacity, as well as the pathogenic potential, of editing-defective NDV recombinants...
  5. ncbi request reprint The isolation and characterisation of astroviruses from chickens
    William Baxendale
    Intervet UK Ltd, The Elms, Thicket Road, Houghton, Huntingdon, Cambs PE28 2BQ, UK
    Avian Pathol 33:364-70. 2004
    ..Taken together, the results indicate that the agent is a new chicken astrovirus belonging to the family Astroviridae...
  6. ncbi request reprint Comparative pathogenesis of the SAD-L16 strain of rabies virus and a mutant modifying the dynein light chain binding site of the rabies virus phosphoprotein in young mice
    Pamini Rasalingam
    Department of Microbiology and Immunology, Queen s University, Kingston, Ont, Canada
    Virus Res 111:55-60. 2005
    ..The precise role of the rabies virus P-dynein interaction in the axonal transport of rabies virus, particularly the importance of this interaction during natural infection, merits further study...
  7. pmc Newcastle disease virus expressing H5 hemagglutinin gene protects chickens against Newcastle disease and avian influenza
    Jutta Veits
    Institute of Molecular Biology, Friedrich Loeffler Institut, Federal Research Institute for Animal Health, Boddenblick 5a, D 17493 Greifswald Insel Riems, Germany
    Proc Natl Acad Sci U S A 103:8197-202. 2006
    ..Therefore, recombinant NDVH5m is suitable as a bivalent vaccine against NDV and AIV and may be used as marker vaccine for the control of avian influenza...
  8. ncbi request reprint Characterization of a recombinant Newcastle disease virus expressing the green fluorescent protein
    Ines Engel-Herbert
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, D 17498, Insel Riems, Germany
    J Virol Methods 108:19-28. 2003
    ..Taken together, these data demonstrate the use of GFP-expressing recombinant NDV for analysis of NDV dissemination and pathogenesis and indicate the potential usefulness of NDV as a vaccine vector...
  9. ncbi request reprint Contribution of the length of the HN protein and the sequence of the F protein cleavage site to Newcastle disease virus pathogenicity
    Angela Römer-Oberdörfer
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, D 17493 Greifswald Insel Riems, Germany
    J Gen Virol 84:3121-9. 2003
    ..5 and suggests the involvement of additional virulence determinants that contribute to the pathogenicity of NDV...