A H V Remels

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi request reprint Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD
    A H Remels
    Department of Respiratory Medicine, University of Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 30:245-52. 2007
  2. doi request reprint Peroxisome proliferator-activated receptors: a therapeutic target in COPD?
    A H Remels
    Dept of Respiratory Medicine, University of Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 31:502-8. 2008
  3. doi request reprint PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle
    A H V Remels
    Department of Respiratory Medicine, Maastricht University, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 297:E174-83. 2009
  4. doi request reprint Regulation of mitochondrial biogenesis during myogenesis
    A H V Remels
    Department of Respiratory Medicine, Maastricht University Medical Centre, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Mol Cell Endocrinol 315:113-20. 2010
  5. doi request reprint Activation of alternative NF-κB signaling during recovery of disuse-induced loss of muscle oxidative phenotype
    A H V Remels
    NUTRIM School for Nutrition, Toxicology, and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 306:E615-26. 2014
  6. doi request reprint Classical NF-κB activation impairs skeletal muscle oxidative phenotype by reducing IKK-α expression
    A H V Remels
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands Electronic address
    Biochim Biophys Acta 1842:175-85. 2014
  7. doi request reprint Regulation of skeletal muscle oxidative phenotype by classical NF-κB signalling
    A H V Remels
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    Biochim Biophys Acta 1832:1313-25. 2013
  8. doi request reprint The mechanisms of cachexia underlying muscle dysfunction in COPD
    A H V Remels
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Appl Physiol (1985) 114:1253-62. 2013
  9. doi request reprint TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia?
    A H V Remels
    Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    FASEB J 24:5052-62. 2010
  10. doi request reprint TNF-α-Induced NF-κB Activation Stimulates Skeletal Muscle Glycolytic Metabolism Through Activation of HIF-1α
    A H V Remels
    NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands
    Endocrinology 156:1770-81. 2015

Detail Information

Publications11

  1. ncbi request reprint Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD
    A H Remels
    Department of Respiratory Medicine, University of Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 30:245-52. 2007
    ..Therefore, a disturbed expression of these regulatory factors may well underlie the disturbed skeletal muscle functioning in chronic obstructive pulmonary disease...
  2. doi request reprint Peroxisome proliferator-activated receptors: a therapeutic target in COPD?
    A H Remels
    Dept of Respiratory Medicine, University of Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 31:502-8. 2008
    ..Proposed mechanisms will be outlined in the present article, as well as the therapeutic potential of peroxisome proliferator-activated receptor modulation in the treatment of skeletal muscle dysfunction...
  3. doi request reprint PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle
    A H V Remels
    Department of Respiratory Medicine, Maastricht University, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 297:E174-83. 2009
    ..These findings demonstrate that muscle-specific inhibition of NF-kappaB activation may be an interesting therapeutic avenue for treatment of several inflammation-associated skeletal muscle abnormalities...
  4. doi request reprint Regulation of mitochondrial biogenesis during myogenesis
    A H V Remels
    Department of Respiratory Medicine, Maastricht University Medical Centre, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Mol Cell Endocrinol 315:113-20. 2010
    ..In particular, PGC-1alpha and PPAR-alpha may be involved in the regulation of mitochondrial biogenesis during myogenesis...
  5. doi request reprint Activation of alternative NF-κB signaling during recovery of disuse-induced loss of muscle oxidative phenotype
    A H V Remels
    NUTRIM School for Nutrition, Toxicology, and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 306:E615-26. 2014
    ..We conclude that RL-induced recovery of muscle OXPHEN is associated with activation of alternative NF-κB signaling. ..
  6. doi request reprint Classical NF-κB activation impairs skeletal muscle oxidative phenotype by reducing IKK-α expression
    A H V Remels
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands Electronic address
    Biochim Biophys Acta 1842:175-85. 2014
    ..We hypothesised that inflammation-induced classical NF-κB activation contributes to loss of muscle OXPHEN in COPD by reducing IKK-α expression...
  7. doi request reprint Regulation of skeletal muscle oxidative phenotype by classical NF-κB signalling
    A H V Remels
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    Biochim Biophys Acta 1832:1313-25. 2013
    ..Therefore, we hypothesised that muscle activation of classical NF-κB signalling is sufficient and required for inflammation-induced impairment of muscle OXPHEN...
  8. doi request reprint The mechanisms of cachexia underlying muscle dysfunction in COPD
    A H V Remels
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Appl Physiol (1985) 114:1253-62. 2013
    ..Furthermore, loss of peripheral muscle oxidative phenotype may increase the muscle's susceptibility to inflammation- and oxidative stress-induced muscle damage and wasting...
  9. doi request reprint TNF-alpha impairs regulation of muscle oxidative phenotype: implications for cachexia?
    A H V Remels
    Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
    FASEB J 24:5052-62. 2010
    ..In conclusion, these results demonstrate that TNF-α impairs muscle oxphen in a NF-κB-dependent manner...
  10. doi request reprint TNF-α-Induced NF-κB Activation Stimulates Skeletal Muscle Glycolytic Metabolism Through Activation of HIF-1α
    A H V Remels
    NUTRIM School of Nutrition and Translational Research in Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, 6202 AZ Maastricht, The Netherlands
    Endocrinology 156:1770-81. 2015
    ..In conclusion, these data show that TNF-α-induced classical NF-κB activation enhances muscle glycolytic metabolism in a HIF-1α-dependent manner. ..
  11. doi request reprint Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease
    R C J Langen
    NUTRIM School for Nutrition, Toxicology and Metabolism, Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands
    Int J Biochem Cell Biol 45:2245-56. 2013
    ..This article is part of a Directed Issue entitled: Molecular basis of muscle wasting. ..