T A Ishunina

Summary

Affiliation: Netherlands Institute of Ecology
Country: The Netherlands

Publications

  1. doi request reprint Transcriptional activity of human brain estrogen receptor-α splice variants: evidence for cell type-specific regulation
    T A Ishunina
    Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    Brain Res 1500:1-9. 2013
  2. doi request reprint Estrogen receptor-alpha splice variants in the human brain
    Tatjana A Ishunina
    Department of Histology and Embryology, Kursk State Medical University, Kursk, Russia
    Gynecol Endocrinol 24:93-8. 2008
  3. ncbi request reprint Alterations in the human brain in menopause
    T A Ishunina
    Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Maturitas 57:20-2. 2007
  4. doi request reprint Decreased alternative splicing of estrogen receptor-α mRNA in the Alzheimer's disease brain
    Tatjana A Ishunina
    Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Neurobiol Aging 33:286-296.e3. 2012
  5. doi request reprint Hippocampal estrogen receptor-alpha splice variant TADDI in the human brain in aging and Alzheimer's disease
    T A Ishunina
    Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Neuroendocrinology 89:187-99. 2009
  6. ncbi request reprint Sex- and age-related P75 neurotrophin receptor expression in the human supraoptic nucleus
    T A Ishunina
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Neuroendocrinology 71:243-51. 2000
  7. ncbi request reprint Metabolic activity of the human ventromedial nucleus neurons in relation to sex and ageing
    T A Ishunina
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
    Brain Res 893:70-6. 2001
  8. ncbi request reprint Increased expression of estrogen receptor alpha and beta in the nucleus basalis of Meynert in Alzheimer's disease
    T A Ishunina
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
    Neurobiol Aging 22:417-26. 2001
  9. ncbi request reprint Structural and functional sex differences in the human hypothalamus
    D F Swaab
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, Amsterdam, 1105 AZ The Netherlands
    Horm Behav 40:93-8. 2001
  10. ncbi request reprint Estrogen receptor alpha and its splice variants in the hippocampus in aging and Alzheimer's disease
    Tatjana A Ishunina
    Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    Neurobiol Aging 28:1670-81. 2007

Detail Information

Publications22

  1. doi request reprint Transcriptional activity of human brain estrogen receptor-α splice variants: evidence for cell type-specific regulation
    T A Ishunina
    Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    Brain Res 1500:1-9. 2013
    ..Functional properties of various ERα splice variants and their cell type-specificity should, thus, be considered as potential confounders of estrogen therapy effects on the brain...
  2. doi request reprint Estrogen receptor-alpha splice variants in the human brain
    Tatjana A Ishunina
    Department of Histology and Embryology, Kursk State Medical University, Kursk, Russia
    Gynecol Endocrinol 24:93-8. 2008
    ..Finally, the level of alternatively spliced ERalpha may also change in AD in a brain area-specific manner and so affect the sensitivity to estrogen therapy...
  3. ncbi request reprint Alterations in the human brain in menopause
    T A Ishunina
    Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Maturitas 57:20-2. 2007
    ..No age-related changes were observed for the mentioned splice forms in women of this group...
  4. doi request reprint Decreased alternative splicing of estrogen receptor-α mRNA in the Alzheimer's disease brain
    Tatjana A Ishunina
    Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Neurobiol Aging 33:286-296.e3. 2012
    ..Our data show that alternative splicing of ERα mRNA is diminished in the AD brain and more prominently in AD female cases...
  5. doi request reprint Hippocampal estrogen receptor-alpha splice variant TADDI in the human brain in aging and Alzheimer's disease
    T A Ishunina
    Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Neuroendocrinology 89:187-99. 2009
    ..We addressed the question whether a novel ER alpha splice variant TADDI is expressed at the protein level in the human brain and whether it changes in relation to aging and Alzheimer's disease (AD)...
  6. ncbi request reprint Sex- and age-related P75 neurotrophin receptor expression in the human supraoptic nucleus
    T A Ishunina
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Neuroendocrinology 71:243-51. 2000
    ..Therefore, our results suggest that p75(NTR) is involved in postmenopausal activation of vasopressinergic neurons in the human SON...
  7. ncbi request reprint Metabolic activity of the human ventromedial nucleus neurons in relation to sex and ageing
    T A Ishunina
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
    Brain Res 893:70-6. 2001
    ..In addition, the GA/cell size ratio correlated significantly with age in men and not in women. Our data suggest that androgens play an inhibitory role with respect to the metabolic activity of the human VMN neurons...
  8. ncbi request reprint Increased expression of estrogen receptor alpha and beta in the nucleus basalis of Meynert in Alzheimer's disease
    T A Ishunina
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
    Neurobiol Aging 22:417-26. 2001
    ..The ApoE genotype had no effect on ER expression in the NBM in AD. In conclusion, whereas only minor sex- and age-related changes in both ERs were found in the human NBM, a clear upregulation of ERalpha and beta was observed in AD...
  9. ncbi request reprint Structural and functional sex differences in the human hypothalamus
    D F Swaab
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, Amsterdam, 1105 AZ The Netherlands
    Horm Behav 40:93-8. 2001
    ..In this brief article we discuss a few examples of structural and functional sex differences in the human brain...
  10. ncbi request reprint Estrogen receptor alpha and its splice variants in the hippocampus in aging and Alzheimer's disease
    Tatjana A Ishunina
    Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands
    Neurobiol Aging 28:1670-81. 2007
    ..4. A novel ERalpha isoform TADDI was isolated and sequenced from two female patients. It lacks 31 bp at the junction between exons 3 and 4 with an insertion of 13 nucleotides from the middle of the exon 2...
  11. ncbi request reprint Estrogen receptors and metabolic activity in the human tuberomamillary nucleus: changes in relation to sex, aging and Alzheimer's disease
    Tatjana A Ishunina
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
    Brain Res 988:84-96. 2003
    ..Concluding, the enhanced cytoplasmic expression of ERbeta in the TMN may be involved in the diminished neuronal metabolism of these neurons in AD patients...
  12. ncbi request reprint [Activity of vasopressin neurons in the human supraoptic nucleus: estrogen inhibitory effect]
    T A Ishunina
    Kursk State Medical University, Kursk, Russia
    Usp Fiziol Nauk 32:48-59. 2001
    ..In conclusion, we discuss the inhibitory role of estrogens in functional activity of human VP neurons, which is most probably mediated directly via ER beta and indirectly by p75 neurotrophin receptor...
  13. ncbi request reprint Changes in metabolic activity and estrogen receptors in the human medial mamillary nucleus: relation to sex, aging and Alzheimer's disease
    Tatjana A Ishunina
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
    Neurobiol Aging 24:817-28. 2003
    ..This inhibitory effect is diminished in postmenopausal women. The role of the enhanced nuclear ERalpha staining in AD, that was also found in other brain areas, remains to be elucidated...
  14. ncbi request reprint Age-dependent ERalpha MB1 splice variant expression in discrete areas of the human brain
    Tatjana A Ishunina
    Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA, Amsterdam, The Netherlands
    Neurobiol Aging 29:1177-89. 2008
    ..No significant changes of this variant were observed in the TMN of AD cases. In conclusion, MB1 may function as a dominant negative isoform in the human brain...
  15. ncbi request reprint Sex differences in androgen receptor immunoreactivity in basal forebrain nuclei of elderly and Alzheimer patients
    Tatjana A Ishunina
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Exp Neurol 176:122-32. 2002
    ..These observations suggest the possible involvement of androgens in the functional changes of the basal forebrain nuclei in aging and AD...
  16. ncbi request reprint Neurohypophyseal peptides in aging and Alzheimer's disease
    Tatjana A Ishunina
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
    Ageing Res Rev 1:537-58. 2002
    ..e. Alzheimer's disease (AD). For those reasons, we will discuss the SON, PVN and SCN separately...
  17. ncbi request reprint Increased neuronal metabolic activity and estrogen receptors in the vertical limb of the diagonal band of Broca in Alzheimer's disease: relation to sex and aging
    Tatjana A Ishunina
    Netherlands Institute for Brain Research, Amsterdam, The Netherlands
    Exp Neurol 183:159-72. 2003
    ..So neither global degeneration or a strongly decreased neuronal metabolism nor a lack of sex hormone receptors in the VDB seems to contribute to the decline in cognition in aging or AD in which the hippocampus plays such a crucial role...
  18. ncbi request reprint Diminished aromatase immunoreactivity in the hypothalamus, but not in the basal forebrain nuclei in Alzheimer's disease
    Tatjana A Ishunina
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Neurobiol Aging 26:173-94. 2005
    ..In conclusion, brain P-450arom-ir and the relationship of its regulation with plasma sex steroid levels, estrogen and androgen receptors in the human hypothalamus and basal forebrain are region-specific...
  19. ncbi request reprint Sex differences in estrogen receptor alpha and beta expression in vasopressin neurons of the supraoptic nucleus in elderly and Alzheimer's disease patients: no relationship with cytoskeletal alterations
    Tatjana A Ishunina
    Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Brain Res 951:322-9. 2002
    ..This indicates that a rise of nuclear ERs is not a generally occurring phenomenon but rather related to the pathogenetic alterations of the AD process...
  20. ncbi request reprint Estrogen receptor-alpha splice variants in the medial mamillary nucleus of Alzheimer's disease patients: identification of a novel MB1 isoform
    Tatjana A Ishunina
    Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands
    J Clin Endocrinol Metab 90:3757-65. 2005
    ....
  21. ncbi request reprint Metabolic alterations in the hypothalamus and basal forebrain in vascular dementia
    Tatjana A Ishunina
    Netherlands Institute for Brain Research, Amsterdam
    J Neuropathol Exp Neurol 63:1243-54. 2004
    ..In the present study we thus found decreased metabolic activity in several hypothalamic nuclei in VD indicating diminished production of certain hormones and neurotransmitters...
  22. ncbi request reprint Sexual differentiation of the human hypothalamus
    Dick F Swaab
    Graduate School Neurosciences Amsterdam, Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
    Adv Exp Med Biol 511:75-100; discussion 100-5. 2002
    ....