Thierry Claudel

Summary

Affiliation: University of Groningen
Country: The Netherlands

Publications

  1. ncbi The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism
    Thierry Claudel
    Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Arterioscler Thromb Vasc Biol 25:2020-30. 2005
  2. ncbi The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism
    Folkert Kuipers
    Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, Academic Hospital, Groningen, The Netherlands
    Rev Endocr Metab Disord 5:319-26. 2004
  3. pmc Plasma bile acids are not associated with energy metabolism in humans
    Gemma Brufau
    Dept, of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
    Nutr Metab (Lond) 7:73. 2010
  4. ncbi Crosstalk between xenobiotics metabolism and circadian clock
    Thierry Claudel
    Department of Pediatrics, Research Laboratory, University Medical Center Groningen, Groningen, ND 9700 RB, The Netherlands
    FEBS Lett 581:3626-33. 2007
  5. ncbi The farnesoid X receptor: a novel drug target?
    Thierry Claudel
    Unité de Recherche 545, Institut National de la Sante et de la Recherche Medicale, Departement d Atherosclerose, Institut Pasteur de Lille and the Faculté de Pharmacie, Universite de Lille II, Lille, France
    Expert Opin Investig Drugs 13:1135-48. 2004
  6. ncbi The farnesoid X receptor induces very low density lipoprotein receptor gene expression
    Audrey Sirvent
    GENFIT, Parc Eurasante, Loos, France
    FEBS Lett 566:173-7. 2004
  7. ncbi Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression
    Thierry Claudel
    UR545 INSERM, Departement d Atherosclerose, Institut Pasteur de Lille, Lille, France
    Gastroenterology 125:544-55. 2003
  8. ncbi FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity
    Olivier Barbier
    U545 INSERM, Department of Atherosclerosis, Faculty of Pharmacy, Lille Pasteur Institute and University of Lille II, 1 rue du Pr Calmette, BP 245, 59019 Lille, France
    Gastroenterology 124:1926-40. 2003
  9. ncbi Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor
    Ines Pineda Torra
    U 545 Institut National de la Santé et de la Recherche Médicale, Departement d Atherosclerose, Institut Pasteur de Lille, 59019 Lille, France
    Mol Endocrinol 17:259-72. 2003
  10. pmc Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element
    Thierry Claudel
    Unité de Recherche 545, Institut National de la Sante et de la Recherche Medicale, Departement d Atherosclerose, Institut Pasteur de Lille, and the Faculté de Pharmacie, Universite de Lille II, Lille, France
    J Clin Invest 109:961-71. 2002

Collaborators

Detail Information

Publications11

  1. ncbi The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism
    Thierry Claudel
    Center for Liver, Digestive, and Metabolic Diseases, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Arterioscler Thromb Vasc Biol 25:2020-30. 2005
    ..This review summarizes recent advances in deciphering the role of FXR in the context of hepatic lipid and glucose homeostasis and discusses the potential of FXR as a pharmacological target for therapeutic applications...
  2. ncbi The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism
    Folkert Kuipers
    Center for Liver, Digestive and Metabolic Diseases, Laboratory of Pediatrics, Academic Hospital, Groningen, The Netherlands
    Rev Endocr Metab Disord 5:319-26. 2004
  3. pmc Plasma bile acids are not associated with energy metabolism in humans
    Gemma Brufau
    Dept, of Pediatrics, Center for Liver, Digestive and Metabolic Diseases, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
    Nutr Metab (Lond) 7:73. 2010
    ..Therefore, our data do not support an important role of circulating BA in the control of human energy metabolism...
  4. ncbi Crosstalk between xenobiotics metabolism and circadian clock
    Thierry Claudel
    Department of Pediatrics, Research Laboratory, University Medical Center Groningen, Groningen, ND 9700 RB, The Netherlands
    FEBS Lett 581:3626-33. 2007
    ..As food seems to be the major regulator of peripheral clock, the possibility that food-contained toxic compounds participate in the entrainment of the clock will be discussed...
  5. ncbi The farnesoid X receptor: a novel drug target?
    Thierry Claudel
    Unité de Recherche 545, Institut National de la Sante et de la Recherche Medicale, Departement d Atherosclerose, Institut Pasteur de Lille and the Faculté de Pharmacie, Universite de Lille II, Lille, France
    Expert Opin Investig Drugs 13:1135-48. 2004
    ..However, for therapeutic purposes the development of selective FXR modulators, which only activate or inhibit specific FXR target genes and as such induce specific responses, will be required...
  6. ncbi The farnesoid X receptor induces very low density lipoprotein receptor gene expression
    Audrey Sirvent
    GENFIT, Parc Eurasante, Loos, France
    FEBS Lett 566:173-7. 2004
    ....
  7. ncbi Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression
    Thierry Claudel
    UR545 INSERM, Departement d Atherosclerose, Institut Pasteur de Lille, Lille, France
    Gastroenterology 125:544-55. 2003
    ..Apolipoprotein CIII (Apo CIII) is a determinant of serum triglyceride metabolism. In this study, we investigated whether activators of the nuclear farnesoid X receptor (FXR) modulate Apo CIII gene expression...
  8. ncbi FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity
    Olivier Barbier
    U545 INSERM, Department of Atherosclerosis, Faculty of Pharmacy, Lille Pasteur Institute and University of Lille II, 1 rue du Pr Calmette, BP 245, 59019 Lille, France
    Gastroenterology 124:1926-40. 2003
    ..The human uridine 5'-diphosphate-glucuronosyltransferase 2B4 (UGT2B4) converts hydrophobic bile acids into more hydrophilic glucuronide derivatives. In this study, we identify UGT2B4 as an FXR target gene...
  9. ncbi Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor
    Ines Pineda Torra
    U 545 Institut National de la Santé et de la Recherche Médicale, Departement d Atherosclerose, Institut Pasteur de Lille, 59019 Lille, France
    Mol Endocrinol 17:259-72. 2003
    ..These results provide molecular evidence for a cross-talk between the FXR and PPARalpha pathways in humans...
  10. pmc Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element
    Thierry Claudel
    Unité de Recherche 545, Institut National de la Sante et de la Recherche Medicale, Departement d Atherosclerose, Institut Pasteur de Lille, and the Faculté de Pharmacie, Universite de Lille II, Lille, France
    J Clin Invest 109:961-71. 2002
    ..FXR bound this site and repressed transcription in a manner independent of retinoid X receptor. The nonsteroidal synthetic FXR agonist GW4064 likewise decreased apoA-I mRNA levels and promoter activity in HepG2 cells...
  11. ncbi High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia
    Atsushi Nohara
    Department of Lipidology, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa 920 8641, Japan
    Arterioscler Thromb Vasc Biol 27:923-8. 2007
    ..Because several nuclear receptors play pivotal roles in lipid metabolism, we tested the hypothesis that genetic variants of nuclear receptors contribute to FCHL...