Ayhan Bilir

Summary

Affiliation: Istanbul University Istanbul Faculty of Medicine
Location: Istanbul, Turkey
Summary:
Histology, Embryology, Cell and Tissue culture, Signal Transduction, Autophagy
Publications:
please write bilir a you can find approximately 65 articles

Publications

  1. doi request reprint Enhancement of vinorelbine-induced cytotoxicity and apoptosis by clomipramine and lithium chloride in human neuroblastoma cancer cell line SH-SY5Y
    Ayhan Bilir
    Department of Histology and Embryology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
    J Neurooncol 100:385-95. 2010
  2. pmc Decreased therapeutic effects of noscapine combined with imatinib mesylate on human glioblastoma in vitro and the effect of midkine
    Mine Erguven
    Yeni Yüzyıl University, Faculty of Medicine, Department of Biochemistry, Istanbul, Turkey
    Cancer Cell Int 11:18. 2011
  3. ncbi request reprint Carvedilol in glioma treatment alone and with imatinib in vitro
    Mine Erguven
    Department of Biochemistry, Istanbul University, Istanbul Faculty of Medicine, Istanbul 34093, Turkey
    Int J Oncol 36:857-66. 2010
  4. ncbi request reprint Medroxyprogesterone acetate alone or synergistic with chemotherapy suppresses colony formation and DNA synthesis in C6 glioma in vitro
    M A Altinoz
    Histology and Embryology Department, Istanbul Medical School, 34390, Istanbul, Turkey
    Int J Dev Neurosci 19:541-7. 2001
  5. ncbi request reprint Biological considerations in locally advanced breast cancer treated with anthracycline-based neoadjuvant chemotherapy: thymidine labelling index is an independent indicator of clinical outcome
    V Ozmen
    Department of Surgery, Istanbul Medical Faculty, University of Istanbul, Turkey
    Breast Cancer Res Treat 68:147-57. 2001
  6. ncbi request reprint Inflammatory breast cancer: results of antracycline-based neoadjuvant chemotherapy
    Vahit Ozmen
    Department of General Surgery, Istanbul Faculty of Medicine, University of Istanbul, Istanbul, Turkey
    Breast J 9:79-85. 2003
  7. ncbi request reprint Medroxyprogesterone and tamoxifen augment anti-proliferative efficacy and reduce mitochondria-toxicity of epirubicin in FM3A tumor cells in vitro
    Meric A Altinoz
    Medical Biology and Genetics, Halic University, Institute of Health Halic Universitesi Merkez, Kampus Mecidiyekoy, Buyukdere Istanbul, Turkey, 34394 Istanbul, Turkey
    Cell Biol Int 31:473-81. 2007
  8. ncbi request reprint The inhibitory effect of suramin on telomerase activity and spheroid growth of C6 glioma cells
    Mine Erguven
    Department of Biochemistry, Istanbul University, Faculty of Pharmacy, Istanbul, Turkey
    Med Sci Monit 14:BR165-73. 2008
  9. ncbi request reprint Thymidine labeling index in epithelial ovarian cancer
    Y Salihoglu
    Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul, Turkey
    Int J Gynaecol Obstet 75:171-6. 2001
  10. doi request reprint The effects of tibolone on the human primary glioblastoma multiforme cell culture and the rat C6 glioma model
    Meric A Altinoz
    Istanbul University, Istanbul, Turkey
    Neurol Res 31:923-7. 2009

Collaborators

Detail Information

Publications30

  1. doi request reprint Enhancement of vinorelbine-induced cytotoxicity and apoptosis by clomipramine and lithium chloride in human neuroblastoma cancer cell line SH-SY5Y
    Ayhan Bilir
    Department of Histology and Embryology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
    J Neurooncol 100:385-95. 2010
    ..Both CIM and LiCl seemed to potentiate VNR-induced cytotoxicity, and MK was not a resistance factor for VNR, LiCl, and CIM...
  2. pmc Decreased therapeutic effects of noscapine combined with imatinib mesylate on human glioblastoma in vitro and the effect of midkine
    Mine Erguven
    Yeni Yüzyıl University, Faculty of Medicine, Department of Biochemistry, Istanbul, Turkey
    Cancer Cell Int 11:18. 2011
    ..Consequently, new treatment modalities are needed. Our aims were to investigate the effects of combined noscapine (NOS) and imatinib mesylate (IM) on human GBM in vitro and the role of midkine (MK) in this new combination treatment...
  3. ncbi request reprint Carvedilol in glioma treatment alone and with imatinib in vitro
    Mine Erguven
    Department of Biochemistry, Istanbul University, Istanbul Faculty of Medicine, Istanbul 34093, Turkey
    Int J Oncol 36:857-66. 2010
    ..These results suggest that carvedilol showed antitumour activity against rat C6 glioma cells and a combination of carvedilol with imatinib mesylate resulted in enhanced in vitro antitumour activity...
  4. ncbi request reprint Medroxyprogesterone acetate alone or synergistic with chemotherapy suppresses colony formation and DNA synthesis in C6 glioma in vitro
    M A Altinoz
    Histology and Embryology Department, Istanbul Medical School, 34390, Istanbul, Turkey
    Int J Dev Neurosci 19:541-7. 2001
    ..Medroxyprogesterone increased procarbazine and cisplatin-induced colony growth and S-phase inhibition, but reduced MTX-induced thymidine-labelling inhibition. In conclusion, progesterone may inhibit growth and sensitize to drugs...
  5. ncbi request reprint Biological considerations in locally advanced breast cancer treated with anthracycline-based neoadjuvant chemotherapy: thymidine labelling index is an independent indicator of clinical outcome
    V Ozmen
    Department of Surgery, Istanbul Medical Faculty, University of Istanbul, Turkey
    Breast Cancer Res Treat 68:147-57. 2001
    ..02). These results suggest that TLI is an important independent indicator of clinical outcome in patients with LABC and these patients with high TLI levels require more effective treatment modalities...
  6. ncbi request reprint Inflammatory breast cancer: results of antracycline-based neoadjuvant chemotherapy
    Vahit Ozmen
    Department of General Surgery, Istanbul Faculty of Medicine, University of Istanbul, Istanbul, Turkey
    Breast J 9:79-85. 2003
    ....
  7. ncbi request reprint Medroxyprogesterone and tamoxifen augment anti-proliferative efficacy and reduce mitochondria-toxicity of epirubicin in FM3A tumor cells in vitro
    Meric A Altinoz
    Medical Biology and Genetics, Halic University, Institute of Health Halic Universitesi Merkez, Kampus Mecidiyekoy, Buyukdere Istanbul, Turkey, 34394 Istanbul, Turkey
    Cell Biol Int 31:473-81. 2007
    ..Further studies would be worthwhile, since the uncoupling of mitochondrial toxicity from the anti-neoplastic effect may also mean obviated cardiac toxicity in clinic...
  8. ncbi request reprint The inhibitory effect of suramin on telomerase activity and spheroid growth of C6 glioma cells
    Mine Erguven
    Department of Biochemistry, Istanbul University, Faculty of Pharmacy, Istanbul, Turkey
    Med Sci Monit 14:BR165-73. 2008
    ..The aim of the study was to investigate the effect of suramin on the telomerase activity of C6 glioma cells and on the growth of C6 glioma spheroids...
  9. ncbi request reprint Thymidine labeling index in epithelial ovarian cancer
    Y Salihoglu
    Department of Obstetrics and Gynecology, Istanbul Faculty of Medicine, Istanbul, Turkey
    Int J Gynaecol Obstet 75:171-6. 2001
    ..Further larger scale studies are needed before definite conclusions can be made about its role as a prognostic factor in this disease...
  10. doi request reprint The effects of tibolone on the human primary glioblastoma multiforme cell culture and the rat C6 glioma model
    Meric A Altinoz
    Istanbul University, Istanbul, Turkey
    Neurol Res 31:923-7. 2009
    ..We thought that tibolone should exert its antiproliferative effects by augmenting glial cell differentiation through the naive, nonhypermethylated estrogen receptors in the glioma cells...
  11. doi request reprint The influence of titanium surfaces in cultures of neonatal rat calvarial osteoblast-like cells: an immunohistochemical study
    Buket Aybar
    Department of Oral Surgery, School of Dentistry, Istanbul University, Istanbul, Turkey
    Implant Dent 18:75-85. 2009
    ..The goal of this present study was to evaluate the behavior of neonatal rat calvarial osteoblast-like cells cultured on different implant surfaces...
  12. ncbi request reprint Biocompatibility of different barrier membranes in cultures of human CRL 11372 osteoblast-like cells: an immunohistochemical study
    Ayhan Bilir
    Department of Histology and Embriology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
    Clin Oral Implants Res 18:46-52. 2007
    ..The aim of this study was to evaluate the biocompatibility of two different barrier materials in cultures of human osteoblast-like cells (CRL 11372) in vitro...
  13. ncbi request reprint Vascularization pattern of C6 glioma is modified with medroxyprogesterone acetate and ibuprofen in Wistar rat brain
    M A Altinoz
    Department of Histology and Embryology, Faculty of Medicine, Istanbul University, General Sukru Kanatli Sok No 36 8, Bakirkoy Istanbul, Turkey
    Pathol Oncol Res 7:185-9. 2001
    ..Coadministration of ibuprofen acted to suppress the peritumoral vessel increase, and to enhance lymphomonocytic infiltration around tumor vessels...
  14. ncbi request reprint Effect of apoptosis and response of extracellular matrix proteins after chemotherapy application on human breast cancer cell spheroids
    G Oktem
    Department of Histology and Embryology, Ege University School of Medicine, TR 35100 Izmir, Turkey
    Oncol Rep 15:335-40. 2006
    ..However, we considered the possibility that there is another control mechanism for the Docetaxel group...
  15. ncbi request reprint Chemotherapy influences inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) activity on 3D breast cancer cell line
    G Oktem
    Department of Histology and Embryology, Ege University School of Medicine, TR 35100 Izmir, Turkey
    Oncol Res 16:195-203. 2006
    ..Therefore, analyzing the expression of both iNOS and eNOS might be very useful for targeting the treatment of breast carcinoma and obtaining better information on prognosis...
  16. ncbi request reprint Role of intercellular communications in breast cancer multicellular tumor spheroids after chemotherapy
    G Oktem
    Department of Histology and Embryology, Ege University School of Medicine, TR 35100 Izmir, Turkey
    Oncol Res 16:225-33. 2006
    ..The MTS model can be used to validate the effects of various combinations or new chemotherapeutic agents as well as documentation of possible mechanisms of new drugs...
  17. ncbi request reprint Cytotoxic effects of calcium hydroxide and mineral trioxide aggregate on 3T3 fibroblast cell line in vitro
    Elif Sepet
    Instanbul University, Dental Faculty, Department of Pedodontics, Istanbul, Turkey
    Quintessence Int 40:e55-61. 2009
    ..To examine the cytotoxic effects of MTA and Ca(OH)2 on 3T3 fibroblasts at different time intervals...
  18. ncbi request reprint Medroxyprogesterone acetate induces c6 glioma chemosensitization via antidepressant-like lysosomal phospholipidosis/myelinosis in vitro
    Meric A Altinoz
    Institute of Health, Halic University, Istanbul, Turkey
    Int J Neurosci 117:1465-80. 2007
    ..Reducing esterification and plasma-membrane localization of cholesterol may lead MPA induction of lysosomal phospholipidosis, growth indolency, and drug sensitization in glioma...
  19. pmc Combination of imatinib mesylate with lithium chloride and medroxyprogesterone acetate is highly active in Ishikawa endometrial carcinoma in vitro
    Ayhan Bilir
    Department of Histology and Embryology, Istanbul University Faculty of Medicine, Istanbul, Turkey
    J Gynecol Oncol 22:225-32. 2011
    ..The aim of the study was to investigate whether lithium chloride and medroxyprogesterone acetate can potentiate the cytotoxicity of imatinib mesylate in human endometrial cancer in vitro and the effect of midkine in these therapies...
  20. ncbi request reprint Potentiation of cytotoxicity by combination of imatinib and chlorimipramine in glioma
    Ayhan Bilir
    Department of Histology and Embryology, Istanbul University, Istanbul Faculty of Medicine, 34093 Capa, Istanbul, Turkey
    Int J Oncol 32:829-39. 2008
    ..Further, the findings suggest the potential clinical application of the combination in the treatment of drug-resistant glioma...
  21. ncbi request reprint Acetaminophen modulations of chemotherapy efficacy in MDAH 2774 human endometrioid ovarian cancer cells in vitro
    A Bilir
    Department of Histology and Embryology, Istanbul Medical School, Faculty of Science, Turkey
    Neoplasma 49:38-42. 2002
    ..Thus, presence of lower doses of oxidizing drugs may help the induction of proliferative signals, but only their sustained presence may overcome such signals and ultimately bring to cell demise...
  22. ncbi request reprint Autophagy and nuclear changes in FM3A breast tumor cells after epirubicin, medroxyprogesterone and tamoxifen treatment in vitro
    A Bilir
    Department of Histology and Embryology, Istanbul Medical Faculty, Istanbul, Turkey
    Pathobiology 69:120-6. 2001
    ....
  23. ncbi request reprint The effect of COX-2 inhibitor, nimesulide, on angiogenetic factors in primary endometrial carcinoma cell culture
    S Genc
    Department of Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa 34093, Istanbul, Turkey
    Clin Exp Med 7:6-10. 2007
    ..These results suggest that COX-2 inhibitors may be effective in the treatment of endometrial cancer via suppression of angiogenesis...
  24. ncbi request reprint Effects of tricalcium phosphate bone graft materials on primary cultures of osteoblast cells in vitro
    Buket Aybar
    Department of Oral Surgery, School of Dentistry, Istanbul University, Istanbul, Turkey
    Clin Oral Implants Res 15:119-25. 2004
    ..The results demonstrate that TCP graft material has no adverse effect on cell count, viability and morphology, and this material provides a matrix that favors limited cell proliferation...
  25. doi request reprint Effects of bone morphogenetic protein on neonatal rat calvarial osteoblast-like cells: an in vitro study
    Buket Aybar
    Department of Oral Surgery, Faculty of Dentistry, Istanbul University, Istanbul, Turkey
    J Biomed Mater Res A 86:560-8. 2008
    ..These results indicate that BMPs have an inductive effect on osteoblast differentiation and a possible inhibitory effect in the early phases of cell proliferation...
  26. ncbi request reprint The effects of naproxen sodium on specific parameters of L-strain cells over guided bone regeneration barrier materials
    Buket Aybar
    Department of Oral Surgery, School of Dentistry, Istanbul University, Istanbul, Turkey
    Clin Oral Implants Res 15:709-15. 2004
    ..These data suggest naproxen have an inhibitory effect on stimulation of DNA synthesis, cell numbers and viabilities. And also lacking adherence of cells to the membranes may be due to the physical properties of the materials...
  27. ncbi request reprint Noscapine and diltiazem augment taxol and radiation-induced S-phase arrest and clonogenic death of C6 glioma in vitro
    Meric A Altinoz
    Golden Horn Halic University, Capa, Istanbul 34390, Turkey
    Surg Neurol 65:478-84; discussion 485. 2006
    ..Noscapine is an opioid antitussive, which acts anti cancer via blocking microtubule dynamics. Diltiazem is a calcium channel-blocking cardiac antiarrythmic, which also blocks tumor growth and P-glycoprotein...
  28. ncbi request reprint Thymidine labeling index: prognostic role in breast cancer
    Ayhan Bilir
    Istanbul University Istanbul Medical Faculty, Department of General Surgery, Turkey correction
    Am J Clin Oncol 27:400-6. 2004
    ..These findings may justify a more aggressive therapeutic approach in patients with high TLI levels. Further large-scale, prospective studies are required before a definite conclusion can be reached.reached...
  29. ncbi request reprint The effects of a caries-removing gel (Carisolv) on FM3A cell-line in vitro
    Elif Sepet
    Department of Pedodontics, Faculty of Dentistry, University of Istanbul, Capa, 34390 Istanbul, Turkey
    J Dent 32:213-8. 2004
    ..The aim of this study was to examine the cytotoxic effects of Carisolv on mouse mammary carcinoma cell line (FM3A) at different application times...
  30. ncbi request reprint Atorvastatin has cardiac safety at intensive cholesterol-reducing protocols for long term, yet its cancer-treatment doses with chemotherapy may cause cardiomyopathy even under coenzyme-Q10 protection
    Metin Caner
    Internal Medicine at Surgery, Department of Cerrahpasa School of Medicine, Istanbul University, Istanbul
    Cell Biochem Funct 25:463-72. 2007
    ....