Berrin Tunca

Summary

Affiliation: Uludag University
Country: Turkey

Publications

  1. doi Overexpression of CK20, MAP3K8 and EIF5A correlates with poor prognosis in early-onset colorectal cancer patients
    Berrin Tunca
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey
    J Cancer Res Clin Oncol 139:691-702. 2013
  2. doi Olea europaea leaf extract alters microRNA expression in human glioblastoma cells
    Berrin Tunca
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey
    J Cancer Res Clin Oncol 138:1831-44. 2012
  3. doi CK19, CK20, EGFR and HER2 status of circulating tumor cells in patients with breast cancer
    Berrin Tunca
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey
    Tumori 98:243-51. 2012
  4. ncbi Investigation of APC mutations in a Turkish familial adenomatous polyposis family by heterodublex analysis
    Berrin Tunca
    Department of Medical Biology and Genetics, Faculty of Medicine, Uludag University, Bursa, Turkey
    Dis Colon Rectum 48:567-71. 2005
  5. ncbi Impact of novel PTEN mutations in Turkish patients with glioblastoma multiforme
    Berrin Tunca
    Department of Medical Biology, School of Medicine, Uludag University, Bursa, Turkey
    J Neurooncol 82:263-9. 2007
  6. ncbi P53 gene mutations in surgical margins and primary tumor tissues of patients with squamous cell carcinoma of the head and neck
    Berrin Tunca
    Department of Medical Biology, School of Medicine, Uludag University, Bursa, Turkey
    Tumori 93:182-8. 2007
  7. ncbi The mutation spectrum of the APC gene in Turkish patients with familial adenomatous polyposis
    Berrin Tunca
    Department of Medical Biology, Faculty of Medicine, Uludag University, Bursa, Turkey
    Dis Colon Rectum 50:1899-904. 2007
  8. doi Analysis of mismatch repair gene mutations in Turkish HNPCC patients
    Berrin Tunca
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey
    Fam Cancer 9:365-76. 2010
  9. ncbi Investigation of mutations and expression of the FHIT gene in Turkish patients with brain metastases derived from non-small cell lung cancer
    Ahmet Bekar
    Department of Neurosurgery, Faculty of Medicine, Uludag University, Bursa, Turkey
    Tumori 93:604-7. 2007
  10. doi Expression and clinical significance of miRNAs that may be associated with the FHIT gene in breast cancer
    Elif Demirdogen Sevinc
    Department of Medical Biology, Faculty of Medicine, University of Uludag, Bursa, Turkey
    Gene 590:278-84. 2016

Collaborators

Detail Information

Publications37

  1. doi Overexpression of CK20, MAP3K8 and EIF5A correlates with poor prognosis in early-onset colorectal cancer patients
    Berrin Tunca
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey
    J Cancer Res Clin Oncol 139:691-702. 2013
    ....
  2. doi Olea europaea leaf extract alters microRNA expression in human glioblastoma cells
    Berrin Tunca
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey
    J Cancer Res Clin Oncol 138:1831-44. 2012
    ..The present study aimed to evaluate whether Olea europaea leaf extract (OLE) has an anticancer effect and modulates miRNA expression in GBM...
  3. doi CK19, CK20, EGFR and HER2 status of circulating tumor cells in patients with breast cancer
    Berrin Tunca
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey
    Tumori 98:243-51. 2012
    ..The aims of the current study were to analyze circulating tumor cells in the blood of breast cancer patients by investigating EGFR, CK19, CK20 and HER2 expression profiles and to evaluate their prognostic importance...
  4. ncbi Investigation of APC mutations in a Turkish familial adenomatous polyposis family by heterodublex analysis
    Berrin Tunca
    Department of Medical Biology and Genetics, Faculty of Medicine, Uludag University, Bursa, Turkey
    Dis Colon Rectum 48:567-71. 2005
    ..This study was designed to investigation of adenomatous polyposis coli (APC) gene mutations in members of familial adenomatous polyposis family to identify individuals at risk of the disease...
  5. ncbi Impact of novel PTEN mutations in Turkish patients with glioblastoma multiforme
    Berrin Tunca
    Department of Medical Biology, School of Medicine, Uludag University, Bursa, Turkey
    J Neurooncol 82:263-9. 2007
    ....
  6. ncbi P53 gene mutations in surgical margins and primary tumor tissues of patients with squamous cell carcinoma of the head and neck
    Berrin Tunca
    Department of Medical Biology, School of Medicine, Uludag University, Bursa, Turkey
    Tumori 93:182-8. 2007
    ..p53 mutations in primary tumors, the effect of the mutations on some clinical and pathological features of head and neck squamous cell carcinoma, and the impact of p53 mutations in the surgical margins on local recurrence were determined,..
  7. ncbi The mutation spectrum of the APC gene in Turkish patients with familial adenomatous polyposis
    Berrin Tunca
    Department of Medical Biology, Faculty of Medicine, Uludag University, Bursa, Turkey
    Dis Colon Rectum 50:1899-904. 2007
    ....
  8. doi Analysis of mismatch repair gene mutations in Turkish HNPCC patients
    Berrin Tunca
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey
    Fam Cancer 9:365-76. 2010
    ..The present study adds new information about MMR gene mutation types and their role in Lynch syndrome. This is the first detailed research on Turkish Lynch syndrome families...
  9. ncbi Investigation of mutations and expression of the FHIT gene in Turkish patients with brain metastases derived from non-small cell lung cancer
    Ahmet Bekar
    Department of Neurosurgery, Faculty of Medicine, Uludag University, Bursa, Turkey
    Tumori 93:604-7. 2007
    ..Furthermore, it is not known whether the FHIT gene has a role in the formation of brain metastases...
  10. doi Expression and clinical significance of miRNAs that may be associated with the FHIT gene in breast cancer
    Elif Demirdogen Sevinc
    Department of Medical Biology, Faculty of Medicine, University of Uludag, Bursa, Turkey
    Gene 590:278-84. 2016
    ..miR-668 may play an important role in breast cancer development and progression by regulating the expression of FHIT. Furthermore, miR-668 and miR-663a may be potential prognostic biomarkers for breast cancer. ..
  11. doi Microsatellite instability status affects gene expression profiles in early onset colorectal cancer patients
    Secil Ak
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey
    J Surg Res 185:626-37. 2013
    ..The aim of this study was to identify the altered gene expression patterns depending on the MSI status of early onset CRC and determine specific biomarkers that could provide novel therapeutic molecular targets in the Turkish population...
  12. doi FHIT gene sequence variants and reduced Fhit protein expression in glioblastoma multiforme
    Gulsah Cecener
    Department of Medical Biology, School of Medicine, Uludag University, Bursa, Turkey
    Cell Mol Neurobiol 30:301-7. 2010
    ..5% of tumors. In conclusion, the reduction or loss of Fhit protein expression by genetic alterations or epigenetic mechanisms in GBM might be associated with brain tumorigenesis...
  13. ncbi Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins
    Ozgur Vatan
    Department of Biology, Science and Art Faculty, Uludag University, Bursa, Turkey
    Tumori 93:473-7. 2007
    ..Molecular methods may be exploited that are sensitive enough to detect small numbers of tumor cells...
  14. ncbi Mutation analysis of the FHIT gene in bronchoscopic specimens from patients with suspected lung cancer
    Gulsah Cecener
    Department of Medical Biology, Faculty of Medicine, Uludag University, Bursa, Turkey
    Tumori 94:845-8. 2008
    ..The aim of this study was to identify FHIT gene alterations in bronchoscopy specimens of patients with suspected lung cancer and to determine the molecular relevance, if any, of FHIT alterations in the development of cancer...
  15. doi The promoter hypermethylation status of GATA6, MGMT, and FHIT in glioblastoma
    Gulsah Cecener
    Department of Medical Biology, School of Medicine, Uludag University, Bursa, Turkey
    Cell Mol Neurobiol 32:237-44. 2012
    ..Furthermore, inactivation of FHIT by epigenetic mechanisms in GBM may not be associated with brain tumorigenesis...
  16. doi BRCA mutations cause reduction in miR-200c expression in triple negative breast cancer
    Elif Erturk
    Vocational School of Health Services, Uludag University, Bursa, Turkey
    Gene 556:163-9. 2015
    ..Further studies and evaluations are required, but this miRNA may provide novel therapeutic molecular targets for TNBC treatment and new directions for the development of anticancer drugs. ..
  17. ncbi Evaluation of genetic variations in miRNA-binding sites of BRCA1 and BRCA2 genes as risk factors for the development of early-onset and/or familial breast cancer
    Elif Erturk
    Department of Medical Biology, Faculty of Medicine, Uludag University, Bursa, Turkey E mail
    Asian Pac J Cancer Prev 15:8319-24. 2014
    ....
  18. doi BRCA1/2 germline mutations and their clinical importance in Turkish breast cancer patients
    Gulsah Cecener
    Department of Medical Biology, Faculty of Medicine, University of Uludag, Turkey, 1
    Cancer Invest 32:375-87. 2014
    ..These data could help guide the management of BRCA1/BRCA2 mutation-carrying patients when considering breast-conserving therapy...
  19. ncbi Importance of novel sequence alterations in the FHIT gene on formation of breast cancer
    Gulsah Cecener
    Department of Medical Biology, Faculty of Medicine, Uludag University, Bursa, Turkey
    Tumori 93:597-603. 2007
    ..Thus, the current study evaluated FHIT gene mutations from breast tissue of women with malignant and benign breast disease and to elucidate the frequency and type of mutations in this gene...
  20. doi Investigation of MMAC/PTEN gene mutations and protein expression in low grade gliomas
    Gulsah Cecener
    Department of Medical Biology, School of Medicine, Uludag University, Bursa, Turkey
    Cell Mol Neurobiol 29:733-8. 2009
    ..08% of tumors. In conclusion, reduced MMAC/PTEN expression by genetic and/or epigenetic mechanisms in low grade gliomas might be associated with glioma tumorigenesis...
  21. ncbi Circulating miR-195 as a Therapeutic Biomarker in Turkish Breast Cancer Patients
    Gulsah Cecene
    Department of Medical Biology, Medical Faculty, Uludag University, Turkey E mail
    Asian Pac J Cancer Prev 17:4241-4246. 2016
    ..At the same time, miRNA expression levels may vary because of ethnic origins. This study aimed to determine expression levels and potential roles of miR-195 in Turkish breast cancer patients...
  22. doi miR-216b Targets FGFR1 and Confers Sensitivity to Radiotherapy in Pancreatic Ductal Adenocarcinoma Patients Without EGFR or KRAS Mutation
    Unal Egeli
    From the Departments of Medical Biology, General Surgery, Pathology, and Medical Oncology, Medical Faculty, Uludag University, Bursa, Turkey
    Pancreas 45:1294-302. 2016
    ..In this study, we examined the potential effect of miRNAs on the resistance to radiotherapy in cases without EGFR or KRAS mutation...
  23. doi MicroRNA expression patterns of tumors in early-onset colorectal cancer patients
    Secil Ak
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey
    J Surg Res 191:113-22. 2014
    ....
  24. doi Expression status of let-7a and miR-335 among breast tumors in patients with and without germ-line BRCA mutations
    Elif Erturk
    Department of Medical Biology, Institute of Health Sciences, Uludag University, Bursa, Turkey
    Mol Cell Biochem 395:77-88. 2014
    ..The expression analysis of these miRNAs might be used as biomarkers of the BRCA mutation status of early-onset and/or familial BC. ..
  25. ncbi Novel germline BRCA1 and BRCA2 mutations in Turkish women with breast and/or ovarian cancer and their relatives
    Unal Egeli
    Department of Medical Biology and Genetics, Faculty of Medicine, Uludag University, Bursa, Turkey
    Cancer Invest 24:484-91. 2006
    ..In conclusion, these findings contribute significantly to what currently is known about the types and impact of germline BRCA1 and BRCA2 mutations in Turkish women...
  26. doi Impact of 3'UTR variation patterns of the KRAS gene on the aggressiveness of pancreatobiliary tumors with the KRAS G13D mutation in a Turkish population
    Unal Egeli
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey Electronic address
    Pancreatology 16:677-86. 2016
    ....
  27. ncbi Association of miR-1266 with recurrence/metastasis potential in estrogen receptor positive breast cancer patients
    Elif Demirdogen Sevinc
    Department of Medical Biology, Faculty of Medicine, University of Uludag, Bursa, Turkey E mail
    Asian Pac J Cancer Prev 16:291-7. 2015
    ..90 fold; p=0.2514) in ER (+) BC cases. Although we suggest that modulation of miR-1266 expression may be an important mechanism underlying the chemoresistance of ER (+) BC, advanced studies and validation are required. ..
  28. ncbi Clinical significance of p53 gene mutation in T1-2N0 non-small cell lung cancer
    Cengiz Gebitekin
    Uludag University, School of Medicine, GKDC ABD Bursa 16059, Turkey
    Asian Cardiovasc Thorac Ann 15:35-8. 2007
    ..Patients with pathologically N0 disease and p53 gene mutation must be carefully monitored for local recurrence or distant metastasis. Neoadjuvant and/or adjuvant therapies may be considered in this group of patients...
  29. doi Mutation analysis of the PARKIN, PINK1, DJ1, and SNCA genes in Turkish early-onset Parkinson's patients and genotype-phenotype correlations
    Sevda Erer
    Department of Neurology, Medical Faculty, Uludag University, Bursa, Turkey Electronic address
    Clin Neurol Neurosurg 148:147-53. 2016
    ..In the current study, we aimed to evaluate the frequencies of variations in PARK genes and the effects of these variations on the phenotypes of Turkish EOPD patients...
  30. doi Ficus carica latex prevents invasion through induction of let-7d expression in GBM cell lines
    Gulçin Tezcan
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey
    Cell Mol Neurobiol 35:175-87. 2015
    ..In addition, the current study is the first to demonstrate the effect of FCL on modulation of let-7d expression, which may be an important underlying mechanism of the anti-invasive effect of this extract...
  31. pmc Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer
    Gulçin Tezcan
    Gulcin Tezcan, Berrin Tunca, Secil Ak, Gulsah Cecener, Unal Egeli, Department of Medical Biology, Faculty of Medicine, Uludag University, 16059 Bursa, Turkey
    World J Gastrointest Oncol 8:83-98. 2016
    ..Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach. ..
  32. doi Association of MDR1, CYP2D6, and CYP2C19 gene polymorphisms with prophylactic migraine treatment response
    Gulfer Atasayar
    Uludag University, Faculty of Medicine, Department of Neurology, Turkey
    J Neurol Sci 366:149-54. 2016
    ..This is the first study to investigate the effect of the polymorphic variants on prophylactic therapy response in migraine patients. ..
  33. doi microRNA expression pattern modulates temozolomide response in GBM tumors with cancer stem cells
    Gulçin Tezcan
    Department of Medical Biology, Medical Faculty, Uludag University, Bursa, Turkey
    Cell Mol Neurobiol 34:679-92. 2014
    ..Further studies and evaluations are required, but this miRNA may provide novel therapeutic molecular targets for GBM treatment and new directions for the development of anticancer drugs...
  34. ncbi Investigation of genetic susceptibility to non-small cell lung cancer by fragile site expression
    Berrin Tunca
    University of Uludag, Faculty of Medicine, Department of Medical Biology and Genetics, Bursa, Turkey
    Teratog Carcinog Mutagen 22:205-15. 2002
    ..001, P < 0.0005, and P < 0.05, respectively). Consequently, we believe that fragile site studies may be helpful to detection of cancer risk...
  35. ncbi An in vitro model for the development of acquired tamoxifen resistance
    Gamze Guney Eskiler
    Department of Medical Biology, Faculty of Medicine, Uludag University, Bursa, 16059, Turkey
    Cell Biol Toxicol 32:563-581. 2016
    ..This work presents a novel procedure for the generation of MCF7-TamR cells, thus enabling the identification and characterization of MCF7-TamR cells...
  36. ncbi Investigation of genotoxic effect of taxol plus radiation on mice bone marrow cells
    Lutfi Ozkan
    Department of Radiation Oncology, Uludag University Medical College, Gorukle, Bursa, Turkey
    Teratog Carcinog Mutagen 22:1-11. 2002
    ..Forty-eight-hour pretreatment of taxol exposure followed by radiation caused significant induction of chromosomal aberrations and a reduction of mitotic index when compared to other taxol timing sequence...
  37. doi First determination of azole resistance in Aspergillus fumigatus strains carrying the TR34/L98H mutations in Turkey
    Gülşah Ece Özmerdiven
    Uludag University, Faculty of Medicine, Department of Medical Microbiology, Gorukle, 16059 Bursa, Turkey
    J Infect Chemother 21:581-6. 2015
    ..8% (n = 66) of isolates. This initial analysis of the resistance mechanism of A. fumigatus from Turkey revealed a common TR34/L98H mutation in the cyp51A gene. ..