Steven T Russell

Summary

Affiliation: Aston University
Country: UK

Publications

  1. doi request reprint Role of β-adrenergic receptors in the anti-obesity and anti-diabetic effects of zinc-α2-glycoprotien (ZAG)
    Steven Thomas Russell
    Nutritional Biomedicine, School of Health Sciences, Aston University, Birmingham B4 7ET, UK
    Biochim Biophys Acta 1821:590-9. 2012
  2. ncbi request reprint Role of β-adrenergic receptors in the oral activity of zinc-α2-glycoprotein (ZAG)
    Steven T Russell
    Department of Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    Endocrinology 153:4696-704. 2012
  3. doi request reprint Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by beta-hydroxy-beta-methylbutyrate
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston Univ, Birmingham, B4 7ET, UK
    Am J Physiol Endocrinol Metab 295:E1409-16. 2008
  4. doi request reprint Mechanism of attenuation of protein loss in murine C2C12 myotubes by D-myo-inositol 1,2,6-triphosphate
    Steven T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
    Exp Cell Res 316:286-95. 2010
  5. ncbi request reprint Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston Univ, Birmingham B4 7ET, UK
    Am J Physiol Endocrinol Metab 293:E923-31. 2007
  6. pmc Effect of branched-chain amino acids on muscle atrophy in cancer cachexia
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Biochem J 407:113-20. 2007
  7. ncbi request reprint Involvement of phosphoinositide 3-kinase and Akt in the induction of muscle protein degradation by proteolysis-inducing factor
    Steven T Russell
    Nutritional Biomedicine, Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Biochem J 409:751-9. 2008
  8. doi request reprint Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-alpha and angiotensin II by beta-hydroxy-beta-methylbutyrate
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston Univ, Birmingham, B4 7ET, UK
    Am J Physiol Endocrinol Metab 295:E1417-26. 2008
  9. doi request reprint Mechanism of attenuation of skeletal muscle atrophy by zinc-alpha2-glycoprotein
    Steven T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    Endocrinology 151:4696-704. 2010
  10. doi request reprint Mechanism of induction of muscle protein loss by hyperglycaemia
    Steven T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B47ET, UK
    Exp Cell Res 315:16-25. 2009

Collaborators

  • Helen L Eley
  • Michael J Tisdale
  • Michael P Wynter
  • Pria S McDonald
  • Jeffrey H Baxter
  • Pradip Mukerji

Detail Information

Publications18

  1. doi request reprint Role of β-adrenergic receptors in the anti-obesity and anti-diabetic effects of zinc-α2-glycoprotien (ZAG)
    Steven Thomas Russell
    Nutritional Biomedicine, School of Health Sciences, Aston University, Birmingham B4 7ET, UK
    Biochim Biophys Acta 1821:590-9. 2012
    ..The goal of the current study is to determine whether the β-adrenoreceptor (β-AR) plays a role in the anti-obesity and anti-diabetic effects of zinc-α2-glycoprotein (ZAG)...
  2. ncbi request reprint Role of β-adrenergic receptors in the oral activity of zinc-α2-glycoprotein (ZAG)
    Steven T Russell
    Department of Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    Endocrinology 153:4696-704. 2012
    ..These results suggest that oral administration of ZAG increases serum levels through interaction with a β-AR in the upper gastrointestinal tract, and gene expression studies showed this to be in the esophagus...
  3. doi request reprint Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by beta-hydroxy-beta-methylbutyrate
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston Univ, Birmingham, B4 7ET, UK
    Am J Physiol Endocrinol Metab 295:E1409-16. 2008
    ..These results suggest that HMB may be effective in attenuating muscle atrophy in a range of catabolic conditions...
  4. doi request reprint Mechanism of attenuation of protein loss in murine C2C12 myotubes by D-myo-inositol 1,2,6-triphosphate
    Steven T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
    Exp Cell Res 316:286-95. 2010
    ..The ability of AT to attenuate muscle atrophy by a range of stimuli suggests that it may be effective in several catabolic conditions...
  5. ncbi request reprint Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston Univ, Birmingham B4 7ET, UK
    Am J Physiol Endocrinol Metab 293:E923-31. 2007
    ..25 g/kg). These results suggest that HMB attenuates the depression of protein synthesis by PIF in myotubes through multiple mechanisms...
  6. pmc Effect of branched-chain amino acids on muscle atrophy in cancer cachexia
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Biochem J 407:113-20. 2007
    ..These changes would be expected to increase protein synthesis, whereas a reduction in the activation of PKR would be expected to attenuate the increased protein degradation...
  7. ncbi request reprint Involvement of phosphoinositide 3-kinase and Akt in the induction of muscle protein degradation by proteolysis-inducing factor
    Steven T Russell
    Nutritional Biomedicine, Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Biochem J 409:751-9. 2008
    ..These results suggest that transient activation of Akt results in an increased protein degradation through activation of NF-kappaB and that this also allows for a specific synthesis of proteasome subunits...
  8. doi request reprint Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-alpha and angiotensin II by beta-hydroxy-beta-methylbutyrate
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston Univ, Birmingham, B4 7ET, UK
    Am J Physiol Endocrinol Metab 295:E1417-26. 2008
    ..Increased ROS formation is known to induce protein degradation through the ubiquitin-proteasome pathway...
  9. doi request reprint Mechanism of attenuation of skeletal muscle atrophy by zinc-alpha2-glycoprotein
    Steven T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    Endocrinology 151:4696-704. 2010
    ..These results suggest that protein accretion in skeletal muscle in response to ZAG may be due to changes in intracellular cAMP and also that ZAG may have a therapeutic application in the treatment of muscle wasting conditions...
  10. doi request reprint Mechanism of induction of muscle protein loss by hyperglycaemia
    Steven T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B47ET, UK
    Exp Cell Res 315:16-25. 2009
    ....
  11. doi request reprint Inhibition of activation of dsRNA-dependent protein kinase and tumour growth inhibition
    Helen L Eley
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, UK
    Cancer Chemother Pharmacol 63:651-9. 2009
    ....
  12. doi request reprint Mechanism of attenuation by beta-hydroxy-beta-methylbutyrate of muscle protein degradation induced by lipopolysaccharide
    Steven T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK
    Mol Cell Biochem 330:171-9. 2009
    ..This suggests that LPS induces protein degradation through a signalling cascade involving activation of caspase-3/-8, activation of PKR and production of ROS through p38MAPK, and that this process is attenuated by HMB...
  13. doi request reprint Antidiabetic properties of zinc-alpha2-glycoprotein in ob/ob mice
    Steven T Russell
    Department of Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, United Kingdom
    Endocrinology 151:948-57. 2010
    ..There was an increase in skeletal muscle mass due to an increase in protein synthesis and a decrease in protein degradation. These results suggest that ZAG may potentially be effective in the treatment of type 2 diabetes...
  14. ncbi request reprint Mechanism of attenuation of angiotensin-II-induced protein degradation by insulin-like growth factor-I (IGF-I)
    Steven T Russell
    Nutritional Biomedicine, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Cell Signal 19:1583-95. 2007
    ....
  15. ncbi request reprint Induction of lipolysis in vitro and loss of body fat in vivo by zinc-alpha2-glycoprotein
    Steven T Russell
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Biochim Biophys Acta 1636:59-68. 2004
    ..These results suggest that ZAG may be effective in the treatment of obesity...
  16. ncbi request reprint Angiotensin II directly inhibits protein synthesis in murine myotubes
    Steven T Russell
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK
    Cancer Lett 231:290-4. 2006
    ..The effect was attenuated by insulin-like growth factor-1 (IGF-1) (25-100 ng/ml). Thus, Ang I/II have the ability to induce muscle atrophy through inhibition of protein synthesis...
  17. ncbi request reprint Effect of n-3 fatty acids on the antitumour effects of cytotoxic drugs
    Michael P Wynter
    Pharmaceutical Sciences Research Institute, Aston University, Birmingham, B4 7ET, UK
    In Vivo 18:543-7. 2004
    ..n-3 fatty acids are increasingly being administered to cancer patients for the treatment of cachexia, and it is thus important to know of any potential interactions with ongoing cytotoxic drug therapy...
  18. ncbi request reprint Mechanism of induction of muscle protein degradation by angiotensin II
    Steven T Russell
    Biomolecular Sciences, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    Cell Signal 18:1087-96. 2006
    ..These results suggest that induction of proteasome expression by angiotensin I/II involves a signalling pathway involving PKC and NF-kappaB...