Peter L Roberts

Summary

Affiliation: Bio Products Laboratory
Country: UK

Publications

  1. ncbi request reprint Comparison of the inactivation of canine and bovine parvovirus by freeze-drying and dry-heat treatment in two high purity factor VIII concentrates
    P L Roberts
    Bio Products Laboratory, Elstree, England
    Biologicals 28:185-8. 2000
  2. ncbi request reprint Virus inactivation by high intensity broad spectrum pulsed light
    Peter Roberts
    Bio Products Laboratory, Research and Development Department, Dagger Lane, Elstree, WD6 3BX, Herts, UK
    J Virol Methods 110:61-5. 2003
  3. doi request reprint Development of an intravenous immunoglobulin with improved safety and functional activity
    Peter L Roberts
    Bio Products Laboratory, Dagger Lane, Elstree, Hertfordshire WD6 3BX, UK Electronic address
    Biologicals 43:123-9. 2015
  4. doi request reprint Virus elimination during the recycling of chromatographic columns used during the manufacture of coagulation factors
    Peter L Roberts
    Bio Products Laboratory, Dagger Lane, Elstree, Hertfordshire, WD6 3BX, United Kingdom Electronic address
    Biologicals 42:184-90. 2014
  5. doi request reprint Removal of TSE agent from plasma products manufactured in the United Kingdom
    P L Roberts
    Bio Products Laboratory Ltd, Elstree, Herts, UK
    Vox Sang 104:299-308. 2013
  6. doi request reprint Virus reduction in an intravenous immunoglobulin by solvent/detergent treatment, ion-exchange chromatography and terminal low pH incubation
    Peter L Roberts
    Bio Products Laboratory, Dagger Lane, Elstree, Hertfordshire WD6 3BX, UK
    Biologicals 40:345-52. 2012
  7. doi request reprint Virus inactivation in albumin by a combination of alkali conditions and high temperature
    Peter L Roberts
    R and D Department, Bio Products Laboratory, Elstree, Hertfordshire WD6 3BX, UK
    Biologicals 39:67-72. 2011
  8. doi request reprint Virus removal from factor IX by filtration: validation of the integrity test and effect of manufacturing process conditions
    Peter L Roberts
    Bio Products Laboratory, Dagger Lane, Elstree, Hertfordshire WD6 3BX, UK
    Biologicals 38:303-10. 2010
  9. doi request reprint Removal of TSE agents by depth or membrane filtration from plasma products
    Peter L Roberts
    Bio Products Laboratory, Dagger Lane, Elstree, Hertfordshire WD6 3BX, UK
    Biologicals 38:158-61. 2010
  10. doi request reprint Virus inactivation in a factor VIII/VWF concentrate treated using a solvent/detergent procedure based on polysorbate 20
    Peter L Roberts
    Bio Products Laboratory, Research and Development Department, Dagger Lane, Elstree, Hertfordshire WD63BX, UK
    Biologicals 37:26-31. 2009

Detail Information

Publications16

  1. ncbi request reprint Comparison of the inactivation of canine and bovine parvovirus by freeze-drying and dry-heat treatment in two high purity factor VIII concentrates
    P L Roberts
    Bio Products Laboratory, Elstree, England
    Biologicals 28:185-8. 2000
    ..e. 2.8-3.4 log after 72 h at 80 degrees C. In conclusion, the resistance of these parvovirus models is dependent both on the type of virus and on the specific product involved...
  2. ncbi request reprint Virus inactivation by high intensity broad spectrum pulsed light
    Peter Roberts
    Bio Products Laboratory, Research and Development Department, Dagger Lane, Elstree, WD6 3BX, Herts, UK
    J Virol Methods 110:61-5. 2003
    ..0->6.4 log, however, HSV-1 (3.8 log), BPV (2.4 log) and SV40 (2.9 log) were all relatively resistant. This virus inactivation procedure may have application for increasing the safety of therapeutic biological products...
  3. doi request reprint Development of an intravenous immunoglobulin with improved safety and functional activity
    Peter L Roberts
    Bio Products Laboratory, Dagger Lane, Elstree, Hertfordshire WD6 3BX, UK Electronic address
    Biologicals 43:123-9. 2015
    ..A new high purity liquid IVIG product has been developed, of high purity and good functional activity and stability. The process includes various steps for the removal of pathogens and procoagulant activity. ..
  4. doi request reprint Virus elimination during the recycling of chromatographic columns used during the manufacture of coagulation factors
    Peter L Roberts
    Bio Products Laboratory, Dagger Lane, Elstree, Hertfordshire, WD6 3BX, United Kingdom Electronic address
    Biologicals 42:184-90. 2014
    ..In summary, these studies demonstrate that potential virus contamination between chromatographic runs can be prevented when an effective column recycling and sanitisation procedure is included...
  5. doi request reprint Removal of TSE agent from plasma products manufactured in the United Kingdom
    P L Roberts
    Bio Products Laboratory Ltd, Elstree, Herts, UK
    Vox Sang 104:299-308. 2013
    ..In the current study, the capacity of various manufacturing processes that were in use both prior to and after this time to remove the TSE agent was tested...
  6. doi request reprint Virus reduction in an intravenous immunoglobulin by solvent/detergent treatment, ion-exchange chromatography and terminal low pH incubation
    Peter L Roberts
    Bio Products Laboratory, Dagger Lane, Elstree, Hertfordshire WD6 3BX, UK
    Biologicals 40:345-52. 2012
    ..The terminal low pH incubation step was also able to inactivate enveloped viruses, as well as some non-enveloped viruses. The combination of these three steps ensures a high margin of virus safety for this product...
  7. doi request reprint Virus inactivation in albumin by a combination of alkali conditions and high temperature
    Peter L Roberts
    R and D Department, Bio Products Laboratory, Elstree, Hertfordshire WD6 3BX, UK
    Biologicals 39:67-72. 2011
    ..This procedure has the potential for increasing the spectrum of viruses inactivated by the 60 °C pasteurisation step...
  8. doi request reprint Virus removal from factor IX by filtration: validation of the integrity test and effect of manufacturing process conditions
    Peter L Roberts
    Bio Products Laboratory, Dagger Lane, Elstree, Hertfordshire WD6 3BX, UK
    Biologicals 38:303-10. 2010
    ..Virus removal from the product was not influenced by filter load mass, flow-rate or pressure. These studies confirm the robustness of this filtration procedure and allow suitable process limits to be set for this manufacturing step...
  9. doi request reprint Removal of TSE agents by depth or membrane filtration from plasma products
    Peter L Roberts
    Bio Products Laboratory, Dagger Lane, Elstree, Hertfordshire WD6 3BX, UK
    Biologicals 38:158-61. 2010
    ..e. 0.6-1.3 log. However under protein free conditions using phosphate buffered saline, filtration was not effective in the case of a PVDF filter but very effective i.e. >2.9 log in the case of a Nylon filter...
  10. doi request reprint Virus inactivation in a factor VIII/VWF concentrate treated using a solvent/detergent procedure based on polysorbate 20
    Peter L Roberts
    Bio Products Laboratory, Research and Development Department, Dagger Lane, Elstree, Hertfordshire WD63BX, UK
    Biologicals 37:26-31. 2009
    ..Polysorbate 20 provides an alternative to the non-ionic detergents currently in use with the solvent/detergent procedure...
  11. doi request reprint Virus inactivation by solvent/detergent treatment using Triton X-100 in a high purity factor VIII
    Peter L Roberts
    Bio Products Laboratory, Research and Development Department, Dagger Lane, Elstree, Hertfordshire, UK
    Biologicals 36:330-5. 2008
    ..These studies demonstrate the robustness of this solvent/detergent procedure based on Triton X-100 and allow suitable process limits to be set for this manufacturing step...
  12. ncbi request reprint Virus inactivation by protein denaturants used in affinity chromatography
    Peter L Roberts
    Bio Products Laboratory, Dagger Lane, Elstree, Hertfordshire, UK
    Biologicals 35:343-7. 2007
    ....
  13. ncbi request reprint Effect of manufacturing process parameters on virus inactivation by dry heat treatment at 80 degrees C in factor VIII
    P L Roberts
    Bio Products Laboratory, Elstree, Herts, UK
    Vox Sang 92:56-63. 2007
    ..In the current study, the effect of this process has been tested on a range of viruses. In addition the effect of various manufacturing process parameters on virus inactivation has been investigated...
  14. ncbi request reprint Effect of manufacturing process parameters on virus inactivation by solvent-detergent treatment in a high-purity factor IX concentrate
    P L Roberts
    Bio Products Laboratory, Elstree, Herts, UK
    Vox Sang 84:170-5. 2003
    ....
  15. ncbi request reprint Effect of sample storage conditions on virus inactivation by solvent/detergent
    Peter Roberts
    Bio Products Laboratory, Dagger Lane, Elstree, Hertfordshire WD6 3BX, UK
    Biologicals 30:255-7. 2002
  16. ncbi request reprint Inactivation of parvovirus B19 and model viruses in factor VIII by dry heat treatment at 80 degrees C
    Peter L Roberts
    Transfusion 46:1648-50; author reply 1650. 2006