Dominique Bonnet

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. ncbi request reprint Haematopoietic stem cells
    Dominique Bonnet
    Cancer Research UK, London Research Institute, London, UK
    J Pathol 197:430-40. 2002
  2. pmc Overexpression of wild-type or mutants forms of CEBPA alter normal human hematopoiesis
    O Quintana-Bustamante
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London, UK
    Leukemia 26:1537-46. 2012
  3. ncbi request reprint Cancer stem cells: AMLs show the way
    D Bonnet
    Hematopoietic Stem Cell Laboratory, Cancer Research UK
    Biochem Soc Trans 33:1531-3. 2005
  4. ncbi request reprint Biology of human bone marrow stem cells
    D Bonnet
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, WC2A3PX London, UK
    Clin Exp Med 3:140-9. 2003
  5. ncbi request reprint Hematopoietic stem cells
    Dominique Bonnet
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, WC2A3PX, UK
    Birth Defects Res C Embryo Today 69:219-29. 2003
  6. ncbi request reprint Cancer stem cells: lessons from leukaemia
    D Bonnet
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London, UK
    Cell Prolif 38:357-61. 2005
  7. ncbi request reprint Leukemic stem cells show the way
    Dominique Bonnet
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A, UK
    Folia Histochem Cytobiol 43:183-6. 2005
  8. ncbi request reprint Normal and leukaemic stem cells
    Dominique Bonnet
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London, UK
    Br J Haematol 130:469-79. 2005
  9. doi request reprint Humanized model to study leukemic stem cells
    Dominique Bonnet
    Cancer Research UK, London Research Institute, Haematopoietic Stem Cell Laboratory, 44 Lincoln s Inn Fields, WC2A 3PX, London, UK
    Methods Mol Biol 538:247-62. 2009
  10. ncbi request reprint Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells
    Elena K Siapati
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, London, UK
    Eur J Haematol 78:303-13. 2007

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Haematopoietic stem cells
    Dominique Bonnet
    Cancer Research UK, London Research Institute, London, UK
    J Pathol 197:430-40. 2002
    ..This review summarizes all the recent advances made in the human HSC field and examines the impacts that these discoveries may have both clinically and in understanding the organization of the human haematopoietic system...
  2. pmc Overexpression of wild-type or mutants forms of CEBPA alter normal human hematopoiesis
    O Quintana-Bustamante
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London, UK
    Leukemia 26:1537-46. 2012
    ..It provides the first insight into the effects of N- and C-ter mutations acting alone and to the combined effects of N/C double mutants. Our results mimicked closely what happens in CEBPA mutated patients...
  3. ncbi request reprint Cancer stem cells: AMLs show the way
    D Bonnet
    Hematopoietic Stem Cell Laboratory, Cancer Research UK
    Biochem Soc Trans 33:1531-3. 2005
    ..This report will review our current knowledge on LSC development and finally demonstrate how these discoveries provide a paradigm for identification of CSCs from solid tumours...
  4. ncbi request reprint Biology of human bone marrow stem cells
    D Bonnet
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, WC2A3PX London, UK
    Clin Exp Med 3:140-9. 2003
    ..We also discuss the recent unexpected degree of differentiation plasticity that have been reported recently and the impacts these new discoveries may have in stem cell therapy...
  5. ncbi request reprint Hematopoietic stem cells
    Dominique Bonnet
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, WC2A3PX, UK
    Birth Defects Res C Embryo Today 69:219-29. 2003
    ..In this review, we will summarize the recent advances made in the human HSC field, and we will examine the impacts these discoveries may have clinically and on our understanding of the organization of the human hematopoietic system...
  6. ncbi request reprint Cancer stem cells: lessons from leukaemia
    D Bonnet
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London, UK
    Cell Prolif 38:357-61. 2005
    ..This report will review our current knowledge on leukaemic stem cells development and finally demonstrate how these discoveries provide a paradigm for identification of cancer stem cells from solid tumours...
  7. ncbi request reprint Leukemic stem cells show the way
    Dominique Bonnet
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A, UK
    Folia Histochem Cytobiol 43:183-6. 2005
    ..This report will review our current knowledge on leukemic stem cell development and finally demonstrate how these discoveries provide a paradigm for identification of Cancer Stem Cell (CSC) from solid tumors...
  8. ncbi request reprint Normal and leukaemic stem cells
    Dominique Bonnet
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London, UK
    Br J Haematol 130:469-79. 2005
    ..This report will review our current knowledge on normal and LSC development and examine the impact of these discoveries may have clinically and in our understanding of the leukaemogenic process...
  9. doi request reprint Humanized model to study leukemic stem cells
    Dominique Bonnet
    Cancer Research UK, London Research Institute, Haematopoietic Stem Cell Laboratory, 44 Lincoln s Inn Fields, WC2A 3PX, London, UK
    Methods Mol Biol 538:247-62. 2009
    ..We will concentrate on the model of acute myeloid leukemia, as it was the first type of leukemia for which the xenotransplantation model was developed...
  10. ncbi request reprint Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells
    Elena K Siapati
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, London, UK
    Eur J Haematol 78:303-13. 2007
    ....
  11. ncbi request reprint Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells
    Elena K Siapati
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Mol Ther 12:537-46. 2005
    ..Interestingly, the presence or absence of Tat in viral preparations did not influence the transduction efficiency of HIV-1 vectors in human HSCs...
  12. ncbi request reprint Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging
    Daniel J Pearce
    Hematopoietic Stem Cell Laboratory, London Research Institute, Cancer Research UK, London, United Kingdom
    Stem Cells 25:828-35. 2007
    ..A possible selection-based mechanism of stem cell pool aging is discussed...
  13. ncbi request reprint Characterization of cells with a high aldehyde dehydrogenase activity from cord blood and acute myeloid leukemia samples
    Daniel J Pearce
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Stem Cells 23:752-60. 2005
    ..Identification and isolation of leukemic cells on the basis of ALDH activity provides a tool for their isolation and further analysis...
  14. pmc AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML
    Daniel J Pearce
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London, UK
    Blood 107:1166-73. 2006
    ..Our results suggest an important difference between leukemic initiating cells between engrafting and nonengrafting AML cases that correlates with treatment response...
  15. pmc Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia
    David C Taussig
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute
    Blood 106:4086-92. 2005
    ..Our findings also provide a challenge to contemporary attempts to improve the outcome of AML using myeloid antigen-targeted therapies, given the potential for HSC killing...
  16. pmc A niche-like culture system allowing the maintenance of primary human acute myeloid leukemia-initiating cells: a new tool to decipher their chemoresistance and self-renewal mechanisms
    Emmanuel Griessinger
    Haematopoietic Stem Cell Laboratory London Research Institute, Cancer Research UK, London, United Kingdom Centre for Haemato Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
    Stem Cells Transl Med 3:520-9. 2014
    ..This would further provide the means by which to identify and target the functionality of the different signaling pathways involved in the maintenance and resistance of LICs to improve acute myeloid leukemia treatments. ..
  17. doi request reprint Multimodal imaging reveals structural and functional heterogeneity in different bone marrow compartments: functional implications on hematopoietic stem cells
    Francois Lassailly
    Haematopoietic Stem Cell Laboratory, Londong Research Institute, Cancer Research UK, London, United Kingdom
    Blood 122:1730-40. 2013
    ..Both types of niches were observed in the calvarium, indicating that endochondral ossification, the process needed for the formation of HSC niches during embryogenesis, is dispensable for the formation of HSC niches during adulthood...
  18. doi request reprint Prospective identification and isolation of murine bone marrow derived multipotent mesenchymal progenitor cells
    Fernando Anjos-Afonso
    Haematopoietic Stem Cell Lab, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Best Pract Res Clin Haematol 24:13-24. 2011
    ....
  19. doi request reprint Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells
    David C Taussig
    Department of Medical Oncology, St Bartholomew s Hospital, London, UK
    Blood 112:568-75. 2008
    ..More importantly, the work suggests that there is greater variation in the phenotypes of leukemia-initiating cells than previously suggested...
  20. ncbi request reprint Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung
    Susana Aguilar
    Hematopoietic Stem Cell Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Stem Cells 25:1586-94. 2007
    ..These findings might be clinically relevant for future stem cell therapy studies. Disclosure of potential conflicts of interest is found at the end of this article...
  21. ncbi request reprint In vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions
    Fernando Anjos-Afonso
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, London
    J Cell Sci 117:5655-64. 2004
    ....
  22. doi request reprint Isolation, culture, and differentiation potential of mouse marrow stromal cells
    Fernando Anjos-Afonso
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom
    Curr Protoc Stem Cell Biol . 2008
    ..A general and easy protocol is presented here for isolating stromal cells from different inbred and transgenic mice commonly used in the stem cell biology field...
  23. ncbi request reprint The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells
    Daniel J Pearce
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London, UK
    Exp Hematol 35:1437-46. 2007
    ..Elevated levels of aldehyde dehydrogenase (ALDH) have been demonstrated in murine and human progenitor cells when compared to other hematopoietic cells...
  24. ncbi request reprint Out of the blue: a comparison of Hoechst side population (SP) analysis of murine bone marrow using 325, 363 and 407 nm excitation sources
    Catherine Simpson
    FACS Laboratory, London Research Institute, Cancer Research UK, London
    J Immunol Methods 310:171-81. 2006
    ..Here we compare the results of SP cells from the same specimens generated on three different instruments...
  25. ncbi request reprint In vivo formation of unstable heterokaryons after liver damage and hematopoietic stem cell/progenitor transplantation
    Karl Kashofer
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, United Kingdom
    Stem Cells 24:1104-12. 2006
    ..Because no selective pressure is applied to retain the human genomic material, it is gradually lost over time, leading to a variable phenotype of the chimeric cells and making their detection difficult...
  26. pmc Active RHOA favors retention of human hematopoietic stem/progenitor cells in their niche
    Bithiah Grace Jaganathan
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Biomed Sci 20:66. 2013
    ..Rho GTPases have been found to control the migration of hematopoietic cells and other cell types. Although the role of RAC1, RAC2 and CDC42 has been studied, the role of RHOA in human hematopoietic stem cells is unclear...
  27. doi request reprint Engraftment defect of cytokine-cultured adult human mobilized CD34(+) cells is related to reduced adhesion to bone marrow niche elements
    Konstantina Kallinikou
    Department of Haematology, Cancer Institute, University College of London, London, UK
    Br J Haematol 158:778-87. 2012
    ..Our findings suggest that cytokine exposure of adult human HSPC results in altered adhesion within bone marrow niches, further leading to reduced engraftment potential in vivo...
  28. pmc Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells
    Lionel Franz Poulin
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    J Exp Med 207:1261-71. 2010
    ..The characterization of human DNGR-1+ BDCA3hi DCs and the ability to grow them in vitro opens the door for exploiting this subset in immunotherapy...
  29. ncbi request reprint Nonhematopoietic/endothelial SSEA-1+ cells define the most primitive progenitors in the adult murine bone marrow mesenchymal compartment
    Fernando Anjos-Afonso
    Haematopoietic Stem Cell Lab, Cancer Research UK, London Research Institute, UK
    Blood 109:1298-306. 2007
    ..Altogether we are proposing a hierarchical organization of the mesenchymal compartment, placing SSEA-1+ cells at the apex of this hierarchy...
  30. doi request reprint Humanized mouse models to study the human haematopoietic stem cell compartment
    Dominique Bonnet
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London, UK
    Methods Mol Biol 506:331-40. 2009
    ..It is not possible to perform these experiments in humans, but xenotransplantation mouse models provide the closest paradigm for the human hematopoietic environment at the present time...
  31. pmc Different Motile Behaviors of Human Hematopoietic Stem versus Progenitor Cells at the Osteoblastic Niche
    Katie Foster
    Haematopoietic Stem Cell Laboratory, The Francis Crick Institute, London WC2A 3LY, UK
    Stem Cell Reports 5:690-701. 2015
    ..Intravital imaging is the only technique to determine where in the bone marrow stem cells stop moving, and future analyses should focus on the environment surrounding the HSC at this point. ..
  32. pmc Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis
    Fabrizio Vianello
    Department of Haematology, Kennedy Institute of Rheumatology, Imperial College, London, UK
    Haematologica 95:1081-9. 2010
    ..Mesenchymal stromal cells in the bone marrow may favor the persistence and progression of leukemia by preserving the proliferation and self-renewal capacities of the malignant progenitor cells...
  33. ncbi request reprint Multiparameter analysis of murine bone marrow side population cells
    Daniel J Pearce
    Hematopoietic Stem Cell Laboratory, London Research Institute, Cancer Research UK, London, UK
    Blood 103:2541-6. 2004
    ..Hence, the SP cell fraction highlights a subset of the long-term repopulating cells found within the already highly purified KTLS fraction...
  34. doi request reprint In vivo evaluation of leukemic stem cells through the xenotransplantation model
    Dominique Bonnet
    Cancer Research UK, London Research Institute, Haematopoietic Stem Cell Laboratory, London, United Kingdom
    Curr Protoc Stem Cell Biol . 2008
    ..Nevertheless, the Basic Protocol could be applied to other sorts of blood disorders...
  35. pmc AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo
    Adedayo Oke
    Medical Oncology, St Bartholomew s Hospital and Medical School, London, UK
    Cancer Res 69:4150-8. 2009
    ..These data suggest that the inhibition of aurora B kinase may be a useful therapeutic strategy in the treatment of AML and that further exploration of dosing and treatment schedules is warranted in clinical trials...
  36. doi request reprint Frequency and Dynamics of Leukemia-Initiating Cells during Short-term Ex Vivo Culture Informs Outcomes in Acute Myeloid Leukemia Patients
    Emmanuel Griessinger
    INSERM U1065, C3M, Team 4, Inflammation, Cancer, Cancer Stem Cells, Nice, France Cancer Research UK, London Research Institute, The Francis Crick Institute, London, United Kingdom
    Cancer Res 76:2082-6. 2016
    ..Cancer Res; 76(8); 2082-6. ©2016 AACR. ..
  37. pmc APOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcripts
    Ahmadreza Niavarani
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom Digestive Disease Research Institute DDRI, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
    PLoS ONE 10:e0120089. 2015
    ..These findings open the way to further investigations into the mechanisms of other potential mRNA changes, which will help to redefine the RNA editing paradigm in both health and disease...
  38. doi request reprint A novel model of dormancy for bone metastatic breast cancer cells
    Rebecca Marlow
    Authors Affiliations Stem Cell Group, Breakthrough Breast Cancer Research Unit, Research Oncology, King s College London School of Medicine, Guy s Hospital Department of Craniofacial Development and Stem Cell Biology, King s College London, Guy s Hospital Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London, United Kingdom and Rutgers New Jersey Medical School, Newark, New Jersey
    Cancer Res 73:6886-99. 2013
    ..These experimental systems will be instrumental for metastasis studies, particularly the study of cellular dormancy...
  39. ncbi request reprint Flexible and dynamic organization of bone marrow stromal compartment
    Fernando Anjos-Afonso
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London, UK
    Br J Haematol 139:373-84. 2007
    ..Several issues concerning lineage commitment and inter-conversion potential between different mesenchymal cell-types are reviewed...
  40. doi request reprint Human mesenchymal stromal cells senesce with exogenous OCT4
    Bithiah Grace Jaganathan
    Haematopoietic Stem Cell Laboratory, Cancer Research UK, London, UK
    Cytotherapy 14:1054-63. 2012
    ..OCT4 has also been studied extensively for its involvement in self-renewal of embryonic stem cells and in cancer cells...
  41. doi request reprint Aerodynamically assisted bio-jetting of hematopoietic stem cells
    Emmanuel Griessinger
    Haematopoietic Stem Cell Laboratory, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Analyst 137:1329-33. 2012
    ..Interestingly these studies pave the way for this technology to undergo development as a flow cell for utility as a sheathless cell most useful in flow cytometry...
  42. doi request reprint "Microenvironmental contaminations" induced by fluorescent lipophilic dyes used for noninvasive in vitro and in vivo cell tracking
    Francois Lassailly
    Hematopoietic Stem Cell Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London, United Kingdom
    Blood 115:5347-54. 2010
    ..We conclude that tracking of labeled cells using non-genetically encoded markers should always be accompanied by drastic cross validation using multimodality approaches...
  43. doi request reprint HIF-2α protects human hematopoietic stem/progenitors and acute myeloid leukemic cells from apoptosis induced by endoplasmic reticulum stress
    Kevin Rouault-Pierre
    Haematopoietic Stem Cell Laboratory, London Research Institute, Cancer Research UK, WC2A 3LY, London, UK INSERM U 1035, Bordeaux, F 33076 France Université Bordeaux Segalen, Bordeaux, F 33076 France
    Cell Stem Cell 13:549-63. 2013
    ..Overall, our data demonstrate a key role for HIF-2α in the maintenance of human HSPCs and in the survival of primary AML cells. ..
  44. doi request reprint DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues
    Lionel F Poulin
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, United Kingdom
    Blood 119:6052-62. 2012
    ..Thus, high expression of DNGR-1 specifically and universally identifies a unique DC subset in mouse and humans. Evolutionarily conserved Batf3 dependence justifies classification of DNGR-1(hi) DCs as a distinct DC lineage...
  45. doi request reprint Ageing within the hematopoietic stem cell compartment
    Daniel Pearce
    Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Mech Ageing Dev 130:54-7. 2009
    ..Here, we have focused on hematopoietic stem cells as they are one of the best-characterized adult stem cell populations, and have been extensively studied for the consequences of ageing in vivo and in vitro...
  46. doi request reprint CD34(-) cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures
    Fernando Anjos-Afonso
    Haematopoietic Stem Cell Lab, Cancer Research UK
    Cell Stem Cell 13:161-74. 2013
    ..Overall, therefore, CD34(-) cells represent an immature and quiescent human HSC population maintained through a distinctive network of cellular signaling interactions. ..
  47. ncbi request reprint Stem cells of the alveolar epithelium
    Mark J D Griffiths
    Unit of Critical Care, Imperial College London at National Heart and Lung Institute and Royal Brompton Hospital, London, UK
    Lancet 366:249-60. 2005
    ..The biology is exciting but not yet well enough understood to support therapeutic advances...
  48. doi request reprint Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact
    Kevin Rouault-Pierre
    a Haematopoietic Stem Cell Laboratory, The Francis Crick Institute, London, UK
    Expert Opin Biol Ther 16:463-76. 2016
    ..Despite an increase in our understanding of the different pathways regulated by HIF-1α and HIF-2α, the role played by each factor in HSC maintenance and leukemogenesis is still controversial...
  49. ncbi request reprint Gene therapy progress and prospects: stem cell plasticity
    K Kashofer
    Haematopoietic Stem Cell Lab, Cancer Research UK, London Research Institute, London, UK
    Gene Ther 12:1229-34. 2005
    ..Identification of putative tissue stem cells would be necessary before purification strategies can be devised. In this review, we discuss the evidence for these models, and the conflicting results obtained to date...
  50. ncbi request reprint Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth
    R Ramasamy
    Stem Cell Biology Section, Kennedy Institute of Rheumatology and Division of Investigative Sciences, Imperial College Faculty of Medicine, London, UK
    Leukemia 21:304-10. 2007
    ..We conclude that the clinical use of MSC in conditions in which a malignant disease is involved should be handled with extreme caution...
  51. ncbi request reprint Implications of the expression of myeloid markers on normal and leukemic stem cells
    Daniel J Pearce
    Cancer Research, UK
    Cell Cycle 5:271-3. 2006
    ..Xenotransplantation assays should be used wherever possible to test the suitability of candidate antigens for targeted therapy, including the assessment of the effect on normal cells...
  52. ncbi request reprint Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3
    Matthew L Smith
    Cancer Research UK Medical Oncology Unit, Charterhouse Square, Barts and the London School of Medicine and Dentistry, London
    Br J Haematol 128:318-23. 2005
    ..A 51-bp deletion was detected in CCND3 in a patient with normal karyotype AML. This validated panel now provides an important tool to evaluate other candidate genes in the genesis of myeloid malignancy...
  53. ncbi request reprint Development of a quantitative real-time polymerase chain reaction method for monitoring CEBPA mutations in normal karyotype acute myeloid leukaemia
    Lan Lan Smith
    Br J Haematol 133:103-5. 2006
  54. doi request reprint WTX is rarely mutated in acute myeloid leukemia
    Carolyn Owen
    Haematologica 93:947-8. 2008