Masashi Narita

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. doi Rags connect mTOR and autophagy
    Masashi Narita
    Cancer Research UK Cambridge Research Institute, Cambridge, UK
    Small Gtpases 3:111-4. 2012
  2. pmc Cellular senescence and chromatin organisation
    M Narita
    Cancer Research UK, Cambridge Research Institute, Robinson Way, Cambridge, UK
    Br J Cancer 96:686-91. 2007
  3. ncbi Autophagy facilitates oncogene-induced senescence
    Masako Narita
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
    Autophagy 5:1046-7. 2009
  4. pmc Quality and quantity control of proteins in senescence
    Masashi Narita
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, United Kingdom
    Aging (Albany NY) 2:311-4. 2010
  5. pmc Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence
    Mahito Sadaie
    Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, United Kingdom
    Genes Dev 27:1800-8. 2013
  6. pmc Spatial coupling of mTOR and autophagy augments secretory phenotypes
    Masako Narita
    Cancer Research UK Cambridge Research Institute CRI, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Science 332:966-70. 2011
  7. pmc High-order chromatin structure and the epigenome in SAHFs
    Tamir Chandra
    Epigenetics and Nuclear Dynamics, The Babraham Institute, Cambridge, UK
    Nucleus 4:23-8. 2013
  8. doi Cell senescence as both a dynamic and a static phenotype
    Andrew R J Young
    Cancer Research UK, Cambridge Research Institute, Cambridge, UK
    Methods Mol Biol 965:1-13. 2013
  9. pmc Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53
    Kristina Kirschner
    Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom
    PLoS Genet 11:e1005053. 2015
  10. doi Spatio-temporal association between mTOR and autophagy during cellular senescence
    Andrew R J Young
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
    Autophagy 7:1387-8. 2011

Collaborators

Detail Information

Publications23

  1. doi Rags connect mTOR and autophagy
    Masashi Narita
    Cancer Research UK Cambridge Research Institute, Cambridge, UK
    Small Gtpases 3:111-4. 2012
    ..Thus, the TASCC provides evidence for the functional relevance of the Rag-mediated association between lysosomes and mTOR, and provides a mechanism for the simultaneous activation of anabolic and catabolic processes...
  2. pmc Cellular senescence and chromatin organisation
    M Narita
    Cancer Research UK, Cambridge Research Institute, Robinson Way, Cambridge, UK
    Br J Cancer 96:686-91. 2007
    ..In this review, recent discoveries on the interplay between senescence and chromatin biology are overviewed...
  3. ncbi Autophagy facilitates oncogene-induced senescence
    Masako Narita
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
    Autophagy 5:1046-7. 2009
    ..We have recently found that autophagy is activated upon acute induction of senescence and facilitates another effector mechanism: the senescence associated secretory phenotype (SASP)...
  4. pmc Quality and quantity control of proteins in senescence
    Masashi Narita
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, United Kingdom
    Aging (Albany NY) 2:311-4. 2010
    ..The new link between autophagy and senescence provides an insight into the diversified downstream effects of autophagy in various cellular contexts...
  5. pmc Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence
    Mahito Sadaie
    Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge CB2 0RE, United Kingdom
    Genes Dev 27:1800-8. 2013
    ..These results suggest that LMNB1 may contribute to senescence in at least two ways due to its uneven genome-wide redistribution: first, through the spatial reorganization of chromatin and, second, through gene repression. ..
  6. pmc Spatial coupling of mTOR and autophagy augments secretory phenotypes
    Masako Narita
    Cancer Research UK Cambridge Research Institute CRI, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Science 332:966-70. 2011
    ..The spatial coupling of cells' catabolic and anabolic machinery could augment their respective functions and facilitate the mass synthesis of secretory proteins...
  7. pmc High-order chromatin structure and the epigenome in SAHFs
    Tamir Chandra
    Epigenetics and Nuclear Dynamics, The Babraham Institute, Cambridge, UK
    Nucleus 4:23-8. 2013
    ..Evidence for the co-association of similar types of chromatin is emerging and SAHFs may provide a unique model system to study the correlation between HOCS and chromatin types, which are readily visible and regulable...
  8. doi Cell senescence as both a dynamic and a static phenotype
    Andrew R J Young
    Cancer Research UK, Cambridge Research Institute, Cambridge, UK
    Methods Mol Biol 965:1-13. 2013
    ..Furthermore, searching for new effector programs of senescence will help to define this heterogeneous and complex phenotype according to cellular contexts...
  9. pmc Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53
    Kristina Kirschner
    Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, United Kingdom
    PLoS Genet 11:e1005053. 2015
    ..Our data reveal distinct phenotype associations of chronic p53 targets that underlie specific gene regulatory mechanisms. ..
  10. doi Spatio-temporal association between mTOR and autophagy during cellular senescence
    Andrew R J Young
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK
    Autophagy 7:1387-8. 2011
    ..Since mTOR inhibits autophagy during the initial stages of autophagosome formation, TASCC formation is likely to facilitate autophagy by sequestering mTOR, suggesting that the TASCC is a self-enhancing structure...
  11. pmc Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation
    Tamir Chandra
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Mol Cell 47:203-14. 2012
    ..These experiments reveal that high-order heterochromatin formation and epigenetic remodeling of the genome can be discrete events...
  12. pmc NOTCH1 mediates a switch between two distinct secretomes during senescence
    Matthew Hoare
    University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK
    Nat Cell Biol 18:979-92. 2016
    ....
  13. pmc Autophagy mediates the mitotic senescence transition
    Andrew R J Young
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom
    Genes Dev 23:798-803. 2009
    ..Furthermore, inhibition of autophagy delays the senescence phenotype, including senescence-associated secretion. Our data suggest that autophagy, and its consequent protein turnover, mediate the acquisition of the senescence phenotype...
  14. doi Translating the effects of mTOR on secretory senescence
    Kosuke Tomimatsu
    University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK
    Nat Cell Biol 17:1230-2. 2015
    ..The mammalian target of rapamycin (mTOR), a master regulator of protein synthesis, is now shown to control the senescence-associated secretory phenotype by modulating gene transcription and mRNA translation and stabilization. ..
  15. doi Inside and out: the activities of senescence in cancer
    Pedro A Perez-Mancera
    Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK
    Nat Rev Cancer 14:547-58. 2014
    ..Senescence is now increasingly considered to be an integrated and widespread component that is potentially important for tumour development, tumour suppression and the response to therapy. ..
  16. doi Normalization of metabolomics data with applications to correlation maps
    Alexandra Jauhiainen
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, PO Box 281, SE 171 77 Stockholm, Sweden and Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Bioinformatics 30:2155-61. 2014
    ..We also investigate how the common use of a calibration standard in nuclear magnetic resonance (NMR) experiments affects the estimation of correlations...
  17. doi Transmitting senescence to the cell neighbourhood
    Matthew Hoare
    Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK
    Nat Cell Biol 15:887-9. 2013
    ..The SASP is now shown to be regulated by inflammasomes and to induce paracrine senescence in healthy cells, indicating that senescence may also represent a non-cell-autonomous tumour suppressor mechanism linked to innate immunity. ..
  18. doi Autophagy in cancer: having your cake and eating it
    Matthew Hoare
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK
    Semin Cancer Biol 21:397-404. 2011
    ..In this review we summarise the current evidence on the relationship between autophagy and cancer, with a focus on its role in senescence...
  19. doi Connecting autophagy to senescence in pathophysiology
    Andrew Rj Young
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, CB2 0RE, United Kingdom
    Curr Opin Cell Biol 22:234-40. 2010
    ..Autophagy seemingly has different impacts on cells responding to stress through a diversity of effects: recycling of metabolic waste, cell survival and protein expression regulation...
  20. ncbi Oncogenic HMGA2: short or small?
    Andrew R J Young
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, United Kingdom
    Genes Dev 21:1005-9. 2007
  21. ncbi Autophagy Detection During Oncogene-Induced Senescence Using Fluorescence Microscopy
    Masako Narita
    Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, CB2 0RE, UK
    Methods Mol Biol 1534:89-98. 2017
    ..Thus, in this chapter, we describe how to generate OIS cells using human diploid fibroblasts (HDFs), the best-characterized cell model of OIS, and how to detect autophagy, particularly focusing on immunofluorescence methods...
  22. ncbi Generation of Ag-specific cytotoxic T lymphocytes by DC transfected with in vitro transcribed influenza virus matrix protein (M1) mRNA
    Y Osman
    First Department of Internal Medicine, Niigata University, Japan
    Cytotherapy 5:161-8. 2003
    ..In this study, Ag-specific cytotoxic T lymphocytes (CTL) were generated by priming lymphocytes with DC transfected with in vitro transcribed (IVT) influenza virus matrix protein M1 (M1) mRNA...
  23. ncbi Effects of fluvoxamine on morphine-induced inhibition of gastrointestinal transit, antinociception and hyperlocomotion in mice
    Y Ise
    Section of Pharmaceutical Service, Nippon Medical School Hospital, 1-1-5 Sendagi, Bunkyou-ku, Tokyo 113-8603, Japan
    Neurosci Lett 299:29-32. 2001
    ..However, further understanding and clinical studies will be required to confirm this possibility...