Santiago Zelenay

Summary

Affiliation: Cancer Research UK
Country: UK

Publications

  1. doi Cutting edge: Intrathymic differentiation of adaptive Foxp3+ regulatory T cells upon peripheral proinflammatory immunization
    Santiago Zelenay
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    J Immunol 185:3829-33. 2010
  2. doi Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions
    João H Duarte
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Eur J Immunol 39:948-55. 2009
  3. doi Steroid treatments in mice do not alter the number and function of regulatory T cells, but amplify cyclophosphamide-induced autoimmune disease
    Maria Francisca Moraes-Fontes
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, Oeiras, Portugal
    J Autoimmun 33:109-20. 2009
  4. pmc Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion
    Santiago Zelenay
    Instituto Gulbenkian de Ciencia, Apartado 14, PT 2781 901 Oeiras, Portugal
    Proc Natl Acad Sci U S A 102:4091-6. 2005
  5. pmc Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery
    Ricardo S Paiva
    Instituto Gulbenkian de Ciencia, 2780 901 Oeiras, Portugal
    Proc Natl Acad Sci U S A 110:6494-9. 2013
  6. ncbi Heme oxygenase-1 is not required for mouse regulatory T cell development and function
    Santiago Zelenay
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 6, Apartado 14, 2780 901 Oeiras, Portugal
    Int Immunol 19:11-8. 2007
  7. ncbi Regulatory T cells in microbial infection
    Jocelyne Demengeot
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, Apartado 14, 2781 901, Oeiras, Portugal
    Springer Semin Immunopathol 28:41-50. 2006
  8. ncbi Physiopathology of natural auto-antibodies: the case for regulation
    Santiago Zelenay
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, Apartado 14, 2781 901 Oeiras, Portugal
    J Autoimmun 29:229-35. 2007
  9. pmc Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    Iris Caramalho
    Instituto Gulbenkian de Ciencia, 2781 901 Oeiras, Portugal
    J Exp Med 197:403-11. 2003

Detail Information

Publications9

  1. doi Cutting edge: Intrathymic differentiation of adaptive Foxp3+ regulatory T cells upon peripheral proinflammatory immunization
    Santiago Zelenay
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    J Immunol 185:3829-33. 2010
    ..Our findings uncover a pathway for T(R) generation with major implications for immunity and tolerance induction...
  2. doi Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions
    João H Duarte
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Eur J Immunol 39:948-55. 2009
    ..Our findings that Treg convert into pathogenic Th cells in absence of IL-2 provide new clues to the success of Treg-based immune therapies...
  3. doi Steroid treatments in mice do not alter the number and function of regulatory T cells, but amplify cyclophosphamide-induced autoimmune disease
    Maria Francisca Moraes-Fontes
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, Oeiras, Portugal
    J Autoimmun 33:109-20. 2009
    ..Our analysis indicates that while a short course of corticosteroids alone is not deleterious to immune regulation, combined therapies, notably with Cyp, should be avoided...
  4. pmc Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion
    Santiago Zelenay
    Instituto Gulbenkian de Ciencia, Apartado 14, PT 2781 901 Oeiras, Portugal
    Proc Natl Acad Sci U S A 102:4091-6. 2005
    ....
  5. pmc Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery
    Ricardo S Paiva
    Instituto Gulbenkian de Ciencia, 2780 901 Oeiras, Portugal
    Proc Natl Acad Sci U S A 110:6494-9. 2013
    ..Our findings indicating that RTEs are the precursors of Tregs differentiated in the periphery should guide the design of Treg-based therapies...
  6. ncbi Heme oxygenase-1 is not required for mouse regulatory T cell development and function
    Santiago Zelenay
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande, 6, Apartado 14, 2780 901 Oeiras, Portugal
    Int Immunol 19:11-8. 2007
    ..Finally, we conclude that under physiological conditions in mice, Treg development, maintenance and function are independent of HO-1 activity...
  7. ncbi Regulatory T cells in microbial infection
    Jocelyne Demengeot
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, Apartado 14, 2781 901, Oeiras, Portugal
    Springer Semin Immunopathol 28:41-50. 2006
    ....
  8. ncbi Physiopathology of natural auto-antibodies: the case for regulation
    Santiago Zelenay
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, Apartado 14, 2781 901 Oeiras, Portugal
    J Autoimmun 29:229-35. 2007
    ....
  9. pmc Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    Iris Caramalho
    Instituto Gulbenkian de Ciencia, 2781 901 Oeiras, Portugal
    J Exp Med 197:403-11. 2003
    ..These findings provide the first evidence that Treg respond directly to proinflammatory bacterial products, a mechanism that likely contributes to the control of inflammatory responses...