C H George

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. doi request reprint Ryanodine receptor dysfunction in arrhythmia and sudden cardiac death
    Christopher H George
    Cardiff University School of Medicine, Department of Cardiology, Wales Heart Research Institute, Heath Park, Cardiff, CF14 4XN, UK
    Future Cardiol 1:531-41. 2005
  2. pmc A network-oriented perspective on cardiac calcium signaling
    Christopher H George
    Wales Heart Research Institute and Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff Univ, Heath Park, Cardiff, Wales, UK CF14 4XN
    Am J Physiol Cell Physiol 303:C897-910. 2012
  3. ncbi request reprint Developing new anti-arrhythmics: clues from the molecular basis of cardiac ryanodine receptor (RyR2) Ca2+-release channel dysfunction
    Christopher H George
    Wales Heart Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, Wales, UK CF14 4XN
    Curr Pharm Des 13:3195-211. 2007
  4. ncbi request reprint Sarcoplasmic reticulum Ca2+ leak in heart failure: mere observation or functional relevance?
    Christopher H George
    Wales Heart Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Cardiovasc Res 77:302-14. 2008
  5. ncbi request reprint Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signaling and susceptibility to apoptosis
    Christopher H George
    Department of Cardiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Circ Res 100:874-83. 2007
  6. ncbi request reprint Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies
    Christopher H George
    Department of Cardiology, Wales Heart Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    J Mol Cell Cardiol 42:34-50. 2007
  7. ncbi request reprint Arrhythmogenic mutation-linked defects in ryanodine receptor autoregulation reveal a novel mechanism of Ca2+ release channel dysfunction
    Christopher H George
    Department of Cardiology, Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff, UK
    Circ Res 98:88-97. 2006
  8. ncbi request reprint Toward a molecular understanding of the structure-function of ryanodine receptor Ca2+ release channels: perspectives from recombinant expression systems
    Christopher H George
    Wales Heart Research Institute, Department of Cardiology, College of Medicine, Cardiff University, UK CF14 4XN
    Cell Biochem Biophys 42:197-222. 2005
  9. ncbi request reprint Rapid determination of gap junction formation using HeLa cells microinjected with cDNAs encoding wild-type and chimeric connexins
    C H George
    Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Biochem Biophys Res Commun 247:785-9. 1998
  10. ncbi request reprint Connexin-aequorin chimerae report cytoplasmic calcium environments along trafficking pathways leading to gap junction biogenesis in living COS-7 cells
    C H George
    Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff, Wales CF4 4XN, United Kingdom
    J Biol Chem 273:29822-9. 1998

Collaborators

Detail Information

Publications23

  1. doi request reprint Ryanodine receptor dysfunction in arrhythmia and sudden cardiac death
    Christopher H George
    Cardiff University School of Medicine, Department of Cardiology, Wales Heart Research Institute, Heath Park, Cardiff, CF14 4XN, UK
    Future Cardiol 1:531-41. 2005
    ....
  2. pmc A network-oriented perspective on cardiac calcium signaling
    Christopher H George
    Wales Heart Research Institute and Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff Univ, Heath Park, Cardiff, Wales, UK CF14 4XN
    Am J Physiol Cell Physiol 303:C897-910. 2012
    ....
  3. ncbi request reprint Developing new anti-arrhythmics: clues from the molecular basis of cardiac ryanodine receptor (RyR2) Ca2+-release channel dysfunction
    Christopher H George
    Wales Heart Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff, Wales, UK CF14 4XN
    Curr Pharm Des 13:3195-211. 2007
    ....
  4. ncbi request reprint Sarcoplasmic reticulum Ca2+ leak in heart failure: mere observation or functional relevance?
    Christopher H George
    Wales Heart Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Cardiovasc Res 77:302-14. 2008
    ....
  5. ncbi request reprint Alternative splicing of ryanodine receptors modulates cardiomyocyte Ca2+ signaling and susceptibility to apoptosis
    Christopher H George
    Department of Cardiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff, UK
    Circ Res 100:874-83. 2007
    ..Thus, we provide the first evidence that RyR2 splice variants exquisitely modulate intracellular Ca(2+) signaling and are key determinants of cardiomyocyte apoptotic susceptibility...
  6. ncbi request reprint Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies
    Christopher H George
    Department of Cardiology, Wales Heart Research Institute, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK
    J Mol Cell Cardiol 42:34-50. 2007
    ..Finally, we evaluate the concept that mechanistic differences between CPVT and other arrhythmogenic disorders may preclude a common therapeutic strategy to normalise RyR2 function in cardiac disease...
  7. ncbi request reprint Arrhythmogenic mutation-linked defects in ryanodine receptor autoregulation reveal a novel mechanism of Ca2+ release channel dysfunction
    Christopher H George
    Department of Cardiology, Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff, UK
    Circ Res 98:88-97. 2006
    ..Our findings also suggest that the mutational locus may be an important mechanistic determinant of Ca2+ release channel dysfunction in arrhythmia and SCD...
  8. ncbi request reprint Toward a molecular understanding of the structure-function of ryanodine receptor Ca2+ release channels: perspectives from recombinant expression systems
    Christopher H George
    Wales Heart Research Institute, Department of Cardiology, College of Medicine, Cardiff University, UK CF14 4XN
    Cell Biochem Biophys 42:197-222. 2005
    ....
  9. ncbi request reprint Rapid determination of gap junction formation using HeLa cells microinjected with cDNAs encoding wild-type and chimeric connexins
    C H George
    Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    Biochem Biophys Res Commun 247:785-9. 1998
    ....
  10. ncbi request reprint Connexin-aequorin chimerae report cytoplasmic calcium environments along trafficking pathways leading to gap junction biogenesis in living COS-7 cells
    C H George
    Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff, Wales CF4 4XN, United Kingdom
    J Biol Chem 273:29822-9. 1998
    ..The implications of the subplasma-membrane Ca2+ levels on the gating of gap junctions are discussed...
  11. pmc Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains
    Christopher H George
    Wales Heart Research Institute, Department of Cardiology, University of Wales College of Medicine, Cardiff, United Kingdom CF14 4XN
    Mol Biol Cell 15:2627-38. 2004
    ..These results provide compelling evidence that specific interaction between cytoplasmic and transmembrane domains is an important mechanism in the intrinsic modulation of RyR Ca(2+) release channels...
  12. ncbi request reprint Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes
    Christopher H George
    Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Circ Res 93:531-40. 2003
    ..Furthermore, equivalent interaction between mutant and WT hRyR2 and FKBP12.6 was demonstrated...
  13. ncbi request reprint Intracellular trafficking pathways in the assembly of connexins into gap junctions
    C H George
    Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, Wales, United Kingdom
    J Biol Chem 274:8678-85. 1999
    ..These contrasting effects of brefeldin A and nocodazole on the trafficking properties and intercellular dye transfer are interpreted to suggest that two pathways contribute to the routing of connexins to the gap junction...
  14. ncbi request reprint Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6
    Christopher H George
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 278:28856-64. 2003
    ..These data demonstrate that defective regulation of RyR causes altered cellular phenotype via profound perturbations in intracellular Ca2+ signaling and highlight a key modulatory role of FKBP12.6 in hRyR2 Ca2+ channel function...
  15. ncbi request reprint Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction
    N L Thomas
    Department of Cardiology, Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, U K
    Biochem Soc Trans 35:946-51. 2007
    ....
  16. ncbi request reprint Analysis of gap junction assembly using mutated connexins detected in Charcot-Marie-Tooth X-linked disease
    P E Martin
    Department of Medical Biochemistry, University of Wales College of Medicine, Cardiff, UK
    J Neurochem 74:711-20. 2000
    ..The results show that modifications in trafficking and assembly of gap junction channels emerge as a major feature of Charcot-Marie-Tooth X-linked disease...
  17. pmc In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6
    Christopher H George
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Biochem J 370:579-89. 2003
    ..6 on hRyR2-mediated intracellular Ca(2+) handling could be antagonized using rapamycin (5 microM). These results suggest that FKBP12.6 associates with hRyR2 in situ to modulate precisely the functionality of hRyR2 Ca(2+)-release channel...
  18. ncbi request reprint Functional heterogeneity of ryanodine receptor mutations associated with sudden cardiac death
    N Lowri Thomas
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, Wales CF14 4XN, UK
    Cardiovasc Res 64:52-60. 2004
    ..We investigated the functional impact of a distinct set of SCD-linked RyR2 mutations (L(433)P, N(2386)I, R(176)Q/T(2504)M) on intracellular Ca(2+) handling...
  19. ncbi request reprint Role of ryanodine receptor mutations in cardiac pathology: more questions than answers?
    N L Thomas
    Department of Cardiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK
    Biochem Soc Trans 34:913-8. 2006
    ..Understanding the causes of aberrant Ca2+ release via RyR2 may assist in the development of effective treatments for the ventricular arrhythmias that often leads to sudden death in HF and in CPVT...
  20. ncbi request reprint Is fish oil good or bad for heart disease? Two trials with apparently conflicting results
    M L Burr
    Department of Epidemiology, Statistics and Public Health, Cardiff University, Wales CF14 4XN, UK
    J Membr Biol 206:155-63. 2005
    ..A mechanism is proposed that could account for these findings...
  21. ncbi request reprint Differential Ca2+ sensitivity of RyR2 mutations reveals distinct mechanisms of channel dysfunction in sudden cardiac death
    N Lowri Thomas
    Department of Cardiology, Wales Heart Research Institute, Cardiff University School of Medicine, Cardiff, Wales CF14 4XN, UK
    Biochem Biophys Res Commun 331:231-8. 2005
    ..Our findings support the hypothesis that SCD-linked mutational loci may be an important mechanistic determinant of RyR2 dysfunction and indicate that there is unlikely to be a unifying mechanism for channel dysfunction in SCD...
  22. doi request reprint Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering
    Anne Catherine Raby
    Department of Medical Biochemistry and Immunology, Cardiff University, United Kingdom
    J Immunol 183:506-17. 2009
    ....
  23. ncbi request reprint Genetic polymorphisms in beta1 and beta2 adrenergic receptors: variations without a theme?
    Christopher H George
    Heart Rhythm 5:822-5. 2008