T M Griffith

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. pmc Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide
    Ambroise Garry
    Department of Diagnostic Radiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Cardiovasc Res 84:218-26. 2009
  2. pmc Ouabain exerts biphasic effects on connexin functionality and expression in vascular smooth muscle cells
    Patricia E M Martin
    Department of Diagnostic Radiology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Br J Pharmacol 140:1261-71. 2003
  3. pmc Enhanced inhibition of the EDHF phenomenon by a phenyl methoxyalaninyl phosphoramidate derivative of dideoxyadenosine
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN
    Br J Pharmacol 142:27-30. 2004
  4. ncbi request reprint Endothelial control of vascular tone by nitric oxide and gap junctions: a haemodynamic perspective
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, UK
    Biorheology 39:307-18. 2002
  5. pmc Endothelium-dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis?
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN
    Br J Pharmacol 141:881-903. 2004
  6. pmc 5-Methyltetrahydrofolate and tetrahydrobiopterin can modulate electrotonically mediated endothelium-dependent vascular relaxation
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 102:7008-13. 2005
  7. ncbi request reprint The obligatory link: role of gap junctional communication in endothelium-dependent smooth muscle hyperpolarization
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Pharmacol Res 49:551-64. 2004
  8. ncbi request reprint Cyclic AMP mediates EDHF-type relaxations of rabbit jugular vein
    T M Griffith
    Cardiovascular Sciences Research Group, University of Wales College of Medicine, Cardiff, CF4 4XN, United Kingdom
    Biochem Biophys Res Commun 263:52-7. 1999
  9. pmc cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 99:6392-7. 2002
  10. pmc Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil
    M D Randall
    Department of Diagnostic Radiology, University of Wales College of Medicine, Health Park, Cardiff
    Br J Pharmacol 109:386-93. 1993

Collaborators

Detail Information

Publications36

  1. pmc Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide
    Ambroise Garry
    Department of Diagnostic Radiology, Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Cardiovasc Res 84:218-26. 2009
    ..Our objective was to investigate whether pro-oxidant properties of ascorbic acid (AA) and tetrahydrobiopterin (BH(4)) modulate endothelium-dependent, electrotonically mediated arterial relaxation...
  2. pmc Ouabain exerts biphasic effects on connexin functionality and expression in vascular smooth muscle cells
    Patricia E M Martin
    Department of Diagnostic Radiology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Br J Pharmacol 140:1261-71. 2003
    ....
  3. pmc Enhanced inhibition of the EDHF phenomenon by a phenyl methoxyalaninyl phosphoramidate derivative of dideoxyadenosine
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN
    Br J Pharmacol 142:27-30. 2004
    ....
  4. ncbi request reprint Endothelial control of vascular tone by nitric oxide and gap junctions: a haemodynamic perspective
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff, UK
    Biorheology 39:307-18. 2002
    ..There is growing evidence that NO/prostanoid independent relaxations involve direct heterocellular signalling between endothelial and smooth muscle cells via gap junctions...
  5. pmc Endothelium-dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis?
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN
    Br J Pharmacol 141:881-903. 2004
    ....
  6. pmc 5-Methyltetrahydrofolate and tetrahydrobiopterin can modulate electrotonically mediated endothelium-dependent vascular relaxation
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 102:7008-13. 2005
    ....
  7. ncbi request reprint The obligatory link: role of gap junctional communication in endothelium-dependent smooth muscle hyperpolarization
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Pharmacol Res 49:551-64. 2004
    ..This review will discuss the roles of these interacting signalling pathways in the mediation of the EDHF phenomenon...
  8. ncbi request reprint Cyclic AMP mediates EDHF-type relaxations of rabbit jugular vein
    T M Griffith
    Cardiovascular Sciences Research Group, University of Wales College of Medicine, Cardiff, CF4 4XN, United Kingdom
    Biochem Biophys Res Commun 263:52-7. 1999
    ..Both mechanisms may contribute to EDHF/gap junction-dependent relaxations...
  9. pmc cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions
    Tudor M Griffith
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 99:6392-7. 2002
    ..These findings support the hypothesis that endothelial hyperpolarization underpins the EDHF phenomenon, with cAMP governing subsequent electrotonic signaling via both myoendothelial and homocellular smooth muscle gap junctions...
  10. pmc Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil
    M D Randall
    Department of Diagnostic Radiology, University of Wales College of Medicine, Health Park, Cardiff
    Br J Pharmacol 109:386-93. 1993
    ..These results suggest that levcromakalim may selectively dilate both hypoxic vessels and vessels with impaired EDRF activity. The results also point to important differences in the pharmacology of levcromakalim and pinacidil...
  11. pmc Effects of BRL 38227, sodium nitroprusside and verapamil on collateral perfusion following acute arterial occlusion in the rabbit isolated ear
    M D Randall
    Department of Diagnostic Radiology, University of Wales College of Medicine, Heath Park, Cardiff
    Br J Pharmacol 106:315-23. 1992
    ..Furthermore, BRL 38227 also improves collateral perfusion following inhibition of EDRF synthesis. It remains to be established whether BRL 38227 has beneficial actions in acute arterial occlusion in vivo...
  12. ncbi request reprint Gap junction-dependent increases in smooth muscle cAMP underpin the EDHF phenomenon in rabbit arteries
    H J Taylor
    Department of Diagnostic Radiology, University of Wales College of Medicine, Cardiff, CF14 4XN, United Kingdom
    Biochem Biophys Res Commun 283:583-9. 2001
    ....
  13. doi request reprint Hydrogen peroxide potentiates the EDHF phenomenon by promoting endothelial Ca2+ mobilization
    David H Edwards
    Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, UK
    Arterioscler Thromb Vasc Biol 28:1774-81. 2008
    ..The purpose of this study was to test the hypothesis that H(2)O(2) contributes to the EDHF phenomenon by mobilizing endothelial Ca(2+) stores...
  14. ncbi request reprint Universal scaling properties of type-I intermittent chaos in isolated resistance arteries are unaffected by endogenous nitric oxide synthesis
    D Parthimos
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, United Kingdom
    Phys Rev E Stat Nonlin Soft Matter Phys 64:061906. 2001
    ..5 both in the presence and absence of NO synthesis...
  15. pmc Differential effects of L-arginine on the inhibition by NG-nitro-L-arginine methyl ester of basal and agonist-stimulated EDRF activity
    M D Randall
    Department of Diagnostic Radiology, University of Wales College of Medicine, Heath Park, Cardiff
    Br J Pharmacol 104:743-9. 1991
    ....
  16. ncbi request reprint Gap junctional communication underpins EDHF-type relaxations evoked by ACh in the rat hepatic artery
    A T Chaytor
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff CF14 4XN, United Kingdom
    Am J Physiol Heart Circ Physiol 280:H2441-50. 2001
    ....
  17. pmc Impaired cyclic nucleotide-mediated vasorelaxation may contribute to closure of the human umbilical artery after birth
    S Renowden
    Department of Diagnostic Radiology, University of Wales College of Medicine, Heath Park, Cardiff
    Br J Pharmacol 106:348-53. 1992
    ..This impaired response to cyclic nucleotides may contribute to closure of the umbilical artery after birth...
  18. ncbi request reprint Relative contributions of NO and gap junctional communication to endothelium-dependent relaxations of rabbit resistance arteries vary with vessel size
    Rodney S Berman
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, Wales, United Kingdom
    Microvasc Res 63:115-28. 2002
    ....
  19. ncbi request reprint Modulation of gap-junction-dependent arterial relaxation by ascorbic acid
    David H Edwards
    Department of Diagnostic Radiology, Wales Heart Research Institute, Cardiff University, Cardiff, UK
    J Vasc Res 44:410-22. 2007
    ..To investigate whether ascorbic acid (AA) can influence endothelium-dependent relaxation by modulating the spread of endothelial hyperpolarization through the arterial wall via gap junctions...
  20. pmc Distinct hyperpolarizing and relaxant roles for gap junctions and endothelium-derived H2O2 in NO-independent relaxations of rabbit arteries
    Andrew T Chaytor
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Proc Natl Acad Sci U S A 100:15212-7. 2003
    ..Endothelium-derived H2O2 may thus be regarded as a relaxing factor, but not a hyperpolarizing factor, in rabbit arteries...
  21. ncbi request reprint Shil'nikov homoclinic chaos is intimately related to type-III intermittency in isolated rabbit arteries: role of nitric oxide
    D Parthimos
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom
    Phys Rev E Stat Nonlin Soft Matter Phys 67:051922. 2003
    ..Simulations of the effects of nitric oxide (NO) by the vascular endothelium on these patterns of behavior closely match experimental observations...
  22. ncbi request reprint Forecasting chaotic cardiovascular time series with an adaptive slope multilayer perceptron neural network
    N Stamatis
    Department of Radiology, University of Wales College of Medicine, Cardiff, U K
    IEEE Trans Biomed Eng 46:1441-53. 1999
    ..The approach is computationally inexpensive as the increase in the parameter space of the network compared to a standard MLP is small...
  23. pmc Connexin-mimetic peptides dissociate electrotonic EDHF-type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery
    Andrew T Chaytor
    Department of Diagnostic Radiology, Wales Heart Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK
    Br J Pharmacol 144:108-14. 2005
    ..The findings provide further evidence that the EDHF phenomenon is electrotonic in nature, and highlight the contribution of myoendothelial and homocellular smooth muscle communication via gap junctions to arterial function...
  24. pmc Abolition of flow-dependent EDRF release before that evoked by agonists in hypercholesterolaemic rabbits
    I R Hutcheson
    Department of Diagnostic Radiology, University of Wales College of Medicine, Heath Park, Cardiff
    Br J Pharmacol 113:190-4. 1994
    ..This is consistent with the view that different transduction mechanisms mediate EDRF release in response to agonists and flow.Keywords: Rabbit aorta; pulsatile flow; hypercholesterolaemia; endothelium-derived relaxing factor (EDRF)..
  25. pmc Modulation of vasodilatation to levcromakalim by adenosine analogues in the rabbit ear: an explanation for hypoxic augmentation
    M D Randall
    Department of Diagnostic Radiology, University of Wales College of Medicine, Heath Park, Cardiff
    Br J Pharmacol 112:49-54. 1994
    ..The findings of this study suggest that levcromakalim may selectively dilate vessels where there is elevated adenosine release...
  26. ncbi request reprint Essential role of Gap junctions in NO- and prostanoid-independent relaxations evoked by acetylcholine in rabbit intracerebral arteries
    Hiroshi Ujiie
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Stroke 34:544-50. 2003
    ....
  27. ncbi request reprint Phosphoramidate derivatives of 2',5'-dideoxyadenosine as potential inhibitors of the EDHF phenomenon
    F Gavazza
    Welsh School of Pharmacy, Redwood Building, Cardiff University, Cardiff CFIO 3XF, UK
    Nucleosides Nucleotides Nucleic Acids 24:553-5. 2005
    ..In the present work a new series of 2',5'-ddA phosphoramidates has been synthesized, representing the first example of phosphoramidate protide not at the 5'-position...
  28. ncbi request reprint Gap junction-dependent and -independent EDHF-type relaxations may involve smooth muscle cAMP accumulation
    Andrew T Chaytor
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Cardiff CF14 4XN, United Kingdom
    Am J Physiol Heart Circ Physiol 282:H1548-55. 2002
    ....
  29. doi request reprint Attenuated store-operated Ca2+ entry underpins the dual inhibition of nitric oxide and EDHF-type relaxations by iodinated contrast media
    Sofia Fernandez-Rodriguez
    Wales Heart Research Institute, Department of Diagnostic Radiology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Cardiovasc Res 84:470-8. 2009
    ....
  30. pmc Dynamics of a three-variable nonlinear model of vasomotion: comparison of theory and experiment
    D Parthimos
    Wales Heart Research Institute, Department of Diagnostic Radiology, Cardiff University, Cardiff, UK
    Biophys J 93:1534-56. 2007
    ..The main conclusion of the study is that a general model of vasomotion that predicts experimental data can be constructed by a low-order system that incorporates nonlinear interactions between dynamical control variables...
  31. ncbi request reprint Integration of non-linear cellular mechanisms regulating microvascular perfusion
    T M Griffith
    Department of Diagnostic Radiology, University of Wales College of Medicine, Cardiff, UK
    Proc Inst Mech Eng H 213:369-83. 1999
    ..The sensitivity of chaotic trajectories to perturbation may nevertheless generate a high degree of variability in the response to pharmacological interventions and altered perfusion conditions...
  32. pmc Effects of connexin-mimetic peptides on gap junction functionality and connexin expression in cultured vascular cells
    Patricia E M Martin
    Department of Diagnostic Radiology, Wales Heart Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN
    Br J Pharmacol 144:617-27. 2005
    ..7. The reversibility and lack of effect of the peptides on plaque formation suggests that they may be considered ideal probes for functional studies of connexin-mediated communication in the vascular wall...
  33. ncbi request reprint Deterministic nonlinear characteristics of in vivo blood flow velocity and arteriolar diameter fluctuations
    D Parthimos
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Phys Med Biol 49:1789-802. 2004
    ..Complexity indices characterizing time series under control conditions were in general higher than those derived from data obtained during superfusion with L-NNA and TBA...
  34. ncbi request reprint Endogenous nitric oxide synthesis differentially modulates pressure-flow and pressure-conductance relationships in the internal and external carotid artery circulations of the rat
    Hiroshi Ujiie
    Department of Diagnostic Radiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Neurol Med Chir (Tokyo) 42:527-34; discussion 535. 2002
    ....
  35. ncbi request reprint Analysis of effects of connexin-mimetic peptides in rat mesenteric small arteries
    Vladimir V Matchkov
    The Water and Salt Research Center, Institute of Physiology and Biophysics, University of Aarhus, Aarhus, Denmark
    Am J Physiol Heart Circ Physiol 291:H357-67. 2006
    ..Taken together, the results indicate that connexin-mimetic peptides block electrical signaling in rat mesenteric small arteries without exerting major nonjunctional effects...
  36. ncbi request reprint Which connexins connect?
    Tudor M Griffith
    Circ Res 101:1219-21. 2007