Stuart W Hughes

Summary

Affiliation: Cardiff University
Country: UK

Publications

  1. ncbi request reprint Cellular mechanisms of the slow (<1 Hz) oscillation in thalamocortical neurons in vitro
    Stuart W Hughes
    School of Biosciences, Cardiff University, Museum Avenue, CF10 3US, Cardiff, United Kingdom
    Neuron 33:947-58. 2002
  2. pmc Temporal framing of thalamic relay-mode firing by phasic inhibition during the alpha rhythm
    Magor L Lorincz
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Neuron 63:683-96. 2009
  3. pmc NeuReal: an interactive simulation system for implementing artificial dendrites and large hybrid networks
    Stuart W Hughes
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    J Neurosci Methods 169:290-301. 2008
  4. pmc Novel modes of rhythmic burst firing at cognitively-relevant frequencies in thalamocortical neurons
    Stuart W Hughes
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    Brain Res 1235:12-20. 2008
  5. ncbi request reprint Synchronized oscillations at alpha and theta frequencies in the lateral geniculate nucleus
    Stuart W Hughes
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, United Kingdom
    Neuron 42:253-68. 2004
  6. ncbi request reprint Neuronal basis of the slow (<1 Hz) oscillation in neurons of the nucleus reticularis thalami in vitro
    Kate L Blethyn
    School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    J Neurosci 26:2474-86. 2006
  7. pmc Activity of cortical and thalamic neurons during the slow (<1 Hz) rhythm in the mouse in vivo
    Vincenzo Crunelli
    Neuroscience Division, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK
    Pflugers Arch 463:73-88. 2012
  8. pmc Novel neuronal and astrocytic mechanisms in thalamocortical loop dynamics
    Vincenzo Crunelli
    School of Biosciences, University of Cardiff, Museum Avenue, Cardiff CF10 3US, UK
    Philos Trans R Soc Lond B Biol Sci 357:1675-93. 2002
  9. pmc ATP-dependent infra-slow (<0.1 Hz) oscillations in thalamic networks
    Magor L Lorincz
    School of Biosciences, Cardiff University, Cardiff, UK
    PLoS ONE 4:e4447. 2009
  10. pmc The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators
    Vincenzo Crunelli
    School of Biosciences, Cardiff University, Cardiff, UK
    Nat Neurosci 13:9-17. 2010

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Cellular mechanisms of the slow (<1 Hz) oscillation in thalamocortical neurons in vitro
    Stuart W Hughes
    School of Biosciences, Cardiff University, Museum Avenue, CF10 3US, Cardiff, United Kingdom
    Neuron 33:947-58. 2002
    ..These results suggest an active role for the thalamus in shaping the slow (<1 Hz) sleep rhythm...
  2. pmc Temporal framing of thalamic relay-mode firing by phasic inhibition during the alpha rhythm
    Magor L Lorincz
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    Neuron 63:683-96. 2009
    ..These results provide a potential cellular substrate for linking the alpha rhythm to perception and further underscore the central role of inhibition in controlling spike timing during cognitively relevant brain oscillations...
  3. pmc NeuReal: an interactive simulation system for implementing artificial dendrites and large hybrid networks
    Stuart W Hughes
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    J Neurosci Methods 169:290-301. 2008
    ..We demonstrate the power of NeuReal with several example experiments and argue that it provides an effective tool for examining various aspects of neuronal function...
  4. pmc Novel modes of rhythmic burst firing at cognitively-relevant frequencies in thalamocortical neurons
    Stuart W Hughes
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    Brain Res 1235:12-20. 2008
    ..Taken together, these results show that TC neurons are considerably more flexible than generally thought and strongly endorse a role for the thalamus in promoting a range of cognitively-relevant brain rhythms...
  5. ncbi request reprint Synchronized oscillations at alpha and theta frequencies in the lateral geniculate nucleus
    Stuart W Hughes
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, United Kingdom
    Neuron 42:253-68. 2004
    ..We propose that mGluR1a-induced oscillations are a potential mechanism whereby the thalamus promotes EEG alpha and theta rhythms in the intact brain...
  6. ncbi request reprint Neuronal basis of the slow (<1 Hz) oscillation in neurons of the nucleus reticularis thalami in vitro
    Kate L Blethyn
    School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    J Neurosci 26:2474-86. 2006
    ..In combination with previous work in thalamocortical neurons, this study suggests that the thalamus plays an important and active role in shaping the slow (<1 Hz) rhythm during deep sleep...
  7. pmc Activity of cortical and thalamic neurons during the slow (<1 Hz) rhythm in the mouse in vivo
    Vincenzo Crunelli
    Neuroscience Division, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK
    Pflugers Arch 463:73-88. 2012
    ..Thus, UP/DOWN state generation appears to be an elemental and conserved process in mammals that underlies the slow (<1 Hz) rhythm in several species, including humans...
  8. pmc Novel neuronal and astrocytic mechanisms in thalamocortical loop dynamics
    Vincenzo Crunelli
    School of Biosciences, University of Cardiff, Museum Avenue, Cardiff CF10 3US, UK
    Philos Trans R Soc Lond B Biol Sci 357:1675-93. 2002
    ..As some of these novel cellular and intracellular properties are not restricted to thalamic astrocytes and neurons, their significance may well apply to (patho)physiological functions of glial and neuronal elements in other brain areas...
  9. pmc ATP-dependent infra-slow (<0.1 Hz) oscillations in thalamic networks
    Magor L Lorincz
    School of Biosciences, Cardiff University, Cardiff, UK
    PLoS ONE 4:e4447. 2009
    ..We argue that this ISO has a likely non-neuronal origin and may contribute to shaping ISOs in the intact brain...
  10. pmc The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators
    Vincenzo Crunelli
    School of Biosciences, Cardiff University, Cardiff, UK
    Nat Neurosci 13:9-17. 2010
    ....
  11. pmc Infraslow (<0.1 Hz) oscillations in thalamic relay nuclei basic mechanisms and significance to health and disease states
    Stuart W Hughes
    Neuroscience Division, School of Biosciences, Cardiff University, Cardiff, UK
    Prog Brain Res 193:145-62. 2011
    ..Last, we consider the relevance of these thalamic ISOs to the pathological activity that occurs in certain types of epilepsy...
  12. pmc Cellular dynamics of cholinergically induced alpha (8-13 Hz) rhythms in sensory thalamic nuclei in vitro
    Magor L Lorincz
    School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    J Neurosci 28:660-71. 2008
    ....
  13. pmc The thalamic low-threshold Ca²⁺ potential: a key determinant of the local and global dynamics of the slow (<1 Hz) sleep oscillation in thalamocortical networks
    Vincenzo Crunelli
    Neuroscience Division, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK
    Philos Trans A Math Phys Eng Sci 369:3820-39. 2011
    ....
  14. pmc Just a phase they're going through: the complex interaction of intrinsic high-threshold bursting and gap junctions in the generation of thalamic alpha and theta rhythms
    Stuart W Hughes
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    Int J Psychophysiol 64:3-17. 2007
    ..We argue that these network dynamics might have important consequences for relating changes in the amplitude of EEG alpha and theta rhythms to the activity of thalamic networks...
  15. pmc Rhythmic dendritic Ca2+ oscillations in thalamocortical neurons during slow non-REM sleep-related activity in vitro
    Adam C Errington
    A C Errington Neuroscience Division, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK
    J Physiol 590:3691-700. 2012
    ....
  16. pmc Thalamic T-type Ca2+ channels and NREM sleep
    Vincenzo Crunelli
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    Cell Calcium 40:175-90. 2006
    ....
  17. pmc The 'window' T-type calcium current in brain dynamics of different behavioural states
    Vincenzo Crunelli
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    J Physiol 562:121-9. 2005
    ....
  18. pmc Thalamic Gap Junctions Control Local Neuronal Synchrony and Influence Macroscopic Oscillation Amplitude during EEG Alpha Rhythms
    Stuart W Hughes
    Neuroscience Division, School of Biosciences, Cardiff University Cardiff, UK
    Front Psychol 2:193. 2011
    ..e., dye-coupling and spikelets) we conclude that these GJs must belong to TC neurons. The potential significance of these findings for relating macroscopic changes in α rhythms to basic cellular processes is discussed...
  19. ncbi request reprint Thalamic mechanisms of EEG alpha rhythms and their pathological implications
    Stuart W Hughes
    School of Biosciences, Cardiff University, Cardiff, UK
    Neuroscientist 11:357-72. 2005
    ..As such, this scenario can explain both the deceleration of alpha rhythms that takes place during early sleep and the chronic slowing that characterizes a host of neurological and psychiatric disorders...
  20. ncbi request reprint GABAA receptor-mediated tonic inhibition in thalamic neurons
    David W Cope
    School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    J Neurosci 25:11553-63. 2005
    ..Thus, tonic current in TC neurons generates an inhibitory tone. Its modulation contributes to the shift between different firing modes, promotes the transition between different behavioral states, and predisposes to absence seizures...
  21. pmc A distinct class of slow (~0.2-2 Hz) intrinsically bursting layer 5 pyramidal neurons determines UP/DOWN state dynamics in the neocortex
    Magor L Lorincz
    Research Group for Cellular and Network Neurophysiology of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, 6726 Szeged, Hungary, Neuroscience Division, School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom, and
    J Neurosci 35:5442-58. 2015
    ..This study, therefore, identifies an important role for cell-type-specific neuronal activity in driving neocortical UP states...
  22. doi request reprint The thalamocortical network as a single slow wave-generating unit
    Vincenzo Crunelli
    Neuroscience Division, School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK Electronic address
    Curr Opin Neurobiol 31:72-80. 2015
    ..Together, these new data confirm the view that a full understanding of slow waves can only be achieved by considering the thalamocortical network as a single functional and dynamic unit for the generation of this key EEG rhythm. ..
  23. pmc Are corticothalamic 'up' states fragments of wakefulness?
    Alain Destexhe
    CNRS, Integrative and Computational Neuroscience Unit 1, Avenue de la Terrasse, Gif sur Yvette Cedex 91198, France
    Trends Neurosci 30:334-42. 2007
    ..This review is part of the INMED/TINS special issue Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com)...
  24. ncbi request reprint Pathway-specific action of gamma-hydroxybutyric acid in sensory thalamus and its relevance to absence seizures
    Nicolas Gervasi
    Neurobiologie des Processus Adaptatifs, Unite Mixte de Recherche, Centre National de la Recherche Scientifique 7102 Université Pierre et Marie Curie, F 75005 Paris, France
    J Neurosci 23:11469-78. 2003
    ..Furthermore, the present data strengthen previous suggestions on the GHB mechanism of sleep promotion and will help focus future studies on the cellular mechanisms underlying its abuse...