E Z Tchilian

Summary

Affiliation: Edward Jenner Institute for Vaccine Research
Country: UK

Publications

  1. pmc CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells
    Jenny Piercy
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
    Immunology 118:250-6. 2006
  2. ncbi Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice
    Elma Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
    Int Immunol 16:1323-32. 2004
  3. ncbi The exon A (C77G) mutation is a common cause of abnormal CD45 splicing in humans
    E Z Tchilian
    Edward Jenner Institute for Vaccine Research, Compton, United Kingdom
    J Immunol 166:6144-8. 2001
  4. ncbi A CD45 polymorphism associated with abnormal splicing is absent in African populations
    Elma Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, Berks RG20 7NN, UK
    Immunogenetics 53:980-3. 2002
  5. ncbi CD45 in memory and disease
    Elma Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, UK
    Arch Immunol Ther Exp (Warsz) 50:85-93. 2002
  6. ncbi Altered CD45 expression and disease
    Elma Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, UK RG 20 7NN
    Trends Immunol 27:146-53. 2006
  7. ncbi A point mutation in CD45 may be associated with an increased risk of HIV-1 infection
    E Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, UK
    AIDS 15:1892-4. 2001
  8. ncbi A deletion in the gene encoding the CD45 antigen in a patient with SCID
    E Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, United Kingdom
    J Immunol 166:1308-13. 2001
  9. pmc Unusual case presentations associated with the CD45 C77G polymorphism
    E Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, UK
    Clin Exp Immunol 146:448-54. 2006
  10. ncbi CD45 is required for type I IFN production by dendritic cells
    Maria Montoya
    The Edward Jenner Institute for Vaccine Research, Compton, UK
    Eur J Immunol 36:2150-8. 2006

Collaborators

Detail Information

Publications17

  1. pmc CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells
    Jenny Piercy
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
    Immunology 118:250-6. 2006
    ..These results show that TLR signalling is increased in CD45-/- dendritic cells and imply that CD45 is a negative regulator of TLR and cytokine receptor signalling in dendritic cells...
  2. ncbi Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice
    Elma Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
    Int Immunol 16:1323-32. 2004
    ..These effects are more prominent in CD8 than CD4 cells. The transgenic mice share several properties with humans expressing variant CD45 alleles and provide a model to understand immune function in variant individuals...
  3. ncbi The exon A (C77G) mutation is a common cause of abnormal CD45 splicing in humans
    E Z Tchilian
    Edward Jenner Institute for Vaccine Research, Compton, United Kingdom
    J Immunol 166:6144-8. 2001
    ..We conclude that the exon A (C77G) mutation is a common cause of abnormal CD45 splicing and that further disease association studies of this mutation are warranted...
  4. ncbi A CD45 polymorphism associated with abnormal splicing is absent in African populations
    Elma Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, Berks RG20 7NN, UK
    Immunogenetics 53:980-3. 2002
    ..Here we report that the variant CD45 C77G allele is absent in African populations. We further show that populations living in the Pamir mountains of Central Asia have a very high prevalence of the C77G variant...
  5. ncbi CD45 in memory and disease
    Elma Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, UK
    Arch Immunol Ther Exp (Warsz) 50:85-93. 2002
    ..Accumulating data from these genetic and biochemical studies promises to elucidate the role of high and low molecular weight isoforms of CD45 in the function of naïve and memory T lymphocytes...
  6. ncbi Altered CD45 expression and disease
    Elma Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, UK RG 20 7NN
    Trends Immunol 27:146-53. 2006
    ..Here, we discuss the new opportunities provided by the human variants for investigating and understanding how CD45 regulates antigen receptor signalling, cytokine responses and apoptosis...
  7. ncbi A point mutation in CD45 may be associated with an increased risk of HIV-1 infection
    E Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, UK
    AIDS 15:1892-4. 2001
    ..Here we show that abnormal CD45 splicing caused by a C77G transversion in exon A of the gene encoding CD45 (PTPRC) is associated with increased susceptibility to HIV-1 infection...
  8. ncbi A deletion in the gene encoding the CD45 antigen in a patient with SCID
    E Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, United Kingdom
    J Immunol 166:1308-13. 2001
    ....
  9. pmc Unusual case presentations associated with the CD45 C77G polymorphism
    E Z Tchilian
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, UK
    Clin Exp Immunol 146:448-54. 2006
    ..All four have the C77G polymorphism of CD45 exon 4, which alters the splicing and CD45RA/CD45R0 phenotype of lymphocytes. We suggest that C77G may be a contributing factor in these unusual cases...
  10. ncbi CD45 is required for type I IFN production by dendritic cells
    Maria Montoya
    The Edward Jenner Institute for Vaccine Research, Compton, UK
    Eur J Immunol 36:2150-8. 2006
    ..These data indicate that lack of CD45 expression in DC has a profound effect on their function. This is largely restored by CD45RABC or CD45RO transgenes...
  11. ncbi CD45 regulates apoptosis in peripheral T lymphocytes
    Zhe Liu
    Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
    Int Immunol 18:959-66. 2006
    ..We conclude that CD45 is an important regulator of spontaneous apoptosis in T lymphocytes and this mechanism may contribute to the disease associations reported for individuals expressing CD45 variant alleles...
  12. ncbi Geographical distribution and disease associations of the CD45 exon 6 138G variant
    Victoria Ward
    Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, Cancer Research UK, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    Immunogenetics 58:235-9. 2006
    ..The allele is widely distributed in the Far East and India, indicating that it may have a significant effect on disease burden in a large part of the human population...
  13. pmc Combinations of CD45 isoforms are crucial for immune function and disease
    Ritu Dawes
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, United Kingdom
    J Immunol 176:3417-25. 2006
    ..CD45(RO/+) cells produce more TNF-alpha and IFN-gamma. Thus, for the first time, we have shown experimentally that it is the combination of CD45 isoforms that affects immune function and disease...
  14. ncbi Disease associations and altered immune function in CD45 138G variant carriers
    Sally Boxall
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
    Hum Mol Genet 13:2377-84. 2004
    ..These data suggest that the 138G variant allele strongly influences these diseases by modulation of immune mechanisms and may have achieved its high frequency as a result of a natural selection probably related to pathogen resistance...
  15. pmc A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression
    Tara Stanton
    Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, Cancer Research UK, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 100:5997-6002. 2003
    ..These phenotypic alterations in the A138G carriers may lead to changes in ligand binding, homodimerization of CD45, and altered immune responses, suggesting the involvement of natural selection in controlling the A138G carrier frequency...
  16. ncbi CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans
    Tara Stanton
    Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, Cancer Research UK, John Radcliffe Hospital, OX3 9DU, Oxford, UK
    Immunogenetics 56:107-10. 2004
    ..This suggests that the 54G variant and CD45 splicing abnormalities might be associated with HIV infection...
  17. ncbi Novel perforin mutation in a patient with hemophagocytic lymphohistiocytosis and CD45 abnormal splicing
    James McCormick
    The Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, United Kingdom
    Am J Med Genet A 117:255-60. 2003
    ..Our findings suggest a combined role for perforin mutation and abnormal CD45 splicing as significant contributory factors in the pathogenesis of HLH...