M G Belvisi

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. ncbi Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-kappaB pathway activation
    Mark A Birrell
    Respiratory Pharmacology Group, Faculty of Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 172:74-84. 2005
  2. pmc Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids
    Sterghios A Moschos
    Biopharmaceutics Research Group, Airway Diseases Unit, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    BMC Genomics 8:240. 2007
  3. doi Cough sensors. III. Opioid and cannabinoid receptors on vagal sensory nerves
    M G Belvisi
    Respiratory Pharmacology, Airway Diseases, National Heart and Lung Institute, Imperial College, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK
    Handb Exp Pharmacol . 2009
  4. pmc Theophylline inhibits the cough reflex through a novel mechanism of action
    Eric Dubuis
    Respiratory Pharmacology, Pharmacology and Toxicology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 133:1588-98. 2014
  5. pmc Cigarette smoke induced airway inflammation is independent of NF-κB signalling
    Joseph M D Rastrick
    Respiratory Pharmacology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 8:e54128. 2013
  6. pmc Pre-clinical studies in cough research: role of Transient Receptor Potential (TRP) channels
    Megan S Grace
    Respiratory Pharmacology, Pharmacology and Toxicology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Pulm Pharmacol Ther 26:498-507. 2013
  7. pmc Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?
    Mark A Birrell
    Respiratory Pharmacology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 133:679-87.e9. 2014
  8. pmc Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin
    Megan Grace
    Respiratory Pharmacology Group, Pharmacology and Toxicology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Thorax 67:891-900. 2012
  9. pmc MMP/TIMP expression profiles in distinct lung disease models: implications for possible future therapies
    Sissie Wong
    Respiratory Pharmacology Group, Airways Disease Section, Imperial College London, Faculty of Medicine, National Heart and Lung Institute, 1st Floor Room 102, Sir Alexander Fleming Building, South Kensington Campus, Exhibition Road, London SW72AZ, UK
    Respir Res 10:72. 2009
  10. ncbi Regulation of inflammatory cell function by corticosteroids
    Maria G Belvisi
    Respiratory Pharmacology Group, Faculty of Medicine, Imperial College London, National Heart and Lung Institute, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK
    Proc Am Thorac Soc 1:207-14. 2004

Collaborators

Detail Information

Publications71

  1. ncbi Steroid-resistant inflammation in a rat model of chronic obstructive pulmonary disease is associated with a lack of nuclear factor-kappaB pathway activation
    Mark A Birrell
    Respiratory Pharmacology Group, Faculty of Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 172:74-84. 2005
    ..The mainstay therapy adopted to treat patients with COPD is glucocorticoids; unfortunately, this treatment has limited impact on disease symptoms or underlying airway inflammation...
  2. pmc Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids
    Sterghios A Moschos
    Biopharmaceutics Research Group, Airway Diseases Unit, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK
    BMC Genomics 8:240. 2007
    ..In these circumstances, patients are commonly treated with corticosteroids such as dexamethasone...
  3. doi Cough sensors. III. Opioid and cannabinoid receptors on vagal sensory nerves
    M G Belvisi
    Respiratory Pharmacology, Airway Diseases, National Heart and Lung Institute, Imperial College, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK
    Handb Exp Pharmacol . 2009
    ..In this chapter, we describe the opioid and cannabinoid receptors, their distribution and the effects they mediate. Moreover, we highlight their potential advantages and disadvantages in the treatment of cough...
  4. pmc Theophylline inhibits the cough reflex through a novel mechanism of action
    Eric Dubuis
    Respiratory Pharmacology, Pharmacology and Toxicology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 133:1588-98. 2014
    ..Cough is the most frequent reason for consultation with a family doctor, and treatment options are limited. Determining how theophylline inhibits cough might lead to the development of optimized compounds...
  5. pmc Cigarette smoke induced airway inflammation is independent of NF-κB signalling
    Joseph M D Rastrick
    Respiratory Pharmacology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    PLoS ONE 8:e54128. 2013
    ..Therefore the NF-κB/IKK-2 signalling pathway may represent a therapeutic target to attenuate the inflammation associated with COPD...
  6. pmc Pre-clinical studies in cough research: role of Transient Receptor Potential (TRP) channels
    Megan S Grace
    Respiratory Pharmacology, Pharmacology and Toxicology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Pulm Pharmacol Ther 26:498-507. 2013
    ..These ion channels are thought to be molecular pain integrators and targets for novel analgesic agents for the treatment of various pain disorders but some are also being developed as anti-tussives...
  7. pmc Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect?
    Mark A Birrell
    Respiratory Pharmacology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Allergy Clin Immunol 133:679-87.e9. 2014
    ..The mechanism by which tiotropium modifies tussive responses is not clear, but an inhibition of vagal tone and a consequent reduction in mucus production from submucosal glands and bronchodilation have been proposed...
  8. pmc Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin
    Megan Grace
    Respiratory Pharmacology Group, Pharmacology and Toxicology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Thorax 67:891-900. 2012
    ..However, how this occurs is not understood...
  9. pmc MMP/TIMP expression profiles in distinct lung disease models: implications for possible future therapies
    Sissie Wong
    Respiratory Pharmacology Group, Airways Disease Section, Imperial College London, Faculty of Medicine, National Heart and Lung Institute, 1st Floor Room 102, Sir Alexander Fleming Building, South Kensington Campus, Exhibition Road, London SW72AZ, UK
    Respir Res 10:72. 2009
    ..Since these models have their own characteristic pathophysiological phenotype, one would speculate that the MMP/TIMP expression profile would also be different...
  10. ncbi Regulation of inflammatory cell function by corticosteroids
    Maria G Belvisi
    Respiratory Pharmacology Group, Faculty of Medicine, Imperial College London, National Heart and Lung Institute, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK
    Proc Am Thorac Soc 1:207-14. 2004
    ..These differences in the responsiveness of activated inflammatory cells may help to explain why inhaled corticosteroid treatment has been more beneficial for patients with asthma than for patients with COPD...
  11. pmc Targeting PPAR receptors in the airway for the treatment of inflammatory lung disease
    Maria G Belvisi
    Respiratory Pharmacology Group, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    Br J Pharmacol 158:994-1003. 2009
    ..In conclusion, PPARs are novel targets for lung disease and continued work with these ligands may result in a potential new treatment for chronic inflammatory lung diseases...
  12. ncbi Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma
    Maria G Belvisi
    Respiratory Pharmacology, Department of Cardiothoracic Surgery, Imperial College School of Medicine at the National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    J Pharmacol Exp Ther 314:568-74. 2005
    ..Furthermore, ciclesonide possesses equivalent anti-inflammatory efficacy through pulmonary activation with a significantly improved safety profile in preclinical animal models compared with fluticasone...
  13. pmc EP4 receptor as a new target for bronchodilator therapy
    James Buckley
    Respiratory Pharmacology, Pharmacology and Toxicology Section, Imperial College London, Faculty of Medicine, National Heart and Lung Institute, Sir Alexander Fleming Building, London SW7 2AZ, UK
    Thorax 66:1029-35. 2011
    ..The aim of the study was to identify the receptor involved in prostaglandin E(2) (PGE(2))-induced relaxation in guinea pig, murine, monkey, rat and human airways in vitro...
  14. ncbi New advances and potential therapies for the treatment of asthma
    Maria G Belvisi
    Respiratory Pharmacology Group, Cardiothoracic Surgery, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, UK
    BioDrugs 18:211-23. 2004
    ....
  15. ncbi Soft steroids: a new approach to the treatment of inflammatory airways diseases
    Maria G Belvisi
    Respiratory Pharmacology Group, Cardiothoracic Surgery, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Pulm Pharmacol Ther 16:321-5. 2003
    ..These drugs may represent a significant step forward in the treatment of inflammatory diseases of the airways...
  16. ncbi New anti-inflammatory therapies and targets for asthma and chronic obstructive pulmonary disease
    Maria G Belvisi
    Respiratory Pharmacology Group, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Expert Opin Ther Targets 8:265-85. 2004
    ..This review will outline new targets and novel approaches currently under investigation, which may provide opportunities for novel anti-inflammatory therapeutic interventions that slow or halt disease progression in asthma and COPD...
  17. doi A role for sensory nerves in the late asthmatic response
    Kristof Raemdonck
    Respiratory Pharmacology Group, Pharmacology and Toxicology, National Heart and Lung Institute, Faculty of Medicine, London, UK
    Thorax 67:19-25. 2012
    ..Although many subjects with asthma consider LAR to be one of the defining symptoms of their disease, and despite its widespread use in the clinical assessment of new therapeutic entities, the mechanism underlying the LAR remains unclear...
  18. pmc Transient receptor potential A1 channels: insights into cough and airway inflammatory disease
    Maria G Belvisi
    Respiratory Pharmacology, Airway Disease Section, National Heart and Lung Institute, and the Centre for Integrative Physiology and Pharmacology, Faculty of Medicine, Imperial College London, London, England
    Chest 140:1040-7. 2011
    ....
  19. pmc Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways
    M G Belvisi
    Respiratory Pharmacology Group, Airway Disease Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK
    Br J Pharmacol 155:547-57. 2008
    ..Cannabinoids are known to inhibit airway sensory nerve function. However, there is still controversy surrounding which receptor is involved in eliciting these effects...
  20. doi Peroxisome proliferator-activated receptors as novel targets in lung disease
    Maria G Belvisi
    National Heart and Lung Institute, Faculty of Medicine, Imperial College, Respiratory Pharmacology Group, Guy Scadding Building, Dovehouse St, London SW3 6LY, UK
    Chest 134:152-7. 2008
    ..PPARs are novel targets for lung disease, and the continued work with PPAR agonists may result in a potential new treatment for these chronic inflammatory lung diseases...
  21. ncbi Preclinical assessment of novel therapeutics on the cough reflex: cannabinoid agonists as potential antitussives
    Maria G Belvisi
    Respiratory Pharmacology Group, National Heart and Lung Institute, NHLI, Faculty of Medicine, Imperial College London, London, UK
    Lung 186:S66-9. 2008
    ....
  22. ncbi Peroxisome proliferator-activated receptor gamma agonists as therapy for chronic airway inflammation
    Maria G Belvisi
    Respiratory Pharmacology, Airway Diseases, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Guy Scadding Building, Dovehouse Street, London, SW3 6LY UK
    Eur J Pharmacol 533:101-9. 2006
    ..This review will outline the anti-inflammatory effects of synthetic and endogenous PPARgamma ligands and discuss their potential therapeutic effects in animal models of inflammatory airway disease...
  23. pmc TRPA1 agonists evoke coughing in guinea pig and human volunteers
    Mark A Birrell
    Respiratory Pharmacology Group, Imperial College London, Exhibition Road, London SW7 2AZ, UK
    Am J Respir Crit Care Med 180:1042-7. 2009
    ..Environmental irritants such as air pollution and cigarette smoke are thought to evoke cough by stimulating airway sensory nerves; however, how this occurs is not fully understood...
  24. ncbi Effects of prostaglandin E2 and cAMP elevating drugs on GM-CSF release by cultured human airway smooth muscle cells. Relevance to asthma therapy
    N Lazzeri
    Thoracic Medicine and Cardiothoracic Surgery, National Heart and Lung Institute, London; Pharmacology Department, Dagenham Research Centre, Dagenham, Essex; and Unit of Critical Care Medicine, Royal Brompton Hospital, IC School of Medicine, London, UK
    Am J Respir Cell Mol Biol 24:44-48. 2001
    ..Thus, when HASM cells are activated with cytokines they release PGE2, which acts as a "braking mechanism" to limit the coproduction of GM-CSF. Moreover, agents that elevate cAMP also reduce GM-CSF formation by these cells...
  25. ncbi Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid
    J A Mitchell
    Department of Anaesthesia and Critical Care Medicine, The Royal Brompton Hospital, London, England
    Mol Pharmacol 51:907-12. 1997
    ..Thus, sodium salicylate is an effective inhibitor of COX-2 activity at concentrations far below those required to inhibit NF-kappaB (20 mg/ml) activation and is easily displaced by arachidonic acid...
  26. doi Beta(2)-agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway
    V C Freund-Michel
    Imperial College School of Medicine, London, UK
    Eur Respir J 35:647-54. 2010
    ..These findings may help to explain the confusion that exists in the clinical literature, and could be exploited to identify novel therapies for the treatment of cough, which is a significant unmet medical need...
  27. pmc Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha)
    P A Finney
    Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London
    Br J Pharmacol 132:1261-70. 2001
    ..The short-acting nature of salmeterol, when administered systemically, and the reduction in beta-adrenoceptor number may be due to metabolism to a biologically-active, short-acting and non-selective beta-adrenoceptor agonist...
  28. doi House dust mite induces direct airway inflammation in vivo: implications for future disease therapy?
    J De Alba
    Respiratory Pharmacology, Pharmacology and Toxicology, Faculty of Medicine, National Heart and Lung Institute, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, London, SW7 2AZ, UK
    Eur Respir J 35:1377-87. 2010
    ..This finding could have important implications in the development of future asthma therapies...
  29. ncbi Nitric oxide as a neurotransmitter in human airways
    M G Belvisi
    Department of Thoracic Medicine, National Heart and Lung Institute, Chelsea, London, U K
    Arch Int Pharmacodyn Ther 329:97-110. 1995
    ..NOS inhibitors appear to enhance the cholinergic bronchoconstriction in human airways in vitro. Therefore, if the nitrergic innervation is dysfunctional in inflammatory conditions, its absence may lead to exaggerated bronchoconstriction...
  30. ncbi Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF-kappaB-independent mechanism
    M A Birrell
    Respiratory Pharmacology, National Heart and Lung Institute, Imperial College London, London, UK
    FASEB J 19:840-1. 2005
    ..These results suggest that resveratrol may possess anti-inflammatory properties via a novel mechanism. Elucidation of this mechanism may lead to potential new therapies for the treatment of chronic inflammation...
  31. pmc Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase
    L Spicuzza
    Department of Thoracic Medicine, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY
    Br J Pharmacol 133:1201-12. 2001
    ....
  32. ncbi Release of nerve growth factor by human pulmonary epithelial cells: role in airway inflammatory diseases
    A J Fox
    Novartis Institute for Medical Sciences, 5 Gower Place, WC1E 6BN, London, UK
    Eur J Pharmacol 424:159-62. 2001
    ..These data suggest that NGF released from structural cells may be an important target for the anti-inflammatory effects of steroids in asthma therapy...
  33. ncbi Utility of exhaled nitric oxide as a noninvasive biomarker of lung inflammation in a disease model
    M A Birrell
    Respiratory Pharmacology Group, Imperial College London, Faculty of Medicine, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Eur Respir J 28:1236-44. 2006
    ..Information from studies such as the current one would suggest that the measurement of exhaled nitric oxide has potential for monitoring inflammatory status in lung tissue...
  34. ncbi Pharmacological assessment of the nitric-oxide synthase isoform involved in eosinophilic inflammation in a rat model of sephadex-induced airway inflammation
    Mark A Birrell
    Respiratory Pharmacology, Cardiothoracic Surgery, Imperial College of Science, Technology and Medicine, Faculty of Medicine, National Heart and Lung Institute, London, United Kingdom
    J Pharmacol Exp Ther 304:1285-91. 2003
    ....
  35. ncbi PPAR-gamma agonists as therapy for diseases involving airway neutrophilia
    M A Birrell
    Respiratory Pharmacology Group, Cardiothoracic Surgery, The National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK
    Eur Respir J 24:18-23. 2004
    ....
  36. doi Modulation of cholinergic contractions of airway smooth muscle by cathinone: potential beneficial effects in airway diseases
    V C Freund-Michel
    Respiratory Pharmacology, Airway Disease Section, National Heart and Lung Institute, Imperial College School of Medicine, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK
    Eur Respir J 32:579-84. 2008
    ..There is some rationale for follow-up of these observations, given previous experience of other traditional remedies being developed for therapeutic use...
  37. ncbi Role of matrix metalloproteinases in the inflammatory response in human airway cell-based assays and in rodent models of airway disease
    Mark A Birrell
    Respiratory Pharmacology Section, Airway Disease Department, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Pharmacol Exp Ther 318:741-50. 2006
    ..However, they do appear to be involved in the elastase-driven breakdown of airway structure, which is not due to a direct effect of the stimulus...
  38. ncbi 8-Epi-PGF2 alpha, a novel noncyclooxygenase-derived prostaglandin, constricts airways in vitro
    I Kawikova
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    Am J Respir Crit Care Med 153:590-6. 1996
    ..However, if 8-epi-PGF2 alpha is formed in asthma, its production, unlike that of other prostanoids, would not be inhibited by cyclooxygenase inhibitors...
  39. pmc Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways
    Mark A Birrell
    Imperial College School of Medicine, London, UK
    Respir Res 4:3. 2003
    ..This question was assessed in a murine model of asthma in which we performed a dose ranging study to establish whether the dose of steroid needed to inhibit the eosinophil infiltration correlated with that needed to block AHR...
  40. ncbi Activation of peroxisome proliferator-activated receptors in human airway smooth muscle cells has a superior anti-inflammatory profile to corticosteroids: relevance for chronic obstructive pulmonary disease therapy
    Hema J Patel
    Respiratory Pharmacology Group, Department of Cardiothoracic Surgery, Faculty of Medicine, The National Heart and Lung Institute, Imperial College School of Medicine, London, United Kingdom
    J Immunol 170:2663-9. 2003
    ..Hence, PPAR ligands might act as potential treatments in human respiratory diseases...
  41. ncbi Nitric oxide as a noninvasive biomarker of lipopolysaccharide-induced airway inflammation: possible role in lung neutrophilia
    Kerryn McCluskie
    Head Respiratory Pharmacology Group, Imperial College London, Faculty of Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    J Pharmacol Exp Ther 311:625-33. 2004
    ..Additionally, it appears using ex-NO as a guide to monitoring airway inflammation may have some use, but data should be interpreted with caution when assessing therapies that may directly impact on NO formation...
  42. ncbi Novel therapies for the treatment of inflammatory airway disease
    David J Hele
    Respiratory Pharmacology Group, Cardiothoracic Surgery, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Dovehouse Street, London, SW3 6LY, UK
    Expert Opin Investig Drugs 12:5-18. 2003
    ..This review will outline the new approaches and targets being investigated, which may provide opportunities for novel therapeutic interventions in these debilitating diseases...
  43. ncbi RANTES release by human airway smooth muscle: effects of prostaglandin E(2) and fenoterol
    N Lazzeri
    Thoracic Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    Eur J Pharmacol 433:231-5. 2001
    ..These data suggest that, in settings where cyclo-oxygenase activity is low, both drugs may relieve the symptoms of airway diseases by reducing RANTES production...
  44. pmc The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis
    D J Hele
    Imperial College School of Medicine, London, UK
    Respir Res 2:169-83. 2001
    ....
  45. pmc Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone
    J A Mitchell
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 113:1008-14. 1994
    ..These findings may be relevant to inflammatory diseases of the lung, such as asthma...
  46. ncbi IkappaB kinase-2-independent and -dependent inflammation in airway disease models: relevance of IKK-2 inhibition to the clinic
    Mark A Birrell
    Head Respiratory Pharmacology Group, Airway Diseases, Faculty of Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Mol Pharmacol 69:1791-800. 2006
    ..If both profiles of inflammation exist in the clinic, then this finding is extremely exciting and may lead to greater understanding of disease pathology and the discovery of novel anti-inflammatory targets...
  47. doi Preclinical animal models of asthma and chronic obstructive pulmonary disease
    Christopher S Stevenson
    Respiratory Pharmacology Group, National Heart and Lung Institute, Guy Scadding Building, Dovehouse Street, London SW3 6LY, UK
    Expert Rev Respir Med 2:631-43. 2008
    ..In spite of these limitations, as long as studies are designed and interpreted appropriately, in vivo models will continue to be vital for furthering our understanding of disease pathogenesis and for developing new therapies...
  48. ncbi Ikappa-B kinase-2 inhibitor blocks inflammation in human airway smooth muscle and a rat model of asthma
    Mark A Birrell
    Respiratory Pharmacology Group, National Heart and Lung Institute, Imperial College Faculty of Medicine, London, UK
    Am J Respir Crit Care Med 172:962-71. 2005
    ..NF-kappaB is held inactive in the cytoplasm, bound to I-kappaB. The removal of I-kappaB, via the actions of inhibitor of kappaB (I-kappaB) kinase-2 (IKK-2), allows NF-kappaB to enter the nucleus...
  49. ncbi Theobromine inhibits sensory nerve activation and cough
    Omar S Usmani
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    FASEB J 19:231-3. 2005
    ..These data indicate the actions of theobromine appear to be peripherally mediated. We conclude theobromine is a novel and promising treatment, which may form the basis for a new class of antitussive drugs...
  50. ncbi Second-generation inhibitors demonstrate the involvement of p38 mitogen-activated protein kinase in post-transcriptional modulation of inflammatory mediator production in human and rodent airways
    Mark A Birrell
    Respiratory Pharmacology, Airway Diseases, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    J Pharmacol Exp Ther 316:1318-27. 2006
    ..These data question whether the effect of p38 inhibitors on gene transcription is related to their potential therapeutic role as anti-inflammatory compounds...
  51. pmc Cough. 7: Current and future drugs for the treatment of chronic cough
    M G Belvisi
    Respiratory Pharmacology Group, Department of Cardiothoracic Surgery, Faculty of Medicine, Imperial College at the National Heart and Lung Institute, London, UK
    Thorax 59:438-40. 2004
    ..There are currently no effective treatments for controlling the cough response with an acceptable therapeutic ratio. However, several new mechanisms have been identified which may lead to the development of new drugs...
  52. doi Estrogen receptor beta: expression profile and possible anti-inflammatory role in disease
    Matthew C Catley
    Respiratory Pharmacology, Airways Diseases, Imperial College London, Faculty of Medicine, National Heart and Lung Institute, London, United Kingdom
    J Pharmacol Exp Ther 326:83-8. 2008
    ..Although ERbeta agonists are anti-inflammatory in certain models, this novel study would suggest that they would not be clinically useful in the treatment of asthma...
  53. pmc Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation
    Hema J Patel
    Respiratory Pharmacology Group, Guy Scadding Building, The National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Dovehouse Street, London SW3 6LY
    Br J Pharmacol 140:261-8. 2003
    ....
  54. pmc Inhibition of excitatory non-adrenergic non-cholinergic bronchoconstriction in guinea-pig airways in vitro by activation of an atypical 5-HT receptor
    J K Ward
    Department of Thoracic Medicine, National Heart and Lung Institute, London
    Br J Pharmacol 111:1095-102. 1994
    ..These data suggest that an atypical 5-HT receptor inhibits the release of neuropeptides from sensory C fibres and may act as other inhibitory neuromodulators via the opening of a common K'channel...
  55. ncbi Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages
    Mark A Birrell
    Respiratory Pharmacology, Airway Disease Section, Imperial College, National Heart and Lung Institute, London, UK
    J Cell Physiol 214:27-37. 2008
    ..In addition, the suppression of the innate response is accompanied by an increase in the neutrophil chemoattractant, IL-8, which may suggest a link to the pathogenesis of smoking-related inflammatory disease...
  56. pmc Effect of dopamine receptor agonists on sensory nerve activity: possible therapeutic targets for the treatment of asthma and COPD
    Mark A Birrell
    Department of Cardiothoracic Surgery, Respiratory Pharmacology Group, Faculty of Medicine, The National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY
    Br J Pharmacol 136:620-8. 2002
    ....
  57. ncbi Liver X receptor agonists increase airway reactivity in a model of asthma via increasing airway smooth muscle growth
    Mark A Birrell
    Respiratory Pharmacology, Airway Disease Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Immunol 181:4265-71. 2008
    ....
  58. pmc Prostaglandin E2 mediates cough via the EP3 receptor: implications for future disease therapy
    Sarah A Maher
    Respiratory Pharmacology, Airways Diseases, Imperial College London, Faculty of Medicine, National Heart and Lung Institute, Sir Alexander Fleming Building, London, SW7 2AZ, UK
    Am J Respir Crit Care Med 180:923-8. 2009
    ..Inhaled prostaglandin E(2) (PGE(2)) is antiinflammatory and a bronchodilator in patients with asthma, but it also causes cough...
  59. doi Prostanoids and the cough reflex
    Sarah A Maher
    Respiratory Pharmacology, Pharmacology and Toxicology Section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Exhibition Road, London, SW7 2AZ, UK
    Lung 188:S9-12. 2010
    ..This has hindered the development of prostanoids for the treatment of airway inflammatory diseases. We discuss here the extensive research into the role of prostanoids in the airways and their modulation of the cough reflex...
  60. ncbi Sensory nerves and airway inflammation: role of A delta and C-fibres
    Maria G Belvisi
    Cardiothoracic Surgery, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Pulm Pharmacol Ther 16:1-7. 2003
    ..This review will concentrate on describing the characteristics of these sensory fibres and their proposed role in airway defensive reflexes and their possible exaggerated function in response to the inflammatory process...
  61. ncbi Drugs Affecting TRP Channels
    M A Wortley
    Respiratory Pharmacology Group, National Heart and Lung Institute, Imperial College, London, UK
    Handb Exp Pharmacol . 2016
    ..For TRPM8 the evidence is less clear, but as with TRPV1, TRPA1 and TRPV4, antagonists are being developed by multiple companies for indications including asthma and COPD, which will help in elucidating their role in respiratory disease...
  62. pmc Transient receptor potential (TRP) channels in the airway: role in airway disease
    M S Grace
    Respiratory Pharmacology, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, UK
    Br J Pharmacol 171:2593-607. 2014
    ..We hope that the article will help the reader understand the role of TRP channels in the normal airway and how their function may be changed in the context of respiratory disease. ..
  63. ncbi The role of matrix metalloproteinases (MMPs) in the pathophysiology of chronic obstructive pulmonary disease (COPD): a therapeutic role for inhibitors of MMPs?
    M G Belvisi
    Imperial College School of Medicine, at the National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, United Kingdom
    Inflamm Res 52:95-100. 2003
    ..The evidence for the role of these MMPs in the pathological processes associated with COPD and prospects for MMP inhibitors as the basis for future therapies will be addressed in this review...
  64. ncbi Airway sensory innervation as a target for novel therapies: an outdated concept?
    Maria G Belvisi
    Respiratory Pharmacology Group, Cardiothoracic Surgery, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Curr Opin Pharmacol 3:239-43. 2003
    ..In particular, the focus is on inhibition of the symptoms associated with airway inflammatory diseases such as asthma, chronic obstructive pulmonary disease and cough of any aetiology...
  65. ncbi Summary: animal models for cough
    Maria G Belvisi
    Respiratory Pharmacology Group, Cardiothoracic Surgery, National Heart and Lung Institute, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Pulm Pharmacol Ther 15:249-50. 2002
  66. pmc E-ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype
    Deborah L Clarke
    Respiratory Pharmacology Group, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Guy Scadding Building, Dovehouse Street, London SW3 6LY
    Br J Pharmacol 141:600-9. 2004
    ....
  67. ncbi Overview of the innervation of the lung
    Maria G Belvisi
    National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Dovehouse Street, SW3 6LY, UK
    Curr Opin Pharmacol 2:211-5. 2002
    ..Recent data suggest that enhanced neural activity may play a key role in the symptomatology and pathophysiology of airway inflammatory diseases...
  68. ncbi Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses
    Mark A Birrell
    Respiratory Pharmacology Group, Airway Diseases Department, Faculty of Medicine, National Heart and Lung Institute, Imperial College, Dovehouse St, London SW3 6LY, United Kingdom
    J Biol Chem 282:31882-90. 2007
    ..Therefore, data suggest that LXR ligands have utility in the treatment of lung diseases that involves chronic inflammation mediated by macrophages and neutrophils...
  69. ncbi Differential effects of ebselen on neutrophil recruitment, chemokine, and inflammatory mediator expression in a rat model of lipopolysaccharide-induced pulmonary inflammation
    El Bdaoui Haddad
    Department of Pharmacology, Aventis Pharma, Bridgewater, NJ, 08807 0800, USA
    J Immunol 169:974-82. 2002
    ....
  70. pmc Functional characterization and biomarker identification in the Brown Norway model of allergic airway inflammation
    Stephen L Underwood
    Department of Respiratory Disease, Aventis Pharma, Route 202 206, Bridgewater, New Jersey, NJ 07928, USA
    Br J Pharmacol 137:263-75. 2002
    ....
  71. ncbi Critical role for T cells in Sephadex-induced airway inflammation: pharmacological and immunological characterization and molecular biomarker identification
    El Bdaoui Haddad
    Pharmacology Department, Dagenham, United Kingdom Respiratory and RA Disease Group, Aventis Pharma, Bridgewater, NJ 08807, USA
    J Immunol 168:3004-16. 2002
    ....