Stephen J Gaunt

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi request reprint Evolutionary shifts of vertebrate structures and Hox expression up and down the axial series of segments: a consideration of possible mechanisms
    S J Gaunt
    Department of Development and Genetics, The Babraham Institute, Cambridge, United Kingdom
    Int J Dev Biol 44:109-17. 2000
  2. ncbi request reprint Gradients and forward spreading of vertebrate Hox gene expression detected by using a Hox/lacZ transgene
    S J Gaunt
    Department of Development and Genetics, Babraham Institute, Cambridge, United Kingdom
    Dev Dyn 221:26-36. 2001
  3. ncbi request reprint Additional enhancer copies, with intact cdx binding sites, anteriorize Hoxa-7/lacZ expression in mouse embryos: evidence in keeping with an instructional cdx gradient
    Stephen J Gaunt
    Department of Development and Genetics, The Babraham Institute, Babraham, Cambridge, UK
    Int J Dev Biol 48:613-22. 2004
  4. ncbi request reprint Evidence that Hoxa expression domains are evolutionarily transposed in spinal ganglia, and are established by forward spreading in paraxial mesoderm
    S J Gaunt
    Department of Development and Genetics, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Mech Dev 82:109-18. 1999
  5. ncbi request reprint Vertebrate caudal gene expression gradients investigated by use of chick cdx-A/lacZ and mouse cdx-1/lacZ reporters in transgenic mouse embryos: evidence for an intron enhancer
    Stephen J Gaunt
    Department of Development and Genetics, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Mech Dev 120:573-86. 2003
  6. doi request reprint Increased Cdx protein dose effects upon axial patterning in transgenic lines of mice
    Stephen J Gaunt
    Department of Development and Genetics, The Babraham Institute, Babraham, Cambridge, UK
    Development 135:2511-20. 2008
  7. ncbi request reprint cdx4/lacZ and cdx2/lacZ protein gradients formed by decay during gastrulation in the mouse
    Stephen J Gaunt
    Department of Development and Genetics, The Babraham Institute, Cambridge, UK
    Int J Dev Biol 49:901-8. 2005
  8. doi request reprint Origins of Cdx1 regulatory elements suggest roles in vertebrate evolution
    Stephen J Gaunt
    Department of Development and Genetics, The Babraham Institute, Babraham, Cambridge, UK
    Int J Dev Biol 55:93-8. 2011
  9. ncbi request reprint Colinearity and non-colinearity in the expression of Hox genes in developing chick skin
    Alasdair I Reid
    Department of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Int J Dev Biol 46:209-15. 2002
  10. ncbi request reprint Conservation in the Hox code during morphological evolution
    S J Gaunt
    Department of Development and Signalling, Babraham Institute, Cambridge, United Kingdom
    Int J Dev Biol 38:549-52. 1994

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Evolutionary shifts of vertebrate structures and Hox expression up and down the axial series of segments: a consideration of possible mechanisms
    S J Gaunt
    Department of Development and Genetics, The Babraham Institute, Cambridge, United Kingdom
    Int J Dev Biol 44:109-17. 2000
    ..We discuss morphogen gradient, timing, spreading, and growth models for the setting of Hoxexpression boundaries, and consider how evolutionary shifts in boundary positions might have been effected in terms of these models...
  2. ncbi request reprint Gradients and forward spreading of vertebrate Hox gene expression detected by using a Hox/lacZ transgene
    S J Gaunt
    Department of Development and Genetics, Babraham Institute, Cambridge, United Kingdom
    Dev Dyn 221:26-36. 2001
    ..Binding motifs for the caudal (cdx) proteins, already proposed as such inducers, are conserved in mouse and chick Hoxa-7 enhancer elements...
  3. ncbi request reprint Additional enhancer copies, with intact cdx binding sites, anteriorize Hoxa-7/lacZ expression in mouse embryos: evidence in keeping with an instructional cdx gradient
    Stephen J Gaunt
    Department of Development and Genetics, The Babraham Institute, Babraham, Cambridge, UK
    Int J Dev Biol 48:613-22. 2004
    ..We discuss how these findings are in keeping with a model where Hox expression boundaries become set along instructional cdx gradients, formed by cdx decay in cells moving away from the primitive streak region...
  4. ncbi request reprint Evidence that Hoxa expression domains are evolutionarily transposed in spinal ganglia, and are established by forward spreading in paraxial mesoderm
    S J Gaunt
    Department of Development and Genetics, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Mech Dev 82:109-18. 1999
    ..We discuss this as evidence that Hox expression in paraxial mesoderm spreads forward, as earlier found for neurectoderm and lateral plate mesoderm, in a process that occurs independently of cell movement...
  5. ncbi request reprint Vertebrate caudal gene expression gradients investigated by use of chick cdx-A/lacZ and mouse cdx-1/lacZ reporters in transgenic mouse embryos: evidence for an intron enhancer
    Stephen J Gaunt
    Department of Development and Genetics, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Mech Dev 120:573-86. 2003
    ..These motifs are structurally conserved in mouse cdx-1...
  6. doi request reprint Increased Cdx protein dose effects upon axial patterning in transgenic lines of mice
    Stephen J Gaunt
    Department of Development and Genetics, The Babraham Institute, Babraham, Cambridge, UK
    Development 135:2511-20. 2008
    ..OE mice display additional defects: forelimb deficiencies in OE1, multiple tail axes, vertebral mis-alignments and axial truncations in OE2...
  7. ncbi request reprint cdx4/lacZ and cdx2/lacZ protein gradients formed by decay during gastrulation in the mouse
    Stephen J Gaunt
    Department of Development and Genetics, The Babraham Institute, Cambridge, UK
    Int J Dev Biol 49:901-8. 2005
    ..An enhancer element located in the first intron of the cdx4 gene is essential for correct transgene expression...
  8. doi request reprint Origins of Cdx1 regulatory elements suggest roles in vertebrate evolution
    Stephen J Gaunt
    Department of Development and Genetics, The Babraham Institute, Babraham, Cambridge, UK
    Int J Dev Biol 55:93-8. 2011
    ..We present evidence that Cdx1 is also a developmental regulator of the female urogenital system, and we suggest that acquisition of the upstream RARE may have contributed to morphological divergence of marsupial and eutherian mammals...
  9. ncbi request reprint Colinearity and non-colinearity in the expression of Hox genes in developing chick skin
    Alasdair I Reid
    Department of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Int J Dev Biol 46:209-15. 2002
    ....
  10. ncbi request reprint Conservation in the Hox code during morphological evolution
    S J Gaunt
    Department of Development and Signalling, Babraham Institute, Cambridge, United Kingdom
    Int J Dev Biol 38:549-52. 1994
    ..The results also suggest that an evolutionary change in body proportions is accomplished by a shift in the relative positions of Hox expression domains during embryonic development...
  11. ncbi request reprint Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wall
    S J Gaunt
    Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK
    Development 117:769-78. 1993
    ..Our findings lead us to suggest that the goosecoid gene product plays a role in spatial programming within discrete embryonic fields, and possibly lineage compartments, during organogenesis stages of mouse development...
  12. ncbi request reprint Forward spreading in the establishment of a vertebrate Hox expression boundary: the expression domain separates into anterior and posterior zones, and the spread occurs across implanted glass barriers
    S J Gaunt
    Cell Determination Laboratory, AFRC Babraham Institute, Cambridge, United Kingdom
    Dev Dyn 199:229-40. 1994
    ..We suggest that the posterior zone marks the source of a morphogen which is the primary activator of Hox gene expression, and we discuss possible models for the mechanism of forward spreading in expression...
  13. pmc Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway
    Felix Krueger
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK
    Cell Signal 21:1846-56. 2009
    ..These results provide important new insights into the regulation of the Cdx2 tumour suppressor by linking it to ERK1/2, a pathway which is frequently activated in CRC...
  14. ncbi request reprint Temporal colinearity in expression of anterior Hox genes in developing chick embryos
    S J Gaunt
    Department of Development and Genetics, Babraham Institute, Cambridge, United Kingdom
    Dev Dyn 207:270-80. 1996
    ..Within posterior primitive streak tissue, there was only limited evidence for temporal colinearity. We discuss these results in terms of possible models for the establishment of Hox gene expression patterns...
  15. ncbi request reprint Mouse homeobox gene transcripts occupy different but overlapping domains in embryonic germ layers and organs: a comparison of Hox-3.1 and Hox-1.5
    S J Gaunt
    Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Cambridge, UK
    Development 103:135-44. 1988
    ..In discussion, two different mechanisms are considered by which positional information might first be generated within the germ layers...
  16. pmc Changes in Cis-regulatory Elements during Morphological Evolution
    Stephen J Gaunt
    The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK
    Biology (Basel) 1:557-74. 2012
    ..In practice these data are incomplete for most of the published studies upon morphological evolution. Here, the investigations are categorized according to how far these analyses have proceeded. ..
  17. ncbi request reprint Isolation and expression of a new mouse homeobox gene
    P T Sharpe
    Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK
    Development 102:397-407. 1988
    ..An anterior boundary of expression is located just behind the hindbrain whereas the boundary in the mesoderm is located at the level of the 7th prevertebra...
  18. ncbi request reprint Homoeobox gene Hox-1.5 expression in mouse embryos: earliest detection by in situ hybridization is during gastrulation
    S J Gaunt
    AFRC Institute of Animal Physiology and Genetics Research, Department of Molecular Embryology, Babraham, Cambridge, UK
    Development 101:51-60. 1987
    ..1986), might start expression at times later in development...
  19. pmc Pig Hox-2.4 has accumulated a frameshift mutation relative to mouse Hox-2.4
    J R Miller
    Department of Molecular Embryology, Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK
    Nucleic Acids Res 16:10364. 1988
  20. ncbi request reprint Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage- and tissue-dependent differences in their regulation
    S J Gaunt
    Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK
    Development 107:131-41. 1989
    ..We also propose how our new findings may help to explain any selective advantage to the vertebrates of homeo-gene duplication to form subfamilies...
  21. ncbi request reprint The mouse has a Polycomb-like chromobox gene
    J J Pearce
    Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK
    Development 114:921-9. 1992
    ..From comparisons of the characteristics of M33 with those of Pc it is proposed that M33 is a Pc-like chromobox gene. The roles of M33 and Pc in models of cellular memory are examined and implications of the memory models addressed...
  22. doi request reprint Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene
    Fairouz Benahmed
    INSERM, U682, Strasbourg, France
    Gastroenterology 135:1238-1247, 1247.e1-3. 2008
    ..The aim of this study was to map genomic regions that regulate the transcription of Cdx2, with a particular interest in the gut...
  23. ncbi request reprint Morphogen gradients formed by decay
    Stephen J Gaunt
    Bioessays 26:1143-4. 2004