Bassam Lajin

Summary

Country: UK

Publications

  1. pmc No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population
    Bassam Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    N Am J Med Sci 3:176-8. 2011
  2. pmc Duplex Detection of TP53 Arg72Pro and 16 bp Del/Ins Polymorphisms by a Simple Optimized PCR-RFLP Method
    B Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    N Am J Med Sci 4:212-5. 2012
  3. pmc The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis
    B Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    Br J Cancer 109:1325-37. 2013
  4. doi Betaine significantly improves multiplex tetra-primer ARMS-PCR methods
    Bassam Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    Mol Biotechnol 54:977-82. 2013
  5. doi Association between polymorphisms in apoptotic genes and susceptibility for developing breast cancer in Syrian women
    Bassam Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    Breast Cancer Res Treat 138:611-9. 2013
  6. doi Association between polymorphisms in the genes for tumor suppressor protein p53 and its regulator NAD(P)H: quinone oxidoreductase 1 (NQO1) and schizophrenia in a Syrian study cohort
    Bassam Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    Arch Med Res 44:121-6. 2013
  7. doi Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria
    Bassam Lajin
    Department of Pharmacology, Cancer Research Lab, Faculty of Pharmacy, University of Aleppo, University Street, Aleppo, Syria
    Breast Cancer 20:62-6. 2013
  8. doi Association between MTHFR C677T and A1298C, and MTRR A66G polymorphisms and susceptibility to schizophrenia in a Syrian study cohort
    Bassam Lajin
    University of Aleppo, Department of Analytical Chemistry, Faculty of Pharmacy, Aleppo, Syria
    Asian J Psychiatr 5:144-9. 2012
  9. doi A quadruplex tetra-primer ARMS-PCR method for the simultaneous detection of TP53 Arg72Pro, IVS3 16bp Del/Ins and IVS6+62A>G, and NQO1 C609T polymorphisms
    Bassam Lajin
    University of Aleppo, Department of Analytical Chemistry, Faculty of Pharmacy, Aleppo, Syria
    Gene 504:268-73. 2012
  10. doi Association of polymorphisms in one-carbon metabolizing genes with breast cancer risk in Syrian women
    Bassam Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    Tumour Biol 33:1133-9. 2012

Detail Information

Publications11

  1. pmc No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population
    Bassam Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    N Am J Med Sci 3:176-8. 2011
    ..The Val158Met single nucleotide polymorphism of the COMT gene has been implicated in the aetiology of schizophrenia, although results from different populations have been conflicting...
  2. pmc Duplex Detection of TP53 Arg72Pro and 16 bp Del/Ins Polymorphisms by a Simple Optimized PCR-RFLP Method
    B Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    N Am J Med Sci 4:212-5. 2012
    ..Two most commonly studied polymorphisms that were shown to affect the biochemical functions of p53 protein are the exon 4 Arg72pro and Intron 3 16 bp Del/Ins polymorphisms...
  3. pmc The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis
    B Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    Br J Cancer 109:1325-37. 2013
    ..The results were inconsistent partly due to low sample sizes. The aim of the present work was to perform a meta-analysis to assess association for all common cancer sites separately and in combination...
  4. doi Betaine significantly improves multiplex tetra-primer ARMS-PCR methods
    Bassam Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    Mol Biotechnol 54:977-82. 2013
    ..Our data support the routine inclusion of Betaine in all TP-ARMS-PCR methods, especially when multiplexing is concerned...
  5. doi Association between polymorphisms in apoptotic genes and susceptibility for developing breast cancer in Syrian women
    Bassam Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    Breast Cancer Res Treat 138:611-9. 2013
    ..22-3.47), P = 0.006). No significant association was found for NQO1 C609T or its combinations with TP53 polymorphisms. Our results support an association for TP53 polymorphisms with breast cancer susceptibility in the Syrian population...
  6. doi Association between polymorphisms in the genes for tumor suppressor protein p53 and its regulator NAD(P)H: quinone oxidoreductase 1 (NQO1) and schizophrenia in a Syrian study cohort
    Bassam Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    Arch Med Res 44:121-6. 2013
    ....
  7. doi Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria
    Bassam Lajin
    Department of Pharmacology, Cancer Research Lab, Faculty of Pharmacy, University of Aleppo, University Street, Aleppo, Syria
    Breast Cancer 20:62-6. 2013
    ..In this study we investigated the relationship between the Vall58Met polymorphism in the COMT gene and breast cancer risk in a population-based case control study in Syria...
  8. doi Association between MTHFR C677T and A1298C, and MTRR A66G polymorphisms and susceptibility to schizophrenia in a Syrian study cohort
    Bassam Lajin
    University of Aleppo, Department of Analytical Chemistry, Faculty of Pharmacy, Aleppo, Syria
    Asian J Psychiatr 5:144-9. 2012
    ..24, 95% CI (0.97-5.15), p=0.053). Our results support the hypothesis of association between schizophrenia and folate-homocystiene metabolic pathway genes...
  9. doi A quadruplex tetra-primer ARMS-PCR method for the simultaneous detection of TP53 Arg72Pro, IVS3 16bp Del/Ins and IVS6+62A>G, and NQO1 C609T polymorphisms
    Bassam Lajin
    University of Aleppo, Department of Analytical Chemistry, Faculty of Pharmacy, Aleppo, Syria
    Gene 504:268-73. 2012
    ....
  10. doi Association of polymorphisms in one-carbon metabolizing genes with breast cancer risk in Syrian women
    Bassam Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    Tumour Biol 33:1133-9. 2012
    ..014; OR = 0.3, 95% CI (0.08-1.11), P = 0.058). In conclusion, our study supports the hypothesis that polymorphisms in one-carbon gene metabolisms modulate the risk for breast cancer, particularly the A1298C polymorphism of the MTHFR gene...
  11. doi Triplex tetra-primer ARMS-PCR method for the simultaneous detection of MTHFR c.677C>T and c.1298A>C, and MTRR c.66A>G polymorphisms of the folate-homocysteine metabolic pathway
    Bassam Lajin
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
    Mol Cell Probes 26:16-20. 2012
    ..We suggest that the use of Betaine may play an important role in multiplex tetra-primer ARMS-PCR or PCR-CTPP based on its potential capacity to close the gap in melting temperature between different primers...