M C Taylor

Summary

Affiliation: London School of Hygiene and Tropical Medicine
Country: UK

Publications

  1. doi request reprint Iron metabolism in trypanosomatids, and its crucial role in infection
    M C Taylor
    Pathogen Molecular Biology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Parasitology 137:899-917. 2010
  2. pmc pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi
    Martin C Taylor
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Biotechnol 6:32. 2006
  3. ncbi request reprint Trypanosoma cruzi adenylyl cyclase is encoded by a complex multigene family
    M C Taylor
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Mol Biochem Parasitol 104:205-17. 1999
  4. ncbi request reprint Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum
    D J Carucci
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
    J Biol Chem 275:22147-56. 2000
  5. pmc Validation of spermidine synthase as a drug target in African trypanosomes
    Martin C Taylor
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Biochem J 409:563-9. 2008
  6. pmc The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase
    Flora J Logan
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Biochem J 407:419-26. 2007
  7. pmc Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression
    Lucia Piacenza
    Departamento de Bioquimica, Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    Biochem J 403:323-34. 2007
  8. pmc TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum
    Shane R Wilkinson
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Biochem J 364:787-94. 2002
  9. ncbi request reprint Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei
    Shane R Wilkinson
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Free Radic Biol Med 40:198-209. 2006
  10. ncbi request reprint The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin
    Shane R Wilkinson
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    J Biol Chem 277:17062-71. 2002

Collaborators

Detail Information

Publications17

  1. doi request reprint Iron metabolism in trypanosomatids, and its crucial role in infection
    M C Taylor
    Pathogen Molecular Biology Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Parasitology 137:899-917. 2010
    ..The central role of iron in both parasite metabolism and the host response is attracting interest as a possible point of therapeutic intervention...
  2. pmc pTcINDEX: a stable tetracycline-regulated expression vector for Trypanosoma cruzi
    Martin C Taylor
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    BMC Biotechnol 6:32. 2006
    ..To this end we report the development of a stable tetracycline-dependent expression vector applicable to this parasite and describe in detail the parameters of the system...
  3. ncbi request reprint Trypanosoma cruzi adenylyl cyclase is encoded by a complex multigene family
    M C Taylor
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, UK
    Mol Biochem Parasitol 104:205-17. 1999
    ..This constitutively active recombinant protein will be a useful tool for dissecting the catalytic mechanism of adenylyl cyclase...
  4. ncbi request reprint Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum
    D J Carucci
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
    J Biol Chem 275:22147-56. 2000
    ..The profound structural differences identified between mammalian and parasite guanylyl cyclases suggest that aspects of this signaling pathway may be mechanistically distinct...
  5. pmc Validation of spermidine synthase as a drug target in African trypanosomes
    Martin C Taylor
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Biochem J 409:563-9. 2008
    ..brucei cannot scavenge sufficient spermidine from their environment to meet growth requirements...
  6. pmc The terminal step in vitamin C biosynthesis in Trypanosoma cruzi is mediated by a FMN-dependent galactonolactone oxidase
    Flora J Logan
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Biochem J 407:419-26. 2007
    ..The conserved lysine residue within this motif (Lys-450) is not required for cofactor binding, but its replacement by glycine renders the protein completely inactive...
  7. pmc Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression
    Lucia Piacenza
    Departamento de Bioquimica, Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    Biochem J 403:323-34. 2007
    ....
  8. pmc TcGPXII, a glutathione-dependent Trypanosoma cruzi peroxidase with substrate specificity restricted to fatty acid and phospholipid hydroperoxides, is localized to the endoplasmic reticulum
    Shane R Wilkinson
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Biochem J 364:787-94. 2002
    ..cruzi oxidative defence system by protecting newly synthesized lipids from peroxidation...
  9. ncbi request reprint Functional characterisation of the iron superoxide dismutase gene repertoire in Trypanosoma brucei
    Shane R Wilkinson
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Free Radic Biol Med 40:198-209. 2006
    ..These experiments therefore identify essential components of the superoxide metabolising arm of the T. brucei oxidative defence system and validate these enzymes as parasite-specific targets for drug design...
  10. ncbi request reprint The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin
    Shane R Wilkinson
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    J Biol Chem 277:17062-71. 2002
    ..The ability of TcGPXI to use alternative electron donors may reflect their availability at the corresponding subcellular sites...
  11. ncbi request reprint The amino terminal domain of a novel WD repeat protein from Trypanosoma cruzi contains a non-canonical mitochondrial targeting signal
    Elizabeth V Bromley
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Parasitol 34:63-71. 2004
    ..Interestingly this region lacks a typical amino terminal presequence suggesting that mitochondrial import is mediated by an alternative targeting signal...
  12. ncbi request reprint Mechanism of genetic exchange in American trypanosomes
    Michael W Gaunt
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Nature 421:936-9. 2003
    ..cruzi. In this instance, aneuploidy through nuclear hybridization results in recombination across far greater genetic distances than mendelian genetic exchange. This mechanism also parallels genome duplication...
  13. pmc Vitamin C biosynthesis in trypanosomes: a role for the glycosome
    Shane R Wilkinson
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    Proc Natl Acad Sci U S A 102:11645-50. 2005
    ..It is implicit, therefore, that bloodstream-form trypanosomes also possess a capacity for ascorbate transport...
  14. pmc Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature
    Samson O Obado
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom
    Genome Res 15:36-43. 2005
    ..This unusual type of organization may represent a paradigm for centromeres in T. cruzi and other primitive eukaryotes...
  15. pmc Distinct trafficking and localization of STEVOR proteins in three stages of the Plasmodium falciparum life cycle
    Louisa McRobert
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel St, WC1E 7HT, UK
    Infect Immun 72:6597-602. 2004
    ..STEVOR variants are therefore likely to perform different functions in each stage of the parasites life cycle in which they occur...
  16. pmc The Trypanosoma cruzi metacyclic-specific protein Met-III associates with the nucleolus and contains independent amino and carboxyl terminal targeting elements
    Eva Gluenz
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Int J Parasitol 37:617-25. 2007
    ..To investigate the function of Met-III, we used gene deletion. This showed that Met-III is not required for the development of metacyclic trypomastigotes and that null mutants can complete the life-cycle in vitro...
  17. pmc A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes
    Shane R Wilkinson
    School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, United Kingdom
    Proc Natl Acad Sci U S A 105:5022-7. 2008
    ..This potential for drug resistance by a simple mechanism has important implications, because nifurtimox is currently undergoing phase III clinical trials against African trypanosomiasis...