C L Relton

Summary

Affiliation: Moor Row
Country: UK

Publications

  1. ncbi Polymorphisms of the DNA repair gene XRCC1 and the frequency of somatic mutations at the glycophorin A locus in newborns
    Caroline L Relton
    Genetics Unit, Westlakes Research Institute, Moor Row, Cumbria, UK
    Mutat Res 502:61-8. 2002
  2. ncbi Genetic susceptibility to neural tube defect pregnancy varies with offspring phenotype
    C L Relton
    Genetics Department, Westlakes Research Institute, Westlakes Science and Technology Park, Cumbria, UK West Cumberland Hospital, Whitehaven, Cumbria, UK
    Clin Genet 64:424-8. 2003
  3. ncbi Low erythrocyte folate status and polymorphic variation in folate-related genes are associated with risk of neural tube defect pregnancy
    Caroline L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE2 4LP, UK
    Mol Genet Metab 81:273-81. 2004
  4. pmc Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population
    C L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    J Med Genet 41:256-60. 2004
  5. ncbi Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations: no evidence of association with longevity
    C S Wilding
    Genetics Department, Westlakes Research Institute, Westlakes Science and Technology Park, CA24 3JY, Moor Row, Cumbria, UK
    Biogerontology 7:35-41. 2006
  6. doi Epigenetics and child health: basic principles
    A Groom
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Arch Dis Child 96:863-9. 2011
  7. pmc Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children
    S J Brown
    Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Br J Dermatol 161:884-9. 2009
  8. doi A lifecourse study of bone resorption in men ages 49-51years: the Newcastle Thousand Families cohort study
    M S Pearce
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Bone 46:952-6. 2010
  9. doi The relationship between gestational age, systolic blood pressure and pulse pressure in children
    C L Relton
    Institute of Health and Society, School of Clinical Medical Sciences Child Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Hum Hypertens 22:352-7. 2008
  10. ncbi DNA repair gene polymorphisms in relation to chromosome aberration frequencies in retired radiation workers
    Craig S Wilding
    Genetics Department, Westlakes Research Institute, Westlakes Science and Technology Park, Moor Row, Cumbria CA24 3JY, UK
    Mutat Res 570:137-45. 2005

Collaborators

Detail Information

Publications20

  1. ncbi Polymorphisms of the DNA repair gene XRCC1 and the frequency of somatic mutations at the glycophorin A locus in newborns
    Caroline L Relton
    Genetics Unit, Westlakes Research Institute, Moor Row, Cumbria, UK
    Mutat Res 502:61-8. 2002
    ..Our results suggest that carriers of the Gln/Gln genotype are over represented in this group but the role that the genotype has in the derivation of high NN Vfs remains to be resolved...
  2. ncbi Genetic susceptibility to neural tube defect pregnancy varies with offspring phenotype
    C L Relton
    Genetics Department, Westlakes Research Institute, Westlakes Science and Technology Park, Cumbria, UK West Cumberland Hospital, Whitehaven, Cumbria, UK
    Clin Genet 64:424-8. 2003
    ....
  3. ncbi Low erythrocyte folate status and polymorphic variation in folate-related genes are associated with risk of neural tube defect pregnancy
    Caroline L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE2 4LP, UK
    Mol Genet Metab 81:273-81. 2004
    ..001) despite assays being conducted many years after the index pregnancy (17.6+/-12.6 years). Erythrocyte folate levels were depressed in the presence of the MTHFR 677C >T variant...
  4. pmc Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population
    C L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    J Med Genet 41:256-60. 2004
    ..To investigate the contribution of polymorphic variation in genes involved in the folate-dependent homocysteine pathway in the aetiology of neural tube defects (NTD)...
  5. ncbi Genotype profiles of loci encoding DNA repair enzymes in newborn and elderly populations: no evidence of association with longevity
    C S Wilding
    Genetics Department, Westlakes Research Institute, Westlakes Science and Technology Park, CA24 3JY, Moor Row, Cumbria, UK
    Biogerontology 7:35-41. 2006
    ..Significant differences in frequency of certain repeat sizes at three microsatellite loci were detected. However, since there is no known functional consequence of these repeat lengths, the action of selection cannot yet be ascribed...
  6. doi Epigenetics and child health: basic principles
    A Groom
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Arch Dis Child 96:863-9. 2011
    ..This review summarises evidence pointing to the determinants of epigenetic patterns, their juxtaposition at the interface of the environment, their influence on gene function and the relevance of this information to child health...
  7. pmc Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children
    S J Brown
    Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Br J Dermatol 161:884-9. 2009
    ..Null mutations within the filaggrin gene (FLG) cause ichthyosis vulgaris and are associated with atopic eczema. However, the dermatological features of filaggrin haploinsufficiency have not been clearly defined...
  8. doi A lifecourse study of bone resorption in men ages 49-51years: the Newcastle Thousand Families cohort study
    M S Pearce
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Bone 46:952-6. 2010
    ....
  9. doi The relationship between gestational age, systolic blood pressure and pulse pressure in children
    C L Relton
    Institute of Health and Society, School of Clinical Medical Sciences Child Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Hum Hypertens 22:352-7. 2008
    ....
  10. ncbi DNA repair gene polymorphisms in relation to chromosome aberration frequencies in retired radiation workers
    Craig S Wilding
    Genetics Department, Westlakes Research Institute, Westlakes Science and Technology Park, Moor Row, Cumbria CA24 3JY, UK
    Mutat Res 570:137-45. 2005
    ..Nonetheless, further research is warranted to examine whether this DNA repair gene variant might be associated with a sub-optimal repair response to smoking-induced DNA damage and hence an increased frequency of translocations...
  11. pmc Pathogenic mitochondrial DNA mutations are common in the general population
    Hannah R Elliott
    Mitochondrial Research Group, Newcastle University, Newcastle upon Tyne, UK
    Am J Hum Genet 83:254-60. 2008
    ..The exclusive detection of m.14484T-->C on haplogroup J implicates the background mtDNA haplotype in mutagenesis. These findings emphasize the importance of developing new approaches to prevent transmission...
  12. ncbi Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema
    Sara J Brown
    J Invest Dermatol 128:1591-4. 2008
  13. ncbi DNA repair gene polymorphisms, pre-natal factors and the frequency of somatic mutations in the glycophorin-A gene among healthy newborns
    Caroline L Relton
    Genetics Unit, Westlakes Research Institute, Moor Row, Cumbria CA24 3JY, UK
    Mutat Res 545:49-57. 2004
    ..It is concluded that the genotypic variation in DNA repair genes examined in this study has no discernable effect on the genesis of the somatic mutations observed at birth...
  14. ncbi Thymidylate synthase repeat polymorphisms and risk of neural tube defects in a population from the northern United Kingdom
    Craig S Wilding
    Genetics Department, Westlakes Research Institute, Cumbria, United Kingdom
    Birth Defects Res A Clin Mol Teratol 70:483-5. 2004
    ..We investigated the association between this polymorphism and risk of NTD in families affected by NTDs and controls from the northern United Kingdom (UK)...
  15. ncbi An investigation of folate-related genetic factors in the determination of birthweight
    Caroline L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, Newcastle Univisersity, Newcastle upon Tyne, UK
    Paediatr Perinat Epidemiol 19:360-7. 2005
    ..However, when placed on a background of deficient maternal nutritional status, they may detrimentally affect fetal growth...
  16. ncbi The influence of erythrocyte folate and serum vitamin B12 status on birth weight
    Caroline L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Br J Nutr 93:593-9. 2005
    ..08, 0.42), P=0.005; n 145). These findings suggest that maternal folate status is an important determinant of infant birth weight. The combined effects of smoking and reduced RBC status on birth weight require further investigation...
  17. ncbi Folic acid supplementation and social deprivation
    Caroline L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Public Health Nutr 8:338-40. 2005
    ..To assess the use of folic acid supplementation in relation to small-area measures of social deprivation...
  18. ncbi Mitochondrial DNA mutations in individuals occupationally exposed to ionizing radiation
    Craig S Wilding
    Genetics Department, Westlakes Research Institute, Moor Row, Cumbria, CA24 3JY, United Kingdom
    Radiat Res 165:202-7. 2006
    ..There was an increase in singleton mutations above that attributable to procedural error in both exposed and control groups that is likely to reflect age-related somatic mutation...
  19. pmc Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Am J Hum Genet 80:1150-61. 2007
    ..In conclusion, we have identified the first type 2 diabetes-susceptibility allele to be reproducibly associated with birth weight. Common gene variants can substantially influence normal birth-weight variation...
  20. doi Filaggrin null mutations and childhood atopic eczema: a population-based case-control study
    Sara J Brown
    Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    J Allergy Clin Immunol 121:940-46.e3. 2008
    ..Null mutations within the filaggrin gene (FLG) are associated with moderate-to-severe atopic eczema; their role in mild-to-moderate eczema in the general population is unknown...