C C Shoulders

Summary

Affiliation: National Institute for Medical Research
Country: UK

Publications

  1. ncbi Genetics of familial combined hyperlipidemia and risk of coronary heart disease
    C C Shoulders
    MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Hum Mol Genet 13:R149-60. 2004
  2. ncbi The FTO (fat mass and obesity-associated) gene: big in adipocyte lipolysis?
    Carol C Shoulders
    Imperial College London
    J Lipid Res 49:495-6. 2008
  3. ncbi Current biology of MTP: implications for selective inhibition
    Carol C Shoulders
    Genomic and Molecular Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Curr Top Med Chem 5:283-300. 2005
  4. ncbi USF1 implicated in the aetiology of familial combined hyperlipidaemia and the metabolic syndrome
    Carol C Shoulders
    MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Trends Mol Med 10:362-5. 2004
  5. ncbi The intracellular transport of chylomicrons requires the small GTPase, Sar1b
    Carol C Shoulders
    Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Curr Opin Lipidol 15:191-7. 2004
  6. ncbi The genes and proteins of atherogenic lipoprotein production
    C C Shoulders
    Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    Biochem Soc Trans 32:70-4. 2004
  7. ncbi Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous cells
    J M Leiper
    Medical Research Council Molecular Medicine Group, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    J Biol Chem 269:21951-4. 1994
  8. pmc Mutations of the microsomal triglyceride-transfer-protein gene in abetalipoproteinemia
    T M Narcisi
    MRC Molecular Medicine Group, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    Am J Hum Genet 57:1298-310. 1995
  9. ncbi A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase
    P Bradbury
    Medical Research Council Molecular Medicine Group, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Biol Chem 274:3159-64. 1999
  10. ncbi Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
    T J Aitman
    MRC Clinical Sciences Centre, and Division of National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Nat Genet 21:76-83. 1999

Collaborators

Detail Information

Publications18

  1. ncbi Genetics of familial combined hyperlipidemia and risk of coronary heart disease
    C C Shoulders
    MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Hum Mol Genet 13:R149-60. 2004
    ....
  2. ncbi The FTO (fat mass and obesity-associated) gene: big in adipocyte lipolysis?
    Carol C Shoulders
    Imperial College London
    J Lipid Res 49:495-6. 2008
  3. ncbi Current biology of MTP: implications for selective inhibition
    Carol C Shoulders
    Genomic and Molecular Medicine, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Curr Top Med Chem 5:283-300. 2005
    ....
  4. ncbi USF1 implicated in the aetiology of familial combined hyperlipidaemia and the metabolic syndrome
    Carol C Shoulders
    MRC Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Trends Mol Med 10:362-5. 2004
    ..The use of chromatin immunoprecipitation methodologies combined with promoter microarray assays will help to define the transcriptional networks that underlie whole-body glucose and lipid homeostasis...
  5. ncbi The intracellular transport of chylomicrons requires the small GTPase, Sar1b
    Carol C Shoulders
    Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Curr Opin Lipidol 15:191-7. 2004
    ..This review focuses on the assembly and structural evolution of COPII (coat protein) transport carriers that are essential for the transport of chylomicrons from the endoplasmic reticulum to the Golgi apparatus...
  6. ncbi The genes and proteins of atherogenic lipoprotein production
    C C Shoulders
    Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK
    Biochem Soc Trans 32:70-4. 2004
    ..Here we report molecular events that co-ordinate whole-body lipid homoeostasis from insects to humans, viewed in the context of rare and common genetic disorders of apolipoprotein B-containing lipoprotein production...
  7. ncbi Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous cells
    J M Leiper
    Medical Research Council Molecular Medicine Group, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    J Biol Chem 269:21951-4. 1994
    ....
  8. pmc Mutations of the microsomal triglyceride-transfer-protein gene in abetalipoproteinemia
    T M Narcisi
    MRC Molecular Medicine Group, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom
    Am J Hum Genet 57:1298-310. 1995
    ..These results establish that defects of the MTP gene are the predominant, if not sole, cause of hereditary ABL and that an intact carboxyl terminus is necessary for activity...
  9. ncbi A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase
    P Bradbury
    Medical Research Council Molecular Medicine Group, Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom
    J Biol Chem 274:3159-64. 1999
    ..The interaction of residues 512-721 of apoB with MTP facilitates lipoprotein production. Mutations of apoB that markedly reduced this interaction also reduced the level of apoB-containing lipoprotein secretion...
  10. ncbi Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
    T J Aitman
    MRC Clinical Sciences Centre, and Division of National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Nat Genet 21:76-83. 1999
    ..We conclude that Cd36 deficiency underlies insulin resistance, defective fatty acid metabolism and hypertriglyceridaemia in SHR and may be important in the pathogenesis of human insulin-resistance syndromes...
  11. ncbi Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein
    C C Shoulders
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Hum Mol Genet 2:2109-16. 1993
    ..These results elucidate a key process in the packaging of apolipoprotein B with lipid, and should increase our understanding of the processes regulating the production of atherogenic lipoproteins...
  12. ncbi Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders
    Bethan Jones
    Genomic and Molecular Medicine Group, MRC Clinical Sciences Centre, Imperial College, London, England, UK
    Nat Genet 34:29-31. 2003
    ..Our data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for transport through the secretory pathways of the cell...
  13. ncbi Confirmed locus on chromosome 11p and candidate loci on 6q and 8p for the triglyceride and cholesterol traits of combined hyperlipidemia
    Rossitza P Naoumova
    Genomic and Molecular Medicine Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Arterioscler Thromb Vasc Biol 23:2070-7. 2003
    ..The etiology of the lipid abnormalities (increased serum cholesterol and triglyceride or either lipid alone) is unknown...
  14. pmc Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia
    Sophie Eichenbaum-Voline
    Genomic and Molecular Medicine Group, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, London, UK
    Arterioscler Thromb Vasc Biol 24:167-74. 2004
    ....
  15. pmc New technologies for delineating and characterizing the lipid exome: prospects for understanding familial combined hyperlipidemia
    Stuart D Horswell
    Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, Du Cane Rd, London, W12 0NN United Kingdom
    J Lipid Res 50:S370-5. 2009
    ....
  16. ncbi Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation
    Christopher J Lelliott
    AstraZeneca R and D, Department of Integrative Pharmacology HE119, SE 431 83 Molndal, Sweden
    Arterioscler Thromb Vasc Biol 27:2707-13. 2007
    ..Here, we examined the in vivo effects of these two coactivators in potentiating the lipid lowering properties of the PPARalpha agonist Wy14,643 (Wy)...
  17. ncbi The transport of triglycerides through the secretory pathway of hepatocytes is impaired in apolipoprotein E deficient mice
    Arjen R Mensenkamp
    Department of Cell Biology, Faculty of Medical Sciences, University Hospital Groningen, 9713 GZ Groningen, The Netherlands
    J Hepatol 40:599-606. 2004
    ..Apolipoprotein E (apoE)-deficient mice develop hepatic steatosis and secrete reduced levels of VLDL-TG...
  18. ncbi USF1 on trial
    Carol C Shoulders
    Nat Genet 36:322-3. 2004