Bryan D Young

Summary

Affiliation: Queen Mary
Country: UK

Publications

  1. pmc Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats
    Marwa H Saied
    Centre of Haemato Oncology, Barts Cancer Institute, Barts and the London School of Medicine, Queen Mary University, London, United Kingdom
    PLoS ONE 7:e33213. 2012
  2. pmc The diagnosis of inherited metabolic diseases by microarray gene expression profiling
    Monica Arenas Hernandez
    Purine Research Laboratory, GSTS Pathology, Guy s and St, Thomas Hospitals, London, UK
    Orphanet J Rare Dis 5:34. 2010
  3. pmc Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes
    Muy Teck Teh
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, UK
    Mol Cancer 9:45. 2010
  4. ncbi request reprint Genetic alterations in primary cutaneous CD30+ anaplastic large cell lymphoma
    Xin Mao
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, London, United Kingdom
    Genes Chromosomes Cancer 37:176-85. 2003
  5. doi request reprint Identification of ZDHHC14 as a novel human tumour suppressor gene
    Marc Yeste-Velasco
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK
    J Pathol 232:566-77. 2014
  6. ncbi request reprint Genome-wide single nucleotide polymorphism analysis reveals frequent partial uniparental disomy due to somatic recombination in acute myeloid leukemias
    Manoj Raghavan
    Cancer Research UK Medical Oncology Laboratory, Barts and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London, United Kingdom
    Cancer Res 65:375-8. 2005
  7. doi request reprint High-resolution genome-wide copy-number analysis suggests a monoclonal origin of multifocal prostate cancer
    Lara K Boyd
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK
    Genes Chromosomes Cancer 51:579-89. 2012
  8. pmc Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia
    Amanda Dixon-McIver
    Institute of Cancer, Medical Oncology Centre, Barts and The London, School of Medicine, London, United Kingdom
    PLoS ONE 3:e2141. 2008
  9. ncbi request reprint Molecular cytogenetic characterization of Sézary syndrome
    Xin Mao
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, London, United Kingdom
    Genes Chromosomes Cancer 36:250-60. 2003
  10. ncbi request reprint Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events
    Silvana Debernardi
    Cancer Research UK, Medical Oncology Unit, Barts and the Royal London School of Medicine and Dentistry, London, United Kingdom
    Genes Chromosomes Cancer 37:149-58. 2003

Collaborators

Detail Information

Publications21

  1. pmc Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats
    Marwa H Saied
    Centre of Haemato Oncology, Barts Cancer Institute, Barts and the London School of Medicine, Queen Mary University, London, United Kingdom
    PLoS ONE 7:e33213. 2012
    ..MeDIP-seq data were validated using bisulfite pyrosequencing and the Infinium array...
  2. pmc The diagnosis of inherited metabolic diseases by microarray gene expression profiling
    Monica Arenas Hernandez
    Purine Research Laboratory, GSTS Pathology, Guy s and St, Thomas Hospitals, London, UK
    Orphanet J Rare Dis 5:34. 2010
    ..We aimed to define gene expression signatures characteristic of defective metabolic pathways...
  3. pmc Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes
    Muy Teck Teh
    Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Turner Street, London E1 2AD, UK
    Mol Cancer 9:45. 2010
    ..This indicates that upregulation of FOXM1 may be an early molecular signal required for aberrant cell cycle and cancer initiation...
  4. ncbi request reprint Genetic alterations in primary cutaneous CD30+ anaplastic large cell lymphoma
    Xin Mao
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, London, United Kingdom
    Genes Chromosomes Cancer 37:176-85. 2003
    ..These results reveal a consistent pattern of genetic alterations in C-ALCL and provide the molecular basis for further investigation of this disease...
  5. doi request reprint Identification of ZDHHC14 as a novel human tumour suppressor gene
    Marc Yeste-Velasco
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK
    J Pathol 232:566-77. 2014
    ....
  6. ncbi request reprint Genome-wide single nucleotide polymorphism analysis reveals frequent partial uniparental disomy due to somatic recombination in acute myeloid leukemias
    Manoj Raghavan
    Cancer Research UK Medical Oncology Laboratory, Barts and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London, United Kingdom
    Cancer Res 65:375-8. 2005
    ..These cryptic chromosomal abnormalities, which seem to be nonrandom, have the characteristics of somatic recombination events and may define an important new subclass of leukemia...
  7. doi request reprint High-resolution genome-wide copy-number analysis suggests a monoclonal origin of multifocal prostate cancer
    Lara K Boyd
    Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK
    Genes Chromosomes Cancer 51:579-89. 2012
    ..These findings, which demonstrate the monoclonal origin of multifocal prostate cancer, should significantly enhance our understanding of prostate carcinogenesis...
  8. pmc Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia
    Amanda Dixon-McIver
    Institute of Cancer, Medical Oncology Centre, Barts and The London, School of Medicine, London, United Kingdom
    PLoS ONE 3:e2141. 2008
    ..sanger.ac.uk), demonstrates the potential for using miRNA expression to sub-classify cancer and suggests a role in the aetiology of leukaemia...
  9. ncbi request reprint Molecular cytogenetic characterization of Sézary syndrome
    Xin Mao
    Skin Tumour Unit, St John s Institute of Dermatology, St Thomas Hospital, London, United Kingdom
    Genes Chromosomes Cancer 36:250-60. 2003
    ....
  10. ncbi request reprint Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events
    Silvana Debernardi
    Cancer Research UK, Medical Oncology Unit, Barts and the Royal London School of Medicine and Dentistry, London, United Kingdom
    Genes Chromosomes Cancer 37:149-58. 2003
    ..These data reveal novel diagnostic and therapeutic targets and demonstrate the potential of microarray-based dissection of AML...
  11. ncbi request reprint Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias
    Jude Fitzgibbon
    Cancer Research UK Medical Oncology Laboratory, Barts and the Royal London School of Medicine, Queen Mary College, London, United Kingdom
    Cancer Res 65:9152-4. 2005
    ..This implies that mutation precedes mitotic recombination which acts as a "second hit" responsible for removal of the remaining wild-type allele, as has recently been shown for the JAK2 gene in myeloproliferative disorders...
  12. pmc Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease
    Kajsa Paulsson
    Cancer Research UK Medical Oncology Centre, Barts and the London School of Medicine, Queen Mary College, London EC1M 6BQ, United Kingdom
    Proc Natl Acad Sci U S A 105:6708-13. 2008
    ..Most importantly, we report that microdeletions of key genes appear to be a common, characteristic feature of ALL that is shared among different clinical, morphological, and cytogenetic subgroups...
  13. doi request reprint Methylation of tumour suppressor gene promoters in the presence and absence of transcriptional silencing in high hyperdiploid acute lymphoblastic leukaemia
    Kajsa Paulsson
    Cancer Research UK Medical Oncology Centre, Barts and the London School of Medicine, Queen Mary College, London, UK
    Br J Haematol 144:838-47. 2009
    ..Taken together, our findings suggest that aberrant methylation of tumour suppressor gene promoters is a common phenomenon in high hyperdiploid ALL...
  14. ncbi request reprint Association between large-scale genomic homozygosity without chromosomal loss and nonseminomatous germ cell tumor development
    Yong Jie Lu
    Department of Medical Oncology, Barts and London School of Medicine and Dentistry, Queen Mary, University of London, London, United Kingdom
    Cancer Res 65:9137-41. 2005
    ..Nonrandom involvement of certain chromosomes also suggests that genes on these chromosome regions may play an important role in nonseminoma development...
  15. pmc AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia
    Jenny Dunne
    Cancer Research UK Medical Oncology Unit, Barts and the London School of Medicine and Dentistry, University of London, London, United Kingdom
    Cancer Res 70:3985-95. 2010
    ..In summary, we identify POU4F1/BRN3A as a novel potential upregulated AML1/ETO target gene whose dramatically high expression may cooperate with AML1/ETO in t(8;21) cells...
  16. pmc Distinct genomic alterations in prostate cancers in Chinese and Western populations suggest alternative pathways of prostate carcinogenesis
    Xueying Mao
    Molecular Oncology and Imaging Centre, Medical Oncology Centre, Institute of Cancer, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
    Cancer Res 70:5207-12. 2010
    ..Our findings suggest that tumors arise in Western and Chinese populations by alternative pathogenetic mechanisms...
  17. pmc Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation
    Derville O'Shea
    Centre for Medical Oncology, Barts and the London School of Medicine, London, United Kingdom
    Blood 113:2298-301. 2009
    ..05). aUPD on 16p was predictive of transformation (P = .03) and correlated with poorer progression-free survival (P = .02). aUPD is frequent at diagnosis of FL and affects probability of disease transformation and clinical outcome...
  18. pmc Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis
    David P Kelsell
    Centre for Cutaneous Research, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Am J Hum Genet 76:794-803. 2005
    ..This finding paves the way for early prenatal diagnosis. In addition, functional studies of ABCA12 will lead to a better understanding of epidermal differentiation and barrier formation...
  19. ncbi request reprint Molecular cloning of a constitutional t(7;22) translocation associated with risk of hematological malignancy
    Alexander S Hill
    Cancer Research UK, Medical Oncology, London, United Kingdom
    Genes Chromosomes Cancer 38:260-4. 2003
    ..As a consequence of this event, the entire IGL locus, less the first three Vlambda elements, is translocated to chromosome 7, whereas the three remaining Vlambda elements on the der(22) are juxtaposed with IGFBP3 and IGFBP1...
  20. ncbi request reprint Comparative genomic hybridization of 49 primary retinoblastoma tumors identifies chromosomal regions associated with histopathology, progression, and patient outcome
    Debra M Lillington
    Department of Medical Oncology, St Bartholomew s Hospital Medical College and the Royal London NHS Trust, London, United Kingdom
    Genes Chromosomes Cancer 36:121-8. 2003
    ..CGH analysis on larger cohorts and in prospective clinical trials will be invaluable in determining whether a genetic classification of retinoblastoma represents a reliable measure of prognosis...
  21. ncbi request reprint Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas
    Xin Mao
    Skin Tumour Unit and Dermatopathology Department, St John s Institute of Dermatology, St Thomas Hospital, London, United Kingdom
    Blood 101:1513-9. 2003
    ..These results have revealed, for the first time, amplification and expression patterns of JUNB in PCL, suggesting that JUNB may be critical in the pathogenesis of primary cutaneous T-cell lymphomas...