Andrew Sunters

Summary

Affiliation: Royal Veterinary College
Country: UK

Publications

  1. pmc A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?
    Imelda M McGonnell
    Department of Veterinary Basic Sciences, The Royal Veterinary College, London, UK
    Front Endocrinol (Lausanne) 3:88. 2012
  2. pmc Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
    Andrew Sunters
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, United Kingdom
    J Biol Chem 285:8743-58. 2010
  3. pmc The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading
    Alaa Moustafa
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, London, UK
    Bone 44:930-5. 2009
  4. pmc Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent
    Gul Zaman
    Department of Veterinary Basic Sciences, Royal Veterinary College, London, NW1 0TU, United Kingdom
    J Biol Chem 287:3946-62. 2012
  5. pmc Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse
    Gul Zaman
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
    Bone 46:628-42. 2010
  6. doi request reprint Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice
    Toshihiro Sugiyama
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
    Bone 43:238-48. 2008
  7. ncbi request reprint Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha
    Victoria J Armstrong
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London, United Kingdom
    J Biol Chem 282:20715-27. 2007
  8. pmc Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes
    Iain R Thompson
    Endocrine Signaling Group, Comparative Biomedical Sciences, Royal Veterinary College, University of London, Royal College Street, London, NW1 0TU, UK
    Cell Tissue Res 355:425-36. 2014

Collaborators

Detail Information

Publications8

  1. pmc A specific role for phosphoinositide 3-kinase and AKT in osteoblasts?
    Imelda M McGonnell
    Department of Veterinary Basic Sciences, The Royal Veterinary College, London, UK
    Front Endocrinol (Lausanne) 3:88. 2012
    ..In this review, we discuss some of these findings and suggest that the PI3K/AKT pathway is a central nexus in the extensive network of extracellular signaling pathways that control the osteoblast...
  2. pmc Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 recept
    Andrew Sunters
    Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, United Kingdom
    J Biol Chem 285:8743-58. 2010
    ..This cascade requires prostanoid/nitric oxide production and is independent of Wnt/LRP5...
  3. pmc The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading
    Alaa Moustafa
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, London, UK
    Bone 44:930-5. 2009
    ..Collectively, these data suggest that the mouse fibula, as well as the tibia and ulna, is a useful bone in which to assess bone cells' early responses to mechanical loading and the adaptive (re)modelling that this engenders...
  4. pmc Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent
    Gul Zaman
    Department of Veterinary Basic Sciences, Royal Veterinary College, London, NW1 0TU, United Kingdom
    J Biol Chem 287:3946-62. 2012
    ..Converting their strain-related responses into coherent "instructions" for adaptive (re)modeling is likely to depend upon their contextual activation, suppression, and interaction probably on more than one occasion...
  5. pmc Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse
    Gul Zaman
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
    Bone 46:628-42. 2010
    ..Many of the genes differentially regulated by the earliest loading-related response were primarily involved in energy metabolism and were not specific to bone...
  6. doi request reprint Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice
    Toshihiro Sugiyama
    Department of Veterinary Basic Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW1 0TU, UK
    Bone 43:238-48. 2008
    ..Together, these data suggest that in female C57BL/6 mice, under some but not all circumstances, mechanical loading exerts an osteogenic response with iPTH (1-34) in trabecular and cortical bone...
  7. ncbi request reprint Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha
    Victoria J Armstrong
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London, United Kingdom
    J Biol Chem 282:20715-27. 2007
    ..Reduced effectiveness of bone cell responses to bone loading, associated with estrogen-related decline in ERalpha, may contribute to the failure to maintain structurally appropriate bone mass in osteoporosis in both men and women...
  8. pmc Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes
    Iain R Thompson
    Endocrine Signaling Group, Comparative Biomedical Sciences, Royal Veterinary College, University of London, Royal College Street, London, NW1 0TU, UK
    Cell Tissue Res 355:425-36. 2014
    ..Guanylyl cyclase receptors thus represent potential novel therapeutic targets for treating growth-hormone-associated disorders. ..