K Thway

Summary

Affiliation: Royal Marsden Hospital
Country: UK

Publications

  1. Thway K, Gibson S, Ramsay A, Sebire N. Beta-catenin expression in pediatric fibroblastic and myofibroblastic lesions: a study of 100 cases. Pediatr Dev Pathol. 2009;12:292-6 pubmed publisher
    ..beta-catenin is not expressed in other common pediatric fibroblastic and myofibroblastic lesions, and the Wnt pathway does not appear to play a role in their pathogenesis. ..
  2. Thway K, Fisher C, Debiec Rychter M, Calonje E. Claudin-1 is expressed in perineurioma-like low-grade fibromyxoid sarcoma. Hum Pathol. 2009;40:1586-90 pubmed publisher
    ..Although positivity for claudin-1 remains useful as an adjunct marker for perineurioma, it should be taken in context with clinical findings, morphology, and the additional immunoprofile. ..
  3. Thway K, Rockcliffe S, Gonzalez D, Swansbury J, Min T, Thompson L, et al. Utility of sarcoma-specific fusion gene analysis in paraffin-embedded material for routine diagnosis at a specialist centre. J Clin Pathol. 2010;63:508-12 pubmed publisher
    ..PCR is less sensitive than FISH, and the use of both techniques is optimal for maximising the detection rate of translocation-positive sarcomas. ..
  4. Mohamed M, Fisher C, Thway K. Low-grade fibromyxoid sarcoma: Clinical, morphologic and genetic features. Ann Diagn Pathol. 2017;28:60-67 pubmed publisher
    ..We review LGFMS and SEF, discussing morphology and immunohistochemistry, genetics and molecular findings, and the differential diagnosis. ..
  5. Mohamed M, Gonzalez D, Fritchie K, Swansbury J, Wren D, Benson C, et al. Desmoplastic small round cell tumor: evaluation of reverse transcription-polymerase chain reaction and fluorescence in situ hybridization as ancillary molecular diagnostic techniques. Virchows Arch. 2017;471:631-640 pubmed publisher
    ..However, in cases with appropriate morphology and a typical pattern of immunostaining, FISH is confirmatory of the diagnosis. ..
  6. Thway K, Mentzel T, Perrett C, Calonje E. Multicentric visceral epithelioid hemangioendothelioma, with extremity dermal deposits, unusual late recurrence on the nasal bridge and TFE3 gene rearrangement. Hum Pathol. 2017;: pubmed publisher
    ..Characterization of the genetics of EHE is important as targeted therapies towards products of the specific WWTR1-CAMTA1 gene fusion may have an impact in the near future. ..
  7. Thway K. Pathology of soft tissue sarcomas. Clin Oncol (R Coll Radiol). 2009;21:695-705 pubmed publisher
    ....
  8. Thway K, Robertson D, Thway Y, Fisher C. Dedifferentiated liposarcoma with meningothelial-like whorls, metaplastic bone formation, and CDK4, MDM2, and p16 expression: a morphologic and immunohistochemical study. Am J Surg Pathol. 2011;35:356-63 pubmed publisher
    ..The CDK4, MDM2, and p16 expression in the whorls suggests that they share a similar genetic background to well-differentiated and dedifferentiated liposarcoma, and that additional genetic events are causal to their distinct morphology...
  9. Thway K, Fisher C. Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: the current status. Am J Surg Pathol. 2012;36:e1-e11 pubmed publisher
    ..We review the clinicopathologic and molecular features of this group of neoplasms unified by the presence of EWSR1-CREB1 and EWSR1-ATF1 genetic fusions. ..

Detail Information

Publications9

  1. Thway K, Gibson S, Ramsay A, Sebire N. Beta-catenin expression in pediatric fibroblastic and myofibroblastic lesions: a study of 100 cases. Pediatr Dev Pathol. 2009;12:292-6 pubmed publisher
    ..beta-catenin is not expressed in other common pediatric fibroblastic and myofibroblastic lesions, and the Wnt pathway does not appear to play a role in their pathogenesis. ..
  2. Thway K, Fisher C, Debiec Rychter M, Calonje E. Claudin-1 is expressed in perineurioma-like low-grade fibromyxoid sarcoma. Hum Pathol. 2009;40:1586-90 pubmed publisher
    ..Although positivity for claudin-1 remains useful as an adjunct marker for perineurioma, it should be taken in context with clinical findings, morphology, and the additional immunoprofile. ..
  3. Thway K, Rockcliffe S, Gonzalez D, Swansbury J, Min T, Thompson L, et al. Utility of sarcoma-specific fusion gene analysis in paraffin-embedded material for routine diagnosis at a specialist centre. J Clin Pathol. 2010;63:508-12 pubmed publisher
    ..PCR is less sensitive than FISH, and the use of both techniques is optimal for maximising the detection rate of translocation-positive sarcomas. ..
  4. Mohamed M, Fisher C, Thway K. Low-grade fibromyxoid sarcoma: Clinical, morphologic and genetic features. Ann Diagn Pathol. 2017;28:60-67 pubmed publisher
    ..We review LGFMS and SEF, discussing morphology and immunohistochemistry, genetics and molecular findings, and the differential diagnosis. ..
  5. Mohamed M, Gonzalez D, Fritchie K, Swansbury J, Wren D, Benson C, et al. Desmoplastic small round cell tumor: evaluation of reverse transcription-polymerase chain reaction and fluorescence in situ hybridization as ancillary molecular diagnostic techniques. Virchows Arch. 2017;471:631-640 pubmed publisher
    ..However, in cases with appropriate morphology and a typical pattern of immunostaining, FISH is confirmatory of the diagnosis. ..
  6. Thway K, Mentzel T, Perrett C, Calonje E. Multicentric visceral epithelioid hemangioendothelioma, with extremity dermal deposits, unusual late recurrence on the nasal bridge and TFE3 gene rearrangement. Hum Pathol. 2017;: pubmed publisher
    ..Characterization of the genetics of EHE is important as targeted therapies towards products of the specific WWTR1-CAMTA1 gene fusion may have an impact in the near future. ..
  7. Thway K. Pathology of soft tissue sarcomas. Clin Oncol (R Coll Radiol). 2009;21:695-705 pubmed publisher
    ....
  8. Thway K, Robertson D, Thway Y, Fisher C. Dedifferentiated liposarcoma with meningothelial-like whorls, metaplastic bone formation, and CDK4, MDM2, and p16 expression: a morphologic and immunohistochemical study. Am J Surg Pathol. 2011;35:356-63 pubmed publisher
    ..The CDK4, MDM2, and p16 expression in the whorls suggests that they share a similar genetic background to well-differentiated and dedifferentiated liposarcoma, and that additional genetic events are causal to their distinct morphology...
  9. Thway K, Fisher C. Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: the current status. Am J Surg Pathol. 2012;36:e1-e11 pubmed publisher
    ..We review the clinicopathologic and molecular features of this group of neoplasms unified by the presence of EWSR1-CREB1 and EWSR1-ATF1 genetic fusions. ..