I A Greenwood

Summary

Affiliation: St George's
Country: UK

Publications

  1. pmc Kv7 and Kv11 channels in myometrial regulation
    Iain A Greenwood
    St George s Medical School, Division of Biomedical Sciences, London SW17 0RE, UK
    Exp Physiol 99:503-9. 2014
  2. doi request reprint Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired β-adrenoceptor-mediated relaxation of renal arteries in hypertension
    Preet S Chadha
    Division of Biomedical Sciences, Pharmacology and Cell Physiology Research Group, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Hypertension 59:877-84. 2012
  3. pmc New tricks for old dogs: KCNQ expression and role in smooth muscle
    Iain A Greenwood
    Division of Basic Medical Sciences, St George s, University of London, London, UK
    Br J Pharmacol 156:1196-203. 2009
  4. ncbi request reprint Overlapping pharmacology of Ca2+-activated Cl- and K+ channels
    Iain A Greenwood
    Ion Channels and Cell Signalling Research Centre, Division of Basic Medical Sciences, St George s, University of London, London SW17 0RE, UK
    Trends Pharmacol Sci 28:1-5. 2007
  5. pmc Loss of functional K+ channels encoded by ether-à-go-go-related genes in mouse myometrium prior to labour onset
    I A Greenwood
    Division of Basic Medical Sciences, Ion Channels and Cell Signaling Research Centre, St George s, University of London, London SW17 0RE, UK
    J Physiol 587:2313-26. 2009
  6. pmc Differential regulation of Ca(2+)-activated Cl(-) currents in rabbit arterial and portal vein smooth muscle cells by Ca(2+)-calmodulin-dependent kinase
    I A Greenwood
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London, UK
    J Physiol 534:395-408. 2001
  7. pmc Modulation of Ca(2+)-activated Cl- currents in rabbit portal vein smooth muscle by an inhibitor of mitochondrial Ca2+ uptake
    I A Greenwood
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London, UK
    J Physiol 505:53-64. 1997
  8. pmc Modulation of the decay of Ca2+-activated Cl- currents in rabbit portal vein smooth muscle cells by external anions
    I A Greenwood
    Department of Pharmacology and Clinical Pharmacology, Cardiovascular Research Group, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Physiol 516:365-76. 1999
  9. pmc Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity
    S Y M Yeung
    Division of Basic Medical Sciences, Ion Channels and Cell Signalling Research Centre, St George s, University of London, London, UK
    Br J Pharmacol 151:758-70. 2007
  10. pmc Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels
    W R Sones
    Division of Basic Medical Sciences, St George s, University of London, London, UK
    Br J Pharmacol 158:521-31. 2009

Collaborators

Detail Information

Publications37

  1. pmc Kv7 and Kv11 channels in myometrial regulation
    Iain A Greenwood
    St George s Medical School, Division of Biomedical Sciences, London SW17 0RE, UK
    Exp Physiol 99:503-9. 2014
    ..Moreover, Kv7 channels may be potential therapeutic targets for the treatment of preterm labour. ..
  2. doi request reprint Reduced KCNQ4-encoded voltage-dependent potassium channel activity underlies impaired β-adrenoceptor-mediated relaxation of renal arteries in hypertension
    Preet S Chadha
    Division of Biomedical Sciences, Pharmacology and Cell Physiology Research Group, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Hypertension 59:877-84. 2012
    ..4 channels is strongly implicated in the impaired β-adrenoceptor pathway in spontaneously hypertensive rats. These findings may provide a novel pathogenic link between arterial dysfunction and hypertension...
  3. pmc New tricks for old dogs: KCNQ expression and role in smooth muscle
    Iain A Greenwood
    Division of Basic Medical Sciences, St George s, University of London, London, UK
    Br J Pharmacol 156:1196-203. 2009
    ..This article will provide an overview of present understanding in this nascent area of KCNQ research and will offer guidance as to future directions...
  4. ncbi request reprint Overlapping pharmacology of Ca2+-activated Cl- and K+ channels
    Iain A Greenwood
    Ion Channels and Cell Signalling Research Centre, Division of Basic Medical Sciences, St George s, University of London, London SW17 0RE, UK
    Trends Pharmacol Sci 28:1-5. 2007
    ....
  5. pmc Loss of functional K+ channels encoded by ether-à-go-go-related genes in mouse myometrium prior to labour onset
    I A Greenwood
    Division of Basic Medical Sciences, Ion Channels and Cell Signaling Research Centre, St George s, University of London, London SW17 0RE, UK
    J Physiol 587:2313-26. 2009
    ..This study provides the first evidence for a regulation of ERG-encoded K(+) channels as a precursor to late pregnancy physiological activity...
  6. pmc Differential regulation of Ca(2+)-activated Cl(-) currents in rabbit arterial and portal vein smooth muscle cells by Ca(2+)-calmodulin-dependent kinase
    I A Greenwood
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London, UK
    J Physiol 534:395-408. 2001
    ..5. The present study shows that regulation of Ca(2+)-dependent Cl(-) channels by CaMKII differs between arterial and portal vein myocytes...
  7. pmc Modulation of Ca(2+)-activated Cl- currents in rabbit portal vein smooth muscle by an inhibitor of mitochondrial Ca2+ uptake
    I A Greenwood
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London, UK
    J Physiol 505:53-64. 1997
    ..In contrast, inhibition of Ca2+ uptake by the sarcoplasmic reticulum ATPase does not seem to influence the time course of ICl(Ca)...
  8. pmc Modulation of the decay of Ca2+-activated Cl- currents in rabbit portal vein smooth muscle cells by external anions
    I A Greenwood
    Department of Pharmacology and Clinical Pharmacology, Cardiovascular Research Group, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Physiol 516:365-76. 1999
    ..7. In conclusion, external anions affect the decay of ICl(Ca) by a mechanism compatible with an interaction with a binding site which modulates Cl- channel kinetics...
  9. pmc Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity
    S Y M Yeung
    Division of Basic Medical Sciences, Ion Channels and Cell Signalling Research Centre, St George s, University of London, London, UK
    Br J Pharmacol 151:758-70. 2007
    ..This study represents a novel characterisation of KCNQ-encoded potassium channels in the vasculature using a variety of pharmacological and molecular tools to determine their role in contractility...
  10. pmc Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels
    W R Sones
    Division of Basic Medical Sciences, St George s, University of London, London, UK
    Br J Pharmacol 158:521-31. 2009
    ..1 inhibited calcium-activated Cl(-) currents (I(ClCa)) and if the pharmacological overlap between K(Ca)1.1 and CaCCs extends to intermediate and small conductance, calcium-activated K(+) channels...
  11. doi request reprint KCNQ-encoded channels regulate Na+ transport across H441 lung epithelial cells
    I A Greenwood
    Division of Basic Medical Sciences, St George s, University of London, London, SW17 0RE, UK
    Pflugers Arch 457:785-94. 2009
    ..These data show for the first time that potassium channels encoded by KCNQ3 or KCNQ5 are crucial determinants of epithelial Na+ flux...
  12. pmc Modulation of volume-sensitive chloride current by noradrenaline in rabbit portal vein myocytes
    D C Ellershaw
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Physiol 542:537-47. 2002
    ..The data suggest that the potentiating and inhibitory effects of noradrenaline are mediated, respectively, by PKC and PKA...
  13. pmc One man's side effect is another man's therapeutic opportunity: targeting Kv7 channels in smooth muscle disorders
    T A Jepps
    Division of Biomedical Sciences, St George s, University of London, Cranmer Terrace, UK
    Br J Pharmacol 168:19-27. 2013
    ..This review discusses the potential of targeting Kv7 channels in the smooth muscle to treat diseases such as hypertension, bladder instability, constipation and preterm labour...
  14. pmc Pharmacological and molecular evidence for the involvement of Kv4.3 in ultra-fast activating K+ currents in murine portal vein myocytes
    S Y M Yeung
    Division of Basic Medical Sciences, Ion Channels and Cell Signalling Research Centre, St George s, University of London, London, UK
    Br J Pharmacol 149:676-86. 2006
    ..The aim of this study was to determine the molecular identity of a transient K+ current (termed IUF) in mouse portal vein myocytes using pharmacological and molecular tools...
  15. ncbi request reprint Direct visualization of sarcoplasmic reticulum regions discharging Ca(2+)sparks in vascular myocytes
    D V Gordienko
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, Cranmer Terrace, London, UK
    Cell Calcium 29:13-28. 2001
    ....
  16. ncbi request reprint Stimulation of Ca2+-gated Cl- currents by the calcium-dependent K+ channel modulators NS1619 [1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one] and isopimaric acid
    Sohag N Saleh
    Ion Channels and Cell Signaling Research Centre, Division of Basic Medical Sciences, St George s, University of London, SW17 0RE London, UK
    J Pharmacol Exp Ther 321:1075-84. 2007
    ..Although nonspecific interactions are possible, one alternative hypothesis is that the channel underlying vascular I(ClCa) shares some structural similarity to the BK(Ca) or that the latter K(+) channel physically interacts with Cl(Ca)...
  17. pmc Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles
    Thomas A Jepps
    Division of Basic Medical Sciences, St George s, University of London, London, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 297:G107-15. 2009
    ..Drugs that selectively block K(v)7.4/7.5 might be promising therapeutics for the treatment of motility disorders such as constipation associated with irritable bowel syndrome...
  18. pmc Cholesterol depletion alters amplitude and pharmacology of vascular calcium-activated chloride channels
    William R Sones
    Division of Basic Medical Sciences, St George s, University of London, London SW17 0RE, UK
    Cardiovasc Res 87:476-84. 2010
    ....
  19. ncbi request reprint Pharmacological and biophysical isolation of K+ currents encoded by ether-à-go-go-related genes in murine hepatic portal vein smooth muscle cells
    Shuk Yin M Yeung
    Division of Basic Medical Sciences, Ion Channels and Cell Signalling Research Centre, St George s, University of London, London SW17 0RE, UK
    Am J Physiol Cell Physiol 292:C468-76. 2007
    ..These data are the first record of ERG channel currents in smooth muscle cells under quasi-physiological conditions that suggest that ERG channels contribute to the resting membrane potential in these cells...
  20. pmc Inhibitory role of phosphatidylinositol 4,5-bisphosphate on TMEM16A-encoded calcium-activated chloride channels in rat pulmonary artery
    H A T Pritchard
    Vascular Biology Research Centre, Institute of Cardiovascular and Cell Sciences, St George s, University of London, London, UK
    Br J Pharmacol 171:4311-21. 2014
    ..Here, we investigated whether these channels are regulated by phosphatidylinositol (4,5) bisphosphate [P(4,5)P2 ], a known regulator of various ion channels...
  21. pmc Dual effect of blocking agents on Ca2+-activated Cl(-) currents in rabbit pulmonary artery smooth muscle cells
    A S Piper
    Department of Pharmacology and Clinical Pharmacology, Cardiovascular Research Group, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
    J Physiol 539:119-31. 2002
    ..These results suggest that NFA and DCDPC, but not DIDS, simultaneously enhance and block I(Cl(Ca)) by binding to an external site, probably close to the mouth of the chloride channel...
  22. pmc Expression profile and protein translation of TMEM16A in murine smooth muscle
    Alison J Davis
    Division of Biomedical Sciences, St George s, University of London, London, United Kingdom
    Am J Physiol Cell Physiol 299:C948-59. 2010
    ..This study shows that TMEM16A expression is robust in murine vascular smooth muscle cells, consolidating the view that this gene is a viable candidate for the native Ca(2+)-activated Cl(-) channel in this cell type...
  23. pmc Anomalous effect of anthracene-9-carboxylic acid on calcium-activated chloride currents in rabbit pulmonary artery smooth muscle cells
    Angela S Piper
    Department of Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London, SW17 0RE, UK
    Br J Pharmacol 138:31-8. 2003
    ..5 The data from the present study confirm previous observations that the inhibitory effect of Cl(-) channel blockers is modified when [Ca(2+)](i) is maintained at higher than normal resting concentrations...
  24. ncbi request reprint Modulation of ICl(Ca) in vascular smooth muscle cells by oxidizing and cysteine-reactive reagents
    Iain A Greenwood
    Department of Pharmacology and Clinical Pharmacology, Cardiovascular Research Group, St Georges Hospital Medical School, London, UK
    Pflugers Arch 443:473-82. 2002
    ..Similar effects were observed with the hydrophilic thiol-reactants thimerosal and p-chloromercuriphenylsulphonic acid (PCMPS). Therefore, the gating and activation of Ca2+-activated Cl- conductance is sensitive to redox modification...
  25. doi request reprint Downregulation of Kv7.4 channel activity in primary and secondary hypertension
    Thomas A Jepps
    Division of Biomedical Sciences, St George s, University of London, United Kingdom
    Circulation 124:602-11. 2011
    ..We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals...
  26. doi request reprint Expression profile and characterisation of a truncated KCNQ5 splice variant
    Shuk Yin M Yeung
    Division of Basic Medical Sciences, Ion Channels and Cell Signalling Research Centre, St George s, University of London, London SW17 0RE, UK
    Biochem Biophys Res Commun 371:741-6. 2008
    ..These data represent an exhaustive characterisation of a truncated KCNQ5 splice variant that may contribute to the native XE991-sensitive channel in murine vasculature...
  27. pmc CLC-3 knockout hints at swelling-activated chloride channel complexity
    Iain A Greenwood
    Department of Basic Medical Sciences, St George s Hospital Medical School, London, UK
    J Physiol 557:343. 2004
  28. pmc Comparison of the properties of CLCA1 generated currents and I(Cl(Ca)) in murine portal vein smooth muscle cells
    Fiona C Britton
    Department of Physiology and Cell Biology and COBRE Program, University of Nevada School of Medicine, Reno, Nevada 89557 0046, USA
    J Physiol 539:107-17. 2002
    ..However, there was some similarity in the pore properties and these data suggest that mCLCA1 alone does not comprise the Cl- channel in portal vein smooth muscle cells...
  29. ncbi request reprint The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1
    Iain A Greenwood
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557 0046, USA
    J Biol Chem 277:22119-22. 2002
    ..These data suggest that activation of CLCA1 can be modified by accessory subunits...
  30. ncbi request reprint Molecular variants of KCNQ channels expressed in murine portal vein myocytes: a role in delayed rectifier current
    Susumu Ohya
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nev 89557 0046, USA
    Circ Res 92:1016-23. 2003
    ..Our data suggest that these two KCNQ1 splice forms are expressed in murine portal vein and contribute to the delayed rectifier current in these myocytes...
  31. ncbi request reprint Calcineurin Aalpha but not Abeta augments ICl(Ca) in rabbit pulmonary artery smooth muscle cells
    Iain A Greenwood
    Department of Basic Medical Sciences, Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London SW17 ORE, United Kingdom
    J Biol Chem 279:38830-7. 2004
    ..These novel data show that in PA myocytes activation of I(Cl(Ca)) is enhanced by Ca(2+)-dependent dephosphorylation and that the regulation of this conductance is highly isoform-specific...
  32. ncbi request reprint Simply the best?: identity of vascular cGMP-dependent Cl- current revealed
    Iain A Greenwood
    Circ Res 103:782-3. 2008
  33. ncbi request reprint Activation of chloride currents in murine portal vein smooth muscle cells by membrane depolarization involves intracellular calcium release
    Sohag N Saleh
    Department of Basic Medical Sciences, Pharmacology and Clinical Pharmacology, St George s Hospital Medical School, London, United Kingdom
    Am J Physiol Cell Physiol 288:C122-31. 2005
    ..In isometric tension recordings, NFA inhibited spontaneous contractions. These data support a role for this conductance in portal vein excitability...
  34. ncbi request reprint Dynamics of Ca2+-dependent Cl- channel modulation by niflumic acid in rabbit coronary arterial myocytes
    Jonathan Ledoux
    Department of Pharmacology Mail Stop 318, Center of Biomedical Research Excellence, Savitt Medical Sciences Building, Room 50, University of Nevada School of Medicine, Reno, NV 89557 0270, USA
    Mol Pharmacol 67:163-73. 2005
    ..Computer simulations derived from a kinetic model involving low (K(i) = 1.25 mM) and high (K(i) < 30 microM) affinity sites could reproduce the properties of the NFA-modulated I(Cl(Ca)) fairly well...
  35. pmc Electrophysiological and functional effects of the KCNQ channel blocker XE991 on murine portal vein smooth muscle cells
    Shuk Yin M Yeung
    Department of Basic Medical Sciences, St George s University of London, Cranmer Terrace, London SW17 0RE
    Br J Pharmacol 146:585-95. 2005
    ..The stimulatory effect of XE991 was not affected by the presence of 4-AP, glibenclamide nor paxilline. These data provide evidence for an important role for KCNQ channels in governing cellular excitability in mPV smooth muscle cells...
  36. ncbi request reprint Regulation of calcium-activated chloride channels in smooth muscle cells: a complex picture is emerging
    Normand Leblanc
    Department of Pharmacology, Centre of Biomedical Research Excellence COBRE, University of Nevada School of Medicine, Reno, NV, USA
    Can J Physiol Pharmacol 83:541-56. 2005
    ....
  37. pmc Mechanism of the inhibition of Ca2+-activated Cl- currents by phosphorylation in pulmonary arterial smooth muscle cells
    Jeff E Angermann
    Department of Pharmacology, Center for Biomedical Research Excellence COBRE, University of Nevada School of Medicine, Reno 89557, USA
    J Gen Physiol 128:73-87. 2006
    ..These data reveal that the phosphorylation status of the Ca2+-activated Cl- channel complex influences current generation dramatically through one or more critical voltage-dependent steps...