Karolina M Stepien

Summary

Affiliation: Nottingham University Hospitals Trust
Location: Nottingham, UK

Publications

  1. ncbi Neuroprotective properties of statins
    Karolina Stepien
    Department of Pathophysiology, Skubiszewski Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 57:561-9. 2005
  2. ncbi Profile of anticonvulsant activity and neuroprotective effects of novel and potential antiepileptic drugs--an update
    Karolina Stepien
    Department of Pathophysiology, Skubiszewski Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 57:719-33. 2005
  3. ncbi Fluoxetine enhances the anticonvulsant effects of conventional antiepileptic drugs in maximal electroshock seizures in mice
    Kinga K Borowicz
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 58:83-90. 2006
  4. pmc Patients' self-assessed functional status in heart failure by New York Heart Association class: a prognostic predictor of hospitalizations, quality of life and death
    Richard Holland
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    J Card Fail 16:150-6. 2010
  5. pmc Acute renal failure, microangiopathic haemolytic anemia, and secondary oxalosis in a young female patient
    Karolina M Stepien
    Clinical Pathology Department, Nottingham University Hospitals Trust, Nottingham NG5 1PB, UK
    Int J Nephrol 2011:679160. 2011
  6. ncbi Statin-induced myopathies
    Michał Tomaszewski
    Department of Cardiology, Medical University of Lublin, Jaczewskiego 8, PL 20 954 Lublin, Poland
    Pharmacol Rep 63:859-66. 2011
  7. doi The interactions of atorvastatin and fluvastatin with carbamazepine, phenytoin and valproate in the mouse maximal electroshock seizure model
    Karolina M Stepien
    Department of Pathophysiology, The Medical University, of Lublin, Poland
    Eur J Pharmacol 674:20-6. 2012
  8. doi Colloidal silver ingestion with copper and caeruloplasmin deficiency
    Karolina M Stepien
    Nottingham University Hospitals Trust, Hucknall Road, NG5 1PB Nottingham, UK
    Ann Clin Biochem 49:300-1. 2012
  9. pmc Lack of association of colonic epithelium telomere length and oxidative DNA damage in Type 2 diabetes under good metabolic control
    Deepak Kejariwal
    Department of Gastroenterology, Norfolk and Norwich University Hospital Colney Lane, Norwich NR4 7UY, UK
    BMC Endocr Disord 8:12. 2008
  10. pmc The Challenges of a Successful Pregnancy in a Patient with Adult Refsum's Disease due to Phytanoyl-CoA Hydroxylase Deficiency
    Karolina M Stepien
    Adult Inherited Metabolic Disorders, The Mark Holland Metabolic Unit, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD, Salford, UK
    JIMD Rep . 2016

Collaborators

Detail Information

Publications14

  1. ncbi Neuroprotective properties of statins
    Karolina Stepien
    Department of Pathophysiology, Skubiszewski Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 57:561-9. 2005
    ..It has been claimed that they suppress inflammatory response and secondary injury after acute ischemia...
  2. ncbi Profile of anticonvulsant activity and neuroprotective effects of novel and potential antiepileptic drugs--an update
    Karolina Stepien
    Department of Pathophysiology, Skubiszewski Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 57:719-33. 2005
    ..In conclusion, some of the newer AEDs show promise as possible neuroprotectants in epilepsy and acute ischemia but more studies are needed before clinical trials in humans could be undertaken...
  3. ncbi Fluoxetine enhances the anticonvulsant effects of conventional antiepileptic drugs in maximal electroshock seizures in mice
    Kinga K Borowicz
    Department of Pathophysiology, Medical University of Lublin, Jaczewskiego 8, PL 20 090 Lublin, Poland
    Pharmacol Rep 58:83-90. 2006
    ..In conclusion, the data suggest that FXT modulates seizure processes in the brain and may be advantageous in the treatment of epilepsy in depressed patients, improving the seizure control in epilepsy...
  4. pmc Patients' self-assessed functional status in heart failure by New York Heart Association class: a prognostic predictor of hospitalizations, quality of life and death
    Richard Holland
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    J Card Fail 16:150-6. 2010
    ..This study aims to test whether patients' self-assessment of functional status by NYHA class predicts hospital admissions, quality of life, and mortality...
  5. pmc Acute renal failure, microangiopathic haemolytic anemia, and secondary oxalosis in a young female patient
    Karolina M Stepien
    Clinical Pathology Department, Nottingham University Hospitals Trust, Nottingham NG5 1PB, UK
    Int J Nephrol 2011:679160. 2011
    ..The patient completed five sessions of plasma exchange and was able to discontinue dialysis. She eventually achieved full renal recovery. She has now discontinued sclerotherapy and vitamin supplementation...
  6. ncbi Statin-induced myopathies
    Michał Tomaszewski
    Department of Cardiology, Medical University of Lublin, Jaczewskiego 8, PL 20 954 Lublin, Poland
    Pharmacol Rep 63:859-66. 2011
    ..Currently, the only effective treatment of statin-induced myopathy is the discontinuation of statin use in patients affected by muscle aches, pains and elevated CK levels...
  7. doi The interactions of atorvastatin and fluvastatin with carbamazepine, phenytoin and valproate in the mouse maximal electroshock seizure model
    Karolina M Stepien
    Department of Pathophysiology, The Medical University, of Lublin, Poland
    Eur J Pharmacol 674:20-6. 2012
    ..The former interaction was pharmacokinetic in nature...
  8. doi Colloidal silver ingestion with copper and caeruloplasmin deficiency
    Karolina M Stepien
    Nottingham University Hospitals Trust, Hucknall Road, NG5 1PB Nottingham, UK
    Ann Clin Biochem 49:300-1. 2012
    ..Low serum copper may result in decreased caeruloplasmin synthesis. We report the case of a 59-year-old woman, who was admitted to hospital with acute psychosis and who had been ingesting chronically, colloidal silver...
  9. pmc Lack of association of colonic epithelium telomere length and oxidative DNA damage in Type 2 diabetes under good metabolic control
    Deepak Kejariwal
    Department of Gastroenterology, Norfolk and Norwich University Hospital Colney Lane, Norwich NR4 7UY, UK
    BMC Endocr Disord 8:12. 2008
    ..We hypothesised that the colonic mucosa in Type 2 diabetes would be characterised by increased DNA damage and telomere shortening...
  10. pmc The Challenges of a Successful Pregnancy in a Patient with Adult Refsum's Disease due to Phytanoyl-CoA Hydroxylase Deficiency
    Karolina M Stepien
    Adult Inherited Metabolic Disorders, The Mark Holland Metabolic Unit, Salford Royal NHS Foundation Trust, Stott Lane, M6 8HD, Salford, UK
    JIMD Rep . 2016
    ..Measures were taken to minimise the risk of acute neurological decompensation. The infant was unaffected and has made normal developmental progress in the subsequent 2 years...
  11. doi Observational clinical study of 22 adult-onset Pompe disease patients undergoing enzyme replacement therapy over 5years
    Karolina M Stepien
    Adult Inherited Metabolic Disorders, The Mark Holland Metabolic Unit, Salford Royal NHS Foundation Trust, Stott Line, M6 8HD, Salford, UK Electronic address
    Mol Genet Metab 117:413-8. 2016
    ..However, in some patients they continued to decline in spite of ERT resulting in increased number of patients requiring ventilation and increase wheel chair dependence at the end of 5years. ..
  12. ncbi Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency--diagnostic difficulties and own experience in multidisciplinary management
    Karolina M Stepien
    The Mark Holland Metabolic Unit, Salford Royal Foundation NHS Trust, Stott Lane, Salford M6 8HD, e mail Phone 0044 161 2064365
    Dev Period Med 19:450-3. 2015
    ..Hence, the liaison between neurologists, rheumatologists and metabolic physicians is essential in early diagnosis and the management of patients with conditions causing myopathy. ..
  13. ncbi The principles of the transition process from paediatric to adult services in inborn errors of metabolism--own experience
    Karolina M Stepien
    The Mark Holland Metabolic Unit, Salford Royal Foundation NHS Trust, Stott Lane, Salford M6 8HD, e mail Phone 0044 161 2064365
    Dev Period Med 19:523-7. 2015
    ..Both healthcare professionals and parents should facilitate the process of building new relationships between the adolescent and the adult metabolic teams. ..
  14. doi Lipoprotein X in a patient with cholestasis and hypertriglyceridaemia
    Karolina M Stepien
    Nottingham University Hospitals Trust, Hucknall Road, Nottingham NG5 1PB, UK
    Ann Clin Biochem 50:173-5. 2013
    ..7 mmol/L. The lipoprotein electrophoresis confirmed the presence of lipoprotein X associated with bile obstruction, which contributed to an increase in total cholesterol. The total cholesterol normalized on improvement of his cholestasis...