R Alberio

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Reprogramming somatic cells into stem cells
    Ramiro Alberio
    School of Biosciences University of Nottingham, Loughborough, NG2 5RD, UK
    Reproduction 132:709-20. 2006
  2. pmc A gene expression atlas of the domestic pig
    Tom C Freeman
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, EH25 9PS, UK
    BMC Biol 10:90. 2012
  3. pmc Modulation of pluripotency in the porcine embryo and iPS cells
    Aida Rodriguez
    School of Biosciences, University of Nottingham, Loughborough, United Kingdom
    PLoS ONE 7:e49079. 2012
  4. doi request reprint Recent advances in stem and germ cell research: implications for the derivation of pig pluripotent cells
    R Alberio
    Division of Animal Sciences, School of Biosciences, University of Nottingham, Loughborough, UK
    Reprod Domest Anim 47:98-106. 2012
  5. pmc Epigenetic reprogramming of breast cancer cells with oocyte extracts
    Cinzia Allegrucci
    Centre for Genetics and Genomics, School of Biology, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Mol Cancer 10:7. 2011
  6. ncbi request reprint Mammalian oocyte activation: lessons from the sperm and implications for nuclear transfer
    R Alberio
    Department of Molecular Animal Breeding and Genetics, Ludwig Maximilian University, Oberschleissheim, Germany
    Int J Dev Biol 45:797-809. 2001
  7. pmc Epigenetic reprogramming in the porcine germ line
    Sara M W Hyldig
    Division of Animal Sciences, School of Biosciences, University of Nottingham, Loughborough, LE12 5RD, UK
    BMC Dev Biol 11:11. 2011
  8. pmc Pig epiblast stem cells depend on activin/nodal signaling for pluripotency and self-renewal
    Ramiro Alberio
    Division of Animal Sciences, School of Biosciences, University of Nottingham, Loughborough, United Kingdom
    Stem Cells Dev 19:1627-36. 2010
  9. ncbi request reprint Activation of bovine oocytes by specific inhibition of cyclin-dependent kinases
    R Alberio
    Department of Molecular Animal Breeding and Genetics, University of Munich, Oberschleissheim, Germany
    Mol Reprod Dev 55:422-32. 2000
  10. ncbi request reprint Remodeling of donor nuclei, DNA-synthesis, and ploidy of bovine cumulus cell nuclear transfer embryos: effect of activation protocol
    R Alberio
    Department of Molecular Animal Breeding and Genetics, Ludwig-Maximilian University, Oberschleissheim, Germany
    Mol Reprod Dev 59:371-9. 2001

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Reprogramming somatic cells into stem cells
    Ramiro Alberio
    School of Biosciences University of Nottingham, Loughborough, NG2 5RD, UK
    Reproduction 132:709-20. 2006
    ..We also overview reprogramming events after somatic cell nuclear transfer (SCNT), as they may further instruct ex ovo strategies for cellular manipulation...
  2. pmc A gene expression atlas of the domestic pig
    Tom C Freeman
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, EH25 9PS, UK
    BMC Biol 10:90. 2012
    ..The new array was used to generate a genome-wide expression atlas of pig tissues derived from 62 tissue/cell types. These data were subjected to network correlation analysis and clustering...
  3. pmc Modulation of pluripotency in the porcine embryo and iPS cells
    Aida Rodriguez
    School of Biosciences, University of Nottingham, Loughborough, United Kingdom
    PLoS ONE 7:e49079. 2012
    ..These improved culture conditions will pave the way for the generation of germline competent stem cells in this species...
  4. doi request reprint Recent advances in stem and germ cell research: implications for the derivation of pig pluripotent cells
    R Alberio
    Division of Animal Sciences, School of Biosciences, University of Nottingham, Loughborough, UK
    Reprod Domest Anim 47:98-106. 2012
    ..Here, we discuss recent developments in stem cell biology that will impact the generation of pluripotent cells from different embryonic origins and will contribute to increase our capacity for generating transgenic animals...
  5. pmc Epigenetic reprogramming of breast cancer cells with oocyte extracts
    Cinzia Allegrucci
    Centre for Genetics and Genomics, School of Biology, University of Nottingham, Queens Medical Centre, Nottingham, UK
    Mol Cancer 10:7. 2011
    ..In this study we apply the reprogramming capacity of oocytes to cancer cells in order to study breast oncogenesis...
  6. ncbi request reprint Mammalian oocyte activation: lessons from the sperm and implications for nuclear transfer
    R Alberio
    Department of Molecular Animal Breeding and Genetics, Ludwig Maximilian University, Oberschleissheim, Germany
    Int J Dev Biol 45:797-809. 2001
    ..Nonetheless, the development of activation protocols that closely imitate the mechanism of activation initiated by the sperm are of special interest to improve the developmental potential of cloned embryos...
  7. pmc Epigenetic reprogramming in the porcine germ line
    Sara M W Hyldig
    Division of Animal Sciences, School of Biosciences, University of Nottingham, Loughborough, LE12 5RD, UK
    BMC Dev Biol 11:11. 2011
    ..Here we report on the dynamic reprogramming of DNA methylation at CpGs of imprinted loci and DNA repeats, and the global changes in H3K27me3 and H3K9me2 in the developing germ line of the domestic pig...
  8. pmc Pig epiblast stem cells depend on activin/nodal signaling for pluripotency and self-renewal
    Ramiro Alberio
    Division of Animal Sciences, School of Biosciences, University of Nottingham, Loughborough, United Kingdom
    Stem Cells Dev 19:1627-36. 2010
    ..This study provides further evidence that maintenance of pluripotency via Activin/Nodal signal is conserved in mammals...
  9. ncbi request reprint Activation of bovine oocytes by specific inhibition of cyclin-dependent kinases
    R Alberio
    Department of Molecular Animal Breeding and Genetics, University of Munich, Oberschleissheim, Germany
    Mol Reprod Dev 55:422-32. 2000
    ..This effect can be improved by combination with ionomycin. The targeting of CDKs in the way to activate bovine oocytes can be an approach to improve the efficiency of mammalian oocyte activation...
  10. ncbi request reprint Remodeling of donor nuclei, DNA-synthesis, and ploidy of bovine cumulus cell nuclear transfer embryos: effect of activation protocol
    R Alberio
    Department of Molecular Animal Breeding and Genetics, Ludwig-Maximilian University, Oberschleissheim, Germany
    Mol Reprod Dev 59:371-9. 2001
    ..The results presented in this study show differences between the protocols compared on the nuclear events during the first cell cycle and on the development to blastocyst. Mol. Reprod. Dev. 59: 371-379, 2001...
  11. ncbi request reprint Nuclear transfer in cattle with non-transfected and transfected fetal or cloned transgenic fetal and postnatal fibroblasts
    V Zakhartchenko
    Department of Molecular Animal Breeding and Genetics, Ludwig-Maximilian University, Oberschleissheim, Germany
    Mol Reprod Dev 60:362-9. 2001
    ....
  12. ncbi request reprint Nuclear transfer in practice
    K H Campbell
    School of Biosciences, University of Nottingham, Leicestershire, United Kingdom
    Cloning Stem Cells 3:201-8. 2001
    ..The present review will discuss the uses of NT, the techniques presently available, and the factors affecting subsequent development...
  13. doi request reprint The Sda/GM2-glycan is a carbohydrate marker of porcine primordial germ cells and of a subpopulation of spermatogonia in cattle, pigs, horses and llama
    K Klisch
    School of Veterinary Medicine and Science, University of Nottingham, Loughborough LE12 5RD, UK
    Reproduction 142:667-74. 2011
    ..Owing to the narrower specificity of the CT1 antibody, compared with DBA, the former is likely to be a useful tool for labelling and isolation of these cells...
  14. ncbi request reprint Cloning: eight years after Dolly
    K H S Campbell
    Animal Development and Biotechnology Group, Division of Animal Physiology, University of Nottingham, School of Biosciences, Sutton Bonington, Loughborough, Leics LE12 5RD, UK
    Reprod Domest Anim 40:256-68. 2005
    ..In particular, we will review the major steps in the procedure and discuss studies from our laboratory and others which have modified the procedure in ways which may impact on development...
  15. ncbi request reprint Differential staining combined with TUNEL labelling to detect apoptosis in preimplantation bovine embryos
    A A Fouladi-Nashta
    School of Biosciences, The University of Nottingham, LE12 5RD, UK
    Reprod Biomed Online 10:497-502. 2005
    ..DST provides a means of assessing the effect of culture conditions on cell number of both embryo compartments (ICM and TE), as well as providing information on the localization of apoptotic nuclei within the blastocyst...
  16. ncbi request reprint Reprogramming the genome: role of the cell cycle
    K H S Campbell
    University of Nottingham, School of Biosciences, Sutton Bonington, Loughbrough, Leicestershire LE12 5RD, UK
    Reprod Suppl 61:477-94. 2003
    ..This paper reviews some of the information currently available and proposes that consideration of the cell cycle may lead to improvement of methods for embryo reconstruction...
  17. ncbi request reprint Epigenetic marks in somatic chromatin are remodelled to resemble pluripotent nuclei by amphibian oocyte extracts
    Yuhong Bian
    Division of Animal Sciences, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, UK
    Epigenetics 4:194-202. 2009
    ..The results demonstrate that axolotl oocyte extracts are a useful tool for studying epigenetic remodelling of somatic cells to a stem cell configuration, and for elucidating oocyte specific mechanisms of nuclear reprogramming...
  18. pmc Axolotl Nanog activity in mouse embryonic stem cells demonstrates that ground state pluripotency is conserved from urodele amphibians to mammals
    James E Dixon
    Institute of Genetics, School of Biology, University of Nottingham, Queens Medical Centre, Nottingham NG2 2UH, UK
    Development 137:2973-80. 2010
    ..Our results show that protein interactions mediated by Nanog dimerization promote proliferation. More importantly, they demonstrate that the mechanisms governing pluripotency are conserved from urodele amphibians to mammals...
  19. ncbi request reprint The effect of activation of Mammalian oocytes on remodeling of donor nuclei after nuclear transfer
    Jan Motlik
    Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Libechov, Czech Republic
    Cloning Stem Cells 4:245-52. 2002
    ..Analysis of two-cell embryos with DNA probes for chromosome 6, 7, and 15 by fluorescence in situ hybridization showed that at least 50% of NT embryos were of normal ploidy, independent of the activation protocol...
  20. pmc Contrasting effects of in vitro fertilization and nuclear transfer on the expression of mtDNA replication factors
    Emma J Bowles
    The Mitochondrial and Reproductive Genetics Group, The Medical School, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Genetics 176:1511-26. 2007
    ..However, the vast majority of these embryos were homoplasmic for recipient oocyte mtDNA. The upreglation in mtDNA replication factors was most likely due to the donor cells still expressing these factors prior to NT...