Charalambos Antoniades

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi request reprint Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress
    Marios Margaritis
    Cardiovascular Medicine Division, University of Oxford, John Radcliffe Hospital, West Wing L6, Headley Way, Oxford OX3 9DU, UK
    Eur Heart J 38:3094-3104. 2017
  2. doi request reprint A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption
    Regent Lee
    Division of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Clin Proteomics 14:22. 2017
  3. ncbi request reprint Gene delivery strategies targeting stable atheromatous plaque
    Tim Van-Assche
    Applied Veterinary Morphology, Department of Veterinary Medicine, University of Antwerp, Universiteitsplein 1, 2610 Antwerpen, Belgium
    Curr Pharm Des 19:1626-37. 2013
  4. pmc Evaluating oxidative stress in human cardiovascular disease: methodological aspects and considerations
    R Lee
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Curr Med Chem 19:2504-20. 2012
  5. pmc Statins as anti-inflammatory agents in atherogenesis: molecular mechanisms and lessons from the recent clinical trials
    Alexios S Antonopoulos
    Department of Cardiovascular Medicine, University of Oxford, West Wing Level 6, John Radcliffe Hospital, Headley Way, OX3 9DU, Oxford UK
    Curr Pharm Des 18:1519-30. 2012
  6. ncbi request reprint Therapeutic strategies targeting endothelial function in humans: clinical implications
    Regent Lee
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Curr Vasc Pharmacol 10:77-93. 2012
  7. doi request reprint Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Am Coll Cardiol 59:60-70. 2012
  8. doi request reprint Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Circulation 122:S66-73. 2010
  9. doi request reprint Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass grafting
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Cardiol 103:216-20. 2009
  10. ncbi request reprint Relationship between the pharmacokinetics of levosimendan and its effects on cardiovascular system
    Charalambos Antoniades
    1st Cardiology Department, Athens University Medical School, Athens Greece
    Curr Drug Metab 10:95-103. 2009

Collaborators

Detail Information

Publications87

  1. doi request reprint Predictive value of telomere length on outcome following acute myocardial infarction: evidence for contrasting effects of vascular vs. blood oxidative stress
    Marios Margaritis
    Cardiovascular Medicine Division, University of Oxford, John Radcliffe Hospital, West Wing L6, Headley Way, Oxford OX3 9DU, UK
    Eur Heart J 38:3094-3104. 2017
    ..We explore the value of blood (BTL) and vascular TL (VTL) as biomarkers of systemic/vascular oxidative stress in humans and test the clinical predictive value of BTL in acute myocardial infarction (AMI)...
  2. doi request reprint A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption
    Regent Lee
    Division of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Clin Proteomics 14:22. 2017
    ....
  3. ncbi request reprint Gene delivery strategies targeting stable atheromatous plaque
    Tim Van-Assche
    Applied Veterinary Morphology, Department of Veterinary Medicine, University of Antwerp, Universiteitsplein 1, 2610 Antwerpen, Belgium
    Curr Pharm Des 19:1626-37. 2013
    ....
  4. pmc Evaluating oxidative stress in human cardiovascular disease: methodological aspects and considerations
    R Lee
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Curr Med Chem 19:2504-20. 2012
    ..Measurement of vascular oxidative stress status is still the only reliable way to evaluate the involvement of oxidative stress in atherogenesis...
  5. pmc Statins as anti-inflammatory agents in atherogenesis: molecular mechanisms and lessons from the recent clinical trials
    Alexios S Antonopoulos
    Department of Cardiovascular Medicine, University of Oxford, West Wing Level 6, John Radcliffe Hospital, Headley Way, OX3 9DU, Oxford UK
    Curr Pharm Des 18:1519-30. 2012
    ..Lastly, the controversy of the recent large randomized clinical trials and the issue of statin withdrawal are also discussed...
  6. ncbi request reprint Therapeutic strategies targeting endothelial function in humans: clinical implications
    Regent Lee
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Curr Vasc Pharmacol 10:77-93. 2012
    ..Evidence for the benefits of gene therapy to improve endothelial function is also emerging. However, the long term direct clinical benefit of these strategies aimed to improve endothelial function still remains unclear...
  7. doi request reprint Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Am Coll Cardiol 59:60-70. 2012
    ..The purpose of this study was to evaluate the role of the myocardial redox state in the development of in-hospital complications after cardiac surgery and the effect of statins on the myocardial redox state...
  8. doi request reprint Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Circulation 122:S66-73. 2010
    ..We hypothesized that short-term treatment with atorvastatin before CABG would improve the redox state in saphenous vein grafts (SVGs), independently of low-density lipoprotein cholesterol (LDL)-lowering...
  9. doi request reprint Relation of preoperative radial artery flow-mediated dilatation to nitric oxide bioavailability in radial artery grafts used in off-pump coronary artery bypass grafting
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Cardiol 103:216-20. 2009
    ..These differences are present and can be identified preoperatively by FMD...
  10. ncbi request reprint Relationship between the pharmacokinetics of levosimendan and its effects on cardiovascular system
    Charalambos Antoniades
    1st Cardiology Department, Athens University Medical School, Athens Greece
    Curr Drug Metab 10:95-103. 2009
    ..In this review article we provide a pharmacokinetic approach for the use of levosimendan in cardiovascular system by discussing its metabolism and mainly the pharmacology of its active metabolites in humans...
  11. ncbi request reprint Nanoparticles: a promising therapeutic approach in atherosclerosis
    Charalambos Antoniades
    Cardiology Department, Athens University Medical School, Greece
    Curr Drug Deliv 7:303-11. 2010
    ..We also discuss their advantages and we expose the existing toxicity issues, making it clear however, that the use of nanoparticles is one of the most promising therapeutic strategies against atherosclerosis...
  12. ncbi request reprint Gene therapy targeting inflammation in atherosclerosis
    Tim Van-Assche
    Laboratory of Microbiology, Parasitology and Hygiene, Department of Pharmacology, University of Antwerp, Belgium
    Curr Pharm Des 17:4210-23. 2011
    ....
  13. doi request reprint Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia
    Marietta Charakida
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 204:532-7. 2009
    ..However, it is unknown whether these abnormalities present in FH children and contribute to their vascular dysfunction...
  14. ncbi request reprint Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis
    Charalambos Antoniades
    A Cardiology Department, Athens University Medical School, Athens, Greece
    Clin Cardiol 30:295-300. 2007
    ..Type 2 diabetes mellitus (T2DM) is characterized by endothelial dysfunction, increased thrombogenicity and abnormal inflammatory response...
  15. ncbi request reprint Methionine-loading rapidly impairs endothelial function, by mechanisms independent of endothelin-1: evidence for an association of fasting total homocysteine with plasma endothelin-1 levels
    Dimitris Tousoulis
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Nutr 27:379-86. 2008
    ..We also examined the role of endothelin-1 (ET-1) in the development of endothelial dysfunction in these two conditions...
  16. ncbi request reprint Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, A Cardiology Department, Greece
    Eur J Heart Fail 7:1126-32. 2005
    ..Both statins and vitamin E separately improve endothelial function in patients with hypercholesterolemia and/or advanced atherosclerosis...
  17. ncbi request reprint Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals
    Gerasimos Siasos
    Athens University Medical School, 1st Cardiology Department, Greece
    Int J Cardiol 126:394-9. 2008
    ..Aim of the present study was to investigate in healthy smokers the effect of a short-term daily L-arginine administration on vascular function...
  18. doi request reprint Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarctation of aorta: a randomized cross-over study
    Stella Brili
    First Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 51:742-9. 2008
    ..The purpose of this study was to evaluate the effect of ramipril on endothelial function and inflammatory process in a group of normotensive subjects with successfully repaired coarctation of the aorta (SCR)...
  19. doi request reprint Acute effects of different alcoholic beverages on vascular endothelium, inflammatory markers and thrombosis fibrinolysis system
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, S Karagiorga Street 69, 166 75 Glifada, Athens, Greece
    Clin Nutr 27:594-600. 2008
    ..We compared the acute effects of several alcoholic beverages on endothelial function, inflammatory process and thrombosis/fibrinolysis system in young adults...
  20. ncbi request reprint Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: effect of oxidative stress and proinflammatory cytokines
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    Am J Clin Nutr 84:781-8. 2006
    ..Homocystinemia is a metabolic abnormality associated with endothelial dysfunction and increased cardiovascular disease risk. The underlying mechanisms of these effects, however, are obscure...
  21. doi request reprint MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Circulation 119:2507-15. 2009
    ..We sought to distinguish the effects of plasma versus vascular tissue 5-MTHF and homocysteine on vascular redox and endothelial nitric oxide bioavailability in human vessels...
  22. doi request reprint Oxidative stress and inflammatory process in patients with atrial fibrillation: the role of left atrium distension
    Dimitris Tousoulis
    1st Cardiology Department, University of Athens, Medical School, Athens, Greece
    Int J Cardiol 136:258-62. 2009
    ..We searched for clinical determinants of oxidative stress status, endothelial function and inflammatory process in patients with chronic atrial fibrillation...
  23. doi request reprint The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance
    Gerasimos Siasos
    Department of Biological Chemistry, Athens University Medical School, Athens, Greece
    Am J Hypertens 22:586-92. 2009
    ..We investigated the effect of L-arginine on vascular function and inflammatory process in healthy smokers at rest and after acute smoking...
  24. doi request reprint Methionine-induced homocysteinemia impairs endothelial function in hypertensives: the role of asymmetrical dimethylarginine and antioxidant vitamins
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Am J Hypertens 24:936-42. 2011
    ..However, the mechanisms regulating ADMA synthesis in hypertension are unclear...
  25. ncbi request reprint Effects of lipid profile on forearm hyperemic response in young subjects
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    Hellenic J Cardiol 47:152-7. 2006
    ..In the present study we examined the effect of lipid profile on forearm vasodilatory response to reactive hyperemia, an index of endothelial function, in a cohort of young, low-risk adults...
  26. doi request reprint Preoperative sCD40L levels predict risk of atrial fibrillation after off-pump coronary artery bypass graft surgery
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, UK
    Circulation 120:S170-6. 2009
    ..Furthermore, we studied the role of inflammation, endothelial function, and redox state in this relation...
  27. pmc Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital OX3 9DU, Oxford, UK
    Circulation 124:335-45. 2011
    ..We examined the direct effects of atorvastatin on tetrahydrobiopterin-mediated endothelial nitric oxide (NO) synthase coupling in patients with coronary artery disease...
  28. ncbi request reprint Combined effects of smoking and hypercholesterolemia on inflammatory process, thrombosis/fibrinolysis system, and forearm hyperemic response
    Charalambos Antoniades
    Department of Cardiology, Athens University Medical School, Athens, Greece
    Am J Cardiol 94:1181-4. 2004
    ..01 for all). This phenomenon was associated with a respective increase in the inflammatory process and changes in the thrombosis/fibrinolysis system...
  29. doi request reprint Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Eur Heart J 30:1142-50. 2009
    ..However, the mechanisms relating ADMA with vascular function have been evaluated in vitro and in animal models, but its effect in human vasculature is unclear...
  30. doi request reprint Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 149:46-9. 2011
    ..We examined the effect of combined therapy with atorvastatin and metformin on glucose-induced variations of inflammatory molecules in patients with newly diagnosed diabetes mellitus type 2 (DM)...
  31. ncbi request reprint Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Glifada, Athens, Greece
    Atherosclerosis 170:261-7. 2003
    ....
  32. doi request reprint Impact of 6 weeks of treatment with low-dose metformin and atorvastatin on glucose-induced changes of endothelial function in adults with newly diagnosed type 2 diabetes mellitus: A single-blind study
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Greece
    Clin Ther 32:1720-8. 2010
    ..Endothelium-dependent dilation (EDD) measured by gauge-strain plethysmography in the forearm is considered to be a reliable marker of endothelial function in forearm resistance vessels...
  33. doi request reprint Combined effects of fibrinogen genetic variability on atherosclerosis in patients with or without stable angina pectoris: focus on the coagulation cascade and endothelial function
    Nikolaos Papageorgiou
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Greece
    Int J Cardiol 168:4602-7. 2013
    ..We examined the combined effects of the G455A and the G58A fibrinogen genetic polymorphisms on prothrombotic profile, endothelial function and the risk of CAD in a Caucasian population...
  34. doi request reprint Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels
    Marios Margaritis
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Circulation 127:2209-21. 2013
    ..Adiponectin is an adipokine with potentially important roles in human cardiovascular disease states. We studied the role of adiponectin in the cross-talk between adipose tissue and vascular redox state in patients with atherosclerosis...
  35. doi request reprint Association of arterial stiffness with the angiotensin-converting enzyme gene polymorphism in healthy individuals
    Ioanna Dima
    Peripheral Vessels Unit, 1st Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece
    Am J Hypertens 21:1354-8. 2008
    ..However, the relationship between ACE polymorphism, arterial stiffness, and wave reflections in healthy, low-risk population has not been defined yet...
  36. ncbi request reprint Genetic polymorphism on endothelial nitric oxide synthase affects endothelial activation and inflammatory response during the acute phase of myocardial infarction
    Charalambos Antoniades
    Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 46:1101-9. 2005
    ....
  37. ncbi request reprint Novel therapies targeting vascular endothelium
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Endothelium 13:411-21. 2006
    ..Although there are a variety of strategies to improve NO bioavailability in human endothelium, it is still unclear whether they have any direct benefit at a clinical level...
  38. ncbi request reprint Genetic polymorphisms G894T on the eNOS gene is associated with endothelial function and vWF levels in premature myocardial infarction survivors
    Charalambos Antoniades
    Athens University Medical School, A Cardiology Department, Hippokration Hospital, S Karagiorga Street 69, 166 75, Glifada, Athens, Greece
    Int J Cardiol 107:95-100. 2006
    ....
  39. ncbi request reprint The impact of early administration of low-dose atorvastatin treatment on inflammatory process, in patients with unstable angina and low cholesterol level
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 109:48-52. 2006
    ..In this study we assessed the effects of low-dose atorvastatin treatment, on inflammatory process in patients admitted for unstable angina with low cholesterol level...
  40. ncbi request reprint Novel therapeutic strategies targeting vascular redox in human atherosclerosis
    Alexis S Antonopoulos
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Recent Pat Cardiovasc Drug Discov 4:76-87. 2009
    ....
  41. ncbi request reprint Effects of atorvastatin on reactive hyperemia and inflammatory process in patients with congestive heart failure
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Athens, Greece
    Atherosclerosis 178:359-63. 2005
    ..These findings indicate that atorvastatin may improve forearm vasodilatory response to reactive hyperemia and depress inflammatory process in patients with heart failure and normal baseline cholesterol levels...
  42. ncbi request reprint Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease
    Cheerag Shirodaria
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    Circulation 115:2262-70. 2007
    ..We compared the effects of folic acid on human vessels using pharmacological high-dose versus low-dose treatment, equivalent to dietary folate fortification...
  43. ncbi request reprint Novel therapeutic approaches targeting matrix metalloproteinases in cardiovascular disease
    Alexandros Briasoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Greece
    Curr Top Med Chem 12:1214-21. 2012
    ..This review discusses pharmacological approaches to MMP inhibition...
  44. doi request reprint Translating the effects of statins: from redox regulation to suppression of vascular wall inflammation
    Alexios S Antonopoulos
    Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
    Thromb Haemost 108:840-8. 2012
    ....
  45. doi request reprint Early diagnosis of perioperative myocardial infarction after coronary bypass grafting: a study using biomarkers and cardiac magnetic resonance imaging
    Chris C S Lim
    Oxford Heart Centre, John Radcliffe Hospital, Oxford, United Kingdom
    Ann Thorac Surg 92:2046-53. 2011
    ..This study characterized early changes in biomarkers after revascularization injury during on-pump CABG...
  46. ncbi request reprint Effects of early administration of atorvastatin treatment on thrombotic process in normocholesterolemic patients with unstable angina
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 106:333-7. 2006
    ..We assessed the effects of short-term atorvastatin treatment on thrombotic/fibrinolysis markers in normocholesterolemic in patients with unstable angina...
  47. ncbi request reprint Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major
    Constadina Aggeli
    Athens University Medical School, A Cardiology Department, Hippokration Hospital, Greece
    Int J Cardiol 105:80-4. 2005
    ..We examined endothelial function and serum levels of inflammatory mediators in transfusion-dependent patients with beta-thalassemia major...
  48. doi request reprint Role of inflammation and oxidative stress in endothelial progenitor cell function and mobilization: therapeutic implications for cardiovascular diseases
    Dimitris Tousoulis
    A Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Atherosclerosis 201:236-47. 2008
    ....
  49. doi request reprint Acute effects of different types of oil consumption on endothelial function, oxidative stress status and vascular inflammation in healthy volunteers
    Dimitris Tousoulis
    Hippokration Hospital, Athens University Medical School, Athens, Greece
    Br J Nutr 103:43-9. 2010
    ..However, all types of oils did not affect inflammatory process and systemic oxidative stress, suggesting that their effect on endothelial function may not be mediated by free radicals bioavailability...
  50. pmc GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function
    Charalambos Antoniades
    Department of Cardiovascular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Am Coll Cardiol 52:158-65. 2008
    ....
  51. doi request reprint Antidepressive treatment as a modulator of inflammatory process in patients with heart failure: effects on proinflammatory cytokines and acute phase protein levels
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    Int J Cardiol 134:238-43. 2009
    ..In the present study we evaluated the impact of antidepressive medication on the expression of proinflammatory cytokines and acute phase response proteins, in patients with HF and major depression...
  52. ncbi request reprint Oxidative stress, antioxidant vitamins, and atherosclerosis. From basic research to clinical practice
    Charalambos Antoniades
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Herz 28:628-38. 2003
    ..New antioxidant strategies are needed to clarify the exact role of antioxidant treatment in coronary atherosclerosis...
  53. ncbi request reprint Pathophysiology of atherosclerosis: the role of inflammation
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Pharm Des 17:4089-110. 2011
    ..The main drug categories that have been proved to ameliorate the inflammatory state in atherosclerosis are angiotensin converting enzyme inhibitors/angiotensin receptors blockers, statins, and antioxidants...
  54. ncbi request reprint Levosimendan: beyond its simple inotropic effect in heart failure
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Pharmacol Ther 114:184-97. 2007
    ....
  55. ncbi request reprint Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675, Glifada, Athens, Greece
    Int J Cardiol 115:203-7. 2007
    ..However, the underlying mechanisms of the acute coronary syndromes are still obscure. We evaluated the differences of inflammatory and thrombotic markers, at the acute phase of unstable angina (UA) and acute myocardial infarction (AMI)...
  56. ncbi request reprint Long-term effects of levosimendan infusion on inflammatory processes and sFas in patients with severe heart failure
    Athanasios Trikas
    Athens University Medical School, A Cardiology Department, Athens, Greece
    Eur J Heart Fail 8:804-9. 2006
    ..The calcium sensitizer levosimendan improves myocardial contractility in patients with heart failure, although its effects on inflammation and apoptosis are unknown...
  57. ncbi request reprint 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Circulation 114:1193-201. 2006
    ..We hypothesized that 5-MTHF would improve endothelial function by decreasing superoxide and peroxynitrite production and by improving eNOS coupling, mediated by BH4 availability...
  58. doi request reprint Rosuvastatin but not ezetimibe improves endothelial function in patients with heart failure, by mechanisms independent of lipid lowering
    Panagiota Gounari
    1st Cardiology Department, Athens University Medical School, Vasilissis Sofias 114, 115 28, Athens, Greece
    Int J Cardiol 142:87-91. 2010
    ..However, its effect in patients with HF is not well studied. Therefore, in the present study we compared the effect of short-term treatment with rosuvastatin or ezetimibe on endothelial function in patients with HF...
  59. doi request reprint Selective serotonin reuptake inhibitors modify the effect of beta-blockers on long-term survival of patients with end-stage heart failure and major depression
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Athens, Greece
    J Card Fail 14:456-64. 2008
    ..We examined the impact of MD on long-term survival of patients with end-stage severe HF. We also evaluated the interaction between antidepressive medication and beta-blockers on the clinical outcome of these patients...
  60. ncbi request reprint Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Circulation 116:2851-9. 2007
    ..We sought to define the relationships between plasma and vascular biopterin levels in patients with coronary artery disease and to determine how BH4 levels affect endothelial function, eNOS coupling, and vascular superoxide production...
  61. ncbi request reprint Matrix metalloproteinases in acute coronary syndromes: current perspectives
    Anna Maria Kampoli
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Top Med Chem 12:1192-205. 2012
    ....
  62. pmc Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Hedley Way, OX3 9DU, Oxford, UK
    Circulation 124:1860-70. 2011
    ..We hypothesized that induction of BH4 synthesis might be an endothelial defense mechanism against inflammation in vascular disease states...
  63. doi request reprint Comparative effects of rosuvastatin and allopurinol on circulating levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with chronic heart failure
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Int J Cardiol 145:438-43. 2010
    ..In the present study, we sought to compare the effects of statins and xanthine oxidase inhibitors on circulating levels of MMPs and TIMPs in patients with chronic HF...
  64. ncbi request reprint Mechanisms of disease: L-arginine in coronary atherosclerosis--a clinical perspective
    Dimitris Tousoulis
    Athens University Medical School, S Karagiorga 69, Glifada, 16675 Athens, Greece
    Nat Clin Pract Cardiovasc Med 4:274-83. 2007
    ..Here, we present a critique of the existing literature about the role of L-arginine in the prevention of atherosclerosis...
  65. doi request reprint Genetic polymorphism on type 2 receptor of angiotensin II, modifies cardiovascular risk and systemic inflammation in hypertensive males
    Dimitris Tousoulis
    1st Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Am J Hypertens 23:237-42. 2010
    ..We examined the impact of A1675G on the risk and the severity of coronary artery disease (CAD), and the expression of proatherogenic inflammatory molecules in hypertensive patients...
  66. doi request reprint Role of asymmetrical dimethylarginine in inflammation-induced endothelial dysfunction in human atherosclerosis
    Charalambos Antoniades
    1st Cardiology Department, Athens University Medical School, Ileias 8, Gerakas Attikis 153 44, Athens, Greece
    Hypertension 58:93-8. 2011
    ..001). Systemic, low-grade inflammation leads to increased ADMA that may induce endothelial dysfunction. This study demonstrated that ADMA may be a link between inflammation and endothelial dysfunction in humans...
  67. ncbi request reprint Diabetes mellitus as a predictor for radial artery vasoreactivity in patients undergoing coronary artery bypass grafting
    Bikram P Choudhary
    Department of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford, United Kingdom
    J Am Coll Cardiol 50:1047-53. 2007
    ..Our purpose was to examine the impact of diabetes mellitus (DM) on vasoreactivity and endothelial function of radial artery (RA) grafts ex vivo...
  68. ncbi request reprint Common community infections and the risk for coronary artery disease and acute myocardial infarction: evidence for chronic over-expression of tumor necrosis factor alpha and vascular cells adhesion molecule-1
    Aggeliki Nikolopoulou
    Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Int J Cardiol 130:246-50. 2008
    ....
  69. ncbi request reprint Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction
    Charalambos Antoniades
    Athens University Medical School, 1st Cardiology Department, Hippokration Hospital, Athens, Greece
    J Am Coll Cardiol 47:1959-66. 2006
    ....
  70. doi request reprint Fibrinogen and cardiovascular disease: genetics and biomarkers
    Dimitris Tousoulis
    Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece
    Blood Rev 25:239-45. 2011
    ....
  71. doi request reprint Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins
    Svetlana N Reilly
    Department of Cardiovascular Medicine, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Circulation 124:1107-17. 2011
    ..Statins inhibit NOX2-NADPH oxidases and prevent postoperative AF but are less effective in AF secondary prevention; the mechanisms underlying these findings are poorly understood...
  72. ncbi request reprint Vitamin C affects thrombosis/ fibrinolysis system and reactive hyperemia in patients with type 2 diabetes and coronary artery disease
    Dimitris Tousoulis
    Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece
    Diabetes Care 26:2749-53. 2003
    ....
  73. ncbi request reprint L-Arginine, the substrate for NO synthesis: an alternative treatment for premature atherosclerosis?
    Gerasimos Siasos
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, S Karagiorga 69, Glifada, 16 675, Athens, Greece
    Int J Cardiol 116:300-8. 2007
    ..In conclusion, L-arginine administration may be useful in patients with premature atherosclerosis...
  74. ncbi request reprint The failure of immunomodulation therapy in heart failure: does the statins "paradigm" prove the rule?
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Curr Vasc Pharmacol 8:114-21. 2010
    ..Thus, more large scale clinical trials are required to evaluate the impact of statins on immune imbalance and its restoration in patients with CHF...
  75. doi request reprint Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials
    Charalambos Antoniades
    1st Cardiology Department, Athens University Medical School, Ilias, Gerakas Attikis, Athens, Greece
    Eur Heart J 30:6-15. 2009
    ..Finally, we provide clinical recommendations regarding the therapeutic strategies targeting homocysteine in the general population...
  76. pmc Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus
    Justin M S Lee
    Department of Cardiovascular Medicine, University of Oxford, Oxford, UK
    Diab Vasc Dis Res 4:44-8. 2007
    ..MRI provides comprehensive vascular phenotyping in patients with type 2 diabetes and is likely to be useful in studies of disease progression and drug therapy...
  77. ncbi request reprint The oxidative stress menace to coronary vasculature: any place for antioxidants?
    Alexandros Briasoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, 16675, Glifada, Athens, Greece
    Curr Pharm Des 15:3078-90. 2009
    ..New antioxidant strategies are needed to clarify the exact role of antioxidant treatment in coronary atherosclerosis...
  78. doi request reprint Biomarkers of premature atherosclerosis
    Anna Maria Kampoli
    Athens University Medical School, 1 st Cardiology Department, Hippokration Hospital, Athens, Greece
    Trends Mol Med 15:323-32. 2009
    ..Here, we review the roles of specific biomarkers that have been implicated in premature atherosclerosis...
  79. ncbi request reprint Targeting redox signaling in the vascular wall: from basic science to clinical practice
    Charalambos Antoniades
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Curr Pharm Des 15:329-42. 2009
    ..Future studies need to define the key redox sensitive pathways in the vascular wall in order to develop effective therapeutic strategies against atherosclerosis...
  80. doi request reprint Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes
    Dimitris Tousoulis
    1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, 16675 Glifada, Athens, Greece
    Trends Mol Med 14:441-9. 2008
    ..Here, we review the progress of candidate gene studies and genome-wide association studies in identifying the genetic bases of complex cardiovascular diseases such as acute coronary syndromes...
  81. ncbi request reprint Levosimendan: a novel agent in heart failure
    Nikolas Koumallos
    Athens University Medical School, A Cardiology Department, Athens, Greece
    Recent Pat Cardiovasc Drug Discov 1:185-91. 2006
    ....
  82. ncbi request reprint L-arginine in cardiovascular disease: dream or reality?
    Dimitris Tousoulis
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Vasc Med 7:203-11. 2002
    ..However, more data derived from large-scale prospective studies evaluating the effects of long-term treatment with L-arginine are needed...
  83. ncbi request reprint Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers
    Charalambos Antoniades
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece
    Thromb Haemost 89:990-5. 2003
    ..In conclusion, combined administration of vitamin C and vitamin E at high dosages, improved endothelial function and decreased plasma levels of PAI-1, vWF and PAI-1/tPA ratio in chronic smokers...
  84. ncbi request reprint Endothelial function and proinflammatory cytokines in patients with ischemic heart disease and dilated cardiomyopathy
    Costas Tentolouris
    Cardiology Units, Hippokration Hospital, Athens University Medical School, 69 S Karagiorga, 16675 Athens, Greece
    Int J Cardiol 94:301-5. 2004
    ..We compared endothelial function and levels of IL-6 and TNF-alpha between patients with ischemic heart failure, dilated cardiomyopathy, CAD and healthy controls...
  85. ncbi request reprint Potential role of endothelial progenitor cells in the pathophysiology of heart failure: clinical implications and perspectives
    Ioannis Andreou
    Athens University Medical School, A Cardiology Department, Hippokration Hospital, S Karagiorga 69, Glifada 16 675, Athens, Greece
    Atherosclerosis 189:247-54. 2006
    ..However, the exact role of EPCs in heart failure and their potential therapeutic implications still remain to be elucidated...
  86. ncbi request reprint Pro-inflammatory cytokines in acute coronary syndromes: from bench to bedside
    Dimitris Tousoulis
    1st Cardiology Unit, Athens University Medical School, Athens, Greece
    Cytokine Growth Factor Rev 17:225-33. 2006
    ..At a clinical level, circulating cytokines have a prognostic role since they are useful markers predicting future coronary events in patients with advanced atherosclerosis and in patients after ACS...
  87. ncbi request reprint Evidence of vascular dysfunction in young patients with successfully repaired coarctation of aorta
    Stella Brili
    Cardiology Unit, Hippokration Hospital, Athens University Medical School, Vasilissis Sofias 114, 11528 Athens, Greece
    Atherosclerosis 182:97-103. 2005
    ..These results may partly explain the high incidence of coronary artery disease in patients with repaired coarctation of the aorta...